# enzymes

entry: 2.4.1.18
sysname: 1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-alpha-D-(1,4-alpha-D-glucano)-transferase
iubmb_reaction: R02110 R06186(G)
name:
--- 
- 1,4-alpha-glucan branching enzyme
- branching enzyme
- amylo-(1,4->1,6)-transglycosylase
- Q-enzyme
- alpha-glucan-branching glycosyltransferase
- amylose isomerase
- enzymatic branching factor
- branching glycosyltransferase
- enzyme Q
- glucosan transglycosylase
- glycogen branching enzyme
- plant branching enzyme
- alpha-1,4-glucan:alpha-1,4-glucan-6-glycosyltransferase
- starch branching enzyme

comment:
Converts amylose into amylopectin. The accepted name requires a qualification depending on the product, glycogen or amylopectin, e.g. glycogen branching enzyme, amylopectin branching enzyme. The latter has frequently been termed Q-enzyme.

reaction:
Transfers a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain [RN:R02110 R06186]


entry: 2.4.1.19
sysname: 1,4-alpha-D-glucan 4-alpha-D-(1,4-alpha-D-glucano)-transferase (cyclizing)
reaction: Cyclizes part of a 1,4-alpha-D-glucan chain by formation of a 1,4-alpha-D-glucosidic bond
name:
--- 
- cyclomaltodextrin glucanotransferase
- Bacillus macerans amylase
- cyclodextrin glucanotransferase
- alpha-cyclodextrin glucanotransferase
- alpha-cyclodextrin glycosyltransferase
- beta-cyclodextrin glucanotransferase
- beta-cyclodextrin glycosyltransferase
- gamma-cyclodextrin glycosyltransferase
- cyclodextrin glycosyltransferase
- cyclomaltodextrin glucotransferase
- cyclomaltodextrin glycosyltransferase
- konchizaimu
- alpha-1,4-glucan 4-glycosyltransferase, cyclizing
- BMA
- CGTase
- neutral-cyclodextrin glycosyltransferase

comment:
Cyclomaltodextrins (Schardinger dextrins) of various sizes (6,7,8, etc. glucose units) are formed reversibly from starch and similar substrates. Will also disproportionate linear maltodextrins without cyclizing (cf. EC 2.4.1.25, 4-alpha-glucanotransferase).


entry: 2.4.1.21
sysname: ADP-glucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase
reaction: ADP-glucose + (1,4-alpha-D-glucosyl)n = ADP + (1,4-alpha-D-glucosyl)(n+1) [RN:R02421 R06049]
iubmb_reaction: R02421 R06049(G)
name:
--- 
- starch synthase
- ADP-glucose-starch glucosyltransferase
- adenosine diphosphate glucose-starch glucosyltransferase
- adenosine diphosphoglucose-starch glucosyltransferase
- ADP-glucose starch synthase
- ADP-glucose synthase
- ADP-glucose transglucosylase
- ADPG starch synthetase
- ADPG-starch glucosyltransferase
- starch synthetase

comment:
The accepted name varies according to the source of the enzyme and the nature of its synthetic product, e.g. starch synthase, bacterial glycogen synthase. Similar to EC 2.4.1.11 [glycogen(starch) synthase] but the preferred or mandatory nucleoside diphosphate sugar substrate is ADP-glucose. The entry covers starch and glycogen synthases utilizing ADP-glucose.


entry: 2.4.1.22
sysname: UDP-galactose:D-glucose 4-beta-D-galactosyltransferase
reaction: UDP-galactose + D-glucose = UDP + lactose [RN:R00503 R06067]
iubmb_reaction: R00503 R06067(G)
name:
--- 
- lactose synthase
- UDP-galactose-glucose galactosyltransferase
- N-acetyllactosamine synthase
- uridine diphosphogalactose-glucose galactosyltransferase
- lactose synthetase
- UDP-galactose:D-glucose 4-beta-D-galactotransferase

comment:
The enzyme is a complex of two proteins, A and B. In the absence of the B protein (alpha-lactalbumin), the enzyme catalyses the transfer of galactose from UDP-galactose to N-acetylglucosamine (EC 2.4.1.90 N-acetyllactosamine synthase).


entry: 2.4.1.23
sysname: UDP-galactose:sphingosine 1-beta-galactosyltransferase
reaction: UDP-galactose + sphingosine = UDP + psychosine [RN:R01928]
iubmb_reaction: R01928
name:
--- 
- sphingosine beta-galactosyltransferase
- psychosine-UDP galactosyltransferase
- galactosyl-sphingosine transferase
- psychosine-uridine diphosphate galactosyltransferase
- UDP-galactose:sphingosine O-galactosyl transferase
- uridine diphosphogalactose-sphingosine beta-galactosyltransferase
- UDP-galactose:sphingosine 1-beta-galactotransferase


entry: 2.4.1.24
sysname: 1,4-alpha-D-glucan:1,4-alpha-D-glucan(D-glucose) 6-alpha-D-glucosyltransferase
name:
--- 
- 1,4-alpha-glucan 6-alpha-glucosyltransferase
- oligoglucan-branching glycosyltransferase
- 1,4-alpha-D-glucan 6-alpha-D-glucosyltransferase
- T-enzyme
- D-glucosyltransferase

reaction:
Transfers an alpha-D-glucosyl residue in a 1,4-alpha-D-glucan to the primary hydroxy group of glucose, free or combined in a 1,4-alpha-D-glucan


entry: 2.4.1.25
sysname: 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase
iubmb_reaction: (other) R05196 R06069(G)
kegg_reaction: R05196 R06069(G)
name:
--- 
- 4-alpha-glucanotransferase
- disproportionating enzyme
- dextrin glycosyltransferase
- D-enzyme
- debranching enzyme maltodextrin glycosyltransferase
- amylomaltase
- dextrin transglycosylase

comment:
This entry covers the former separate entry for EC 2.4.1.3 (amylomaltase). The plant enzyme has been termed D-enzyme. An enzymic activity of this nature forms part of the mammalian and yeast glycogen debranching system (see EC 3.2.1.33 amylo-alpha-1,6-glucosidase).

reaction:
Transfers a segment of a 1,4-alpha-D-glucan to a new position in an acceptor, which may be glucose or a 1,4-alpha-D-glucan


entry: 2.4.1.26
sysname: UDP-glucose:DNA alpha-D-glucosyltransferase
reaction: Transfers an alpha-D-glucosyl residue from UDP-glucose to an hydroxymethylcytosine residue in DNA
name:
--- 
- DNA alpha-glucosyltransferase
- uridine diphosphoglucose-deoxyribonucleate alpha-glucosyltransferase
- UDP-glucose-DNA alpha-glucosyltransferase
- T2-HMC-alpha-glucosyl transferase
- T4-HMC-alpha-glucosyl transferase
- T6-HMC-alpha-glucosyl transferase


entry: 2.4.1.27
sysname: UDP-glucose:DNA beta-D-glucosyltransferase
reaction: Transfers a beta-D-glucosyl residue from UDP-glucose to an hydroxymethylcytosine residue in DNA
name:
--- 
- DNA beta-glucosyltransferase
- T4-HMC-beta-glucosyl transferase
- T4-beta-glucosyl transferase
- T4 phage beta-glucosyltransferase
- UDP glucose-DNA beta-glucosyltransferase
- uridine diphosphoglucose-deoxyribonucleate beta-glucosyltransferase


entry: 2.4.1.28
sysname: UDP-glucose:D-glucosyl-DNA beta-D-glucosyltransferase
name:
--- 
- glucosyl-DNA beta-glucosyltransferase
- T6-glucosyl-HMC-beta-glucosyl transferase
- T6-beta-glucosyl transferase
- uridine diphosphoglucose-glucosyldeoxyribonucleate beta-glucosyltransferase

reaction:
Transfers a beta-D-glucosyl residue from UDP-glucose to a glucosylhydroxymethylcytosine residue in DNA


entry: 2.4.1.29
sysname: GDP-glucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase
reaction: GDP-glucose + (1,4-beta-D-glucosyl)n = GDP + (1,4-beta-D-glucosyl)(n+1) [RN:R02890 R06030]
iubmb_reaction: R02890 R06030(G)
name:
--- 
- cellulose synthase (GDP-forming)
- cellulose synthase (guanosine diphosphate-forming)
- cellulose synthetase
- guanosine diphosphoglucose-1,4-beta-glucan glucosyltransferase
- guanosine diphosphoglucose-cellulose glucosyltransferase

comment:
Involved in the synthesis of cellulose. A similar enzyme [EC 2.4.1.12, cellulose synthase (UDP-forming)] utilizes UDP-glucose.


entry: 2.4.1.30
sysname: 1,3-beta-D-oligoglucan:phosphate alpha-D-glucosyltransferase
iubmb_reaction: R03116 R06018(G)
name:
--- 
- 1,3-beta-oligoglucan phosphorylase
- beta-1,3-oligoglucan:orthophosphate glucosyltransferase II
- beta-1,3-oligoglucan phosphorylase

comment:
Does not act on laminarin. Differs in specificity from EC 2.4.1.31 (laminaribiose phosphorylase) and EC 2.4.1.97 (1,3-beta-D-glucan phosphorylase).

reaction:
(1,3-beta-D-glucosyl)n + phosphate = (1,3-beta-D-glucosyl)(n-1) + alpha-D-glucose 1-phosphate [RN:R03116 R06018]


entry: 2.4.1.31
name: --- - laminaribiose phosphorylase
sysname: 3-beta-D-glucosyl-D-glucose:phosphate alpha-D-glucosyltransferase
iubmb_reaction: R00953 R06058(G)
comment:
Also acts on 1,3-beta-D-oligoglucans. Differs in specificity from EC 2.4.1.30 (1,3-beta-oligoglucan phosphorylase) and EC 2.4.1.97 (1,3-beta-D-glucan phosphorylase).

reaction:
3-beta-D-glucosyl-D-glucose + phosphate = D-glucose + alpha-D-glucose 1-phosphate [RN:R00953 R06058]


entry: 2.4.1.32
sysname: GDPmannose:glucomannan 1,4-beta-D-mannosyltransferase
reaction: GDP-mannose + (glucomannan)n = GDP + (glucomannan)(n+1) [RN:R03829]
iubmb_reaction: R03829
name:
--- 
- glucomannan 4-beta-mannosyltransferase
- GDP-man-beta-mannan manosyltransferase
- glucomannan-synthase


entry: 2.4.1.34
sysname: UDP-glucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase
reaction: UDP-glucose + (1,3-beta-D-glucosyl)n = UDP + (1,3-beta-D-glucosyl)(n+1) [RN:R03118 R06020]
iubmb_reaction: R03118 R06020(G)
name:
--- 
- 1,3-beta-glucan synthase
- 1,3-beta-D-glucan-UDP glucosyltransferase
- UDP-glucose-1,3-beta-D-glucan glucosyltransferase
- callose synthetase
- paramylon synthetase
- UDP-glucose-beta-glucan glucosyltransferase
- GS-II
- (1,3)-beta-glucan (callose) synthase
- beta-1,3-glucan synthase
- beta-1,3-glucan synthetase
- 1,3-beta-D-glucan synthetase
- 1,3-beta-D-glucan synthase
- 1,3-beta-glucan-uridine diphosphoglucosyltransferase
- callose synthase
- UDP-glucose-1,3-beta-glucan glucosyltransferase
- UDP-glucose:(1,3)beta-glucan synthase
- uridine diphosphoglucose-1,3-beta-glucan glucosyltransferase


entry: 2.4.1.35
sysname: UDP-glucose:phenol beta-D-glucosyltransferase
comment: Acts on a wide range of phenols.
reaction: UDP-glucose + a phenol = UDP + an aryl beta-D-glucoside
iubmb_reaction: (other) R01240 R03526
kegg_reaction: R01240 R03526
name:
--- 
- phenol beta-glucosyltransferase
- UDPglucosyltransferase
- phenol-beta-D-glucosyltransferase
- UDP glucosyltransferase
- UDP-glucose glucosyltransferase
- uridine diphosphoglucosyltransferase


entry: 2.4.1.36
sysname: GDP-glucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase
comment: See also EC 2.4.1.15 [alpha,alpha-trehalose-phosphate synthase (UDP-forming)].
reaction: GDP-glucose + glucose 6-phosphate = GDP + alpha,alpha-trehalose 6-phosphate [RN:R02168 R06125]
iubmb_reaction: R02168 R06125(G)
name:
--- 
- alpha,alpha-trehalose-phosphate synthase (GDP-forming)
- GDP-glucose-glucose-phosphate glucosyltransferase
- guanosine diphosphoglucose-glucose phosphate glucosyltransferase
- trehalose phosphate synthase (GDP-forming)


entry: 2.4.1.37
sysname: UDP-galactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase
comment: Acts on blood group substance, and can use a number of 2-fucosyl-galactosides as acceptors.
iubmb_reaction: R04548 > R06029(G) R06168(G) R06190(G)
name:
--- 
- fucosylgalactoside 3-alpha-galactosyltransferase
- UDP-galactose:O-alpha-L-fucosyl(1->2)D-galactose alpha-D-galactosyltransferase
- UDPgalactose:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-alpha-D-galactosyltransferase
- "[blood group substance] alpha-galactosyltransferase"
- blood-group substance B-dependent galactosyltransferase
- glycoprotein-fucosylgalactoside alpha-galactosyltransferase
- histo-blood group B transferase
- histo-blood substance B-dependent galactosyltransferase

reaction:
(1) UDP-galactose + alpha-L-fucosyl-(1->2)-D-galactosyl-R = UDP + alpha-D-galactosyl-(1->3)-[alpha-L-fucosyl(1->2)]-D-galactosyl-R [RN:R04548]; (2) where R can be OH, an oligosaccharide or a glycoconjugate


entry: 2.4.1.38
sysname: UDP-galactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase
iubmb_reaction: R04495 > R05989(G)
name:
--- 
- beta-N-acetylglucosaminyl-glycopeptide beta-1,4-galactosyltransferase
- UDP-galactose-glycoprotein galactosyltransferase
- glycoprotein 4-beta-galactosyl-transferase
- beta-N-acetyl-beta1-4-galactosyltransferase
- thyroid glycoprotein beta-galactosyltransferase
- glycoprotein beta-galactosyltransferase
- thyroid galactosyltransferase
- uridine diphosphogalactose-glycoprotein galactosyltransferase

comment:
Terminal N-acetyl-beta-D-glucosaminyl residues in polysaccharides, glycoproteins and glycopeptides can act as acceptor. High activity is shown towards such residues in branched-chain polysaccharides when these are linked by beta-1,6-links to galactose residues; lower activity towards residues linked to galactose by beta-1,3-links. A component of EC 2.4.1.22 (lactose synthase).

reaction:
UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminylglycopeptide [RN:R04495]


entry: 2.4.1.39
iubmb_reaction: R04451
name:
--- 
- steroid N-acetylglucosaminyltransferase
- hydroxy steroid acetylglucosaminyltransferase
- steroid acetylglucosaminyltransferase
- uridine diphosphoacetylglucosamine-steroid acetylglucosaminyltransferase

sysname:
UDP-N-acetyl-D-glucosamine:estradiol-17alpha-3-D-glucuronoside 17alpha-N-acetylglucosaminyltransferase

reaction:
UDP-N-acetyl-D-glucosamine + estradiol-17alpha 3-D-glucuronoside = UDP + 17alpha-(N-acetyl-D-glucosaminyl)-estradiol 3-D-glucuronoside [RN:R04451]


entry: 2.4.1.40
comment: acts on blood group substance, and can use a number of 2-fucosyl-galactosides as acceptors.
iubmb_reaction: R04423
kegg_reaction: R06167(G) R06187(G) R06191(G) R06193(G) R06197(G)
name:
--- 
- glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase
- A-transferase
- histo-blood group A glycosyltransferase (Fucalpha1->2Galalpha1->3-N-acetylgalactosaminyltransferase)
- UDP-GalNAc:Fucalpha1->2Galalpha1->3-N- acetylgalactosaminyltransferase
- alpha-3-N-acetylgalactosaminyltransferase
- blood-group substance alpha-acetyltransferase
- blood-group substance A-dependent acetylgalactosaminyltransferase
- fucosylgalactose acetylgalactosaminyltransferase
- histo-blood group A acetylgalactosaminyltransferase
- histo-blood group A transferase
- UDP-N-acetyl-D-galactosamine:alpha-L-fucosyl-1,2-D-galactose 3-N-acetyl-D-galactosaminyltransferase

sysname:
UDP-N-acetyl-D-galactosamine:glycoprotein-alpha-L-fucosyl-(1,2)-D-ga lactose 3-N-acetyl-D-galactosaminyltransferase

reaction:
UDP-N-acetyl-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)-[alpha-L-fucosyl- (1,2)]-D-galactose [RN:R04423]


entry: 2.4.1.41
sysname: UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyl-transferase
iubmb_reaction: R02183 > R05907(G)
name:
--- 
- polypeptide N-acetylgalactosaminyltransferase
- protein-UDP acetylgalactosaminyltransferase
- UDP-GalNAc:polypeptide N-acetylgalactosaminyl transferase
- UDP-N-acetylgalactosamine:kappa-casein polypeptide N-acetylgalactosaminyltransferase
- uridine diphosphoacetylgalactosamine-glycoprotein acetylgalactosaminyltransferase
- glycoprotein acetylgalactosaminyltransferase
- polypeptide-N-acetylgalactosamine transferase
- UDP-acetylgalactosamine-glycoprotein acetylgalactosaminyltransferase
- UDP-acetylgalactosamine:peptide-N-galactosaminyltransferase
- UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase
- UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase
- UDP-N-acetylgalactosamine-glycoprotein N-acetylgalactosaminyltransferase
- UDP-N-acetylgalactosamine-protein N-acetylgalactosaminyltransferase
- UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase
- UDP-N-acetylgalactosamine:protein N-acetylgalactosaminyl transferase

comment:
Requires both Mn2+ and Ca2+. The glycosyl residue is transferred to threonine or serine hydroxy groups on the polypeptide core of submaxillary mucin, kappa-casein, apofetuin and some other acceptors of high molecular mass.

reaction:
UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide [RN:R02183]


entry: 2.4.1.42
name: --- - Deleted entry
comment:
Deleted entry: UDP-glucuronate-estriol 17beta-D-glucuronosyltransferase. Now included with EC 2.4.1.17 UDP-glucuronosyltransferase (EC 2.4.1.42 created 1972, deleted 1984)


entry: 2.4.1.43
sysname: UDP-D-galacturonate:1,4-alpha-poly-D-galacturonate 4-alpha-D-galacturonosyltransferase
iubmb_reaction: R04343 R06072(G)
kegg_reaction: R05191 R06278(G)
name:
--- 
- polygalacturonate 4-alpha-galacturonosyltransferase
- UDP galacturonate-polygalacturonate alpha-galacturonosyltransferase
- uridine diphosphogalacturonate-polygalacturonate alpha-galacturonosyltransferase

reaction:
UDP-D-galacturonate + (1,4-alpha-D-galacturonosyl)n = UDP + (1,4-alpha-D-galacturonosyl)(n+1) [RN:R04343 R06072]


entry: 2.4.1.44
sysname: UDP-galactose:lipopolysaccharide 3-alpha-D-galactosyltransferase
iubmb_reaction: R01997
name:
--- 
- lipopolysaccharide 3-alpha-galactosyltransferase
- UDP-galactose:lipopolysaccharide alpha,3-galactosyltransferase
- UDP-galactose:polysaccharide galactosyltransferase
- uridine diphosphate galactose:lipopolysaccharide alpha-3-galactosyltransferase
- uridine diphosphogalactose-lipopolysaccharide alpha,3-galactosyltransferase

comment:
Transfers D-galactosyl residues to D-glucose in the partially completed core of lipopolysaccharide [cf. EC 2.4.1.56 (lipopolysaccharide N-acetylglucosaminyltransferase), EC 2.4.1.58 (lipopolysaccharide glucosyltransferase I) and EC 2.4.1.73 (lipopolysaccharide glucosyltransferase II)].

reaction:
UDP-galactose + lipopolysaccharide = UDP + 3-alpha-D-galactosyl-[lipopolysaccharide glucose] [RN:R01997]


entry: 2.4.1.45
sysname: UDP-galactose:2-(2-hydroxyacyl)sphingosine 1-beta-D-galactosyl-transferase
comment: Highly specific.
iubmb_reaction: R04322
name:
--- 
- 2-hydroxyacylsphingosine 1-beta-galactosyltransferase
- uridine diphosphogalactose-2-hydroxyacylsphingosine galactosyltransferase
- UDPgalactose-2-hydroxyacylsphingosine galactosyltransferase
- UDP-galactose:ceramide galactosyltransferase
- UDP-galactose:2-2-hydroxyacylsphingosine galactosyltransferase

reaction:
UDP-galactose + 2-(2-hydroxyacyl)sphingosine = UDP + 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine [RN:R04322]


entry: 2.4.1.46
sysname: UDP-galactose:1,2-diacyl-sn-glycerol 3-beta-D-galactosyltransferase
iubmb_reaction: R02691
name:
--- 
- monogalactosyldiacylglycerol synthase
- uridine diphosphogalactose-1,2-diacylglycerol galactosyltransferase
- UDP-galactose:diacylglycerol galactosyltransferase
- MGDG synthase
- UDP galactose-1,2-diacylglycerol galactosyltransferase
- UDP-galactose-diacylglyceride galactosyltransferase
- UDP-galactose:1,2-diacylglycerol 3-beta-D-galactosyltransferase
- 1beta-MGDG
- 1,2-diacylglycerol 3-beta-galactosyltransferase

comment:
This enzyme adds only one galactosyl group to the diacylglycerol; EC 2.4.1.241, digalactosyldiacylglycerol synthase, adds a galactosyl group to the product of the above reaction. There are three isoforms in Arabidopsis that can be divided into two types, A-type (MGD1) and B-type (MGD2 and MGD3). MGD1 is the isoform responsible for the bulk of monogalactosyldiacylglycerol (MGDG) synthesis in Arabidopsis [4].

reaction:
UDP-galactose + 1,2-diacyl-sn-glycerol = UDP + 3-beta-D-galactosyl-1,2-diacyl-sn-glycerol [RN:R02691]


entry: 2.4.1.47
sysname: UDP-galactose:N-acylsphingosine D-galactosyltransferase
reaction: UDP-galactose + N-acylsphingosine = UDP + D-galactosylceramide [RN:R01500 R06277]
iubmb_reaction: R01500 R06277(G)
name:
--- 
- N-acylsphingosine galactosyltransferase
- UDP galactose-N-acylsphingosine galactosyltransferase
- uridine diphosphogalactose-acylsphingosine galactosyltransferase


entry: 2.4.1.48
sysname: GDP-mannose:heteroglycan 2-(or 3-)-alpha-D-mannosyltransferase
reaction: GDP-mannose + heteroglycan = GDP + 2(or 3)-alpha-D-mannosyl-heteroglycan [RN:R03768 R03769]
iubmb_reaction: R03768 R03769
name:
--- 
- heteroglycan alpha-mannosyltransferase
- GDP mannose alpha-mannosyltransferase
- guanosine diphosphomannose-heteroglycan alpha-mannosyltransferase

comment:
The acceptor is a heteroglycan primer containing mannose, galactose and xylose. 1,2- and 1,3-mannosyl bonds are formed.


entry: 2.4.1.49
name: --- - cellodextrin phosphorylase - beta-1,4-oligoglucan:orthophosphate glucosyltransferase
sysname: 1,4-beta-D-oligo-D-glucan:phosphate alpha-D-glucosyltransferase
iubmb_reaction: R02888 R06022(G)
reaction:
(1,4-beta-D-glucosyl)n + phosphate = (1,4-beta-D-glucosyl)(n-1) + alpha-D-glucose 1-phosphate [RN:R02888 R06022]


entry: 2.4.1.50
sysname: UDP-galactose:procollagen-5-hydroxy-L-lysine D-galactosyltransferase
iubmb_reaction: R03380
kegg_reaction: R03379
name:
--- 
- procollagen galactosyltransferase
- hydroxylysine galactosyltransferase
- collagen galactosyltransferase
- collagen hydroxylysyl galactosyltransferase
- UDP galactose-collagen galactosyltransferase
- uridine diphosphogalactose-collagen galactosyltransferase
- UDPgalactose:5-hydroxylysine-collagen galactosyltransferase

comment:
Probably involved in the synthesis of carbohydrate units in complement (cf EC 2.4.1.66 procollagen glucosyltransferase).

reaction:
UDP-galactose + procollagen 5-hydroxy-L-lysine = UDP + procollagen 5-(D-galactosyloxy)-L-lysine [RN:R03380]


entry: 2.4.1.51
name: --- - Deleted entry
comment:
Deleted entry: UDP-N-acetylglucosamine-glycoprotein N-acetylglucosaminyltransferase. Now listed as EC 2.4.1.101 (alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase), EC 2.4.1.143 (alpha-1,6-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase), EC 2.4.1.144 (beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase) and EC 2.4.1.145 (alpha-1,3-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase) (EC 2.4.1.51 created 1972, deleted 1984)


entry: 2.4.1.52
sysname: UDP-glucose:poly(glycerol-phosphate) alpha-D-glucosyltransferase
iubmb_reaction: R04041
name:
--- 
- poly(glycerol-phosphate) alpha-glucosyltransferase
- UDP glucose-poly(glycerol-phosphate) alpha-glucosyltransferase
- uridine diphosphoglucose-poly(glycerol-phosphate) alpha-glucosyltransferase

reaction:
UDP-glucose + poly(glycerol phosphate) = UDP + O-(alpha-D-glucosyl)poly(glycerol phosphate) [RN:R04041]


entry: 2.4.1.53
sysname: UDP-glucose:poly(ribitol-phosphate) beta-D-glucosyltransferase
iubmb_reaction: R02716 R06181(G)
name:
--- 
- poly(ribitol-phosphate) beta-glucosyltransferase
- UDP glucose-poly(ribitol-phosphate) beta-glucosyltransferase
- uridine diphosphoglucose-poly(ribitol-phosphate) beta-glucosyltransferase
- UDP-D-glucose polyribitol phosphate glucosyl transferase
- UDP-D-glucose:polyribitol phosphate glucosyl transferase

reaction:
UDP-glucose + poly(ribitol phosphate) = UDP + (beta-D-glucosyl)poly(ribitol phosphate) [RN:R02716 R06181]


entry: 2.4.1.54
sysname: GDP-mannose:undecaprenyl-phosphate D-mannosyltransferase
comment: Requires phosphatidylglycerol.
reaction: GDP-mannose + undecaprenyl phosphate = GDP + D-mannosyl-1-phosphoundecaprenol [RN:R07257]
iubmb_reaction: R07257
name:
--- 
- undecaprenyl-phosphate mannosyltransferase
- guanosine diphosphomannose-undecaprenyl phosphate mannosyltransferase
- GDP mannose-undecaprenyl phosphate mannosyltransferase
- GDP-D-mannose:lipid phosphate transmannosylase


entry: 2.4.1.55
name: --- - Transferred to 2.7.8.14
comment:
Transferred entry: now EC 2.7.8.14 CDP-ribitol ribitolphosphotransferase (EC 2.4.1.55 created 1972, deleted 1982)


entry: 2.4.1.56
sysname: UDP-N-acetyl-D-glucosamine:lipopolysaccharide N-acetyl-D-glucosaminyltransferase
iubmb_reaction: R01996
name:
--- 
- lipopolysaccharide N-acetylglucosaminyltransferase
- UDP-N-acetylglucosamine-lipopolysaccharide N-acetylglucosaminyltransferase
- uridine diphosphoacetylglucosamine-lipopolysaccharide acetylglucosaminyltransferase

comment:
Transfers N-acetylglucosaminyl residues to a D-galactose residue in the partially completed lipopolysaccharide core [cf. EC 2.4.1.44 (lipopolysaccharide 3-alpha-galactosyltransferase), EC 2.4.1.58 (lipopolysaccharide glucosyltransferase I) and EC 2.4.1.73 (lipopolysaccharide glucosyltransferase II)].

reaction:
UDP-N-acetyl-D-glucosamine + lipopolysaccharide = UDP + N-acetyl-D-glucosaminyllipopolysaccharide [RN:R01996]


entry: 2.4.1.57
sysname: GDP-mannose:1-phosphatidyl-1D-myo-inositol alpha-D-mannosyltransferase
name:
--- 
- phosphatidylinositol alpha-mannosyltransferase
- GDP mannose-phosphatidyl-myo-inositol alpha-mannosyltransferase
- GDPmannose:1-phosphatidyl-myo-inositol alpha-D-mannosyltransferase
- guanosine diphosphomannose-phosphatidyl-inositol alpha-mannosyltransferase
- phosphatidyl-myo-inositol alpha-mannosyltransferase

reaction:
Transfers one or more alpha-D-mannose residues from GDP-mannose to positions 2,6 and others in 1-phosphatidyl-myo-inositol


entry: 2.4.1.58
sysname: UDP-glucose:lipopolysaccharide glucosyltransferase
reaction: UDP-glucose + lipopolysaccharide = UDP + D-glucosyl-lipopolysaccharide [RN:R01994]
iubmb_reaction: R01994
name:
--- 
- lipopolysaccharide glucosyltransferase I
- UDP-glucose:lipopolysaccharide glucosyltransferase I
- lipopolysaccharide glucosyltransferase
- uridine diphosphate glucose:lipopolysaccharide glucosyltransferase I
- uridine diphosphoglucose-lipopolysaccharide glucosyltransferase

comment:
Transfers glucosyl residues to the backbone portion of lipopolysaccharide [cf. EC 2.4.1.44 (lipopolysaccharide 3-alpha-galactosyltransferase, EC 2.4.1.56 (lipopolysaccharide N-acetylglucosaminyltransferase) and EC 2.4.1.73 (lipopolysaccharide glucosyltransferase II)].


entry: 2.4.1.59
name: --- - Deleted entry
comment:
Deleted entry: UDP-glucuronate-estradiol glucuronosyltransferase. Now included with EC 2.4.1.17 UDP-glucuronosyltransferase (EC 2.4.1.59 created 1972, deleted 1984)


entry: 2.4.1.60
name: --- - abequosyltransferase - trihexose diphospholipid abequosyltransferase
sysname: CDP-abequose:D-mannosyl-L-rhamnosyl-D-galactose-1-diphospholipid D-abequosyltransferase
iubmb_reaction: R04581
reaction:
CDP-abequose + D-mannosyl-L-rhamnosyl-D-galactose-1-diphospholipid = CDP + D-abequosyl-D-mannosyl-rhamnosyl-D-galactose-1-diphospholipid [RN:R04581]


entry: 2.4.1.61
name: --- - Deleted entry
comment:
Deleted entry: UDP-glucuronate-estriol 16alpha-glucuronosyltransferase. Now included with EC 2.4.1.17 UDP-glucuronosyltransferase (EC 2.4.1.61 created 1972, deleted 1984)


entry: 2.4.1.62
comment: The substrate is also known as G(M2).
iubmb_reaction: R04631 R05941(G)
kegg_reaction: R05110 R05111 R05948(G) R05953(G) R05956(G)
name:
--- 
- ganglioside galactosyltransferase
- UDP-galactose-ceramide galactosyltransferase
- uridine diphosphogalactose-ceramide galactosyltransferase
- UDP galactose-LAC Tet-ceramide alpha-galactosyltransferase
- UDP-galactose-G(M2) galactosyltransferase
- uridine diphosphogalactose-G(M2) galactosyltransferase
- uridine diphosphate D-galactose:glycolipid galactosyltransferase
- UDP-galactose:N-acetylgalactosaminyl-(N-acetylneuraminyl) galactosyl-glucosyl-ceramide galactosyltransferase
- UDP-galactose-G(M2) ganglioside galactosyltransferase
- G(M1)-synthase

sysname:
UDP-galactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galac tosyl-D-glucosyl-N-acylsphingosine beta-1,3-D-galactosyltransferase

reaction:
UDP-galactose + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-1,4- beta-D-glucosyl-N-acylsphingosine = UDP + D-galactosyl-1,3-beta-N-acetyl-D-galactosaminyl-(N- acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine [RN:R04631 R05941]


entry: 2.4.1.63
sysname: UDP-glucose:2-hydroxy-2-methylpropanenitrile beta-D-glucosyltransferase
comment: The enzyme glucosylates the cyanohydrins of butanone and pentan-3-one as well as that of acetone.
reaction: UDP-glucose + 2-hydroxy-2-methylpropanenitrile = UDP + linamarin [RN:R03625]
iubmb_reaction: R03625
name:
--- 
- linamarin synthase
- uridine diphosphoglucose-ketone glucosyltransferase
- uridine diphosphate-glucose-ketone cyanohydrin beta-glucosyltransferase
- UDP glucose ketone cyanohydrin glucosyltransferase
- UDP-glucose:ketone cyanohydrin beta-glucosyltransferase
- uridine diphosphoglucose-ketone cyanohydrin glucosyltransferase


entry: 2.4.1.65
sysname: GDP-L-fucose:3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 4I-alpha-L-fucosyltransferase
iubmb_reaction: R04553 > R06155(G)
kegg_reaction: R06162(G) R06163(G) R06164(G) R06165(G)
name:
--- 
- 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase
- (Le(a))-dependent (alpha-3/4)-fucosyltransferase
- alpha(1,3/1,4) fucosyltransferase III
- alpha-(1->4)-L-fucosyltransferase
- alpha-4-L-fucosyltransferase
- beta-acetylglucosaminylsaccharide fucosyltransferase
- FucT-II
- Lewis alpha-(1->3/4)-fucosyltransferase
- Lewis blood group alpha-(1->3/4)-fucosyltransferase
- Lewis(Le) blood group gene-dependent alpha-(1->3/4)-L-fucosyltransferase
- blood group Lewis alpha-4-fucosyltransferase
- blood-group substance Le(a)-dependent fucosyltransferase
- guanosine diphosphofucose-beta-acetylglucosaminylsaccharide 4-alpha-L-fucosyltransferase
- guanosine diphosphofucose-glycoprotein 4-alpha-L-fucosyltransferase
- guanosine diphosphofucose-glycoprotein 4-alpha-fucosyltransferase
- 3-alpha-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase
- GDP-beta-L-fucose:3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 4I-alpha-L-fucosyltransferase

comment:
This enzyme is the product of the Lewis blood group gene. Normally acts on a glycoconjugate where R (see reaction) is a glycoprotein or glycolipid. Although it is a 4-fucosyltransferase, it has a persistent 3-fucosyltransferase activity towards the glucose residue in free lactose. This enzyme fucosylates on O-4 of an N-acetylglucosamine that carries a galactosyl group on O-3, unlike EC 2.4.1.152, 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase, which fucosylates on O-3 of an N-acetylglucosamine that carries a galactosyl group on O-4. Enzymes catalysing the 4-alpha-fucosylation of the GlcNAc in beta-D-Gal-(1->3)-beta-GlcNAc sequences (with some activity also as 3-alpha-fucosyltransferases) are present in plants, where the function in vivo is the modification of N-glycans. In addition, the fucTa gene of Helicobacter strain UA948 encodes a fucosyltransferase with both 3-alpha- and 4-alpha-fucosyltransferase activities.

reaction:
GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D- glucosaminyl-R [RN:R04553]


entry: 2.4.1.66
sysname: UDP-glucose:5-(D-galactosyloxy)-L-lysine-procollagen D-glucosyltransferase
iubmb_reaction: R04491
name:
--- 
- procollagen glucosyltransferase
- galactosylhydroxylysine glucosyltransferase
- collagen glucosyltransferase
- collagen hydroxylysyl glucosyltransferase
- galactosylhydroxylysyl glucosyltransferase
- UDP-glucose-collagenglucosyltransferase
- uridine diphosphoglucose-collagen glucosyltransferase

comment:
Probably involved in the synthesis of carbohydrate units in complement (cf. EC 2.4.1.50 procollagen galactosyltransferase).

reaction:
UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen = UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen [RN:R04491]


entry: 2.4.1.67
name: --- - galactinol-raffinose galactosyltransferase - stachyose synthetase
sysname: alpha-D-galactosyl-(1->3)-myo-inositol:raffinose galactosyltransferase
reaction: alpha-D-galactosyl-(1->3)-1D-myo-inositol + raffinose = myo-inositol + stachyose [RN:R03418 R06042]
iubmb_reaction: R03418 R06042(G)
comment:
This enzyme also catalyses galactosyl transfer from stachyose to raffinose (shown by labelling) [4]. For synthesis of the substrate, see EC 2.4.1.123, inositol 3-alpha-galactosyltransferase. See also EC 2.4.1.82, galactinol-sucrose galactosyltransferase.


entry: 2.4.1.68
iubmb_reaction: R05988(G)
name:
--- 
- glycoprotein 6-alpha-L-fucosyltransferase
- GDP-fucose-glycoprotein fucosyltransferase
- GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1->6fucosyltransferase
- GDP-L-fucose-glycoprotein fucosyltransferase
- glycoprotein fucosyltransferase
- guanosine diphosphofucose-glycoprotein fucosyltransferase

sysname:
GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-a cetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-man nosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glu cosaminyl}asparagine) 6-alpha-L-fucosyltransferase

comment:
This enzyme catalyses a reaction similar to that of EC 2.4.1.214, glycoprotein 3-alpha-L-fucosyltransferase, but transfers the L-fucosyl group from GDP-beta-L-fucose to form an alpha1,6-linkage rather than an alpha1,3-linkage.

reaction:
GDP-L-fucose + N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N- acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D- mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D- glucosaminyl}asparagine = GDP + N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N- acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D- mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-[alpha-L- fucosyl-(1->6)]-N-acetyl-beta-D-glucosaminyl}asparagine [RN:R05988]


entry: 2.4.1.69
sysname: GDP-beta-L-fucose:beta-D-galactosyl-R 2-alpha-L-fucosyltransferase
reaction: GDP-beta-L-fucose + beta-D-galactosyl-R = GDP + alpha-L-fucosyl-1,2-beta-D-galactosyl-R [RN:R04081]
kegg_reaction: R06170(G)
name:
--- 
- galactoside 2-alpha-L-fucosyltransferase
- blood group H alpha-2-fucosyltransferase
- guanosine diphosphofucose-galactoside 2-L-fucosyltransferase
- alpha-(1->2)-L-fucosyltransferase
- alpha-2-fucosyltransferase
- alpha-2-L-fucosyltransferase
- blood-group substance H-dependent fucosyltransferase
- guanosine diphosphofucose-glycoprotein 2-alpha-fucosyltransferase
- guanosine diphosphofucose-lactose fucosyltransferase
- GDP fucose-lactose fucosyltransferase
- guanosine diphospho-L-fucose-lactose fucosyltransferase
- guanosine diphosphofucose-beta-D-galactosyl-alpha-2-L-fucosyltransferase
- guanosine diphosphofucose- galactosylacetylglucosaminylgalactosylglucosylceramide alpha-L-fucosyltransferase
- guanosine diphosphofucose-glycoprotein 2-alpha-L-fucosyltransferase
- H-gene-encoded beta-galactoside alpha1->2fucosyltransferase
- secretor-type beta-galactoside alpha1->2fucosyltransferase
- beta-galactoside alpha1->2fucosyltransferase
- GDP-L-fucose:lactose fucosyltransferase

comment:
Free lactose can act as acceptor. Normally acts on a glycoconjugate where R (see reaction) is a glycoprotein or glycolipid. The action on glycolipid was previously listed as EC 2.4.1.89.

iubmb_reaction:
R04081 > R05968(G) R06024(G) R06031(G) R06035(G) R06041(G) R06085(G) R06086(G) R06089(G) R06090(G) R06156(G)


entry: 2.4.1.70
sysname: UDP-N-acetyl-D-glucosamine:poly(ribitol-phosphate) N-acetyl-D-glucosaminyltransferase
comment: Involved in the synthesis of teichoic acids.
iubmb_reaction: R02717 R06182(G)
name:
--- 
- poly(ribitol-phosphate) N-acetylglucosaminyl-transferase
- UDP acetylglucosamine-poly(ribitol phosphate) acetylglucosaminyltransferase
- uridine diphosphoacetylglucosamine-poly(ribitol phosphate) acetylglucosaminyltransferase

reaction:
UDP-N-acetyl-D-glucosamine + poly(ribitol phosphate) = UDP + (N-acetyl-D-glucosaminyl)poly(ribitol phosphate) [RN:R02717 R06182]


entry: 2.4.1.71
sysname: UDP-glucose:arylamine N-D-glucosyltransferase
reaction: UDP-glucose + an arylamine = UDP + an N-D-glucosylarylamine [RN:R02388]
iubmb_reaction: R02388
name:
--- 
- arylamine glucosyltransferase
- UDP glucose-arylamine glucosyltransferase
- uridine diphosphoglucose-arylamine glucosyltransferase


entry: 2.4.1.72
name: --- - Transferred to 2.4.2.24
comment:
Transferred entry: now EC 2.4.2.24 1,4-beta-D-xylan synthase (EC 2.4.1.72 created 1972, deleted 1976)


entry: 2.4.1.73
sysname: UDP-glucose:galactosyl-lipopolysaccharide alpha-D-glucosyltransferase
reaction: UDP-glucose + lipopolysaccharide = UDP + alpha-D-glucosyl-lipopolysaccharide [RN:R01995]
iubmb_reaction: R01995
name:
--- 
- lipopolysaccharide glucosyltransferase II
- uridine diphosphoglucose-galactosylpolysaccharide glucosyltransferase

comment:
Transfers glucosyl residues to the D-galactosyl-D-glucosyl side-chains in the partially completed core of lipopolysaccharides. cf. EC 2.4.1.44 (lipopolysaccharide 3-alpha-galactosyltransferase), EC 2.4.1.56 (lipopolysaccharide N-acetylglucosaminyltransferase) and EC 2.4.1.58 (lipopolysaccharide glucosyltransferase I).


entry: 2.4.1.74
sysname: UDP-galactose:glycosaminoglycan D-galactosyltransferase
comment: Involved in the biosynthesis of galactose-containing glycosaminoglycan of Dictyostelium discoideum.
reaction: UDP-galactose + glycosaminoglycan = UDP + D-galactosylglycosaminoglycan [RN:R03981]
iubmb_reaction: R03981
name:
--- 
- glycosaminoglycan galactosyltransferase
- uridine diphosphogalactose-mucopolysaccharide galactosyltransferase


entry: 2.4.1.75
name: --- - Deleted entry
comment:
Deleted entry: insufficient evidence to conclude that this is a different enzyme from EC 2.4.1.43, polygalacturonate 4-alpha-galacturonosyltransferase (EC 2.4.1.75 created 1976, deleted 2005)


entry: 2.4.1.76
name: --- - Deleted entry
comment:
Deleted entry: UDP-glucuronate-bilirubin glucuronosyltransferase. Now included with EC 2.4.1.17, UDP-glucuronosyltransferase (EC 2.4.1.76 created 1976, deleted 1984)


entry: 2.4.1.77
name: --- - Deleted entry
comment:
Deleted entry: UDP-glucuronate-bilirubin-glucuronoside glucuronosyltransferase. Now included with EC 2.4.1.17, UDP-glucuronosyltransferase (EC 2.4.1.77 created 1976, deleted 1984)


entry: 2.4.1.78
sysname: UDP-glucose:phosphopolyprenol D-glucosyltransferase
reaction: UDP-glucose + polyprenyl phosphate = UDP + polyprenylphosphate-glucose [RN:R03190]
iubmb_reaction: R03190
name:
--- 
- phosphopolyprenol glucosyltransferase
- uridine diphosphoglucose-polyprenol monophosphate glucosyltransferase
- UDP-glucose:polyprenol monophosphate glucosyltransferase

comment:
Ficaprenyl phosphate is the best substrate; other polyprenols can also act as substrates, but more slowly.


entry: 2.4.1.79
iubmb_reaction: R05631 R05962(G)
name:
--- 
- globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase
- uridine diphosphoacetylgalactosamine-galactosylgalactosylglucosylceramide acetylgalactosaminyltransferase
- globoside synthetase
- UDP-N-acetylgalactosamine:globotriaosylceramide beta-3-N-acetylgalactosaminyltransferase
- galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase
- UDP-N-acetylgalactosamine:globotriaosylceramide beta1,3-N-acetylgalactosaminyltransferase
- globoside synthase
- UDP-N-acetyl-D-galactosamine:D-galactosyl-1,4-D-galactosyl-1,4-D- glucosylceramide beta-N-acetyl-D-galactosaminyltransferase
- beta3GalNAc-T1

sysname:
UDP-N-acetyl-D-galactosamine:alpha-D-galactosyl-(1->4)-beta-D-galact osyl-(1->4)-beta-D-glucosylceramide 3III-beta-N-acetyl-D-galactosaminyltransferase

comment:
Globoside is a neutral glycosphingolipid in human erythrocytes and has blood-group-P-antigen activity [4]. The enzyme requires a divalent cation for activity, with Mn2+ required for maximal activity [3]. UDP-GalNAc is the only sugar donor that is used efficiently by the enzyme: UDP-Gal and UDP-GlcNAc result in very low enzyme activity [3]. Lactosylceramide, globoside and gangliosides GM3 and GD3 are not substrates [4]. For explanation of the superscripted 'III' in the systematic name, see 2-carb.37.

reaction:
UDP-N-acetyl-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D- glucosylceramide = UDP + beta-N-acetyl-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)- beta-D-galactosyl-(1->4)-beta-D-glucosylceramide [RN:R05631 R05962]


entry: 2.4.1.80
sysname: UDP-glucose:N-acylsphingosine D-glucosyltransferase
comment: Sphingosine and dihydrosphingosine can also act as acceptors; CDP-glucose can act as donor.
reaction: UDP-glucose + an N-acylsphingosine = UDP + a D-glucosyl-N-acylsphingosine [RN:R01497 R06275]
iubmb_reaction: R01497 R06275(G)
name:
--- 
- ceramide glucosyltransferase
- UDP-glucose:ceramide glucosyltransferase
- ceramide:UDP-Glc glucosyltransferase
- uridine diphosphoglucose-ceramide glucosyltransferase
- ceramide:UDP-glucose glucosyltransferase
- glucosylceramide synthase


entry: 2.4.1.81
sysname: UDP-glucose:5,7,3',4'-tetrahydroxyflavone 7-O-beta-D-glucosyltransferase
iubmb_reaction: R03588
kegg_reaction: R03574
name:
--- 
- flavone 7-O-beta-glucosyltransferase
- UDP-glucose-apigenin beta-glucosyltransferase
- UDP-glucose-luteolin beta-D-glucosyltransferase
- uridine diphosphoglucose-luteolin glucosyltransferase
- uridine diphosphoglucose-apigenin 7-O-glucosyltransferase
- UDP-glucosyltransferase

comment:
A number of flavones, flavanones and flavonols can function as acceptors. Different from EC 2.4.1.91 (flavonol 3-O-glucosyltransferase).

reaction:
UDP-glucose + 5,7,3',4'-tetrahydroxyflavone = UDP + 7-O-beta-D-glucosyl-5,7,3',4'-tetrahydroxyflavone [RN:R03588]


entry: 2.4.1.82
sysname: alpha-D-galactosyl-(1->3)-myo-inositol:sucrose 6-alpha-D-galactosyltransferase
reaction: alpha-D-galactosyl-(1->3)-1D-myo-inositol + sucrose = myo-inositol + raffinose [RN:R02411 R06071]
iubmb_reaction: R02411 R06071(G)
name:
--- 
- galactinol-sucrose galactosyltransferase
- 1-alpha-D-galactosyl-myo-inositol:sucrose 6-alpha-D-galactosyltransferase

comment:
4-Nitrophenyl alpha-D-galactopyranoside can also act as donor. The enzyme also catalyses an exchange reaction between raffinose and sucrose (cf. EC 2.4.1.123, inositol 3-alpha-galactosyltransferase).


entry: 2.4.1.83
sysname: GDP-mannose:dolichyl-phosphate beta-D-mannosyltransferase
reaction: GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate [RN:R01009]
iubmb_reaction: R01009
name:
--- 
- dolichyl-phosphate beta-D-mannosyltransferase
- GDP-Man:DolP mannosyltransferase
- dolichyl mannosyl phosphate synthase
- dolichyl-phospho-mannose synthase
- GDP-mannose:dolichyl-phosphate mannosyltransferase
- guanosine diphosphomannose-dolichol phosphate mannosyltransferase
- dolichol phosphate mannose synthase
- dolichyl phosphate mannosyltransferase
- dolichyl-phosphate mannose synthase
- GDP-mannose-dolichol phosphate mannosyltransferase
- GDP-mannose-dolichylmonophosphate mannosyltransferase
- mannosylphosphodolichol synthase
- mannosylphosphoryldolichol synthase

comment:
Acts only on long-chain polyprenyl phosphates and alpha-dihydropolyprenyl phosphates that are larger than C35.


entry: 2.4.1.84
name: --- - Deleted entry
comment:
Deleted entry: UDP-glucuronate-1,2-diacylglycerol glucuronosyltransferase. Now included with EC 2.4.1.17, UDP-glucuronosyltransferase (EC 2.4.1.84 created 1976, deleted 1984)


entry: 2.4.1.85
sysname: UDP-D-glucose:(S)-4-hydroxymandelonitrile beta-D-glucosyltransferase
iubmb_reaction: R04296
kegg_reaction: R04948
name:
--- 
- cyanohydrin beta-glucosyltransferase
- uridine diphosphoglucose-p-hydroxymandelonitrile glucosyltransferase
- UDP-glucose-p-hydroxymandelonitrile glucosyltransferase
- uridine diphosphoglucose-cyanohydrin glucosyltransferase
- uridine diphosphoglucose:aldehyde cyanohydrin beta-glucosyltransferase
- UDP-glucose:(S)-4-hydroxymandelonitrile beta-D-glucosyltransferase
- UGT85B1
- UDP-glucose:p-hydroxymandelonitrile-O-glucosyltransferase

comment:
Acts on a wide range of substrates in vitro, including cyanohydrins, terpenoids, phenolics, hexanol derivatives and plant hormones, in a regiospecific manner [3]. This enzyme is involved in the biosynthesis of the cyanogenic glucoside dhurrin in sorghum, along with EC 1.14.13.41, tyrosine N-monooxygenase and EC 1.14.13.68, 4-hydroxyphenylacetaldehyde oxime monooxygenase. This reaction prevents the disocciation and release of toxic hydrogen cyanide [3].

reaction:
UDP-D-glucose + (S)-4-hydroxymandelonitrile = UDP + (S)-4-hydroxymandelonitrile beta-D-glucoside [RN:R04296]


entry: 2.4.1.86
iubmb_reaction: R04610 R06006(G)
name:
--- 
- glucosaminylgalactosylglucosylceramide beta-galactosyltransferase
- uridine diphosphogalactose-acetyl-glucosaminylgalactosylglucosylceramide galactosyltransferase
- GalT-4
- paragloboside synthase

sysname:
UDP-galactose:N-acetyl-D-glucosaminyl-1,3-D-galactosyl-1,4-D-glucosy lceramide beta-D-galactosyltransferase

reaction:
UDP-galactose + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-D-glucosylceramide = UDP + 1,3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl- 1,4-D-glucosylceramide [RN:R04610 R06006]


entry: 2.4.1.87
sysname: UDP-galactose:N-acetyllactosaminide 3-alpha-D-galactosyltransferase
iubmb_reaction: R02791 > R04531 R04605 R05978(G) R06145(G) R06169(G)
name:
--- 
- N-acetyllactosaminide 3-alpha-galactosyltransferase
- alpha-galactosyltransferase
- UDP-Gal:beta-D-Gal(1,4)-D-GlcNAc alpha(1,3)-galactosyltransferase
- UDP-Gal:N-acetyllactosaminide alpha(1,3)-galactosyltransferase
- UDP-Gal:N-acetyllactosaminide alpha-1,3-D-galactosyltransferase
- UDP-Gal:Galbeta1->4GlcNAc-R alpha1->3-galactosyltransferase
- UDP-galactose-acetyllactosamine alpha-D-galactosyltransferase
- UDPgalactose:beta-D-galactosyl-beta-1,4-N-acetyl-D-glucosaminyl- glycopeptide alpha-1,3-D-galactosyltransferase
- glucosaminylglycopeptide alpha-1,3-galactosyltransferase
- uridine diphosphogalactose-acetyllactosamine alpha1->3-galactosyltransferase
- uridine diphosphogalactose-acetyllactosamine galactosyltransferase
- uridine diphosphogalactose- galactosylacetylglucosaminylgalactosylglucosylceramide galactosyltransferase
- beta-D-galactosyl-N-acetylglucosaminylglycopeptide alpha-1,3-galactosyltransferase

comment:
Acts on beta-galactosyl-1,4-N-acetylglucosaminyl termini on asialo-alpha1-acid glycoprotein and N-acetyllactosamine (beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine), but not on 2'-fucosylated-N-acetyllactosamine. The non-reducing terminal N-acetyllactosamine residues of glycoproteins can also act as acceptor. Now includes EC 2.4.1.124 and EC 2.4.1.151.

reaction:
(1) UDP-galactose + beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R = UDP + alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-N- acetylglucosaminyl-R [RN:R02791]; (2) where R can be OH, an oligosaccharide or a glycoconjugate


entry: 2.4.1.88
iubmb_reaction: R04182 R05965(G)
name:
--- 
- globoside alpha-N-acetylgalactosaminyltransferase
- uridine diphosphoacetylgalactosamine-globoside alpha-acetylgalactosaminyltransferase
- Forssman synthase
- globoside acetylgalactosaminyltransferase

sysname:
UDP-N-acetyl-D-galactosamine:N-acetyl-D-galactosaminyl-1,3-D-galacto syl-1,4-D-galactosyl-1,4-D-glucosylceramide alpha-N-acetyl-D-galactosaminyltransferase

reaction:
UDP-N-acetyl-D-galactosamine + N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D- glucosylceramide = UDP + N-acetyl-D-galactosaminyl-N-acetyl-D-galactosaminyl-1,3-D- galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide [RN:R04182 R05965]


entry: 2.4.1.89
name: --- - Deleted entry
comment:
Deleted entry: Galactosylglucosaminylgalactosylglucosylceramide alpha-L-fucosyltransferase - now included with EC 2.4.1.69 galactoside 2-L-fucosyltransferase (EC 2.4.1.89 created 1976, deleted 1984)


entry: 2.4.1.90
sysname: UDP-galactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase
reaction: UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine [RN:R01205 R06055]
iubmb_reaction: R01205 R06055(G)
name:
--- 
- N-acetyllactosamine synthase
- UDP-galactose-N-acetylglucosamine beta-D-galactosyltransferase
- uridine diphosphogalactose-acetylglucosamine galactosyltransferase
- beta-1,4-galactosyltransferase
- acetyllactosamine synthetase
- lactosamine synthase
- lactosamine synthetase
- lactose synthetase A protein
- N-acetyllactosamine synthetase
- UDP-galactose N-acetylglucosamine beta-4-galactosyltransferase
- UDP-galactose-acetylglucosamine galactosyltransferase
- UDP-galactose-N-acetylglucosamine beta-1,4-galactosyltransferase
- UDP-galactose-N-acetylglucosamine galactosyltransferase
- beta1-4-galactosyltransferase
- UDP-Gal:N-acetylglucosamine beta1-4-galactosyltransferase
- beta1-4GalT
- NAL synthetase
- UDP-beta-1,4-galactosyltransferase
- Gal-T
- UDP-galactose:N-acetylglucosaminide beta1-4-galactosyltransferase
- UDPgalactose:N-acetylglucosaminyl(beta1-4)galactosyltransferase
- beta-N-acetylglucosaminide beta1-4-galactosyltransferase

comment:
The reaction is catalysed by a component of EC 2.4.1.22 (lactose synthase), which is identical with EC 2.4.1.38 (beta-N-acetylglucosaminyl-glycopeptide beta-1,4-galactosyltransferase), and by an enzyme from the Golgi apparatus of animal tissues. Formerly listed also as EC 2.4.1.98.


entry: 2.4.1.91
sysname: UDP-glucose:flavonol 3-O-D-glucosyltransferase
reaction: UDP-glucose + a flavonol = UDP + a flavonol 3-O-beta-D-glucoside [RN:R03267]
iubmb_reaction: R03267 > R02158 R06611
kegg_reaction: R06534 R06535 R06536
name:
--- 
- flavonol 3-O-glucosyltransferase
- GTI
- uridine diphosphoglucose-flavonol 3-O-glucosyltransferase
- UDP-glucose:flavonol 3-O-glucosyltransferase
- UDPG:flavonoid-3-O-glucosyltransferase

comment:
Acts on a variety of flavonols, including quercetin and quercetin 7-O-glucoside. Different from EC 2.4.1.81 (flavone 7-O-beta-glucosyltransferase).


entry: 2.4.1.92
iubmb_reaction: R04584 R05939(G)
kegg_reaction: R03490 R05109 R05938(G) R05946(G) R05952(G)
name:
--- 
- (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase
- uridine diphosphoacetylgalactosamine-ganglioside GM3 acetylgalactosaminyltransferase
- ganglioside GM2 synthase
- ganglioside GM3 acetylgalactosaminyltransferase
- GM2 synthase
- UDP acetylgalactosamine-(N-acetylneuraminyl)-D-galactosyl-D- glucosylceramide acetylgalactosaminyltransferase
- UDP-N-acetylgalactosamine GM3 N-acetylgalactosaminyltransferase
- uridine diphosphoacetylgalactosamine- acetylneuraminylgalactosylglucosylceramide acetylgalactosaminyltransferase
- uridine diphosphoacetylgalactosamine-hematoside acetylgalactosaminyltransferase
- GM2/GD2-synthase
- beta-1,4N-aetylgalactosaminyltransferase
- asialo-GM2 synthase
- GalNAc-T
- UDP-N-acetyl-D-galactosamine:(N-acetylneuraminyl)-D-galactosyl-D- glucosylceramide N-acetyl-D-galactosaminyltransferase

sysname:
UDP-N-acetyl-D-galactosamine:1-O-[O-(N-acetyl-alpha-neuraminosyl)-(2 ->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]-ceramid e 1,4-beta-N-acetyl-D-galactosaminyltransferase

comment:
This enzyme catalyses the formation of the gangliosides (i.e. sialic-acid-containing glycosphingolipids) GM2, GD2 and SM2 from GM3, GD3 and SM3, respectively. Asialo-GM3 [3] and lactosylceramide [2] are also substrates, but glycoproteins and oligosaccharides are not substrates.

reaction:
UDP-N-acetyl-D-galactosamine + 1-O-[O-(N-acetyl-alpha-neuraminosyl)-(2->3)-O-beta-D- galactopyranosyl-(1->4)-beta-D-glucopyranosyl]-ceramide = UDP + 1-O-[O-2-(acetylamino)-2-deoxy-beta-D-galactopyranosyl-(1->4)-O-[N- acetyl-alpha-neuraminosyl-(2->3)]-O-beta-D-galactopyranosyl-(1->4)- beta-D-glucopyranosyl]-ceramide [RN:R04584 R05939]


entry: 2.4.1.93
name: --- - Transferred to 4.2.2.18
comment:
Transferred entry: now EC 4.2.2.18, inulin fructotransferase (DFA-III-forming). The enzyme was wrongly classified as a transferase rather than a lyase. (EC 2.4.1.93 created 1976, deleted 2004).


entry: 2.4.1.94
sysname: UDP-N-acetyl-D-glucosamine:protein beta-N-acetyl-D-glucosaminyl-transferase
comment: The acceptor is the asparagine residue in a sequence of the form Asn-Xaa-Thr or Asn-Xaa-Ser.
reaction: UDP-N-acetyl-D-glucosamine + protein = UDP + 4-N-(N-acetyl-D-glucosaminyl)-protein [RN:R00417]
iubmb_reaction: R00417
name:
--- 
- protein N-acetylglucosaminyltransferase
- uridine diphosphoacetylglucosamine-protein acetylglucosaminyltransferase
- uridine diphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyltransferase
- O-GlcNAc transferase


entry: 2.4.1.95
sysname: bilirubin-glucuronoside:bilirubin-glucuronoside D-glucuronosyltransferase
reaction: 2 bilirubin-glucuronoside = bilirubin + bilirubin-bisglucuronoside [RN:R00062]
iubmb_reaction: R00062
name:
--- 
- bilirubin-glucuronoside glucuronosyltransferase
- bilirubin monoglucuronide transglucuronidase
- bilirubin glucuronoside glucuronosyltransferase


entry: 2.4.1.96
sysname: UDP-galactose:sn-glycerol-3-phosphate 1-alpha-D-galactosyltransferase
iubmb_reaction: R00854
name:
--- 
- sn-glycerol-3-phosphate 1-galactosyltransferase
- isofloridoside-phosphate synthase
- UDP-Gal:sn-glycero-3-phosphoric acid 1-alpha-galactosyl-transferase
- UDPgalactose:sn-glycerol-3-phosphate alpha-D-galactosyltransferase
- uridine diphosphogalactose-glycerol phosphate galactosyltransferase
- glycerol 3-phosphate 1alpha-galactosyltransferase

comment:
The product is hydrolysed by a phosphatase to isofloridoside, which is involved in osmoregulation (cf. EC 2.4.1.137 sn-glycerol-3-phosphate 2-alpha-galactosyltransferase).

reaction:
UDP-galactose + sn-glycerol 3-phosphate = UDP + alpha-D-galactosyl-(1,1')-sn-glycerol 3-phosphate [RN:R00854]


entry: 2.4.1.97
sysname: 1,3-beta-D-glucan:phosphate alpha-D-glucosyltransferase
iubmb_reaction: R03116 R06018(G)
name:
--- 
- 1,3-beta-D-glucan phosphorylase
- laminarin phosphoryltransferase
- 1,3-beta-D-glucan:orthophosphate glucosyltransferase

comment:
Acts on a range of beta-1,3-oligoglucans, and on glucans of laminarin type. Different from EC 2.4.1.30 (1,3-beta-oligoglucan phosphorylase) and EC 2.4.1.31 (laminaribiose phosphorylase).

reaction:
(1,3-beta-D-glucosyl)n + phosphate = (1,3-beta-D-glucosyl)(n-1) + alpha-D-glucose 1-phosphate [RN:R03116 R06018]


entry: 2.4.1.98
name: --- - Deleted entry
comment:
Deleted entry: UDP-galactose-N-acetylglucosamine beta-D-galactosyl-transferase. Now included with EC 2.4.1.90, N-acetyllactosamine synthase (EC 2.4.1.98 created 1980, deleted 1984)


entry: 2.4.1.99
iubmb_reaction: R00015 R06135(G)
name:
--- 
- sucrose:sucrose fructosyltransferase
- SST
- sucrose:sucrose 1-fructosyltransferase
- sucrose-sucrose 1-fructosyltransferase
- sucrose 1F-fructosyltransferase
- sucrose:sucrose 1F-beta-D-fructosyltransferase

sysname:
sucrose:sucrose 1'-beta-D-fructosyltransferase For definition of the prime in the systematic name, see 2-Carb-36.2

reaction:
2 sucrose = D-glucose + beta-D-fructofuranosyl-(2->1)-beta-D-fructofuranosyl alpha-D-glucopyranoside [RN:R00015 R06135]


entry: 2.4.1.100
sysname: 2,1-beta-D-fructan:2,1-beta-D-fructan 1-beta-D-fructosyltransferase
iubmb_reaction: R04193 R06183(G)
name:
--- 
- 2,1-fructan:2,1-fructan 1-fructosyltransferase
- 1,2-beta-D-fructan 1F-fructosyltransferase
- fructan:fructan fructosyl transferase
- FFT
- 1,2-beta-fructan 1F-fructosyltransferase
- 1,2-beta-D-fructan:1,2-beta-D-fructan 1F-beta-D-fructosyltransferase
- fructan:fructan 1-fructosyl transferase

reaction:
[beta-D-fructosyl-(2->1)-]m + [beta-D-fructosyl-(2->1)-]n = [beta-D-fructosyl-(2->1)-](m-1) + [beta-D-fructosyl-(2->1)-](n+1) [RN:R04193 R06183]


entry: 2.4.1.101
iubmb_reaction: R05983(G)
name:
--- 
- alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
- N-acetylglucosaminyltransferase I
- N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I
- uridine diphosphoacetylglucosamine-alpha-1,3-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase
- UDP-N-acetylglucosaminyl:alpha-1,3-D-mannoside-beta-1,2-N- acetylglucosaminyltransferase I
- UDP-N-acetylglucosaminyl:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I
- alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase

sysname:
UDP-N-acetyl-D-glucosamine:3-(alpha-D-mannosyl)-beta-D-mannosyl-glyc oprotein 2-beta-N-acetyl-D-glucosaminyltransferase

reaction:
UDP-N-acetyl-D-glucosamine + 3-(alpha-D-mannosyl)-beta-D-mannosyl-R = UDP + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D- mannosyl-R [RN:R05983]


entry: 2.4.1.102
iubmb_reaction: R04575 R05912(G)
kegg_reaction: R05910(G)
name:
--- 
- beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
- O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I
- beta6-N-acetylglucosaminyltransferase
- uridine diphosphoacetylglucosamine-mucin beta-(1->6)-acetylglucosaminyltransferase
- core 2 acetylglucosaminyltransferase
- core 6-beta-GlcNAc-transferase A

sysname:
UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R) beta-1,6-N-acetyl-D-glucosaminyltransferase

comment:
cf. EC 2.4.1.146 (beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase), EC 2.4.1.147 (acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase) and EC 2.4.1.148 (acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase).

reaction:
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R = UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D- galactosaminyl-R [RN:R04575 R05912]


entry: 2.4.1.104
sysname: UDP-glucose:7,8-dihydroxycoumarin 7-O-beta-D-glucosyltransferase
reaction: UDP-glucose + 7,8-dihydroxycoumarin = UDP + daphnin [RN:R03548]
iubmb_reaction: R03548
name:
--- 
- o-dihydroxycoumarin 7-O-glucosyltransferase
- uridine diphosphoglucose-o-dihydroxycoumarin 7-O-glucosyltransferase
- UDP-glucose:o-dihydroxycoumarin glucosyltransferase

comment:
Converts the aglycone daphetin into daphnin and, more slowly, esculetin into cichoriin, umbelliferone into skimmin, hydrangetin into hydrangin and scopoletin into scopolin.


entry: 2.4.1.106
sysname: UDP-glucose:isovitexin 2"-O-beta-D-glucosyltransferase
comment: Isovitexin is a flavonoid from petals of Silene alba.
reaction: UDP-glucose + isovitexin = UDP + isovitexin 2"-O-beta-D-glucoside [RN:R03686]
iubmb_reaction: R03686
name:
--- 
- isovitexin beta-glucosyltransferase
- uridine diphosphoglucose-isovitexin 2"-glucosyltransferase


entry: 2.4.1.107
name: --- - Deleted entry
comment:
Deleted entry: UDP-glucuronate-testosterone glucuronosyltransferase. Now included with EC 2.4.1.17, UDP-glucuronosyltransferase (EC 2.4.1.107 created 1983, deleted 1984)


entry: 2.4.1.108
name: --- - Deleted entry
comment:
Deleted entry: UDP-glucuronate-phenol glucuronosyltransferase. Now included with EC 2.4.1.17, UDP-glucuronosyltransferase (EC 2.4.1.108 created 1983, deleted 1984)


entry: 2.4.1.109
sysname: dolichyl-phosphate-D-mannose:protein O-D-mannosyltransferase
reaction: dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein [RN:R04072]
iubmb_reaction: R04072
name:
--- 
- dolichyl-phosphate-mannose-protein mannosyltransferase
- dolichol phosphomannose-protein mannosyltransferase
- protein O-D-mannosyltransferase

comment:
The enzyme transfers mannosyl residues to the hydroxy group of serine or threonine residues, producing cell-wall mannoproteins. It acts only on long-chain alpha-dihydropolyprenyl derivatives, larger than C35.


entry: 2.4.1.111
sysname: UDP-glucose:coniferyl-alcohol 4'-beta-D-glucosyltransferase
comment: Sinapyl alcohol can also act as acceptor.
reaction: UDP-glucose + coniferyl alcohol = UDP + coniferin [RN:R02594]
iubmb_reaction: R02594
kegg_reaction: R03605 R04005
name:
--- 
- coniferyl-alcohol glucosyltransferase
- uridine diphosphoglucose-coniferyl alcohol glucosyltransferase
- UDP-glucose coniferyl alcohol glucosyltransferase


entry: 2.4.1.112
sysname: UDP-glucose:protein 4-alpha-glucosyltransferase
reaction: UDP-glucose + protein = UDP + alpha-D-glucosyl-protein [RN:R00290]
iubmb_reaction: R00290
name:
--- 
- alpha-1,4-glucan-protein synthase (UDP-forming)
- UDP-glucose:protein glucosyltransferase
- glycogen initiator synthase
- UDPGlc:protein transglucosylase
- UPTG
- uridine diphosphoglucose protein transglucosylase I
- proglycogen synthase
- uridine diphosphoglucose-protein 4-alpha-glucosyltransferase
- uridine diphosphoglucose-protein glucosyltransferase
- UDP-glucose protein transglucosylase
- UDP-glucose-protein glucosyltransferase
- uridine diphosphate glucose-protein transglucosylase I

comment:
The enzyme builds up alpha-1,4-glucan chains covalently bound to protein, thus acting as an initiator of glycogen synthesis.


entry: 2.4.1.113
sysname: ADP-glucose:protein 4-alpha-D-glucosyltransferase
reaction: ADP-glucose + protein = ADP + alpha-D-glucosyl-protein [RN:R02420]
iubmb_reaction: R02420
name:
--- 
- alpha-1,4-glucan-protein synthase (ADP-forming)
- ADP-glucose:protein glucosyltransferase
- adenosine diphosphoglucose-protein glucosyltransferase

comment:
The enzyme builds up alpha-1,4-glucan chains covalently bound to protein, thus acting as an initiator of glycogen synthesis.


entry: 2.4.1.114
sysname: UDP-glucose:trans-2-hydroxycinnamate O-beta-D-glucosyltransferase
comment: Coumarinate (cis-2-hydroxycinnamate) does not act as acceptor.
reaction: UDP-glucose + trans-2-hydroxycinnamate = UDP + trans-beta-D-glucosyl-2-hydroxycinnamate [RN:R03710]
iubmb_reaction: R03710
name:
--- 
- 2-coumarate O-beta-glucosyltransferase
- uridine diphosphoglucose-o-coumarate glucosyltransferase
- UDPG:o-coumaric acid O-glucosyltransferase


entry: 2.4.1.115
sysname: UDP-D-glucose:anthocyanidin 3-O-beta-D-glucosyltransferase
reaction: UDP-D-glucose + an anthocyanidin = UDP + an anthocyanidin-3-O-beta-D-glucoside [RN:R03797]
iubmb_reaction: R03797 > R06534 R06535 R06536
name:
--- 
- anthocyanidin 3-O-glucosyltransferase
- uridine diphosphoglucose-anthocyanidin 3-O-glucosyltransferase
- UDP-glucose:anthocyanidin/flavonol 3-O-glucosyltransferase
- UDP-glucose:cyanidin-3-O-glucosyltransferase
- UDP-glucose:anthocyanidin 3-O-D-glucosyltransferase
- 3-GT

comment:
The anthocyanidin compounds cyanidin, delphinidin, peonidin and to a lesser extent pelargonidin can act as substrates. The enzyme does not catalyse glucosylation of the 5-position of cyanidin and does not act on flavanols such as quercetin and kaempferol (cf. EC 2.4.1.91 flavonol 3-O-glucosyltransferase). In conjunction with EC 1.14.11.19, leucocyanidin oxygenase, it is involved in the conversion of leucoanthocyanidin into anthocyanidin 3-glucoside. It may act on the pseudobase precursor of the anthocyanidin rather than on the anthocyanidin itself [3].


entry: 2.4.1.116
sysname: UDP-glucose:cyanidin-3-O-beta-L-rhamnosyl-(1->6)-beta-D-glucoside 5-O-beta-D-glucosyltransferase
reaction: UDP-glucose + cyanidin 3-O-rutinoside = UDP + cyanidin 3-O-rutinoside 5-O-beta-D-glucoside
iubmb_reaction: (other) R06803 R06819
kegg_reaction: R06803 R06819
name:
--- 
- cyanidin 3-O-rutinoside 5-O-glucosyltransferase
- uridine diphosphoglucose-cyanidin 3-rhamnosylglucoside 5-O-glucosyltransferase
- cyanidin-3-rhamnosylglucoside 5-O-glucosyltransferase
- UDP-glucose:cyanidin-3-O-D-rhamnosyl-1,6-D-glucoside 5-O-D-glucosyltransferase

comment:
Also acts on pelargonidin-3-rutinoside. The enzyme does not catalyse the glucosylation of the 5-hydroxy group of cyanidin-3-glucoside.


entry: 2.4.1.117
sysname: UDP-glucose:dolichyl-phosphate beta-D-glucosyltransferase
comment: Solanesyl phosphate and ficaprenyl phosphate can act as acceptors, but more slowly.
reaction: UDP-glucose + dolichyl phosphate = UDP + dolichyl beta-D-glucosyl phosphate [RN:R01005]
iubmb_reaction: R01005
name:
--- 
- dolichyl-phosphate beta-glucosyltransferase
- polyprenyl phosphate:UDP-D-glucose glucosyltransferase
- UDP-glucose dolichyl-phosphate glucosyltransferase
- uridine diphosphoglucose-dolichol glucosyltransferase
- UDP-glucose:dolichol phosphate glucosyltransferase
- UDP-glucose:dolicholphosphoryl glucosyltransferase
- UDP-glucose:dolichyl monophosphate glucosyltransferase
- UDP-glucose:dolichyl phosphate glucosyltransferase


entry: 2.4.1.118
sysname: UDP-glucose:zeatin 7-glucosyltransferase
reaction: UDP-glucose + N6-alkylaminopurine = UDP + N6-alkylaminopurine-7-beta-D-glucoside [RN:R04071]
iubmb_reaction: R04071
name:
--- 
- cytokinin 7-beta-glucosyltransferase
- uridine diphosphoglucose-zeatin 7-glucosyltransferase
- cytokinin 7-glucosyltransferase

comment:
Acts on a range of N6-substituted adenines, including zeatin [N6-(4-hydroxy-3-methylbut-trans-2-enylamino)purine] and N6-benzylaminopurine, but not N6-benzyladenine. With some acceptors, 9-beta-D-glucosides are also formed.


entry: 2.4.1.119
sysname: dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase
iubmb_reaction: R04216 > R05976(G)
name:
--- 
- dolichyl-diphosphooligosaccharide-protein glycotransferase
- dolichyldiphosphooligosaccharide-protein glycosyltransferase
- asparagine N-glycosyltransferase
- dolichyldiphosphooligosaccharide-protein oligosaccharyltransferase
- dolichylpyrophosphodiacetylchitobiose-protein glycosyltransferase
- oligomannosyltransferase
- oligosaccharide transferase
- dolichyldiphosphoryloligosaccharide-protein oligosaccharyltransferase

comment:
Transfers the glucosyl-mannosyl-glucosamine polysaccharide side-chains of glycoproteins to an asparagine residue in the sequence Asn-Xaa-Ser or Asn-Xaa-Thr in the nascent polypeptide chains of the protein moiety.

reaction:
dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-glycosyl linkage to protein L-asparagine [RN:R04216]


entry: 2.4.1.120
sysname: UDP-glucose:sinapate D-glucosyltransferase
reaction: UDP-glucose + sinapate = UDP + 1-sinapoyl-D-glucose [RN:R02380]
iubmb_reaction: R02380
name:
--- 
- sinapate 1-glucosyltransferase
- uridine diphosphoglucose-sinapate glucosyltransferase
- UDP-glucose:sinapic acid glucosyltransferase
- uridine 5'-diphosphoglucose-hydroxycinnamic acid acylglucosyltransferase

comment:
Some other hydroxycinnamates, including 4-coumarate, ferulate and caffeate, can act as acceptors, but more slowly. Only glucose esters, not glucosides, are formed (cf. EC 2.4.1.126 hydroxycinnamate 4-beta-glucosyltransferase).


entry: 2.4.1.121
sysname: UDP-glucose:(indol-3-yl)acetate beta-D-glucosyltransferase
reaction: UDP-glucose + (indol-3-yl)acetate = UDP + 1-O-(indol-3-yl)acetyl-beta-D-glucose [RN:R03094]
iubmb_reaction: R03094
name:
--- 
- indole-3-acetate beta-glucosyltransferase
- uridine diphosphoglucose-indoleacetate glucosyltransferase
- UDPG-indol-3-ylacetyl glucosyl transferase
- UDP-glucose:indol-3-ylacetate glucosyltransferase
- indol-3-ylacetylglucose synthase
- UDP-glucose:indol-3-ylacetate glucosyl-transferase
- IAGlu synthase
- IAA-glucose synthase
- UDP-glucose:indole-3-acetate beta-D-glucosyltransferase


entry: 2.4.1.122
sysname: UDP-galactose:glycoprotein-N-acetyl-D-galactosamine 3-beta-D-galactosyltransferase
iubmb_reaction: R05908(G)
name:
--- 
- glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase
- uridine diphosphogalactose-mucin beta-(1->3)-galactosyltransferase

comment:
The non-reducing O-serine-linked N-acetylgalactosamine residues in mucin glycoproteins can act as acceptors.

reaction:
UDP-galactose + glycoprotein N-acetyl-D-galactosamine = UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine [RN:R05908]


entry: 2.4.1.123
sysname: UDP-galactose:myo-inositol 3-alpha-D-galactosyltransferase
reaction: UDP-galactose + myo-inositol = UDP + O-alpha-D-galactosyl-(1->3)-1D-myo-inositol [RN:R01192 R06214]
iubmb_reaction: R01192 R06214(G)
name:
--- 
- inositol 3-alpha-galactosyltransferase
- UDP-D-galactose:inositol galactosyltransferase
- UDP-galactose:myo-inositol 1-alpha-D-galactosyltransferase
- UDPgalactose:myo-inositol 1-alpha-D-galactosyltransferase
- galactinol synthase
- inositol 1-alpha-galactosyltransferase
- uridine diphosphogalactose-inositol galactosyltransferase

comment:
An enzyme from plants involved in the formation of raffinose and stachyose [cf. EC 2.4.1.67 (galactinol-raffinose galactosyltransferase) and EC 2.4.1.82 (galactinol-sucrose galactosyltransferase)].


entry: 2.4.1.124
name: --- - Transferred to 2.4.1.87
comment:
Transferred entry: now included with EC 2.4.1.87, N-acetyllactosaminide 3-alpha-galactosyltransferase (EC 2.4.1.124 created 1984, deleted 2002)


entry: 2.4.1.125
sysname: sucrose:1,6-alpha-D-glucan 3(6)-alpha-D-glucosyltransferase
reaction: sucrose + (1,6-alpha-D-glucosyl)n = D-fructose + (1,6-alpha-D-glucosyl)(n+1) [RN:R02120 R06066]
iubmb_reaction: R02120 R06066(G)
name:
--- 
- sucrose-1,6-alpha-glucan 3(6)-alpha-glucosyltransferase
- water-soluble-glucan synthase
- GTF-S
- sucrose:1,6-alpha-D-glucan 3-alpha- and 6-alpha-glucosyltransferase
- sucrose:1,6-, 1,3-alpha-D-glucan 3-alpha- and 6-alpha-D-glucosyltransferase

comment:
Also transfers glucosyl residues to the 3-position on glucose residues in glucans, producing a highly-branched 1,6-alpha-D-glucan.


entry: 2.4.1.126
sysname: UDP-glucose:trans-4-hydroxycinnamate 4-O-beta-D-glucosyltransferase
reaction: UDP-glucose + trans-4-hydroxycinnamate = UDP + 4-O-beta-D-glucosyl-4-hydroxycinnamate [RN:R02951]
iubmb_reaction: R02951
name:
--- 
- hydroxycinnamate 4-beta-glucosyltransferase
- uridine diphosphoglucose-hydroxycinnamate glucosyltransferase
- UDP-glucose-hydroxycinnamate glucosyltransferase
- hydroxycinnamoyl glucosyltransferase

comment:
Acts on 4-coumarate, ferulate, caffeate and sinapate, forming a mixture of 4-glucosides and glucose esters (cf. EC 2.4.1.120 sinapate 1-glucosyltransferase).


entry: 2.4.1.127
sysname: UDP-glucose:(-)-menthol O-beta-D-glucosyltransferase
comment: (+)-Neomenthol can also act as acceptor.
reaction: UDP-glucose + (-)-menthol = UDP + (-)-menthyl O-beta-D-glucoside [RN:R02179]
iubmb_reaction: R02179
name:
--- 
- monoterpenol beta-glucosyltransferase
- uridine diphosphoglucose-monoterpenol glucosyltransferase
- UDPglucose:monoterpenol glucosyltransferase


entry: 2.4.1.128
sysname: UDP-glucose:scopoletin O-beta-D-glucosyltransferase
reaction: UDP-glucose + scopoletin = UDP + scopolin [RN:R03594]
iubmb_reaction: R03594
name:
--- 
- scopoletin glucosyltransferase
- uridine diphosphoglucose-scopoletin glucosyltransferase
- UDP-glucose:scopoletin glucosyltransferase
- SGTase


entry: 2.4.1.129
iubmb_reaction: R06178 R06179(G)
kegg_reaction: R04519 R06177(G)
name:
--- 
- peptidoglycan glycosyltransferase
- PG-II
- bactoprenyldiphospho-N-acetylmuramoyl-(N-acetyl-D-glucosaminyl)- pentapeptide:peptidoglycan N-acetylmuramoyl-N-acetyl-D-glucosaminyltransferase
- penicillin binding protein (3 or 1B)
- peptidoglycan transglycosylase

sysname:
undecaprenyldiphospho-(N-acetyl-D-glucosaminyl-(1->4)-(N-acetyl-D-mu ramoylpentapeptide):undecaprenyldiphospho-(N-acetyl-D-glucosaminyl-( 1->4)-N-acetyl-D-muramoylpentapeptide) disaccharidetransferase Involved in the synthesis of cell-wall peptidoglycan.

reaction:
[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n- diphosphoundecaprenol + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)- diphosphoundecaprenol = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D- Ala)](n+1)-diphosphoundecaprenol + undecaprenyl diphosphate [RN:R06178 R06179]


entry: 2.4.1.130
sysname: dolichyl-phosphate-D-mannose:glycolipid alpha-D-mannosyltransferase
name:
--- 
- dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase
- dolichol phosphomannose-oligosaccharide-lipid mannosyltransferase
- oligomannosylsynthase

comment:
Four of the nine mannosyl residues in the main membrane lipid-linked oligosaccharide of the structure Glc3Man9GlcNAc2 are produced by the action of this enzyme.

reaction:
Transfers an alpha-D-mannosyl residue from dolichyl-phosphate D-mannose into membrane lipid-linked oligosaccharide


entry: 2.4.1.131
sysname: GDP-mannose:glycolipid 1,2-alpha-D-mannosyltransferase
iubmb_reaction: (other) R06127(G) R06128(G)
kegg_reaction: R06127(G) R06128(G)
name:
--- 
- glycolipid 2-alpha-mannosyltransferase
- guanosine diphosphomannose-oligosaccharide-lipid mannosyltransferase
- GDP-mannose-oligosaccharide-lipid mannosyltransferase
- oligosaccharide-lipid mannosyltransferase

comment:
The two 1,2-linked mannosyl residues in the mammalian lipid-linked oligosaccharide of the structure Glc3Man9GlcNAc2 are produced by the action of this enzyme.

reaction:
Transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-1,2-D-mannosyl-D-mannose linkage


entry: 2.4.1.132
sysname: GDP-mannose:glycolipid 1,3-alpha-D-mannosyltransferase
iubmb_reaction: R05002 R05973(G)
name:
--- 
- glycolipid 3-alpha-mannosyltransferase
- mannosyltransferase II
- guanosine diphosphomannose-oligosaccharide-lipid II mannosyltransferase
- GDP-mannose-oligosaccharide-lipid mannosyltransferase II

comment:
The 1,3-linked mannosyl residue in the mammalian lipid-linked oligosaccharide of the structure Glc3Man9GlcNAc2 is produced by this enzyme.

reaction:
Transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-1,3-D-mannosyl-D-mannose linkage [RN:R05002 R05973]


entry: 2.4.1.133
sysname: UDP-galactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase
iubmb_reaction: R05926(G)
name:
--- 
- xylosylprotein 4-beta-galactosyltransferase
- UDP-D-galactose:D-xylose galactosyltransferase
- UDP-D-galactose:xylose galactosyltransferase
- galactosyltransferase I
- uridine diphosphogalactose-xylose galactosyltransferase

comment:
Involved in the biosynthesis of the linkage region of glycosaminoglycan chains as part of proteoglycan biosynthesis (chondroitin, dermatan and heparan sulfates). Requires Mn2+.

reaction:
UDP-galactose + O-beta-D-xylosylprotein = UDP + 4-beta-D-galactosyl-O-beta-D-xylosylprotein [RN:R05926]


entry: 2.4.1.134
sysname: UDP-galactose:4-beta-D-galactosyl-O-beta-D-xylosylprotein 3-beta-D-galactosyltransferase
iubmb_reaction: R05927(G)
name:
--- 
- galactosylxylosylprotein 3-beta-galactosyltransferase
- galactosyltransferase II
- uridine diphosphogalactose-galactosylxylose galactosyltransferase

comment:
Involved in the biosynthesis of the linkage region of glycosaminoglycan chains as part of proteoglycan biosynthesis (chondroitin, dermatan and heparan sulfates). Requires Mn2+.

reaction:
UDP-galactose + 4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein [RN:R05927]


entry: 2.4.1.135
iubmb_reaction: R04607 R05928(G)
name:
--- 
- galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase
- glucuronosyltransferase I
- uridine diphosphate glucuronic acid:acceptor glucuronosyltransferase

sysname:
UDP-glucuronate:3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xyl osyl-protein D-glucuronosyltransferase

comment:
Involved in the biosynthesis of the linkage region of glycosaminoglycan chains as part of proteoglycan biosynthesis (chondroitin, dermatan and heparan sulfates). Requires Mn2+.

reaction:
UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O- beta-D-xylosylprotein [RN:R04607 R05928]


entry: 2.4.1.136
sysname: UDP-glucose:gallate beta-D-glucosyltransferase
reaction: UDP-glucose + gallate = UDP + 1-galloyl-beta-D-glucose [RN:R03297]
iubmb_reaction: R03297
name:
--- 
- gallate 1-beta-glucosyltransferase
- UDP-glucose-vanillate 1-glucosyltransferase
- UDPglucose:vanillate 1-O-glucosyltransferase
- UDPglucose:gallate glucosyltransferase

comment:
A number of substituted benzoic acids and, more slowly, cinnamic acids, can act as acceptors. Vanillin is the best acceptor investigated.


entry: 2.4.1.137
sysname: UDP-galactose:sn-glycerol-3-phosphate 2-alpha-D-galactosyltransferase
iubmb_reaction: R00853
name:
--- 
- sn-glycerol-3-phosphate 2-alpha-galactosyltransferase
- floridoside-phosphate synthase
- UDP-galactose:sn-glycerol-3-phosphate-2-D-galactosyl transferase
- FPS
- UDP-galactose, sn-3-glycerol phosphate:1->2' galactosyltransferase
- floridoside phosphate synthetase
- floridoside phosphate synthase

comment:
The product is hydrolysed by a phosphatase to floridoside (cf. EC 2.4.1.96 sn-glycerol-3-phosphate 1-galactosyltransferase).

reaction:
UDP-galactose + sn-glycerol 3-phosphate = UDP + 2-(alpha-D-galactosyl)-sn-glycerol 3-phosphate [RN:R00853]


entry: 2.4.1.138
sysname: UDP-N-acetyl-D-glucosamine:mannotetraose alpha-N-acetyl-D-glucosaminyltransferase
iubmb_reaction: R04619 R06014(G)
name:
--- 
- mannotetraose 2-alpha-N-acetylglucosaminyltransferase
- alpha-N-acetylglucosaminyltransferase
- uridine diphosphoacetylglucosamine mannoside alpha1->2-alphacetylglucosaminyltransferase

reaction:
UDP-N-acetyl-D-glucosamine + 1,3-alpha-D-mannosyl-1,2-alpha-D-mannosyl-1,2-alpha-D-mannosyl-D- mannose = UDP + 1,3-alpha-D-mannosyl-1,2-(N-acetyl-alpha-D-glucosaminyl-alpha-D- mannosyl)-1,2-alpha-D-mannosyl-D-mannose [RN:R04619 R06014]


entry: 2.4.1.139
name: --- - maltose synthase
comment: Neither free phosphate nor maltose 1-phosphate is an intermediate in the reaction.
reaction: 2 alpha-D-glucose 1-phosphate + H2O = maltose + 2 phosphate [RN:R00957 R06061]
iubmb_reaction: R00957 R06061(G)
sysname:
alpha-D-glucose-1-phosphate:alpha-D-glucose-1-phosphate 4-alpha-D-glucosyltransferase (dephosphorylating)


entry: 2.4.1.140
sysname: sucrose:1,6(1,3)-alpha-D-glucan 6(3)-alpha-D-glucosyltransferase
comment: The product, which has quite different properties from other dextrans, has been called alternan.
name:
--- 
- alternansucrase
- sucrose-1,6(3)-alpha-glucan 6(3)-alpha-glucosyltransferase
- sucrose:1,6-, 1,3-alpha-D-glucan 3-alpha- and 6-alpha-D-glucosyltransferase

reaction:
Transfers alternately an alpha-D-glucosyl residue from sucrose to the 6-position and the 3-position of the non-reducing terminal residue of an alpha-D-glucan, thus producing a glucan having alternating alpha-1,6- and alpha-1,3-linkages


entry: 2.4.1.141
iubmb_reaction: R04494 R05970(G)
name:
--- 
- N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase
- UDP-GlcNAc:dolichyl-pyrophosphoryl-GlcNAc GlcNAc transferase
- uridine diphosphoacetylglucosamine-dolichylacetylglucosamine pyrophosphate acetylglucosaminyltransferase
- N,N'-diacetylchitobiosylpyrophosphoryldolichol synthase

sysname:
UDP-N-acetyl-D-glucosamine:N-acetyl-D-glucosaminyl-diphosphodolichol N-acetyl-D-glucosaminyltransferase

reaction:
UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosaminyl-diphosphodolichol = UDP + N,N'-diacetylchitobiosyl-diphosphodolichol [RN:R04494 R05970]


entry: 2.4.1.142
sysname: GDP-mannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase
iubmb_reaction: R04502 R05972(G)
name:
--- 
- chitobiosyldiphosphodolichol beta-mannosyltransferase
- guanosine diphosphomannose-dolichol diphosphochitobiose mannosyltransferase
- GDP-mannose-dolichol diphosphochitobiose mannosyltransferase

reaction:
GDP-mannose + chitobiosyldiphosphodolichol = GDP + beta-1,4-D-mannosylchitobiosyldiphosphodolichol [RN:R04502 R05972]


entry: 2.4.1.143
iubmb_reaction: R07258
kegg_reaction: R04653 R05985(G)
name:
--- 
- alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
- N-acetylglucosaminyltransferase II
- N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II
- acetylglucosaminyltransferase II
- uridine diphosphoacetylglucosamine-mannoside alpha1->6-acetylglucosaminyltransferase
- uridine diphosphoacetylglucosamine-alpha-1,6-mannosylglycoprotein beta-1-2-N-acetylglucosaminyltransferase
- uridine diphosphoacetylglucosamine-alpha-D-mannoside beta1-2-acetylglucosaminyltransferase
- UDP-GlcNAc:mannoside alpha1-6 acetylglucosaminyltransferase
- alpha-1,6-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase

sysname:
UDP-N-acetyl-D-glucosamine:6-(alpha-D-mannosyl)-beta-D-mannosyl-glyc oprotein 2-beta-N-acetyl-D-glucosaminyltransferase

reaction:
UDP-N-acetyl-D-glucosamine + 6-(alpha-D-mannosyl)-beta-D-mannosyl-R = UDP + 6-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D- mannosyl-R [RN:R07258]


entry: 2.4.1.144
sysname: UDP-N-acetyl-D-glucosamine:beta-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase
iubmb_reaction: R07259
kegg_reaction: R05986(G)
name:
--- 
- beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
- N-acetylglucosaminyltransferase III
- N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III
- uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase III
- beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase

reaction:
UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R = UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R [RN:R07259]


entry: 2.4.1.145
iubmb_reaction: R04662
kegg_reaction: R05987(G)
name:
--- 
- alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
- N-acetylglucosaminyltransferase IV
- N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV
- beta-acetylglucosaminyltransferase IV
- uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase IV
- alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase

sysname:
UDP-N-acetyl-D-glucosamine:3-[2-(N-acetyl-beta-D-glucosaminyl)-alpha -D-mannosyl]-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase

reaction:
UDP-N-acetyl-D-glucosamine + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D- mannosyl-R = UDP + 3-(2,4-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D- mannosyl-R [RN:R04662]


entry: 2.4.1.146
iubmb_reaction: R04636 R05901(G)
name:
--- 
- beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase
- O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II
- uridine diphosphoacetylglucosamine-mucin beta(1->3)-acetylglucosaminyltransferase (elongating)
- elongation 3beta-GalNAc-transferase

sysname:
UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to -D-galactose of beta-D-galactosyl-1,3-(N-acetyl-D-glucosaminyl-1,6)-N-acetyl-D-galac tosaminyl-R) beta-1,3-N-acetyl-D-glucosaminyltransferase

comment:
cf. EC 2.4.1.102 (beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase), EC 2.4.1.147 (acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase) and EC 2.4.1.148 (acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase).

reaction:
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-(N-acetyl-D-glucosaminyl-1,6)-N-acetyl-D- galactosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,3-(N-acetyl- beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R [RN:R04636 R05901]


entry: 2.4.1.147
iubmb_reaction: R03513
kegg_reaction: R05909(G)
name:
--- 
- acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase
- O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III
- uridine diphosphoacetylglucosamine-mucin beta(1->3)-acetylglucosaminyltransferase
- mucin core 3 beta3-GlcNAc-transferase
- Core 3beta-GlcNAc-transferase

sysname:
UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosaminyl-R) beta-1,3-N-acetyl-D-glucosaminyltransferase

comment:
cf. EC 2.4.1.102 (beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase), EC 2.4.1.146 (beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase) and EC 2.4.1.148 (acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase).

reaction:
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-galactosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-beta-D-galactosaminyl-R [RN:R03513]


entry: 2.4.1.148
iubmb_reaction: R03514 R05915(G)
kegg_reaction: R05910(G)
name:
--- 
- acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
- O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV
- uridine diphosphoacetylglucosamine-mucin beta(1->6)-acetylglucosaminyltransferase B
- core 4 beta6-GalNAc-transferase
- core 6beta-GalNAc-transferase B

sysname:
UDP-N-acetyl-D-glucosamine:O-oligosaccharide-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R) beta-1,6-N-acetyl-D-glucosaminyltransferase

comment:
cf. EC 2.4.1.102 (beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase), EC 2.4.1.146 (beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase) and EC 2.4.1.147 (acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase).

reaction:
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)- N-acetyl-D-galactosaminyl-R [RN:R03514 R05915]


entry: 2.4.1.149
iubmb_reaction: R02789 > R05974(G) R05975(G)
kegg_reaction: R04659
name:
--- 
- N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase
- uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->3-acetylglucosaminyltransferase
- poly-N-acetyllactosamine extension enzyme
- Galbeta1->4GlcNAc-R beta1->3 N-acetylglucosaminyltransferase
- UDP-GlcNAc:GalR, beta-D-3-N-acetylglucosaminyltransferase
- N-acetyllactosamine beta(1-3)N-acetylglucosaminyltransferase
- UDP-GlcNAc:Galbeta1->4GlcNAcbeta-Rbeta1->3-N- acetylglucosaminyltransferase

sysname:
UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-D-glucosam ine beta-1,3-acetyl-D-glucosaminyltransferase

comment:
Acts on beta-galactosyl-1,4-N-acetylglucosaminyl termini on asialo-alpha1-acid glycoprotein and other glycoproteins and oligosaccharides.

reaction:
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-D- glucosaminyl-R [RN:R02789]


entry: 2.4.1.150
comment: Acts on beta-galactosyl-1,4-N-acetylglucosaminyl termini on asialo-alpha1-acid glycoprotein.
iubmb_reaction: R02790
kegg_reaction: R06189(G)
name:
--- 
- N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase
- N-acetylglucosaminyltransferase
- uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->6-acetylglucosaminyltransferase
- Galbeta1->4GlcNAc-R beta1->6 N-acetylglucosaminyltransferase
- UDP-GlcNAc:Gal-R, beta-D-6-N-acetylglucosaminyltransferase

sysname:
UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-D-glucosam inide beta-1,6-N-acetyl-D-glucosaminyltransferase

reaction:
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-D- glucosaminyl-R [RN:R02790]


entry: 2.4.1.151
name: --- - Transferred to 2.4.1.87
comment:
Transferred entry: now included with EC 2.4.1.87, N-acetyllactosaminide 3-alpha-galactosyltransferase (EC 2.4.1.151 created 1984, deleted 2002)


entry: 2.4.1.152
sysname: GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-alpha-L-fucosyltransferase
iubmb_reaction: R03519 > R05904(G) R06025(G) R06038(G) R06039(G)
kegg_reaction: R06075(G) R06076(G) R06095(G)
name:
--- 
- 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase
- Lewis-negative alpha-3-fucosyltransferase
- plasma alpha-3-fucosyltransferase
- guanosine diphosphofucose-glucoside alpha1->3-fucosyltransferase
- galactoside 3-fucosyltransferase
- GDP-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-L-fucosyltransferase
- GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-L-fucosyltransferase

comment:
Normally acts on a glycoconjugate where R (see reaction) is a glycoprotein or glycolipid. This enzyme fucosylates on O-3 of an N-acetylglucosamine that carries a galactosyl group on O-4, unlike EC 2.4.1.65, 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase, which fucosylates on O-4 of an N-acetylglucosamine that carries a galactosyl group on O-3.

reaction:
GDP-beta-L-fucose + 1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R = GDP + 1,4-beta-D-galactosyl-(alpha-1,3-L-fucosyl)-N-acetyl-D-glucosaminyl- R [RN:R03519]


entry: 2.4.1.153
sysname: UDP-N-acetyl-D-glucosamine:dolichyl-phosphate alpha-N-acetyl-D-glucosaminyltransferase
iubmb_reaction: R01008
name:
--- 
- dolichyl-phosphate alpha-N-acetylglucosaminyltransferase
- uridine diphosphoacetylglucosamine-dolichol phosphate acetylglucosaminyltransferase
- dolichyl phosphate acetylglucosaminyltransferase
- dolichyl phosphate N-acetylglucosaminyltransferase
- UDP-N-acetylglucosamine-dolichol phosphate N-acetylglucosaminyltransferase

reaction:
UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UDP + dolichyl N-acetyl-alpha-D-glucosaminyl phosphate [RN:R01008]


entry: 2.4.1.154
name: --- - Deleted entry
comment:
Deleted entry: globotriosylceramide beta-1,6-N-acetylgalactosaminyl-transferase. The enzyme is identical to EC 2.4.1.79, globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase. The reference cited referred to a 1->3 linkage and not to a 1->6 linkage, as indicated in the enzyme entry. (EC 2.4.1.154 created 1986, deleted 2006)


entry: 2.4.1.155
iubmb_reaction: R04665
kegg_reaction: R05991(G)
name:
--- 
- alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase
- N-acetylglucosaminyltransferase V
- alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase
- uridine diphosphoacetylglucosamine-alpha-mannoside beta1->6-acetylglucosaminyltransferase
- UDP-N-acetylglucosamine:alpha-mannoside-beta1,6 N-acetylglucosaminyltransferase
- alpha-1,3(6)-mannosylglycoprotein beta-1,6-N-acetylglucosaminyltransferase

sysname:
UDP-N-acetyl-D-glucosamine:6-[2-(N-acetyl-beta-D-glucosaminyl)-alpha -D-mannosyl]-glycoprotein 6-beta-N-acetyl-D-glucosaminyltransferase

reaction:
UDP-N-acetyl-D-glucosamine + 6-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D- mannosyl-R = UDP + 6-(2,6-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D- mannosyl-R [RN:R04665]


entry: 2.4.1.156
sysname: UDP-galactose:(indol-3-yl)acetyl-myo-inositol 5-O-D-galactosyltransferase
iubmb_reaction: R04334
name:
--- 
- indolylacetyl-myo-inositol galactosyltransferase
- uridine diphosphogalactose-indolylacetylinositol galactosyltransferase
- indol-3-ylacetyl-myo-inositol galactoside synthase
- UDP-galactose:indol-3-ylacetyl-myo-inositol 5-O-D-galactosyltransferase

reaction:
UDP-galactose + (indol-3-yl)acetyl-myo-inositol = UDP + 5-O-(indol-3-yl)acetyl-myo-inositol) D-galactoside [RN:R04334]


entry: 2.4.1.157
sysname: UDP-glucose:1,2-diacylglycerol 3-D-glucosyltransferase
comment: Many diacylglycerols with long-chain acyl groups can act as acceptors.
reaction: UDP-glucose + 1,2-diacylglycerol = UDP + 3-D-glucosyl-1,2-diacylglycerol [RN:R02689]
iubmb_reaction: R02689
name:
--- 
- 1,2-diacylglycerol 3-glucosyltransferase
- UDP-glucose:diacylglycerol glucosyltransferase
- UDP-glucose:1,2-diacylglycerol glucosyltransferase
- uridine diphosphoglucose-diacylglycerol glucosyltransferase
- UDP-glucose-diacylglycerol glucosyltransferase


entry: 2.4.1.158
sysname: UDP-glucose:13-hydroxydocosanoate 13-beta-D-glucosyltransferase
reaction: UDP-glucose + 13-hydroxydocosanoate = UDP + 13-beta-D-glucosyloxydocosanoate [RN:R04127]
iubmb_reaction: R04127
name:
--- 
- 13-hydroxydocosanoate 13-beta-glucosyltransferase
- 13-glucosyloxydocosanoate 2'-beta-glucosyltransferase
- UDP-glucose:13-hydroxydocosanoic acid glucosyltransferase
- uridine diphosphoglucose-hydroxydocosanoate glucosyltransferase
- UDP-glucose-13-hydroxydocosanoate glucosyltransferase

comment:
13-beta-D-Glucosyloxydocosanoate can also act as acceptor, leading to the formation by Candida bogoriensis of the extracellular glycolipid, hydroxydocosanoate sophoroside diacetate.


entry: 2.4.1.159
sysname: UDP-L-rhamnose:flavonol-3-O-D-glucoside 6"-O-L-rhamnosyltransferase
iubmb_reaction: R03880 > R04900
name:
--- 
- flavonol-3-O-glucoside L-rhamnosyltransferase
- uridine diphosphorhamnose-flavonol 3-O-glucoside rhamnosyltransferase
- UDP-rhamnose:flavonol 3-O-glucoside rhamnosyltransferase

comment:
Converts flavonol 3-O-glucosides to 3-O-rutinosides. Also acts, more slowly, on rutin, quercetin 3-O-galactoside and flavonol 3-O-rhamnosides.

reaction:
UDP-L-rhamnose + flavonol 3-O-D-glucoside = UDP + flavonol 3-O-[beta-L-rhamnosyl-(1->6)-beta-D-glucoside] [RN:R03880]


entry: 2.4.1.160
sysname: UDP-glucose:pyridoxine 5'-O-beta-D-glucosyltransferase
comment: 4'-Deoxypyridoxine and pyridoxamine can also act as acceptors, but more slowly.
reaction: UDP-glucose + pyridoxine = UDP + 5'-O-beta-D-glucosylpyridoxine [RN:R01912]
iubmb_reaction: R01912
name:
--- 
- pyridoxine 5'-O-beta-D-glucosyltransferase
- UDP-glucose:pyridoxine 5'-O-beta-glucosyltransferase
- uridine diphosphoglucose-pyridoxine 5'-beta-glucosyltransferase
- UDP-glucose-pyridoxine glucosyltransferase


entry: 2.4.1.161
sysname: 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase
name:
--- 
- oligosaccharide 4-alpha-D-glucosyltransferase
- amylase III
- 1,4-alpha-glucan:1,4-alpha-glucan 4-alpha-glucosyltransferase

comment:
Acts on amylose, amylopectin, glycogen and maltooligosaccharides, but not on maltose. No detectable free glucose is formed.

reaction:
Transfers the non-reducing terminal alpha-D-glucose residue from a 1,4-alpha-D-glucan to the 4-position of an alpha-D-glucan, thus bringing about the hydrolysis of oligosaccharides


entry: 2.4.1.162
name: --- - aldose beta-D-fructosyltransferase
sysname: alpha-D-aldosyl-beta-D-fructoside:aldose 1-beta-D-fructosyltransferase
iubmb_reaction: R04422
reaction:
alpha-D-aldosyl1 beta-D-fructoside + D-aldose2 = D-aldose1 + alpha-D-aldosyl2 beta-D-fructoside [RN:R04422]


entry: 2.4.1.163
comment: Requires Mn2+.
iubmb_reaction: R04659 R05975(G)
kegg_reaction: R04654 R06013(G)
name:
--- 
- beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase
- uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->3-acetylglucosaminyltransferase
- poly-N-acetyllactosamine extension enzyme

sysname:
UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-beta-D-glu cosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide beta-1,3-acetylglucosaminyltransferase

reaction:
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D- galactosyl-1,4-beta-D-glucosylceramide = UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-beta-D- glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide [RN:R04659 R05975]


entry: 2.4.1.164
comment: Requires Mn2+.
iubmb_reaction: R04654 R06013(G)
name:
--- 
- galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,6-N-acetylglucosaminyltransferase
- uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->6-acetylglucosaminyltransferase

sysname:
UDP-N-acetyl-D-glucosamine:D-galactosyl-1,4-N-acetyl-beta-D-glucosam inyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide beta-1,6-N-acetylglucosaminyltransferase

reaction:
UDP-N-acetyl-D-glucosamine + D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl- 1,4-beta-D-glucosylceramide = UDP + N-acetyl-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-beta-D- glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide [RN:R04654 R06013]


entry: 2.4.1.165
iubmb_reaction: R04615 R06011(G)
name:
--- 
- N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase
- uridine diphosphoacetylgalactosamine-acetylneuraminyl(alpha2- >3)galactosyl(beta1->4)glucosyl beta1->4-acetylgalactosaminyltransferase

sysname:
UDP-N-acetyl-D-galactosamine:N-acetylneuraminyl-2,3-alpha-D-galactos yl-1,4-beta-D-glucosylceramide beta-1,4-N-acetylgalactosaminyltransferase

comment:
Requires Mn2+. Only substances containing sialic acid residues can act as acceptors; bovine fetuin is the best acceptor tested.

reaction:
UDP-N-acetyl-D-galactosamine + N-acetylneuraminyl-2,3-alpha-D-galactosyl-1,4-beta-D- glucosylceramide = UDP + N-acetyl-D-galactosaminyl-1,4-beta-N-acetylneuraminyl-2,3-alpha-D- galactosyl-1,4-beta-D-glucosylceramide [RN:R04615 R06011]


entry: 2.4.1.166
sysname: raffinose:raffinose alpha-D-galactosyltransferase
reaction: 2 raffinose = 1F-alpha-D-galactosylraffinose + sucrose [RN:R00039 R06139]
iubmb_reaction: R00039 R06139(G)
name:
--- 
- raffinose-raffinose alpha-galactosyltransferase
- raffinose (raffinose donor) galactosyltransferase
- raffinose:raffinose alpha-galactosyltransferase
- raffinose-raffinose alpha-galactotransferase

comment:
The 3F position of raffinose can also act as galactosyl acceptor; the enzyme is involved in the accumulation of the tetrasaccharides lychnose and isolychnose in the leaves of Cerastium arvense and other plants of the family Caryophyllaceae during late autumn.


entry: 2.4.1.167
sysname: UDP-galactose:sucrose 6F-alpha-D-galactosyltransferase
reaction: UDP-galactose + sucrose = UDP + 6F-alpha-D-galactosylsucrose [RN:R00809 R06130]
iubmb_reaction: R00809 R06130(G)
name:
--- 
- sucrose 6F-alpha-galactosyltransferase
- uridine diphosphogalactose-sucrose 6F-alpha-galactosyltransferase
- UDPgalactose:sucrose 6fru-alpha-galactosyltransferase
- sucrose 6F-alpha-galactotransferase

comment:
The enzyme is involved in the synthesis of the trisaccharide planteose and higher analogues in the seeds of Plantago and Sesamum species.


entry: 2.4.1.168
sysname: UDP-glucose:xyloglucan 1,4-beta-D-glucosyltransferase
name:
--- 
- xyloglucan 4-glucosyltransferase
- uridine diphosphoglucose-xyloglucan 4beta-glucosyltransferase
- xyloglucan 4beta-D-glucosyltransferase
- xyloglucan glucosyltransferase

comment:
In association with EC 2.4.2.39 (xyloglucan 6-xylosyltransferase), this enzyme brings about the synthesis of xyloglucan; concurrent transfers of glucose and xylose are essential for this synthesis. Not identical with EC 2.4.1.12 cellulose synthase (UDP-forming).

reaction:
Transfers a beta-D-glucosyl residue from UDP-glucose on to a glucose residue in xyloglucan, forming a beta-1,4-D-glucosyl-D-glucose linkage


entry: 2.4.1.169
name: --- - Transferred to 2.4.2.39
comment:
Transferred entry: now EC 2.4.2.39, xyloglucan 6-xylosyltransferase (EC 2.4.1.169 created 1989, deleted 2003)


entry: 2.4.1.170
sysname: UDP-glucose:isoflavone 7-O-beta-D-glucosyltransferase
reaction: UDP-glucose + an isoflavone = UDP + an isoflavone 7-O-beta-D-glucoside [RN:R07332]
iubmb_reaction: R07332 > R02932 R06795
name:
--- 
- isoflavone 7-O-glucosyltransferase
- uridine diphosphoglucose-isoflavone 7-O-glucosyltransferase
- UDPglucose-favonoid 7-O-glucosyltransferase
- UDPglucose:isoflavone 7-O-glucosyltransferase

comment:
The 4'-methoxy isoflavones biochanin A and formononetin and, more slowly, the 4'-hydroxyisoflavones genistein and daidzein, can act as acceptors. The enzyme does not act on isoflavanones, flavones, flavanones, flavanols or coumarins.


entry: 2.4.1.171
sysname: UDP-glucose:methyl-ONN-azoxymethanol beta-D-glucosyltransferase
reaction: UDP-glucose + methyl-ONN-azoxymethanol = UDP + cycasin [RN:R03547]
iubmb_reaction: R03547
name:
--- 
- methyl-ONN-azoxymethanol beta-D-glucosyltransferase
- cycasin synthase
- uridine diphosphoglucose-methylazoxymethanol glucosyltransferase
- UDP-glucose-methylazoxymethanol glucosyltransferase

comment:
Brings about the biosynthesis of the toxic substance cycasin in the leaves of Japanese cycad, Cycas revoluta.


entry: 2.4.1.172
sysname: UDP-glucose:salicyl-alcohol beta-D-glucosyltransferase
reaction: UDP-glucose + salicyl alcohol = UDP + salicin [RN:R03558]
iubmb_reaction: R03558
name:
--- 
- salicyl-alcohol beta-D-glucosyltransferase
- uridine diphosphoglucose-salicyl alcohol 2-glucosyltransferase
- UDPglucose:salicyl alcohol phenyl-glucosyltransferase


entry: 2.4.1.173
sysname: UDP-glucose:sterol 3-O-beta-D-glucosyltransferase
reaction: UDP-glucose + a sterol = UDP + a sterol 3-beta-D-glucoside [RN:R02113]
iubmb_reaction: R02113
name:
--- 
- sterol 3beta-glucosyltransferase
- UDPG:sterol glucosyltransferase
- UDP-glucose-sterol beta-glucosyltransferase
- sterol:UDPG glucosyltransferase
- UDPG-SGTase
- uridine diphosphoglucose-poriferasterol glucosyltransferase
- uridine diphosphoglucose-sterol glucosyltransferase
- sterol glucosyltransferase
- sterol-beta-D-glucosyltransferase
- UDP-glucose-sterol glucosyltransferase

comment:
Not identical with EC 2.4.1.192 (nuatigenin 3beta-glucosyltransferase) or EC 2.4.1.193 (sarsapogenin 3beta-glucosyltransferase).


entry: 2.4.1.174
iubmb_reaction: R05929(G)
name:
--- 
- glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase
- N-acetylgalactosaminyltransferase I
- glucuronylgalactosylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase
- uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase I

sysname:
UDP-N-acetyl-D-galactosamine:D-glucuronyl-1,3-beta-D-galactosyl-prot eoglycan beta-1,4-N-acetylgalactosaminyltransferase

comment:
Requires Mn2+. Involved in the biosynthesis of chondroitin sulfate. Key enzyme activity for the initiation of chondroitin and dermatan sulfates, transferring GalNAc to the GlcA-Gal-Gal-Xyl-Ser core.

reaction:
UDP-N-acetyl-D-galactosamine + beta-D-glucuronyl-1,3-D-galactosyl-proteoglycan = UDP + N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-1,3-beta-D- galactosylproteoglycan [RN:R05929]


entry: 2.4.1.175
iubmb_reaction: R04603 > R05932(G) R05934(G)
name:
--- 
- glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase
- N-acetylgalactosaminyltransferase II
- UDP-N-acetyl-D-galactosamine:D-glucuronyl-N-acetyl-1,3-beta-D- galactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase
- chondroitin synthase
- glucuronyl-N-acetylgalactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase
- uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase II

sysname:
UDP-N-acetyl-D-galactosamine:beta-D-glucuronosyl-(1->3)-N-acetyl-bet a-D-galactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase

comment:
Involved in the biosynthesis of chondroitin sulfate. The human form of this enzyme is a bifunctional glycosyltransferase, which also has the 3-beta-glucuronosyltransferase (EC 2.4.1.226, N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase) activity required for the synthesis of the chondroitin sulfate disaccharide repeats. Similar chondroitin synthase 'co-polymerases' can be found in Pasteurella multocida and Escherichia coli.

reaction:
UDP-N-acetyl-D-galactosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl- proteoglycan = UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N- acetyl-beta-D-galactosaminyl-proteoglycan [RN:R04603]


entry: 2.4.1.176
sysname: UDP-glucose:gibberellin 2-O-beta-D-glucosyltransferase
comment: Acts on the plant hormone gibberellin GA3 and related compounds.
reaction: UDP-glucose + gibberellin = UDP + gibberellin 2-O-beta-D-glucoside [RN:R03680]
iubmb_reaction: R03680
name:
--- 
- gibberellin beta-D-glucosyltransferase
- uridine diphosphoglucose-gibberellate 7-glucosyltransferase
- uridine diphosphoglucose-gibberellate 3-O-glucosyltransferase


entry: 2.4.1.177
sysname: UDP-glucose:trans-cinnamate beta-D-glucosyltransferase
reaction: UDP-glucose + trans-cinnamate = UDP + trans-cinnamoyl beta-D-glucoside [RN:R02256]
iubmb_reaction: R02256
name:
--- 
- cinnamate beta-D-glucosyltransferase
- uridine diphosphoglucose-cinnamate glucosyltransferase
- UDPG:t-cinnamate glucosyltransferase

comment:
4-Coumarate, 2-coumarate, benzoate, feruloate and caffeate can also act as acceptors, but more slowly. Involved in the biosynthesis of chlorogenic acid in the root of the sweet potato, Ipomoea batatas.


entry: 2.4.1.178
sysname: UDP-glucose:4-hydroxymandelonitrile glucosyltransferase
comment: 3,4-Dihydroxymandelonitrile can also act as acceptor.
reaction: UDP-glucose + 4-hydroxymandelonitrile = UDP + taxiphyllin [RN:R02709]
iubmb_reaction: R02709
name:
--- 
- hydroxymandelonitrile glucosyltransferase
- cyanohydrin glucosyltransferase
- uridine diphosphoglucose-cyanohydrin glucosyltransferase


entry: 2.4.1.179
sysname: UDP-galactose:D-galactosyl-1,4-beta-D-glucosyl-R beta-1,3-galactosyltransferase
iubmb_reaction: R04431
name:
--- 
- lactosylceramide beta-1,3-galactosyltransferase
- uridine diphosphogalactose-lactosylceramide beta1->3-galactosyltransferase

comment:
R may be an oligosaccharide or a glycolipid; lactose can also act as acceptor, but more slowly. Involved in the elongation of oligosaccharide chains, especially in glycolipids.

reaction:
UDP-galactose + D-galactosyl-1,4-beta-D-glucosyl-R = UDP + D-galactosyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosyl-R [RN:R04431]


entry: 2.4.1.180
comment: Involved in the biosynthesis of common antigen in Enterobacteriaceae.
iubmb_reaction: R04477
name:
--- 
- lipopolysaccharide N-acetylmannosaminouronosyltransferase
- ManNAcA transferase
- uridine diphosphoacetylmannosaminuronate- acetylglucosaminylpyrophosphorylundecaprenol acetylmannosaminuronosyltransferase

sysname:
UDP-N-acetyl-beta-D-mannosaminouronate:lipopolysaccharide N-acetyl-beta-D-mannosaminouronosyltransferase

reaction:
UDP-N-acetyl-beta-D-mannosaminouronate + lipopolysaccharide = UDP + N-acetyl-beta-D-mannosaminouronosyl-1,4-lipopolysaccharide [RN:R04477]


entry: 2.4.1.181
sysname: UDP-glucose:hydroxyanthraquinone O-glucosyltransferase
reaction: UDP-glucose + an hydroxyanthraquinone = UDP + a glucosyloxyanthraquinone [RN:R04108]
iubmb_reaction: R04108
name:
--- 
- hydroxyanthraquinone glucosyltransferase
- uridine diphosphoglucose-anthraquinone glucosyltransferase
- anthraquinone-specific glucosyltransferase

comment:
A range of anthraquinones and some flavones can act as acceptors; best substrates are emodin, anthrapurpurin, quinizarin, 2,6-dihydroanthraquinone and 1,8-dihydroxyanthraquinone.


entry: 2.4.1.182
name: --- - lipid-A-disaccharide synthase
iubmb_reaction: R04606
sysname:
UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine:2,3-bis-(3-hydroxytet radecanoyl)-beta-D-glucosaminyl-1-phosphate 2,3-bis(3-hydroxytetradecanoyl)-glucosaminyltransferase

comment:
Involved with EC 2.3.1.129 (acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase) and EC 2.7.1.130 (tetraacyldisaccharide 4'-kinase) in the biosynthesis of the phosphorylated glycolipid, Lipid A, in the outer membrane of Escherichia coli.

reaction:
UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3- hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate [RN:R04606]


entry: 2.4.1.183
sysname: UDP-glucose:alpha-D-(1-3)-glucan 3-alpha-D-glucosyltransferase
reaction: UDP-glucose + [alpha-D-glucosyl-(1-3)]n = UDP + [alpha-D-glucosyl-(1-3)]n+1 [RN:R03996 R06045]
iubmb_reaction: R03996 R06045(G)
name:
--- 
- alpha-1,3-glucan synthase
- uridine diphosphoglucose-1,3-alpha-glucan glucosyltransferase
- 1,3-alpha-D-glucan synthase

comment:
A glucan primer is needed to begin the reaction, which brings about elongation of the glucan chains.


entry: 2.4.1.184
iubmb_reaction: R04472
name:
--- 
- galactolipid galactosyltransferase
- galactolipid-galactolipid galactosyltransferase
- galactolipid:galactolipid galactosyltransferase
- interlipid galactosyltransferase
- GGGT
- DGDG synthase (ambiguous)
- digalactosyldiacylglycerol synthase (ambiguous)

sysname:
3-(beta-D-galactosyl)-1,2-diacyl-sn-glycerol:mono-3-(beta-D-galactos yl)-1,2-diacyl-sn-glycerol beta-D-galactosyltransferase

comment:
By further transfers of galactosyl residues to the digalactosyldiacylglycerol, trigalactosyldiacylglycerol and tetragalactosyldiacylglycerol are also formed. This enzyme was originally thought to be the major enzyme involved in the production of digalactosyldiacylglycerol in plants as it masked the effect of the true enzyme (EC 2.4.1.241, digalactosyldiacylglycerol synthase) [4,5]. Its activity is localized to chloroplast envelope membranes, but it does not contribute to net galactolipid synthesis in plants [4].

reaction:
2 3-(beta-D-galactosyl)-1,2-diacyl-sn-glycerol = 3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-1,2-diacyl-sn- glycerol + 1,2-diacyl-sn-glycerol [RN:R04472]


entry: 2.4.1.185
sysname: UDP-glucose:flavanone 7-O-beta-D-glucosyltransferase
comment: Naringenin and hesperetin can act as acceptors. No action on flavones or flavonols.
reaction: UDP-glucose + a flavanone = UDP + a flavanone 7-O-beta-D-glucoside [RN:R07333]
iubmb_reaction: R07333 > R02897
name:
--- 
- flavanone 7-O-beta-glucosyltransferase
- uridine diphosphoglucose-flavanone 7-O-glucosyltransferase
- naringenin 7-O-glucosyltransferase
- hesperetin 7-O-glucosyl-transferase


entry: 2.4.1.186
name: --- - glycogenin glucosyltransferase - glycogenin - priming glucosyltransferase
sysname: UDP-glucose:glycogenin glucosyltransferase
reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin [RN:R03681]
iubmb_reaction: R03681
comment:
The glycogenin sub-unit of glycogen synthase [EC 2.4.1.11, glycogen(starch) synthase] catalyses this reaction, i.e. the enzyme catalyses its own autoglucosylation. Five molecules of glucose can be transferred to one molecule of glycogenin. The product acts as a primer for the reaction catalysed by glycogen synthase.


entry: 2.4.1.187
comment: Involved in the biosynthesis of teichoic acid linkage units in bacterial cell walls.
iubmb_reaction: R05566 R06129(G)
name:
--- 
- N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase
- uridine diphosphoacetyl- mannosamineacetylglucosaminylpyrophosphorylundecaprenol acetylmannosaminyltransferase
- N-acetylmannosaminyltransferase
- UDP-N-acetylmannosamine:N-acetylglucosaminyl diphosphorylundecaprenol N-acetylmannosaminyltransferase

sysname:
UDP-N-acetyl-D-mannosamine:N-acetyl-beta-D-glucosaminyldiphosphounde caprenol beta-1,4-N-acetylmannosaminyltransferase

reaction:
UDP-N-acetyl-D-mannosamine + N-acetyl-D-glucosaminyldiphosphoundecaprenol = UDP + N-acetyl-beta-D-mannosaminyl-1,4-N-acetyl-D- glucosaminyldiphosphoundecaprenol [RN:R05566 R06129]


entry: 2.4.1.188
sysname: UDP-glucose:N-acetyl-D-glucosaminyldiphosphoundecaprenol 4-beta-D-glucosyltransferase
iubmb_reaction: R06047 R06062(G)
name:
--- 
- N-acetylglucosaminyldiphosphoundecaprenol glucosyltransferase
- UDP-D-glucose:N-acetylglucosaminyl pyrophosphorylundecaprenol glucosyltransferase
- uridine diphosphoglucose-acetylglucosaminylpyrophosphorylundecaprenol glucosyltransferase

reaction:
UDP-glucose + N-acetyl-D-glucosaminyldiphosphoundecaprenol = UDP + beta-D-glucosyl-1,4-N-acetyl-D-glucosaminyldiphosphoundecaprenol [RN:R06047 R06062]


entry: 2.4.1.189
sysname: UDP-glucuronate:luteolin 7-O-glucuronosyltransferase
reaction: UDP-glucuronate + luteolin = UDP + luteolin 7-O-beta-D-glucuronide [RN:R03589]
iubmb_reaction: R03589
name:
--- 
- luteolin 7-O-glucuronosyltransferase
- uridine diphosphoglucuronate-luteolin 7-O-glucuronosyltransferase
- LGT


entry: 2.4.1.190
sysname: UDP-glucuronate:luteolin-7-O-beta-D-glucuronide 2"-O-glucuronosyltransferase
iubmb_reaction: R06827
name:
--- 
- luteolin-7-O-glucuronide 2"-O-glucuronosyltransferase
- uridine diphosphoglucuronate-luteolin 7-O-glucuronide glucuronosyltransferase
- LMT
- UDP-glucuronate:luteolin 7-O-glucuronide-glucuronosyltransferase

reaction:
UDP-glucuronate + luteolin 7-O-beta-D-glucuronide = UDP + luteolin 7-O-[beta-D-glucuronosyl-(1->2)-beta-D-glucuronide] [RN:R06827]


entry: 2.4.1.191
sysname: UDP-glucuronate:luteolin-7-O-beta-D-diglucuronide 4'-O-glucuronosyltransferase
iubmb_reaction: R06828
name:
--- 
- luteolin-7-O-diglucuronide 4'-O-glucuronosyltransferase
- uridine diphosphoglucuronate-luteolin 7-O-diglucuronide glucuronosyltransferase
- UDP-glucuronate:luteolin 7-O-diglucuronide-glucuronosyltransferase
- UDPglucuronate:luteolin 7-O-diglucuronide-4'-O-glucuronosyl-transferase
- LDT

reaction:
UDP-glucuronate + luteolin 7-O-beta-D-diglucuronide = UDP + luteolin 7-O-[beta-D-glucuronosyl-(1->2)-beta-D-glucuronide]-4'-O-beta-D- glucuronide [RN:R06828]


entry: 2.4.1.192
sysname: UDP-glucose:(20S,22S,25S)-22,25-epoxyfurost-5-ene-3beta,26-diol 3-O-beta-D-glucosyltransferase
iubmb_reaction: R04577
name:
--- 
- nuatigenin 3beta-glucosyltransferase
- uridine diphosphoglucose-nuatigenin glucosyltransferase

comment:
Some other sapogenins can act as glucosyl acceptors. Involved in the biosynthesis of plant saponins. Not identical with EC 2.4.1.173 (sterol 3beta-glucosyltransferase) or EC 2.4.1.193 (sarsapogenin 3beta-glucosyltransferase).

reaction:
UDP-glucose + (20S,22S,25S)-22,25-epoxyfurost-5-ene-3beta,26-diol = UDP + (20S,22S,25S)-22,25-epoxyfurost-5-ene-3beta,26-diol 3-O-beta-D-glucoside [RN:R04577]


entry: 2.4.1.193
sysname: UDP-glucose:(25S)-5beta-spirostan-3beta-ol 3-O-beta-D-glucosyltransferase
iubmb_reaction: R04359
name:
--- 
- sarsapogenin 3beta-glucosyltransferase
- uridine diphosphoglucose-sarsapogenin glucosyltransferase

comment:
Specific to 5beta-spirostanols. Involved in the biosynthesis of plant saponins. Not identical with EC 2.4.1.173 (sterol 3beta-glucosyltransferase) or EC 2.4.1.192 (nuatigenin 3beta-glucosyltransferase).

reaction:
UDP-glucose + (25S)-5beta-spirostan-3beta-ol = UDP + (25S)-5beta-spirostan-3beta-ol 3-O-beta-D-glucoside [RN:R04359]


entry: 2.4.1.194
sysname: UDP-glucose:4-hydroxybenzoate 4-O-beta-D-glucosyltransferase
reaction: UDP-glucose + 4-hydroxybenzoate = UDP + 4-(beta-D-glucosyloxy)benzoate [RN:R01304]
iubmb_reaction: R01304
name:
--- 
- 4-hydroxybenzoate 4-O-beta-D-glucosyltransferase
- uridine diphosphoglucose-4-hydroxybenzoate glucosyltransferase
- UDP-glucose:4-(beta-D-glucopyranosyloxy)benzoic acid glucosyltransferase
- HBA glucosyltransferase
- p-hydroxybenzoate glucosyltransferase
- PHB glucosyltransferase
- PHB-O-glucosyltransferase


entry: 2.4.1.195
sysname: UDP-glucose:N-hydroxy-2-phenylethanethioamide S-beta-D-glucosyltransferase
reaction: UDP-glucose + N-hydroxy-2-phenylethanethioamide = UDP + desulfoglucotropeolin [RN:R03213]
iubmb_reaction: R03213
name:
--- 
- N-hydroxythioamide S-beta-glucosyltransferase
- desulfoglucosinolate-uridine diphosphate glucosyltransferase
- uridine diphosphoglucose-thiohydroximate glucosyltransferase
- thiohydroximate beta-D-glucosyltransferase
- UDPG:thiohydroximate glucosyltransferase
- thiohydroximate S-glucosyltransferase
- thiohydroximate glucosyltransferase
- UDP-glucose:thiohydroximate S-beta-D-glucosyltransferase

comment:
Involved with EC 2.8.2.24, desulfoglucosinolate sulfotransferase, in the biosynthesis of thioglucosides in cruciferous plants.


entry: 2.4.1.196
sysname: UDP-glucose:nicotinate N-glucosyltransferase
reaction: UDP-glucose + nicotinate = UDP + N-glucosylnicotinate [RN:R01722]
iubmb_reaction: R01722
name:
--- 
- nicotinate glucosyltransferase
- uridine diphosphoglucose-nicotinate N-glucosyltransferase
- UDP-glucose:nicotinic acid-N-glucosyltransferase


entry: 2.4.1.197
sysname: UDP-N-acetyl-D-glucosamine:high-mannose-oligosaccharide beta-1,4-N-acetylglucosaminyltransferase
name:
--- 
- high-mannose-oligosaccharide beta-1,4-N-acetylglucosaminyltransferase
- uridine diphosphoacetylglucosamine-oligosaccharide acetylglucosaminyltransferase
- acetylglucosamine-oligosaccharide acetylglucosaminyltransferase
- UDP-GlcNAc:oligosaccharide beta-N-acetylglucosaminyltransferase

comment:
The activity of the intersecting mannose residue as acceptor is dependent on two other mannose residues attached by alpha-1,3 and alpha-1,6 links.

reaction:
Transfers an N-acetyl-D-glucosamine residue from UDP-N-acetyl-D-glucosamine to the 4-position of a mannose linked alpha-1,6 to the core mannose of high-mannose oligosaccharides produced by Dictyostelium discoideum


entry: 2.4.1.198
iubmb_reaction: R02654 R05916(G)
name:
--- 
- phosphatidylinositol N-acetylglucosaminyltransferase
- UDP-N-acetyl-D-glucosamine:phosphatidylinositol N-acetyl-D-glucosaminyltransferase
- uridine diphosphoacetylglucosamine alpha1,6-acetyl-D-glucosaminyltransferase

sysname:
UDP-N-acetyl-D-glucosamine:1-phosphatidyl-1D-myo-inositol 6-(N-acetyl-alpha-D-glucosaminyl)transferase

comment:
Involved in the first step of glycosylphosphatidylinositol (GPI) anchor formation in all eukaryotes. In mammalian cells, the enzyme is composed of at least five subunits (PIG-A, PIG-H, PIG-C, GPI1 and PIG-P). PIG-A subunit is the catalytic subunit. In some species, the long-chain acyl groups of the phosphatidyl group are partly replaced by long-chain alkyl or alk-1-enyl groups.

reaction:
UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol [RN:R02654 R05916]


entry: 2.4.1.199
comment: Involved in the formation of mannooligosaccharides in the membrane of Mycobacterium smegmatis.
iubmb_reaction: R06046 R06074(G)
name:
--- 
- beta-mannosylphosphodecaprenol-mannooligosaccharide 6-mannosyltransferase
- mannosylphospholipid-methylmannoside alpha-1,6-mannosyltransferase

sysname:
beta-D-mannosylphosphodecaprenol:1,6-alpha-D-mannosyloligosaccharide 1,6-alpha-D-mannosyltransferase

reaction:
beta-D-mannosylphosphodecaprenol + 1,6-alpha-D-mannosyloligosaccharide = decaprenol phosphate + 1,6-alpha-D-mannosyl-1,6-alpha-D-mannosyl-oligosaccharide [RN:R06046 R06074]


entry: 2.4.1.200
name: --- - Transferred to 4.2.2.17
comment:
Transferred entry: now EC 4.2.2.17, inulin fructotransferase (DFA-I-forming). The enzyme was wrongly classified as a transferase rather than a lyase. (EC 2.4.1.200 created 1992, deleted 2004)


entry: 2.4.1.201
iubmb_reaction: R04642 > R05992(G)
name:
--- 
- alpha-1,6-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
- N-acetylglucosaminyltransferase VI
- N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase VI
- uridine diphosphoacetylglucosamine-glycopeptide beta-1->4-acetylglucosaminyltransferase VI
- mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase

sysname:
UDP-N-acetyl-D-glucosamine:2,6-bis(N-acetyl-beta-D-glucosaminyl)-alp ha-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase

reaction:
UDP-N-acetyl-D-glucosamine + 2,6-bis(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl-R = UDP + 2,4,6-tris(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl-R [RN:R04642]


entry: 2.4.1.202
sysname: UDP-glucose:2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase
iubmb_reaction: R04579
name:
--- 
- 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase
- uridine diphosphoglucose-2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-glucosyltransferase

reaction:
UDP-glucose + 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one = UDP + 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucoside [RN:R04579]


entry: 2.4.1.203
sysname: UDP-glucose:trans-zeatin O-beta-D-glucosyltransferase
reaction: UDP-glucose + trans-zeatin = UDP + O-beta-D-glucosyl-trans-zeatin [RN:R02118]
iubmb_reaction: R02118
name:
--- 
- trans-zeatin O-beta-D-glucosyltransferase
- zeatin O-beta-D-glucosyltransferase
- uridine diphosphoglucose-zeatin O-glucosyltransferase
- zeatin O-glucosyltransferase

comment:
Unlike EC 2.4.1.215, cis-zeatin O-beta-D-glucosyltransferase, UDP-D-xylose can also act as donor (cf. EC 2.4.2.40, zeatin O-beta-D-xylosyltransferase).


entry: 2.4.1.204
name: --- - Transferred to 2.4.2.40
comment:
Transferred entry: now EC 2.4.2.40, zeatin O-beta-D-xylosyltransferase (EC 2.4.1.204 created 1992, deleted 2003)


entry: 2.4.1.205
sysname: UDP-galactose:galactogen beta-1,6-D-galactosyltransferase
comment: Galactogen from Helix pomatia is the most effective acceptor.
reaction: UDP-galactose + galactogen = UDP + 1,6-beta-D-galactosylgalactogen [RN:R03679]
iubmb_reaction: R03679
name:
--- 
- galactogen 6beta-galactosyltransferase
- uridine diphosphogalactose-galactogen galactosyltransferase
- 1,6-D-galactosyltransferase
- beta-(1-6)-D-galactosyltransferase


entry: 2.4.1.206
iubmb_reaction: R04493 R05971(G)
name:
--- 
- lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase
- LA2 synthase
- beta1->3-N-acetylglucosaminyltransferase
- uridine diphosphoacetylglucosamine-lactosylceramide beta-acetylglucosaminyltransferase
- lactosylceramide beta-acetylglucosaminyltransferase

sysname:
UDP-N-acetyl-D-glucosamine:D-galactosyl-1,4-beta-D-glucosylceramide beta-1,3-acetylglucosaminyltransferase

reaction:
UDP-N-acetyl-D-glucosamine + D-galactosyl-1,4-beta-D-glucosylceramide = UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D- glucosylceramide [RN:R04493 R05971]


entry: 2.4.1.207
sysname: xyloglucan:xyloglucan xyloglucanotransferase
comment: does not use cello-oligosaccharides as either donor or acceptor.
name:
--- 
- xyloglucan:xyloglucosyl transferase
- endo-xyloglucan transferase
- xyloglucan endotransglycosylase

reaction:
breaks a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan


entry: 2.4.1.208
sysname: UDP-glucose:1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol (1->2) glucosyltransferase
comment: the enzyme from Acholeplasma laidlawii requires Mg2+.
iubmb_reaction: R05164
name:
--- 
- diglucosyl diacylglycerol synthase
- monoglucosyl diacylglycerol (1->2) glucosyltransferase
- MGlcDAG (1->2) glucosyltransferase
- DGlcDAG synthase

reaction:
UDP-glucose + 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol = 1,2-diacyl-3-O-(alpha-D-glucopyranosyl(1->2)-O-alpha-D- glucopyranosyl)sn-glycerol + UDP [RN:R05164]


entry: 2.4.1.209
name: --- - cis-p-coumarate glucosyltransferase
sysname: UDP-glucose:cis-p-coumarate beta-D-glucosyltransferase
reaction: UDP-glucose + cis-p-coumarate = 4'-O-beta-D-glucosyl-cis-p-coumarate + UDP [RN:R05324]
iubmb_reaction: R05324
comment:
cis-Caffeic acid also serves as a glucosyl acceptor with the enzyme from Sphagnum fallax kinggr. The corresponding trans-isomers are not substrates.


entry: 2.4.1.210
name: --- - limonoid glucosyltransferase
sysname: uridine diphosphoglucose-limonoid glucosyltransferase
reaction: UDP-glucose + limonin = glucosyl-limonin + UDP [RN:R05325]
iubmb_reaction: R05325
comment:
The enzyme purified from navel orange albedo tissue also acts on the related tetranortriterpenoid nomilin.


entry: 2.4.1.211
name: --- - 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase
sysname: beta-D-galactopyranosyl-(1->3)-N-acetyl-D-hexosamine:phosphate galactosyltransferase
iubmb_reaction: R05326 R06057(G)
comment:
Reaction also occurs with beta-D-galactopyranosyl-(1->3)-N-acetyl-D-galactosamine as the substrate, giving N-acetyl-D-galactosamine as the product.

reaction:
beta-D-galactopyranosyl-(1->3)-N-acetyl-D-glucosamine + phosphate = alpha-D-galactopyranose 1-phosphate + N-acetyl-D-glucosamine [RN:R05326 R06057]


entry: 2.4.1.212
name: --- - hyaluronan synthase
iubmb_reaction: R05327 R06068(G)
comment:
The enzyme from Streptococcus Group A and Group C requires Mg2+. It is highly specific for UDP-GlcNAc and UDP-GlcA; no copolymerization is observed if either is replaced by UDP-Glc, UDP-Gal, UDP-GalNAc or UDP-GalA. Similar enzymes have been found in a variety of organisms.

reaction:
n UDP-N-acetyl-D-glucosamine + n UDP-D-glucuronate = [beta-N-acetyl-D-glucosaminyl(1-> 4)beta-D-glucuronosyl(1-> 3)]n+ 2n UDP [RN:R05327 R06068]


entry: 2.4.1.213
name: --- - glucosylglycerol-phosphate synthase
sysname: ADP-glucose:sn-glycerol-3-phosphate 2-beta-D-glucosyltransferase
iubmb_reaction: R05328
comment:
Acts with EC 3.1.3.69 (glucosylglycerol phosphatase) to form glucosylglycerol, an osmolyte that endows cyanobacteria with resistance to salt.

reaction:
ADP-glucose + sn-glycerol 3-phosphate = 2-(beta-D-glucosyl)-sn-glycerol 3-phosphate + ADP [RN:R05328]


entry: 2.4.1.214
iubmb_reaction: R06015(G)
name:
--- 
- glycoprotein 3-alpha-L-fucosyltransferase
- GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,3-fucosyltransferase
- GDP-L-Fuc:Asn-linked GlcNAc alpha1,3-fucosyltransferase
- GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fucalpha1->6GlcNAc)-Asn-peptide) alpha1->3-fucosyltransferase

sysname:
GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-a cetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-man nosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glu cosaminyl}asparagine) 3-alpha-L-fucosyl-transferase

comment:
Requires Mn2+. The enzyme transfers to N-linked oligosaccharide structures (N-glycans), generally with a specificity for N-glycans with one unsubstituted non-reducing terminal GlcNAc residue. This enzyme catalyses a reaction similar to that of EC 2.4.1.68, glycoprotein 6-alpha-L-fucosyltransferase, but transferring the L-fucosyl group from GDP-beta-L-fucose to form an alpha1,3-linkage rather than an alpha1,6-linkage. The N-glycan products of this enzyme are present in plants, insects and some other invertebrates (e.g., Schistosoma, Haemonchus, Lymnaea).

reaction:
GDP-L-fucose + N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N- acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D- mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D- glucosaminyl}asparagine = GDP + N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N- acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D- mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-[alpha-L- fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl}asparagine [RN:R06015]


entry: 2.4.1.215
name: --- - cis-zeatin O-beta-D-glucosyltransferase
sysname: UDP-glucose:cis-zeatin O-beta-D-glucosyltransferase
reaction: UDP-glucose + cis-zeatin = UDP + O-beta-D-glucosyl-cis-zeatin [RN:R07260]
iubmb_reaction: R07260
comment:
The enzyme from maize can use cis-zeatin and UDP-glucose as substrates, but not cis-ribosylzeatin, trans-zeatin or trans-ribosylzeatin. Unlike EC 2.4.1.203, trans-zeatin O-beta-D-glucosyltransferase, UDP-D-xylose cannot act as a donor.


entry: 2.4.1.216
name: --- - trehalose 6-phosphate phosphorylase
sysname: trehalose 6-phosphate:phosphate beta-D-glucosyltransferase
iubmb_reaction: R05767 R06044(G)
comment:
The enzyme from Lactococcus lactis is specific for trehalose 6-phosphate. Differs from EC 2.4.1.64, alpha,alpha-trehalose phosphorylase, in that trehalose is not a substrate.

reaction:
trehalose 6-phosphate + phosphate = glucose 6-phosphate + beta-D-glucose 1-phosphate [RN:R05767 R06044]


entry: 2.4.1.217
name: --- - mannosyl-3-phosphoglycerate synthase - MPG synthase
sysname: GDP-mannose:3-phosphoglycerate 3-alpha-D-mannosyltransferase
reaction: GDP-mannose + 3-phospho-D-glycerate = GDP + 2-(alpha-D-mannosyl)-3-phosphoglycerate [RN:R05768]
iubmb_reaction: R05768
comment:
Requires Mg2+. The enzyme is absolutely specific for GDPmannose and 3-phosphoglycerate, and transfers the mannosyl group with retention of configuration. In the hyperthermophilic archaeon Pyrococcus horikoshii, the mannosyl-3-phosphoglycerate formed is subsequently dephosphorylated by a specific phosphatase, EC 3.1.3.70 (mannosyl-3-phosphoglycerate phosphatase), producing mannosylglycerate.


entry: 2.4.1.218
name: --- - hydroquinone glucosyltransferase - arbutin synthase - hydroquinone:O-glucosyltransferase
sysname: UDP-glucose:hydroquinone-O-beta-D-glucosyltransferase
reaction: UDP-glucose + hydroquinone = UDP + hydroquinone-O-beta-D-glucopyranoside [RN:R05769]
iubmb_reaction: R05769
comment:
Hydroquinone is the most effective acceptor, but over 40 phenolic compounds are also glucosylated, but at lower rates.


entry: 2.4.1.220
name: --- - indoxyl-UDPG glucosyltransferase - indoxyl-UDPG-glucosyltransferase
sysname: UDP-glucose:indoxyl 3-O-beta-D-glucosyltransferase
reaction: UDP-glucose + indoxyl = UDP + indican [RN:R06048]
iubmb_reaction: R06048
comment:
Also acts to a limited extent on 4-, 5-, 6- and 7-hydroxyindole. After enzymic or chemical hydrolysis, indican forms indoxyl, which, in turn, is converted in the presence of oxygen to the dye indigo.


entry: 2.4.1.221
sysname: GDP-beta-L-fucose:polypeptide O-alpha-L-fucosyltransferase
name:
--- 
- peptide-O-fucosyltransferase
- GDP-L-fucose:polypeptide fucosyltransferase
- GDP-fucose protein O-fucosyltransferase
- GDP-fucose:polypeptide fucosyltransferase

comment:
Involved in the biosynthesis of O-fucosylated epidermal growth factor (EGF) and thrombospondin type 1 repeats. The attachment of O-linked fucose to serine or threonine occurs on EGF domains within the sequence Cys-Xaa-Xaa-Gly-Gly-Ser/Thr-Cys.

reaction:
transfers an alpha-L-fucosyl residue from GDP-beta-L-fucose to the serine hydroxy group of a protein acceptor


entry: 2.4.1.222
sysname: UDP-D-GlcNAc:O-L-fucosylpeptide 3-beta-N-acetyl-D-glucosaminyltransferase
name:
--- 
- O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
- O-fucosylpeptide beta-1,3-N-acetylglucosaminyltransferase

comment:
O-Fucosylpeptide 3-beta-N-acetylglucosaminyltransferases are the products of fringe genes. O-linked fucose is an unusual form of glycosylation where the fucose is attached directly to proteins through the hydroxy groups of Ser or Thr residues.

reaction:
transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor


entry: 2.4.1.223
iubmb_reaction: R05930(G)
kegg_reaction: R07397
name:
--- 
- glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase
- alpha-N-acetylglucosaminyltransferase I
- alpha1,4-N-acetylglucosaminyltransferase
- glucuronosylgalactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase

sysname:
UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->3)-beta-D-galacto syl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan 4IV-alpha-N-acetyl-D-glucosaminyltransferase

comment:
Enzyme involved in the initiation of heparin and heparan sulfate synthesis, transferring GlcNAc to the (GlcA-Gal-Gal-Xyl-)Ser core. Apparently products of both the human EXTL2 and EXTL3 genes can catalyse this reaction. In Caenorhabditis elegans, the product of the rib-2 gene displays this activity as well as that of EC 2.4.1.224, glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase. For explanation of the use of a superscript in the systematic name, see 2-Carb-37.2.

reaction:
UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D- galactosyl-(1->4)-beta-D-xylosyl-proteoglycan = UDP + alpha-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)- beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl- proteoglycan [RN:R05930]


entry: 2.4.1.224
iubmb_reaction: R07334 > R05936(G)
name:
--- 
- glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase
- alpha-N-acetylglucosaminyltransferase II glucuronyl-N-acetylglucosaminylproteoglycan alpha-1,4-N-acetylglucosaminyltransferase

sysname:
UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->4)-N-acetyl-alpha -D-glucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase

comment:
Involved in the biosynthesis of heparin and heparan sulfate. Some forms of the enzyme from human (particularly the enzyme complex encoded by the EXT1 and EXT2 genes) act as bifunctional glycosyltransferases, which also have the 4-beta-glucuronosyltransferase (EC 2.4.1.225, N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase) activity required for the synthesis of the heparan sulfate disaccharide repeats. Other human forms of this enzyme (e.g. the product of the EXTL1 gene) have only the 4-alpha-N-acetylglucosaminyltransferase activity. In Caenorhabditis elegans, the product of the rib-2 gene displays the activities of this enzyme as well as EC 2.4.1.223, glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase.

reaction:
UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl- proteoglycan = UDP + N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->4)-N- acetyl-alpha-D-glucosaminyl-proteoglycan [RN:R07334]


entry: 2.4.1.225
iubmb_reaction: R07335 > R05935(G)
name:
--- 
- N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase
- N-acetylglucosaminylproteoglycan beta-1,4-glucuronyltransferase
- heparan glucuronyltransferase II

sysname:
UDP-alpha-D-glucuronate:N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D- glucuronosyl-proteoglycan 4-beta-glucuronosyltransferase

comment:
Involved in the biosynthesis of heparin and heparan sulfate. Some forms of the human enzyme (particularly the enzyme complex encoded by the EXT1 and EXT2 genes) act as bifunctional glycosyltransferases, which also have the glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase (EC 2.4.1.224) activity required for the synthesis of the heparan sulfate disaccharide repeats.

reaction:
UDP-alpha-D-glucuronate + N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl- proteoglycan = UDP + beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-(1->4)- beta-D-glucuronosyl-proteoglycan [RN:R07335]


entry: 2.4.1.226
iubmb_reaction: R07336 > R05931(G) R05933(G)
name:
--- 
- N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase
- chondroitin glucuronyltransferase II

sysname:
alpha-D-glucuronate:N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glu curonosyl-proteoglycan 3-beta-glucuronosyltransferase

comment:
Involved in the biosynthesis of chondroitin and dermatan sulfate. The human chondroitin synthetase is a bifunctional glycosyltransferase, which has the 3-beta-glucuronosyltransferase and 4-beta-N-acetylgalactosaminyltransferase (EC 2.4.1.175) activities required for the synthesis of the chondroitin sulfate disaccharide repeats. Similar chondroitin synthase 'co-polymerases' can be found in Pasteurella multocida and Escherichia coli. There is also another human protein with apparently only the 3-beta-glucuronosyltransferase activity.

reaction:
UDP-alpha-D-glucuronate + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl- proteoglycan = UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)- beta-D-glucuronosyl-proteoglycan [RN:R07336]


entry: 2.4.1.227
iubmb_reaction: R05662 R06173(G)
kegg_reaction: R05027 R05032 R06172(G) R06174(G)
name:
--- 
- undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase
- MurG transferase

sysname:
UDP-N-acetyl-D-glucosamine:N-acetyl-alpha-D-muramyl(oyl-L-Ala-gamma- D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol beta-1,4-N-acetylglucosaminlytransferase

reaction:
UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)- diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)- diphosphoundecaprenol [RN:R05662 R06173]


entry: 2.4.1.228
sysname: UDP-galactose:lactosylceramide 4II-alpha-D-galactosyltransferase
comment: For explanation of superscript II in systematic name, see 2-carb.37.
iubmb_reaction: R03486 R05960(G)
name:
--- 
- lactosylceramide 4-alpha-galactosyltransferase
- Galbeta1-4Glcbeta1-Cer alpha1,4-galactosyltransferase
- globotriaosylceramide/CD77 synthase
- histo-blood group Pk UDP-galactose

reaction:
UDP-galactose + beta-D-galactosyl-(1->4)-D-glucosylceramide = UDP + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-D- glucosylceramide [RN:R03486 R05960]


entry: 2.4.1.229
sysname: UDP-N-acetyl-D-glucosamine:[Skp1-protein]-hydroxyproline N-acetyl-D-glucosaminyl-transferase
name:
--- 
- "[Skp1-protein]-hydroxyproline N-acetylglucosaminyltransferase"
- Skp1-HyPro GlcNAc-transferase
- UDP-N-acetylglucosamine (GlcNAc):hydroxyproline polypeptide GlcNAc-transferase
- UDP-GlcNAc:Skp1-hydroxyproline GlcNAc-transferase
- UDP-GlcNAc:hydroxyproline polypeptide GlcNAc-transferase

comment:
Requires dithiothreitol and a divalent cation for activity. This enzyme commences the building up of a pentasaccharide (Galalpha1-6Galalpha1-L-Fucalpha1-2Galbeta1-3GlcNAc) on Hyp-143 of the Dictyostelium protein Skp1, which is required for the ubiquitination of cell-cycle regulatory proteins and transcription factors. The fucose residue is probably in the alpha configuration [3]. The specificity of the enzyme for Skp1-Hyp-143 and its high affinity for this substrate suggests that it is the GlcNAc-transferase that modifies Skp1 in vivo.

reaction:
UDP-N-acetylglucosamine + [Skp1-protein]-hydroxyproline = UDP + [Skp1-protein]-O-(N-acetyl-D-glucosaminyl)hydroxyproline


entry: 2.4.1.230
name: --- - kojibiose phosphorylase
sysname: 2-alpha-D-glucosyl-D-glucose:phosphate beta-D-glucosyltransferase
reaction: 2-alpha-D-glucosyl-D-glucose + phosphate = D-glucose + beta-D-glucose 1-phosphate [RN:R07264]
iubmb_reaction: R07264
comment:
The enzyme from Thermoanaerobacter brockii can act with alpha-1,2-oligoglucans, such as selaginose, as substrate, but more slowly. The enzyme is inactive when dissaccharides with linkages other than alpha-1,2 linkages, such as sophorose, trehalose, neotrehalose, nigerose, laminaribiose, maltose, cellobiose, isomaltose, gentiobiose, sucrose and lactose, are used as substrates.


entry: 2.4.1.231
sysname: alpha,alpha-trehalose:phosphate alpha-D-glucosyltransferase
reaction: alpha,alpha-trehalose + phosphate = alpha-D-glucose + alpha-D-glucose 1-phosphate [RN:R07265]
iubmb_reaction: R07265
name:
--- 
- alpha,alpha-trehalose phosphorylase (configuration-retaining)
- trehalose phosphorylase[ambiguous]

comment:
Unlike EC 2.4.1.64, alpha,alpha-trehalose phosphorylase, this enzyme retains its anomeric configuration. Vanadate is a strong competitive inhibitor of this reversible reaction.


entry: 2.4.1.232
sysname: GDP-mannose:oligosaccharide 1,6-alpha-D-mannosyltransferase
iubmb_reaction: (other) R06986(G)
kegg_reaction: R06986(G)
name:
--- 
- initiation-specific alpha-1,6-mannosyltransferase
- alpha-1,6-mannosyltransferase
- GDP-mannose:oligosaccharide 1,6-alpha-D-mannosyltransferase
- GDP-mannose:glycolipid 1,6-alpha-D-mannosyltransferase
- glycolipid 6-alpha-mannosyltransferase

comment:
Requires Mn2+. In Saccharomyces cerevisiae, this enzyme catalyses an essential step in the outer chain elongation of N-linked oligosaccharides. Man8GlcNAc and Man9GlcNAc are equally good substrates.

reaction:
Transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-1,6-D-mannosyl-D-mannose linkage


entry: 2.4.1.233
name: --- - Deleted entry
comment:
Deleted entry: anthocyanidin 3-O-glucosyltransferase. The enzyme is identical to EC 2.4.1.115, anthocyanidin 3-O-glucosyltransferase (EC 2.4.1.233 created 2004, deleted 2005)


entry: 2.4.1.234
name: --- - kaempferol 3-O-galactosyltransferase - F3GalTase
sysname: UDP-galactose:kaempferol 3-O-beta-D-galactosyltransferase
reaction: UDP-galactose + kaempferol = UDP + kaempferol 3-O-beta-D-galactoside [RN:R06808]
iubmb_reaction: R06808
comment:
Acts on the endogenous flavonols kaempferol and quercetin, to a lesser extent on myricetin and fisetin, and weakly on galangin and isorhamnetin. The reaction can occur equally well in both directions.


entry: 2.4.1.235
name: --- - Deleted entry
comment:
Deleted entry: Enzyme is identical to EC 2.4.1.116, cyanidin 3-O-rutinoside 5-O-glucosyltransferase (EC 2.4.1.235 created 2004, deleted 2006)


entry: 2.4.1.236
sysname: UDP-L-rhamnose:flavanone-7-O-glucoside 2"-O-beta-L-rhamnosyltransferase
iubmb_reaction: R07337 > R06820
kegg_reaction: R06826 R06829
name:
--- 
- flavanone 7-O-glucoside 2"-O-beta-L-rhamnosyltransferase
- UDP-rhamnose:flavanone-7-O-glucoside-2"-O-rhamnosyltransferase
- 1->2 UDP-rhamnosyltransferase

comment:
Acts on the 7-O-glucoside of naringenin and hesperetin, also the flavone 7-O-glucosides of luteolin and apigenin.

reaction:
UDP-L-rhamnose + a flavanone 7-O-glucoside = UDP + a flavanone 7-O-[beta-L-rhamnosyl-(1->2)-beta-D-glucoside] [RN:R07337]


entry: 2.4.1.237
name: --- - flavonol 7-O-beta-glucosyltransferase - UDP-glucose:flavonol 7-O-glucosyltransferase
sysname: UDP-glucose:flavonol 7-O-beta-D-glucosyltransferase
reaction: UDP-glucose + a flavonol = UDP + a flavonol 7-O-beta-D-glucoside [RN:R07338]
iubmb_reaction: R07338 > R06810
comment:
Acts on the flavonols gossypetin (8-hydroxyquercetin) and to a lesser extent on quercetin, kaempferol and myricetin.


entry: 2.4.1.238
sysname: UDP-glucose:anthocyanin 3'-O-beta-D-glucosyltransferase
reaction: UDP-glucose + an anthocyanin = UDP + an anthocyanin 3'-O-beta-D-glucoside [RN:R07266]
iubmb_reaction: R07266
name:
--- 
- anthocyanin 3'-O-beta-glucosyltransferase
- UDP-glucose:anthocyanin 3'-O-glucosyltransferase
- 3'GT

comment:
This enzyme specifically glucosylates the 3'-hydroxy group of delphinidin 3,5-di-O-beta-D-glucoside to form delphinidin 3,5,3'-tri-O-beta-D-glucoside in gentian (Gentiana triflora).


entry: 2.4.1.239
name: --- - flavonol-3-O-glucoside glucosyltransferase
sysname: UDP-glucose:flavonol-3-O-glucoside 2"-O-beta-D-glucosyltransferase
iubmb_reaction: R07339 > R06804 R06812
comment:
One of three specific glucosyltransferases in pea (Pisum sativum) that successively add a beta-D-glucosyl group first to O-3 of kaempferol, and then to O-2 of the previously added glucosyl group giving the 3-O-sophoroside and then the 3-O-sophorotrioside (see also EC 2.4.1.91, flavonol 3-O-glucosyltransferase and EC 2.4.1.240, flavonol-3-O-glycoside glucosyltransferase). TDP-glucose can replace UDP-glucose as the glucose donor but the reaction proceeds more slowly.

reaction:
UDP-glucose + a flavonol 3-O-beta-D-glucoside = UDP + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside [RN:R07339]


entry: 2.4.1.240
name: --- - flavonol-3-O-glycoside glucosyltransferase
sysname: UDP-glucose:flavonol-3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside 2'''-O-beta-D-glucosyltransferase
iubmb_reaction: R07340 > R06805 R06813
comment:
One of three specific glucosyltransferases in pea (Pisum sativum) that successively add a beta-D-glucosyl group first to O-3 of kaempferol, and then to O-2 of the previously added glucosyl group giving the 3-O-sophoroside and then the 3-O-sophorotrioside (see also EC 2.4.1.91 flavonol 3-O-glucosyltransferase, and EC 2.4.1.239 flavonol-3-O-glucoside glucosyltransferase).

reaction:
UDP-glucose + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside = UDP + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside [RN:R07340]


entry: 2.4.1.241
sysname: UDP-galactose:3-(beta-D-galactosyl)-1,2-diacyl-sn-glycerol 6-alpha-galactosyltransferase
iubmb_reaction: R04469
name:
--- 
- digalactosyldiacylglycerol synthase
- DGD1
- DGD2
- DGDG synthase (ambiguous)
- UDP-galactose-dependent DGDG synthase
- UDP-galactose-dependent digalactosyldiacylglycerol synthase
- UDP-galactose:MGDG galactosyltransferase

comment:
Requires Mg2+. Diacylglycerol cannot serve as an acceptor molecule for galactosylation as in the reaction catalysed by EC 2.4.1.46, monogalactosyldiacylglyerol synthase. When phosphate is limiting, phospholipids in plant membranes are reduced but these are replaced, at least in part, by the glycolipids digalactosyldiacylglycerol (DGDG) and sulfoquinovosyldiacylglycerol [3]. While both DGD1 and DGD2 are increased under phosphate-limiting conditions, DGD2 does not contribute significantly under optimal growth conditions. DGD2 is responsible for the synthesis of DGDG molecular species that are rich in C16 fatty acids at sn-1 of diacylglycerol whereas DGD1 leads to molecular species rich in C18 fatty acids [3]. The enzyme has been localized to the outer side of chloroplast envelope membranes.

reaction:
UDP-galactose + 3-(beta-D-galactosyl)-1,2-diacyl-sn-glycerol = UDP + 3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-1,2-diacyl-sn- glycerol [RN:R04469]


entry: 2.4.1.242
sysname: NDP-glucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase
reaction: NDP-glucose + (1,4-alpha-D-glucosyl)n = NDP + (1,4-alpha-D-glucosyl)(n+1) [RN:R07261]
iubmb_reaction: R07261
name:
--- 
- NDP-glucose-starch glucosyltransferase
- granule-bound starch synthase
- starch synthase II (ambiguous)
- waxy protein
- starch granule-bound nucleoside diphosphate glucose-starch glucosyltransferase
- granule-bound starch synthase I
- GBSSI
- granule-bound starch synthase II
- GBSSII
- GBSS
- NDPglucose-starch glucosyltransferase

comment:
Unlike EC 2.4.1.11, glycogen(starch) synthase and EC 2.4.1.21, starch synthase, which use UDP-glucose and ADP-glucose, respectively, this enzyme can use either UDP- or ADP-glucose. Mutants that lack the Wx (waxy) allele cannot produce this enzyme, which plays an important role in the normal synthesis of amylose. In such mutants, only amylopectin is produced in the endosperm [3] or pollen [5].


entry: 2.4.1.243
sysname: 1F-oligo[beta-D-fructofuranosyl-(2->1)-]sucrose 6G-beta-D-fructotransferase
name:
--- 
- 6G-fructosyltransferase
- fructan:fructan 6G-fructosyltransferase
- 1F(1-beta-D-fructofuranosyl)m sucrose:1F(1-beta-D-fructofuranosyl)nsucrose 6G-fructosyltransferase
- 6G-FFT
- 6G-FT
- 6G-fructotransferase

comment:
This enzyme catalyses the transfer of the terminal (2->1)-linked beta-D-fructosyl group of a mono- or oligosaccharide substituent on O-1 of the fructose residue of sucrose onto O-6 of its glucose residue [1]. For example, if 1-kestose [1F-(beta-D-fructofuranosyl)sucrose] is both the donor and recipient in the reaction shown above, i.e., if m = 1 and n = 1, then the products will be sucrose and 1F,6G-di-beta-D-fructofuranosylsucrose. In this notation, the superscripts F and G are used to specify whether the fructose or glucose residue of the sucrose carries the substituent. Alternatively, this may be indicated by the presence and/or absence of primes (see 2-Carb-36.2). Sucrose cannot be a donor substrate in the reaction (i.e. m cannot be zero) and inulin cannot act as an acceptor. Side reactions catalysed are transfer of a beta-D-fructosyl group between compounds of the structure 1F-(1-beta-D-fructofuranosyl)m-6G-(1-beta-D-fructofuranosyl)n sucrose, where m >= 0 and n = 1 for the donor, and m >= 0 and n >= 0 for the acceptor.

reaction:
[1-beta-D-fructofuranosyl-(2->1)-](m+1) alpha-D-glucopyranoside + [1-beta-D-fructofuranosyl-(2->1)-](n+1) alpha-D-glucopyranoside = [1-beta-D-fructofuranosyl-(2->1)-]m alpha-D-glucopyranoside + [1-beta-D-fructofuranosyl-(2->1)-](n+1) beta-D-fructofuranosyl-(2->6)-alpha-D-glucopyranoside (m > 0; n >= 0)


entry: 2.4.1.244
name:
--- 
- N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase
- beta1,4-N-acetylgalactosaminyltransferase III
- beta4GalNAc-T3
- beta1,4-N-acetylgalactosaminyltransferase IV
- beta4GalNAc-T4

sysname:
UDP-N-acetyl-D-galactosamine:N-acetyl-D-glucosaminyl-group beta-1,4-N-acetylgalactosaminyltransferase

comment:
The enzyme from human can transfer N-acetyl-D-galactosamine (GalNAc) to N-glycan and O-glycan substrates that have N-acetyl-D-glucosamine (GlcNAc) but not D-glucuronic acid (GlcUA) at their non-reducing end. The N-acetyl-beta-D-glucosaminyl group is normally on a core oligosaccharide although benzyl glycosides have been used in enzyme-characterization experiments. Some glycohormones, e.g. lutropin and thyrotropin contain the N-glycan structure containing the N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group.

reaction:
UDP-N-acetyl-D-galactosamine + N-acetyl-beta-D-glucosaminyl group = UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group


entry: 2.4.1.-
name: --- []
reaction:
(1) GDP-mannose + Mannan(n) <=> GDP + Mannan(n+1) [RN:R00887]; (2) GDP-mannose + 1,4-beta-D-Mannan <=> GDP + 1,4-beta-D-Mannan [RN:R00890 R06213]; (3) Glucosylceramide + UDP-D-galactose <=> beta-D-Galactosyl-1,4-beta-D-glucosylceramide + UDP [RN:R03354 R06276]; (4) Galactosylceramide + UDP-D-galactose <=> Digalactosylceramide + UDP [RN:R04016 R06234]; (5) GDP-mannose + N,N'-Diacetylchitobiosyldiphosphodolichol <=> GDP + alpha-D-Mannosylchitobiosyldiphosphodolichol [RN:R04331]; (6) 3-D-Glucosyl-1,2-diacylglycerol + UDP-glucose <=> Diglucosyl-diacylglycerol + UDP [RN:R04377]; (7) UDP-N-acetyl-D-glucosamine + Galactosylgloboside <=> UDP + G00102 [RN:R05902]; (8) UDP-D-galactose + G00102 <=> UDP + G00103 [RN:R05903]; (9) Dolichyl phosphate D-mannose + G00147 <=> Dolichyl phosphate + G00148 [RN:R05921]; (10) UDP-D-galactose + Lc3Cer <=> UDP + Paragloboside [RN:R05977]; (11) UDP-D-galactose + G00077 <=> UDP + iso-nLc8Cer [RN:R06021]; (12) GDP-L-fucose + nLc5Cer <=> GDP + Type II B antigen [RN:R06027]; (13) UDP-D-galactose + nLc5Cer <=> UDP + nLc6Cer [RN:R06033]; (14) UDP-D-galactose + nLc7Cer <=> UDP + nLc8Cer [RN:R06097]; (15) G00005 + GDP-D-mannose <=> G10526 + GDP [RN:R06127]; (16) G10526 + GDP-D-mannose <=> G00006 + GDP [RN:R06128]; (17) UDP-D-galactose + G00072 <=> UDP + G00073 [RN:R06192]; (18) UDP-D-galactose + Type II A antigen <=> UDP + G00057 [RN:R06198]; (19) GDP-D-mannose + G10532(n) <=> GDP + G10532(n+1) [RN:R06213]; (20) GDP-L-fucose + V3Fuc-nLc6Cer <=> GDP + V3Fuc,III3Fuc-nLc6Cer [RN:R06221]; (21) GDP-L-fucose + G00084 <=> GDP + G00085 [RN:R06222]; (22) GDP-L-fucose + G00085 <=> GDP + G00086 [RN:R06224]; (23) GDP-L-fucose + G00081 <=> GDP + G00082 [RN:R06227]; (24) GDP-L-fucose + nLc6Cer <=> GDP + III3Fuc-nLc6Cer [RN:R06230]; (25) Galactosylceramide + UDP-D-galactose <=> Ga2-Cer + UDP [RN:R06234]; (26) GDP-D-mannose + G00004 <=> GDP + G00005 [RN:R06238]; (27) Dolichyl phosphate D-mannose + G00006 <=> Dolichyl phosphate + G10595 [RN:R06258]; (28) Dolichyl phosphate D-mannose + G10595 <=> Dolichyl phosphate + G10596 [RN:R06259]; (29) Dolichyl phosphate D-mannose + G10596 <=> Dolichyl phosphate + G10597 [RN:R06260]; (30) Dolichyl phosphate D-mannose + G10597 <=> Dolichyl phosphate + G00007 [RN:R06261]; (31) Dolichyl D-glucosyl phosphate + G00007 <=> Dolichyl phosphate + G10598 [RN:R06262]; (32) Dolichyl D-glucosyl phosphate + G10598 <=> Dolichyl phosphate + G10599 [RN:R06263]; (33) Dolichyl D-glucosyl phosphate + G10599 <=> Dolichyl phosphate + G00008 [RN:R06264]; (34) Glucocerebroside + UDP-D-galactose <=> Lactosylceramide + UDP [RN:R06276]; (35) Cyanidin 3-O-glucoside <=> Cyanin [RN:R06546]; (36) Cyanidin 3-O-(6-O-p-coumaroyl)glucoside <=> Cyanidin 3-O-(6-O-p-coumaroyl)glucoside-5-O-glucoside [RN:R06547]


entry: 2.4.2.1
sysname: purine-nucleoside:phosphate ribosyltransferase
reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate [RN:R02342]
iubmb_reaction: R02342
kegg_reaction: R01561 R01863 R01969 R02147 R02294 R02295 R02297 R02484 R02557 R02748
name:
--- 
- purine-nucleoside phosphorylase
- inosine phosphorylase
- PNPase
- PUNPI
- PUNPII
- inosine-guanosine phosphorylase
- nucleotide phosphatase
- purine deoxynucleoside phosphorylase
- purine deoxyribonucleoside phosphorylase
- purine nucleoside phosphorylase
- purine ribonucleoside phosphorylase

comment:
Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase.


entry: 2.4.2.4
sysname: thymidine:phosphate deoxy-alpha-D-ribosyltransferase
reaction: thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate [RN:R01570]
iubmb_reaction: R01570
kegg_reaction: R01969 R02484 R02557 R02748
name:
--- 
- thymidine phosphorylase
- pyrimidine phosphorylase
- thymidine-orthophosphate deoxyribosyltransferase
- animal growth regulators, blood platelet-derived endothelial cell growth factors
- blood platelet-derived endothelial cell growth factor
- deoxythymidine phosphorylase
- gliostatins
- pyrimidine deoxynucleoside phosphorylase
- thymidine:phosphate deoxy-D-ribosyltransferase

comment:
The enzyme in some tissues also catalyses deoxyribosyltransferase reactions of the type catalysed by EC 2.4.2.6, nucleoside deoxyribosyltransferase.


entry: 2.4.2.6
sysname: nucleoside:purine(pyrimidine) deoxy-D-ribosyltransferase
comment: Base1 and base2 represent various purines and pyrimidines.
reaction: 2-deoxy-D-ribosyl-base1 + base2 = 2-deoxy-D-ribosyl-base2 + base1 [RN:R04168]
iubmb_reaction: R04168 > R02806
name:
--- 
- nucleoside deoxyribosyltransferase
- purine(pyrimidine) nucleoside:purine(pyrimidine) deoxyribosyl transferase
- deoxyribose transferase
- nucleoside trans-N-deoxyribosylase
- trans-deoxyribosylase
- trans-N-deoxyribosylase
- trans-N-glycosidase
- "nucleoside deoxyribosyltransferase I (purine nucleoside:purine deoxyribosyltransferase: strictly specific for transfer between purine bases)"
- nucleoside deoxyribosyltransferase II [purine(pyrimidine) nucleoside:purine(pyrimidine) deoxyribosyltransferase]


entry: 2.4.2.7
sysname: AMP:diphosphate phospho-D-ribosyltransferase
comment: 5-Amino-4-imidazolecarboxamide can replace adenine.
reaction: AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate [RN:R00190]
iubmb_reaction: R00190
kegg_reaction: R01229 R04378
name:
--- 
- adenine phosphoribosyltransferase
- AMP pyrophosphorylase
- transphosphoribosidase
- APRT
- AMP-pyrophosphate phosphoribosyltransferase
- adenine phosphoribosylpyrophosphate transferase
- adenosine phosphoribosyltransferase
- adenylate pyrophosphorylase
- adenylic pyrophosphorylase


entry: 2.4.2.8
sysname: IMP:diphosphate phospho-D-ribosyltransferase
comment: Guanine and 6-mercaptopurine can replace hypoxanthine.
reaction: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate [RN:R01132]
iubmb_reaction: R01132
kegg_reaction: R00190 R01229 R02142
name:
--- 
- hypoxanthine phosphoribosyltransferase
- IMP pyrophosphorylase
- transphosphoribosidase
- hypoxanthine-guanine phosphoribosyltransferase
- guanine phosphoribosyltransferase
- GPRT
- HPRT
- guanosine 5'-phosphate pyrophosphorylase
- IMP-GMP pyrophosphorylase
- HGPRTase
- 6-hydroxypurine phosphoribosyltransferase
- 6-mercaptopurine phosphoribosyltransferase
- GMP pyrophosphorylase
- guanine-hypoxanthine phosphoribosyltransferase
- guanosine phosphoribosyltransferase
- guanylate pyrophosphorylase
- guanylic pyrophosphorylase
- inosinate pyrophosphorylase
- inosine 5'-phosphate pyrophosphorylase
- inosinic acid pyrophosphorylase
- inosinic pyrophosphorylase
- purine-6-thiol phosphoribosyltransferase


entry: 2.4.2.9
sysname: UMP:diphosphate phospho-alpha-D-ribosyltransferase
reaction: UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate [RN:R00966]
iubmb_reaction: R00966
name:
--- 
- uracil phosphoribosyltransferase
- UMP pyrophosphorylase
- UPRTase
- UMP:pyrophosphate phosphoribosyltransferase
- uridine 5'-phosphate pyrophosphorylase
- uridine monophosphate pyrophosphorylase
- uridylate pyrophosphorylase
- uridylic pyrophosphorylase


entry: 2.4.2.10
sysname: orotidine-5'-phosphate:diphosphate phospho-alpha-D-ribosyl-transferase
reaction: orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate [RN:R01870]
iubmb_reaction: R01870
name:
--- 
- orotate phosphoribosyltransferase
- orotidylic acid phosphorylase
- orotidine-5'-phosphate pyrophosphorylase
- OPRTase
- orotate phosphoribosyl pyrophosphate transferase
- orotic acid phosphoribosyltransferase
- orotidine 5'-monophosphate pyrophosphorylase
- orotidine monophosphate pyrophosphorylase
- orotidine phosphoribosyltransferase
- orotidylate phosphoribosyltransferase
- orotidylate pyrophosphorylase
- orotidylic acid pyrophosphorylase
- orotidylic phosphorylase
- orotidylic pyrophosphorylase

comment:
The enzyme from higher eukaryotes also catalyses the reaction listed as EC 4.1.1.23, orotidine-5'-phosphate decarboxylase.


entry: 2.4.2.11
sysname: nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase
iubmb_reaction: R01724
name:
--- 
- nicotinate phosphoribosyltransferase
- niacin ribonucleotidase
- nicotinic acid mononucleotide glycohydrolase
- nicotinic acid mononucleotide pyrophosphorylase
- nicotinic acid phosphoribosyltransferase

reaction:
nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate [RN:R01724]


entry: 2.4.2.12
sysname: nicotinamide-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase
iubmb_reaction: R01271
name:
--- 
- nicotinamide phosphoribosyltransferase
- NMN pyrophosphorylase
- nicotinamide mononucleotide pyrophosphorylase
- nicotinamide mononucleotide synthetase
- NMN synthetase

reaction:
nicotinamide D-ribonucleotide + diphosphate = nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate [RN:R01271]


entry: 2.4.2.13
name: --- - Transferred to 2.5.1.6
comment:
Transferred entry: now EC 2.5.1.6 methionine adenosyltransferase (EC 2.4.2.13 created 1961, deleted 1965)


entry: 2.4.2.14
sysname: 5-phosphoribosylamine:diphosphate phospho-alpha-D-ribosyltransferase (glutamate-amidating)
iubmb_reaction: R01072
name:
--- 
- amidophosphoribosyltransferase
- phosphoribosyldiphosphate 5-amidotransferase
- glutamine phosphoribosyldiphosphate amidotransferase
- alpha-5-phosphoribosyl-1-pyrophosphate amidotransferase
- 5'-phosphoribosylpyrophosphate amidotransferase
- 5-phosphoribosyl-1-pyrophosphate amidotransferase
- 5-phosphororibosyl-1-pyrophosphate amidotransferase
- glutamine 5-phosphoribosylpyrophosphate amidotransferase
- glutamine ribosylpyrophosphate 5-phosphate amidotransferase
- phosphoribose pyrophosphate amidotransferase
- phosphoribosyl pyrophosphate amidotransferase
- phosphoribosylpyrophosphate glutamyl amidotransferase

reaction:
5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O [RN:R01072]


entry: 2.4.2.16
sysname: urate-ribonucleotide:phosphate alpha-D-ribosyltransferase
reaction: urate D-ribonucleotide + phosphate = urate + alpha-D-ribose 1-phosphate [RN:R02645]
iubmb_reaction: R02645
kegg_reaction: R02646
name:
--- 
- urate-ribonucleotide phosphorylase
- UAR phosphorylase
- urate-ribonucleotide:phosphate D-ribosyltransferase


entry: 2.4.2.17
sysname: 1-(5-phospho-D-ribosyl)-ATP:diphosphate phospho-alpha-D-ribosyl-transferase
iubmb_reaction: R01071
name:
--- 
- ATP phosphoribosyltransferase
- phosphoribosyl-ATP pyrophosphorylase
- adenosine triphosphate phosphoribosyltransferase
- phosphoribosyladenosine triphosphate:pyrophosphate phosphoribosyltransferase
- phosphoribosyl ATP synthetase
- phosphoribosyl ATP:pyrophosphate phosphoribosyltransferase
- phosphoribosyl-ATP:pyrophosphate-phosphoribosyl phosphotransferase
- phosphoribosyladenosine triphosphate pyrophosphorylase
- phosphoribosyladenosine triphosphate synthetase

reaction:
1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate [RN:R01071]


entry: 2.4.2.18
sysname: N-(5-phospho-D-ribosyl)-anthranilate:diphosphate phospho-alpha-D-ribosyltransferase
iubmb_reaction: R01073
name:
--- 
- anthranilate phosphoribosyltransferase
- phosphoribosyl-anthranilate pyrophosphorylase
- PRT
- anthranilate 5-phosphoribosylpyrophosphate phosphoribosyltransferase
- anthranilate phosphoribosylpyrophosphate phosphoribosyltransferase
- phosphoribosylanthranilate pyrophosphorylase
- phosphoribosylanthranilate transferase
- anthranilate-PP-ribose-P phosphoribosyltransferase

comment:
In some organisms, this enzyme is part of a multifunctional protein together with one or more other components of the system for biosynthesis of tryptophan [EC 4.1.1.48 (indole-3-glycerol-phosphate synthase), EC 4.1.3.27 (anthranilate synthase), EC 4.2.1.20 (tryptophan synthase) and EC 5.3.1.24 (phosphoribosylanthranilate isomerase)].

reaction:
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate [RN:R01073]


entry: 2.4.2.19
sysname: nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase (carboxylating)
iubmb_reaction: R03348
name:
--- 
- nicotinate-nucleotide diphosphorylase (carboxylating)
- quinolinate phosphoribosyltransferase (decarboxylating)
- quinolinic acid phosphoribosyltransferase
- QAPRTase
- NAD pyrophosphorylase
- nicotinate mononucleotide pyrophosphorylase (carboxylating)
- quinolinic phosphoribosyltransferase

reaction:
nicotinate D-ribonucleotide + diphosphate + CO2 = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate [RN:R03348]


entry: 2.4.2.20
sysname: 2,4-dioxotetrahydropyrimidine-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase
iubmb_reaction: R04346
name:
--- 
- dioxotetrahydropyrimidine phosphoribosyltransferase
- dioxotetrahydropyrimidine-ribonucleotide pyrophosphorylase
- dioxotetrahydropyrimidine phosphoribosyl transferase
- dioxotetrahydropyrimidine ribonucleotide pyrophosphorylase

comment:
Acts (in the reverse direction) on uracil and other pyrimidines and pteridines containing a 2,4-diketo structure.

reaction:
A 2,4-dioxotetrahydropyrimidine D-ribonucleotide + diphosphate = a 2,4-dioxotetrahydropyrimidine + 5-phospho-alpha-D-ribose 1-diphosphate [RN:R04346]


entry: 2.4.2.21
sysname: nicotinate-nucleotide:dimethylbenzimidazole phospho-D-ribosyltransferase
iubmb_reaction: R04148
name:
--- 
- nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase
- nicotinate mononucleotide-dimethylbenzimidazole phosphoribosyltransferase
- nicotinate ribonucleotide:benzimidazole (adenine) phosphoribosyltransferase
- nicotinate-nucleotide:dimethylbenzimidazole phospho-D-ribosyltransferase
- CobT
- nicotinate mononucleotide (NaMN):5,6-dimethylbenzimidazole phosphoribosyltransferase

comment:
Also acts on benzimidazole, and the clostridial enzyme acts on adenine to form 7-alpha-D-ribosyladenine 5'-phosphate. The product of the reaction, alpha-ribazole 5'-phosphate, forms part of the corrin-biosynthesis pathway and is a substrate for EC 2.7.8.26, adenosylcobinamide-GDP ribazoletransferase [4]. It can also be dephosphorylated to form alpha-ribazole by the action of EC 3.1.3.73, alpha-ribazole phosphatase.

reaction:
beta-nicotinate D-ribonucleotide + dimethylbenzimidazole = nicotinate + N1-(5-phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole [RN:R04148]


entry: 2.4.2.22
sysname: XMP:diphosphate 5-phospho-alpha-D-ribosyltransferase
reaction: XMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine [RN:R02142]
iubmb_reaction: R02142
kegg_reaction: R01229
name:
--- 
- xanthine phosphoribosyltransferase
- Xan phosphoribosyltransferase
- xanthosine 5'-phosphate pyrophosphorylase
- xanthylate pyrophosphorylase
- xanthylic pyrophosphorylase
- XMP pyrophosphorylase
- 5-phospho-alpha-D-ribose-1-diphosphate:xanthine phospho-D-ribosyltransferase
- 9-(5-phospho-beta-D-ribosyl)xanthine:diphosphate 5-phospho-alpha-D-ribosyltransferase


entry: 2.4.2.23
sysname: 2'-deoxyuridine:phosphate 2-deoxy-alpha-D-ribosyltransferase
reaction: 2'-deoxyuridine + phosphate = uracil + 2-deoxy-alpha-D-ribose 1-phosphate [RN:R02484]
iubmb_reaction: R02484
name:
--- 
- deoxyuridine phosphorylase
- deoxyuridine:phosphate deoxy-D-ribosyltransferase
- 2'-deoxyuridine:phosphate deoxy-alpha-D-ribosyltransferase


entry: 2.4.2.24
sysname: UDP-D-xylose:1,4-beta-D-xylan 4-beta-D-xylosyltransferase
comment: Formerly EC 2.4.1.72.
reaction: UDP-D-xylose + (1,4-beta-D-xylan)n = UDP + (1,4-beta-D-xylan)(n+1) [RN:R03928 R06083]
iubmb_reaction: R03928 R06083(G)
name:
--- 
- 1,4-beta-D-xylan synthase
- uridine diphosphoxylose-1,4-beta-xylan xylosyltransferase
- 1,4-beta-xylan synthase
- xylan synthase
- xylan synthetase


entry: 2.4.2.25
sysname: UDP-apiose:5,4'-dihydroxyflavone 7-O-beta-D-glucoside 2"-O-beta-D-apiofuranosyltransferase
comment: 7-O-beta-D-Glucosides of a number of flavonoids and of 4-substituted phenols can act as acceptors.
iubmb_reaction: R04526
name:
--- 
- flavone apiosyltransferase
- uridine diphosphoapiose-flavone apiosyltransferase
- UDP-apiose:7-O-(beta-D-glucosyl)-flavone apiosyltransferase

reaction:
UDP-apiose + 5,7,4'-trihydroxyflavone 7-O-beta-D-glucoside = UDP + 5,7,4'-trihydroxyflavone 7-O-[beta-D-apiosyl-(1->2)-beta-D-glucoside] [RN:R04526]


entry: 2.4.2.26
sysname: UDP-D-xylose:protein beta-D-xylosyltransferase
iubmb_reaction: R05925(G)
name:
--- 
- protein xylosyltransferase
- UDP-D-xylose:core protein beta-D-xylosyltransferase
- UDP-D-xylose:core protein xylosyltransferase
- UDP-D-xylose:proteoglycan core protein beta-D-xylosyltransferase
- UDP-xylose-core protein beta-D-xylosyltransferase
- uridine diphosphoxylose-core protein beta-xylosyltransferase
- uridine diphosphoxylose-protein xylosyltransferase

comment:
Involved in the biosynthesis of the linkage region of glycosaminoglycan chains as part of proteoglycan biosynthesis (chondroitin, dermatan and heparan sulfates).

reaction:
Transfers a beta-D-xylosyl residue from UDP-D-xylose to the serine hydroxy group of an acceptor protein substrate [RN:R05925]


entry: 2.4.2.27
sysname: dTDP-L-dihydrostreptose:streptidine-6-phosphate dihydrostreptosyltransferase
iubmb_reaction: R04222
name:
--- 
- dTDP-dihydrostreptose-streptidine-6-phosphate dihydrostreptosyltransferase
- thymidine diphosphodihydrostreptose-streptidine 6-phosphate dihydrostreptosyltransferase

reaction:
dTDP-L-dihydrostreptose + streptidine 6-phosphate = dTDP + O-1,4-alpha-L-dihydrostreptosyl-streptidine 6-phosphate [RN:R04222]


entry: 2.4.2.28
sysname: S-methyl-5-thioadenosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase
comment: Also acts on 5'-deoxyadenosine and other analogues having 5'-deoxy groups.
iubmb_reaction: R01402
name:
--- 
- S-methyl-5'-thioadenosine phosphorylase
- 5'-methylthioadenosine nucleosidase
- 5'-deoxy-5'-methylthioadenosine phosphorylase
- MTA phosphorylase
- MeSAdo phosphorylase
- MeSAdo/Ado phosphorylase
- methylthioadenosine phosphorylase
- methylthioadenosine nucleoside phosphorylase
- 5'-methylthioadenosine:phosphate methylthio-D-ribosyl-transferase
- S-methyl-5-thioadenosine phosphorylase

reaction:
S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate [RN:R01402]


entry: 2.4.2.29
sysname: tRNA-guanine:queuine tRNA-D-ribosyltransferase
reaction: [tRNA]-guanine + queuine = [tRNA]-queuine + guanine [RN:R03789]
iubmb_reaction: R03789
name:
--- 
- queuine tRNA-ribosyltransferase
- tRNA-guanine transglycosylase
- guanine insertion enzyme
- tRNA transglycosylase
- Q-insertase
- queuine transfer ribonucleate ribosyltransferase
- transfer ribonucleate glycosyltransferase
- tRNA guanine transglycosidase
- guanine, queuine-tRNA transglycosylase

comment:
The enzyme also catalyses the exchange of precursors of queuine and of guanine itself for guanine located in the first position of certain tRNA anticodons.


entry: 2.4.2.30
sysname: NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase
reaction: NAD+ + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor + H+ [RN:R04176]
iubmb_reaction: R04176
name:
--- 
- NAD+ ADP-ribosyltransferase
- poly(ADP-ribose) synthase
- ADP-ribosyltransferase (polymerizing)
- NAD ADP-ribosyltransferase

comment:
The ADP-D-ribosyl group of NAD+ is transferred to an acceptor carboxy group on a histone or the enzyme itself, and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.


entry: 2.4.2.31
sysname: NAD(P)+:protein-L-arginine ADP-D-ribosyltransferase
iubmb_reaction: R00555
name:
--- 
- NAD(P)+-protein-arginine ADP-ribosyltransferase
- ADP-ribosyltransferase
- mono(ADP-ribosyl)transferase
- NAD+:L-arginine ADP-D-ribosyltransferase
- NAD(P)+-arginine ADP-ribosyltransferase
- NAD(P)+:L-arginine ADP-D-ribosyltransferase

comment:
Arginine residues in proteins act as acceptors. Free arginine, agmatine [(4-aminobutyl)guanidine], arginine methyl ester and guanidine can also do so. The enzyme catalyses the NAD+-dependent activation of EC 4.6.1.1, adenylate cyclase. Some bacterial enterotoxins possess similar enzymatic activities. (cf. EC 2.4.2.36 NAD+--diphthamide ADP-ribosyltransferase).

reaction:
NAD(P)+ + protein L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine [RN:R00555]


entry: 2.4.2.34
sysname: UDP-L-arabinose:(indol-3-yl)acetyl-myo-inositol L-arabinosyltransferase
iubmb_reaction: R04335
name:
--- 
- indolylacetylinositol arabinosyltransferase
- arabinosylindolylacetylinositol synthase
- UDP-L-arabinose:indol-3-ylacetyl-myo-inositol L-arabinosyltransferase

reaction:
UDP-L-arabinose + (indol-3-yl)acetyl-1D-myo-inositol = UDP + (indol-3-yl)acetyl-myo-inositol 3-L-arabinoside [RN:R04335]


entry: 2.4.2.35
name: --- - flavonol-3-O-glycoside xylosyltransferase
sysname: UDP-D-xylose:flavonol-3-O-glycoside 2"-O-beta-D-xylosyltransferase
comment: Flavonol 3-O-glucoside, flavonol 3-O-galactoside and, more slowly, rutin, can act as acceptors.
iubmb_reaction: R03268 > R06811 R06814
reaction:
UDP-D-xylose + a flavonol 3-O-glycoside = UDP + a flavonol 3-[-D-xylosyl-(1->2)-beta-D-glycoside] [RN:R03268]


entry: 2.4.2.36
sysname: NAD+:peptide-diphthamide N-(ADP-D-ribosyl)transferase
reaction: NAD+ + peptide diphthamide = nicotinamide + peptide N-(ADP-D-ribosyl)diphthamide [RN:R04074]
iubmb_reaction: R04074
name:
--- 
- NAD+-diphthamide ADP-ribosyltransferase
- ADP-ribosyltransferase
- mono(ADPribosyl)transferase
- NAD-diphthamide ADP-ribosyltransferase

comment:
Diphtheria toxin and some other bacterial toxins catalyse this reaction. The acceptor is a diphthamide residue in elongation factor 2. cf. EC 2.4.2.31 NAD(P)+-protein-arginine ADP-ribosyltransferase.


entry: 2.4.2.37
sysname: NAD+:[dinitrogen reductase] (ADP-D-ribosyl)transferase
reaction: NAD+ + [dinitrogen reductase] = nicotinamide + ADP-D-ribosyl-[dinitrogen reductase] [RN:R03447]
iubmb_reaction: R03447
name:
--- 
- NAD+-dinitrogen-reductase ADP-D-ribosyltransferase
- NAD-azoferredoxin (ADPribose)transferase
- NAD-dinitrogen-reductase ADP-D-ribosyltransferase

comment:
Together with EC 3.2.2.24 (ADP-ribosyl-[dinitrogen reductase] hydrolase), controls the level of activity of EC 1.18.6.1 nitrogenase.


entry: 2.4.2.38
name: --- - glycoprotein 2-beta-D-xylosyltransferase - beta1,2-xylosyltransferase
comment: Specific for N-linked oligosaccharides (N-glycans).
iubmb_reaction: R06016(G)
sysname:
UDP-D-xylose:glycoprotein (D-xylose to the 3,6-disubstituted mannose of N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-a cetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-man nosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glu cosaminyl}asparagine) 2-beta-D-xylosyltransferase

reaction:
UDP-D-xylose + N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N- acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D- mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D- glucosaminyl}asparagine = UDP + N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N- acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-[beta-D- xylosyl-(1->2)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl- (1->4)-N-acetyl-beta-D-glucosaminyl}asparagine [RN:R06016]


entry: 2.4.2.39
sysname: UDP-D-xylose:xyloglucan 1,6-alpha-D-xylosyltransferase
name:
--- 
- xyloglucan 6-xylosyltransferase
- uridine diphosphoxylose-xyloglucan 6alpha-xylosyltransferase
- xyloglucan 6-alpha-D-xylosyltransferase

comment:
In association with EC 2.4.1.168 (xyloglucan 4-glucosyltransferase), this enzyme brings about the synthesis of xyloglucan; concurrent transfers of glucose and xylose are necessary for this synthesis.

reaction:
Transfers an alpha-D-xylosyl residue from UDP-D-xylose to a glucose residue in xyloglucan, forming an alpha-1,6-D-xylosyl-D-glucose linkage


entry: 2.4.2.40
sysname: UDP-D-xylose:zeatin O-beta-D-xylosyltransferase
comment: Does not act on UDP-glucose (cf. EC 2.4.1.103 alizarin 2-beta-glucosyltransferase).
reaction: UDP-D-xylose + zeatin = UDP + O-beta-D-xylosylzeatin [RN:R02119]
iubmb_reaction: R02119
name:
--- 
- zeatin O-beta-D-xylosyltransferase
- uridine diphosphoxylose-zeatin xylosyltransferase
- zeatin O-xylosyltransferase


entry: 2.4.99.1
name: --- - beta-galactoside alpha-2,6-sialyltransferase
iubmb_reaction: R04532 R06188(G)
kegg_reaction: R05580 R05905(G) R05906(G) R05990(G)
sysname:
CMP-N-acetylneuraminate:beta-D-galactosyl-1,4-N-acetyl-beta-D-glucos amine alpha-2,6-N-acetylneuraminyltransferase

comment:
The terminal beta-D-galactosyl residue of the oligosaccharide of glycoproteins, as well as lactose, can act as acceptor.

reaction:
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D- glucosamine [RN:R04532 R06188]


entry: 2.4.99.2
name: --- - monosialoganglioside sialyltransferase
comment: May be identical with EC 2.4.99.4 beta-galactoside alpha-2,3-sialyltransferase.
iubmb_reaction: R04648 R05942(G)
sysname:
CMP-N-acetylneuraminate:D-galactosyl-N-acetyl-D-galactosaminyl-(N-ac etylneuraminyl)-D-galactosyl-D-glucosylceramide N-acetylneuraminyltransferase

reaction:
CMP-N-acetylneuraminate + D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D- galactosyl-D-glucosylceramide = CMP + N-acetylneuraminyl-D-galactosyl-N-acetyl-D-galactosaminyl-(N- acetylneuraminyl)-D-galactosyl-D-glucosylceramide [RN:R04648 R05942]


entry: 2.4.99.3
name: --- - alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase
iubmb_reaction: R05911(G) > R05914(G) R06273(G)
sysname:
CMP-N-acetylneuraminate:glycano-1,3-(N-acetyl-alpha-D-galactosaminyl )-glycoprotein alpha-2,6-N-acetylneuraminyltransferase

comment:
alpha-N-Acetylgalactosamine linked to threonine or serine is also an acceptor, when substituted at the 3-position.

reaction:
CMP-N-acetylneuraminate + glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)- glycoprotein [RN:R05911]


entry: 2.4.99.4
name: --- - beta-galactoside alpha-2,3-sialyltransferase
sysname: CMP-N-acetylneuraminate:beta-D-galactoside alpha-2,3-N-acetylneuraminyl-transferase
iubmb_reaction: R04590 R05913(G)
kegg_reaction: R04648 R05116 R05942(G) R05949(G) R05957(G) R05967(G)
comment:
The acceptor is Galbeta1,3GalNAc-R, where R is H, a threonine or serine residue in a glycoprotein, or a glycolipid. Lactose can also act as acceptor. May be identical with EC 2.4.99.2 monosialoganglioside sialyltransferase.

reaction:
CMP-N-acetylneuraminate + beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3-N-acetyl-alpha-D- galactosaminyl-R [RN:R04590 R05913]


entry: 2.4.99.5
name: --- - galactosyldiacylglycerol alpha-2,3-sialyltransferase
sysname: CMP-N-acetylneuraminate:1,2-diacyl-3-beta-D-galactosyl-sn-glycerol N-acetylneuraminyltransferase
comment: The beta-D-galactosyl residue of the oligosaccharide of glycoproteins may also act as acceptor.
iubmb_reaction: R03468
reaction:
CMP-N-acetylneuraminate + 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol = CMP + 1,2-diacyl-3-[3-(alpha-D-N-acetylneuraminyl)-beta-D-galactosyl]-sn- glycerol [RN:R03468]


entry: 2.4.99.6
comment: Acts on beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl termini on glycoprotein.
iubmb_reaction: R04596
kegg_reaction: R06153(G)
name:
--- 
- N-acetyllactosaminide alpha-2,3-sialyltransferase
- sialyltransferase
- cytidine monophosphoacetylneuraminate-beta-galactosyl(1- >4)acetylglucosaminide alpha2->3-sialyltransferase
- alpha2->3 sialyltransferase

sysname:
CMP-N-acetylneuraminate:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminy l-glycoprotein alpha-2,3-N-acetylneuraminyltransferase

reaction:
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-D- glucosaminyl-glycoprotein [RN:R04596]


entry: 2.4.99.7
iubmb_reaction: R04635
name:
--- 
- alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N- acetylgalactosaminide 6-alpha-sialyltransferase
- sialyltransferase
- cytidine monophosphoacetylneuraminate-(alpha-N-acetylneuraminyl-2,3-beta- galactosyl-1,3)-N-acetylgalactosaminide-alpha-2,6-sialyltransferase
- alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl- galactosaminide alpha-2,6-sialyltransferase
- SIAT7
- ST6GALNAC
- (alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl- galactosaminide 6-alpha-sialyltransferase
- CMP-N-acetylneuraminate:(alpha-N-acetylneuraminyl-2,3-beta-D- galactosyl-1,3)-N-acetyl-D-galactosaminide alpha-2,6-N-acetylneuraminyl-transferase

sysname:
CMP-N-acetylneuraminate:(alpha-N-acetylneuraminyl-2,3-beta-D-galacto syl-1,3)-N-acetyl-D-galactosaminide galactosamine-6-alpha-N-acetylneuraminyltransferase

comment:
Attaches N-acetylneuraminic acid in alpha-2,6-linkage to N-acetyl-galactosamine only when present in the structure of alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetylgalactosam inyl-R, where R may be protein or p-nitrophenol. Not identical with EC 2.4.99.3 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase.

reaction:
CMP-N-acetylneuraminate + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl- D-galactosaminyl-R = CMP + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl- alpha-neuraminyl-(2->6)]-N-acetyl-D-galactosaminyl-R [RN:R04635]


entry: 2.4.99.8
comment: Gangliosides act as acceptors.
iubmb_reaction: R04564 > R04583 R05940(G) R06032(G)
kegg_reaction: R04632 R04649 R04661 R05113 R05995(G) R06000(G) R06005(G) R06009(G)
name:
--- 
- alpha-N-acetylneuraminate alpha-2,8-sialyltransferase
- cytidine monophosphoacetylneuraminate-ganglioside GM3
- alpha-2,8-sialyltransferase
- ganglioside GD3 synthase
- ganglioside GD3 synthetase sialyltransferase
- CMP-NeuAc:LM1(alpha2-8) sialyltranferase
- GD3 synthase
- SAT-2

sysname:
CMP-N-acetylneuraminate:alpha-N-acetylneuraminyl-2,3-beta-D-galactos ide alpha-2,8-N-acetylneuraminyltransferase

reaction:
CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-2,8-alpha-N-acetylneuraminyl-2,3-beta-D- galactosyl-R [RN:R04564]


entry: 2.4.99.9
sysname: CMP-N-acetylneuraminate:lactosylceramide alpha-2,3-N-acetylneuraminyltransferase
comment: Lactose cannot act as acceptor.
iubmb_reaction: R03488 R05937(G)
kegg_reaction: R04630 R04647 R06003(G) R06007(G)
name:
--- 
- lactosylceramide alpha-2,3-sialyltransferase
- cytidine monophosphoacetylneuraminate-lactosylceramide alpha2,3- sialyltransferase
- CMP-acetylneuraminate-lactosylceramide-sialyltransferase
- CMP-acetylneuraminic acid:lactosylceramide sialyltransferase
- CMP-sialic acid:lactosylceramide-sialyltransferase
- cytidine monophosphoacetylneuraminate-lactosylceramide sialyltransferase
- ganglioside GM3 synthetase
- GM3 synthase
- GM3 synthetase
- SAT 1

reaction:
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-beta-D-glucosylceramide = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D- glucosylceramide [RN:R03488 R05937]


entry: 2.4.99.10
sysname: CMP-N-acetylneuraminate:neolactotetraosylceramide alpha-2,3-sialyltransferase
iubmb_reaction: R04656 R06026(G)
kegg_reaction: R06037(G)
name:
--- 
- neolactotetraosylceramide alpha-2,3-sialyltransferase
- sialyltransferase
- cytidine monophosphoacetylneuraminate-neolactotetraosylceramide sialyltransferase
- sialyltransferase 3
- SAT-3

reaction:
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D- galactosyl-1,4-D-glucosylceramide = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-beta-D- glucosaminyl-1,3-beta-D-galactosyl-1,4-D-glucosylceramide [RN:R04656 R06026]


entry: 2.4.99.11
sysname: CMP-N-acetylneuraminate:lactosylceramide alpha-2,6-N-acetylneuraminyltransferase
iubmb_reaction: (other) R03489 R06121(G)
kegg_reaction: R03489 R06121(G)
name:
--- 
- lactosylceramide alpha-2,6-N-sialyltransferase
- cytidine monophosphoacetylneuraminate-lactosylceramide sialyltransferase
- CMP-acetylneuraminate-lactosylceramide-sialyltransferase
- CMP-N-acetylneuraminic acid:lactosylceramide sialyltransferase
- CMP-sialic acid:lactosylceramide sialyltransferase

reaction:
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-beta-D-glucosylceramide = CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-beta-D- glucosylceramide


entry: 2.4.99.-
name: --- []
reaction:
(1) CMP-N-acetylneuraminate + N-Acetylneuraminyl-D-galactosyl-N-acetyl-D-galactosaminyl-(N- acetylneuraminyl)-D-galactosyl-D-glucosylceramide <=> CMP + GT1a [RN:R04660 R05943]; (2) CMP-N-acetylneuraminate + GT1b <=> CMP + GQ1 [RN:R05114 R05950]; (3) CMP-N-acetylneuraminate + Paragloboside <=> CMP + Sialyl-6-paragloboside [RN:R06215]; (4) CMP-N-acetylneuraminate + nLc6Cer <=> CMP + VI6NeuAc-nLc6Cer [RN:R06216]; (5) CMP-N-acetylneuraminate + V3Fuc-nLc6Cer <=> CMP + G00091 [RN:R06232]; (6) CMP-N-acetylneuraminate + G04461 <=> CMP + G04135 [RN:R06274]


entry: 2.5.1.1
sysname: dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallyltranstransferase
comment: This enzyme will not accept larger prenyl diphosphates as efficient donors.
reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate [RN:R01658]
iubmb_reaction: R01658
kegg_reaction: R02003
name:
--- 
- dimethylallyltranstransferase
- geranyl-diphosphate synthase
- prenyltransferase
- dimethylallyltransferase
- DMAPP:IPP-dimethylallyltransferase
- (2E,6E)-farnesyl diphosphate synthetase
- diprenyltransferase
- geranyl pyrophosphate synthase
- geranyl pyrophosphate synthetase
- trans-farnesyl pyrophosphate synthetase


entry: 2.5.1.2
sysname: thiamine:base 2-methyl-4-aminopyrimidine-5-methenyltransferase
comment: Various bases and thiol compounds can act instead of pyridine.
iubmb_reaction: R02863
name:
--- 
- thiamine pyridinylase
- pyrimidine transferase
- thiaminase I
- thiamin hydrolase
- thiamin pyridinolase
- thiaminase
- thiamine pyridinolase
- thiamin pyridinylase
- thiamin:base 2-methyl-4-aminopyrimidine-5-methenyltransferase

reaction:
thiamine + pyridine = 1-[(4-amino-2-methylpyrimidin-5-yl)methyl]pyridinium + 4-methyl-5-(2-hydroxyethyl)thiazole [RN:R02863]


entry: 2.5.1.3
iubmb_reaction: R03223
name:
--- 
- thiamine-phosphate diphosphorylase
- thiamine phosphate pyrophosphorylase
- thiamine monophosphate pyrophosphorylase
- TMP-PPase

sysname:
2-methyl-4-amino-5-hydroxymethylpyrimidine-diphosphate:4-methyl-5-(2 -phosphoethyl)thiazole 2-methyl-4-aminopyrimidine-5-methenyltransferase

reaction:
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)thiazole = diphosphate + thiamine phosphate [RN:R03223]


entry: 2.5.1.5
sysname: D-galactose-6-sulfate:alkyltransferase (cyclizing)
name:
--- 
- galactose-6-sulfurylase
- porphyran sulfatase
- galactose-6-sulfatase
- galactose 6-sulfatase

reaction:
Eliminates sulfate from the D-galactose 6-sulfate residues of porphyran, producing 3,6-anhydrogalactose residues


entry: 2.5.1.6
sysname: ATP:L-methionine S-adenosyltransferase
comment: Formerly EC 2.4.2.13, methionine adenosyltransferase.
reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine [RN:R00177]
iubmb_reaction: R00177
kegg_reaction: R04771
name:
--- 
- methionine adenosyltransferase
- adenosylmethionine synthetase
- ATP-methionine adenosyltransferase
- methionine S-adenosyltransferase
- methionine-activating enzyme
- S-adenosyl-L-methionine synthetase
- S-adenosylmethionine synthase
- S-adenosylmethionine synthetase
- AdoMet synthetase


entry: 2.5.1.7
sysname: phosphoenolpyruvate:UDP-N-acetyl-D-glucosamine 1-carboxyvinyltransferase
iubmb_reaction: R00660
name:
--- 
- UDP-N-acetylglucosamine 1-carboxyvinyltransferase
- MurA transferase
- UDP-N-acetylglucosamine 1-carboxyvinyl-transferase
- UDP-N-acetylglucosamine enoylpyruvyltransferase
- enoylpyruvate transferase
- phosphoenolpyruvate-UDP-acetylglucosamine-3-enolpyruvyltransferase
- phosphoenolpyruvate:UDP-2-acetamido-2-deoxy-D-glucose 2-enoyl-1-carboxyethyltransferase
- phosphoenolpyruvate:uridine diphosphate N-acetylglucosamine enolpyruvyltransferase
- phosphoenolpyruvate:uridine-5'-diphospho-N-acetyl-2-amino-2- deoxyglucose 3-enolpyruvyltransferase
- phosphopyruvate-uridine diphosphoacetylglucosamine pyruvatetransferase
- pyruvate-UDP-acetylglucosamine transferase
- pyruvate-uridine diphospho-N-acetylglucosamine transferase
- pyruvate-uridine diphospho-N-acetyl-glucosamine transferase
- pyruvic-uridine diphospho-N-acetylglucosaminyltransferase

reaction:
phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine [RN:R00660]


entry: 2.5.1.8
sysname: isopentenyl-diphosphate:tRNA isopentenyltransferase
reaction: isopentenyl diphosphate + tRNA = diphosphate + tRNA containing 6-isopentenyladenosine [RN:R01122]
iubmb_reaction: R01122
name:
--- 
- tRNA isopentenyltransferase
- transfer ribonucleate isopentenyltransferase
- delta2-isopentenyl pyrophosphate:tRNA-delta2-isopentenyl transferase
- delta2-isopentenyl pyrophosphate:transfer ribonucleic acid delta2-isopentenyltransferase


entry: 2.5.1.9
comment: A flavoprotein (riboflavin).
iubmb_reaction: R00066
name:
--- 
- riboflavin synthase
- heavy riboflavin synthase
- light riboflavin synthase
- riboflavin synthetase
- riboflavine synthase
- riboflavine synthetase

sysname:
6,7-dimethyl-8-(1-D-ribityl)lumazine:6,7-dimethyl-8-(1-D-ribityl)lum azine 2,3-butanediyltransferase

reaction:
2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine [RN:R00066]


entry: 2.5.1.10
sysname: geranyl-diphosphate:isopentenyl-diphosphate geranyltranstransferase
iubmb_reaction: R02003
kegg_reaction: R01658
name:
--- 
- geranyltranstransferase
- farnesyl-diphosphate synthase
- geranyl transferase I
- prenyltransferase
- farnesyl pyrophosphate synthetase
- farnesylpyrophosphate synthetase

comment:
Some forms of this enzyme will also use dimethylallyl diphosphate as a substrate. The enzyme will not accept larger prenyl diphosphates as efficient donors.

reaction:
geranyl diphosphate + isopentenyl diphosphate = diphosphate + trans,trans-farnesyl diphosphate [RN:R02003]


entry: 2.5.1.11
sysname: (E)-octaprenyl-diphosphate:isopentenyl-diphosphate octaprenyltranstransferase
iubmb_reaction: R07267
kegg_reaction: R05611
name:
--- 
- trans-octaprenyltranstransferase
- all-trans-nonaprenyl-diphosphate synthase
- solanesyl-diphosphate synthase
- solanesyl pyrophosphate synthetase
- SPP synthase
- nonaprenyl pyrophosphate synthetase
- polyprenylpyrophosphate synthetase
- terpenoidallyltransferase
- terpenyl pyrophosphate synthetase
- trans-prenyltransferase

comment:
This enzyme will also use geranyl diphosphate and all-trans-prenyl diphosphates of intermediate size as donors, but not dimethylallyl diphosphate.

reaction:
all-trans-octaprenyl diphosphate + isopentenyl diphosphate = diphosphate + all-trans-nonaprenyl diphosphate [RN:R07267]


entry: 2.5.1.12
name: --- - Deleted entry
comment:
Deleted entry: glutathione S-alkyltransferase. Now included with EC 2.5.1.18 glutathione transferase (EC 2.5.1.12 created 1972, deleted 1976)


entry: 2.5.1.13
name: --- - Deleted entry
comment:
Deleted entry: glutathione S-aryltransferase. Now included with EC 2.5.1.18 glutathione transferase (EC 2.5.1.13 created 1972, deleted 1976)


entry: 2.5.1.14
name: --- - Deleted entry
comment:
Deleted entry: glutathione S-aralkyltransferase. Now included with EC 2.5.1.18 glutathione transferase (EC 2.5.1.14 created 1972, deleted 1976)


entry: 2.5.1.15
iubmb_reaction: R03067
kegg_reaction: R03066
name:
--- 
- dihydropteroate synthase
- dihydropteroate pyrophosphorylase
- DHPS
- 7,8-dihydropteroate synthase
- 7,8-dihydropteroate synthetase
- 7,8-dihydropteroic acid synthetase
- dihydropteroate synthetase
- dihydropteroic synthetase
- 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine- diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase

sysname:
(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl-diphosphate:4-ami nobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase

reaction:
(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate [RN:R03067]


entry: 2.5.1.16
sysname: S-adenosylmethioninamine:putrescine 3-aminopropyltransferase
reaction: S-adenosylmethioninamine + putrescine = 5'-methylthioadenosine + spermidine [RN:R01920]
iubmb_reaction: R01920
kegg_reaction: R02869
name:
--- 
- spermidine synthase
- aminopropyltransferase
- putrescine aminopropyltransferase
- spermidine synthetase
- SpeE

comment:
This enzyme is not identical with EC 2.5.1.22, spermine synthase. The mammalian enzyme is highly specific but the bacterial enzyme can use other acceptors and can synthesize spermine.


entry: 2.5.1.17
sysname: ATP:cob(I)yrinic acid-a,c-diamide Cobeta-adenosyltransferase
iubmb_reaction: R05220 R07268
kegg_reaction: R01492
name:
--- 
- cob(I)yrinic acid a,c-diamide adenosyltransferase
- CobA
- CobO
- ATP:corrinoid adenosyltransferase
- cob(I)alamin adenosyltransferase
- aquacob(I)alamin adenosyltransferase
- aquocob(I)alamin vitamin B12s adenosyltransferase
- ATP:cob(I)alamin Cobeta-adenosyltransferase

comment:
The corrinoid adenosylation pathway comprises three steps: (i) reduction of Co(III) to Co(II) by a one-electron transfer. This can be carried out by EC 1.16.1.3, aquacobalamin reductase or non-enzymically in the presence of dihydroflavin nucleotides [2]. (ii) Co(II) is reduced to Co(I) in a second single-electron transfer by EC 1.16.1.4, cob(II)alamin reductase and (iii) the Co(I) conducts a nucleophilic attack on the adenosyl moiety of ATP to leave the cobalt atom in a Co(III) state (EC 2.5.1.17). The enzyme responsible for the adenosylation reaction is the product of the gene cobO in the aerobic bacterium Pseudomonas denitrificans and of the gene cobA in the anaerobic bacterium Salmonella typhimurium. In P. denitrificans, the enzyme shows specificity for cobyrinic acid a,c-diamide and the corrinoids that occur later in the biosynthetic pathway whereas CobA seems to have broader specificity [3]. While CobA has a preference for ATP and Mn2+, it is able to transfer a variety of nucleosides to the cobalt, including CTP, UTP and GTP, in decreasing order of preference [4] and to use Mg2+ instead of Mn2+.

reaction:
(1) ATP + cob(I)yrinic acid a,c-diamide = triphosphate + adenosylcob(III)yrinic acid a,c-diamide [RN:R05220]; (2) ATP + cobinamide = triphosphate + adenosylcobinamide [RN:R07268]


entry: 2.5.1.18
sysname: RX:glutathione R-transferase
reaction: RX + glutathione = HX + R-S-glutathione [RN:R03522]
iubmb_reaction: R03522 > R07084 R07092 R07093 R07094 R07100 R07116
kegg_reaction: R07002 R07003 R07004 R07023 R07024 R07025 R07026 R07069 R07070 R07083 R07091 R07113
name:
--- 
- glutathione transferase
- glutathione S-transferase
- glutathione S-alkyltransferase
- glutathione S-aryltransferase
- S-(hydroxyalkyl)glutathione lyase
- glutathione S-aralkyltransferase
- glutathione S-alkyl transferase
- GST

comment:
A group of enzymes of broad specificity. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. Also catalyses the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrile, certain isomerization reactions and disulfide interchange.


entry: 2.5.1.19
sysname: phosphoenolpyruvate:3-phosphoshikimate 5-O-(1-carboxyvinyl)-transferase
iubmb_reaction: R03460
name:
--- 
- 3-phosphoshikimate 1-carboxyvinyltransferase
- 5-enolpyruvylshikimate-3-phosphate synthase
- 3-enolpyruvylshikimate 5-phosphate synthase
- 3-enolpyruvylshikimic acid-5-phosphate synthetase
- 5'-enolpyruvylshikimate-3-phosphate synthase
- 5-enolpyruvyl-3-phosphoshikimate synthase
- 5-enolpyruvylshikimate-3-phosphate synthetase
- 5-enolpyruvylshikimate-3-phosphoric acid synthase
- enolpyruvylshikimate phosphate synthase
- EPSP synthase

reaction:
phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate [RN:R03460]


entry: 2.5.1.20
sysname: poly-cis-polyprenyl-diphosphate:isopentenyl-diphosphate polyprenylcistransferase
comment: Rubber particles act as acceptor.
iubmb_reaction: R03917
name:
--- 
- rubber cis-polyprenylcistransferase
- rubber allyltransferase
- rubber transferase
- isopentenyl pyrophosphate cis-1,4-polyisoprenyl transferase
- cis-prenyl transferase
- rubber polymerase
- rubber prenyltransferase

reaction:
poly-cis-polyprenyl diphosphate + isopentenyl diphosphate = diphosphate + a poly-cis-polyprenyl diphosphate longer by one C5 unit [RN:R03917]


entry: 2.5.1.21
sysname: farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase
iubmb_reaction: R00702 R02872
kegg_reaction: R06223
name:
--- 
- squalene synthase
- farnesyltransferase
- presqualene-diphosphate synthase
- presqualene synthase
- squalene synthetase
- farnesyl-diphosphate farnesyltransferase

comment:
The enzyme from yeast requires either Mg2+ or Mn2+ for activity. In the absence of NAD(P)H, presqualene diphosphate is accumulated.

reaction:
(1) 2 farnesyl diphosphate = diphosphate + presqualene diphosphate [RN:R00702]; (2) presqualene diphosphate + NAD(P)H + H+ = squalene + diphosphate + NAD(P)+ [RN:R02872]


entry: 2.5.1.22
name: --- - spermine synthase - spermidine aminopropyltransferase - spermine synthetase
sysname: S-adenosylmethioninamine:spermidine 3-aminopropyltransferase
reaction: S-adenosylmethioninamine + spermidine = 5'-methylthioadenosine + spermine [RN:R02869]
iubmb_reaction: R02869
comment:
This enzyme is not identical with EC 2.5.1.16 (spermidine synthase) or EC 2.5.1.23 (sym-norspermidine synthase).


entry: 2.5.1.23
name: --- - sym-norspermidine synthase
sysname: S-adenosylmethioninamine:propane-1,3-diamine 3-aminopropyltransferase
iubmb_reaction: R03271
comment:
This enzyme is not identical with EC 2.5.1.16 (spermidine synthase) or EC 2.5.1.22 (spermine synthase).

reaction:
S-adenosylmethioninamine + propane-1,3-diamine = 5'-methylthioadenosine + bis(3-aminopropyl)amine [RN:R03271]


entry: 2.5.1.24
name: --- - discadenine synthase - discadenine synthetase
sysname: S-adenosyl-L-methionine:N6-(delta2-isopentenyl)-adenine 3-(3-amino-3-carboxypropyl)-transferase
comment: Discadenine is 3-(3-amino-3-carboxypropyl)-N6-(delta2-isopentenyl)-adenine.
iubmb_reaction: R03726
reaction:
S-adenosyl-L-methionine + N6-(delta2-isopentenyl)-adenine = 5'-methylthioadenosine + discadenine [RN:R03726]


entry: 2.5.1.25
name: --- - tRNA-uridine aminocarboxypropyltransferase
sysname: S-adenosyl-L-methionine:tRNA-uridine 3-(3-amino-3-carboxypropyl)transferase
iubmb_reaction: R03019
reaction:
S-adenosyl-L-methionine + tRNA uridine = 5'-methylthioadenosine + tRNA 3-(3-amino-3-carboxypropyl)-uridine [RN:R03019]


entry: 2.5.1.26
sysname: 1-acyl-glycerone-3-phosphate:long-chain-alcohol O-3-phospho-2-oxopropanyltransferase
iubmb_reaction: R04311
name:
--- 
- alkylglycerone-phosphate synthase
- alkyldihydroxyacetonephosphate synthase
- alkyldihydroxyacetone phosphate synthetase
- alkyl DHAP synthetase
- alkyl-DHAP
- dihydroxyacetone-phosphate acyltransferase
- DHAP-AT

comment:
The ester-linked fatty acid of the substrate is cleaved and replaced by a long-chain alcohol in an ether linkage.

reaction:
1-acyl-glycerone 3-phosphate + a long-chain alcohol = an alkyl-glycerone 3-phosphate + a long-chain acid anion [RN:R04311]


entry: 2.5.1.27
sysname: dimethylallyl-diphosphate:AMP dimethylallyltransferase
iubmb_reaction: R04038
name:
--- 
- adenylate dimethylallyltransferase
- cytokinin synthase
- isopentenyltransferase
- 2-isopentenyl-diphosphate:AMP delta2-isopentenyltransferase
- adenylate isopentenyltransferase

reaction:
dimethylallyl diphosphate + AMP = diphosphate + N6-(dimethylallyl)adenosine 5'-phosphate [RN:R04038]


entry: 2.5.1.29
sysname: trans,trans-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase
iubmb_reaction: R02061
kegg_reaction: R01658 R02003
name:
--- 
- farnesyltranstransferase
- geranylgeranyl-diphosphate synthase
- geranylgeranyl pyrophosphate synthetase
- geranylgeranyl-PP synthetase
- farnesyltransferase
- geranylgeranyl pyrophosphate synthase

comment:
Some forms of this enzyme will also use geranyl diphosphate and dimethylallyl diphosphate as donors; it will not use larger prenyl diphosphates as efficient donors.

reaction:
trans,trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate [RN:R02061]


entry: 2.5.1.30
sysname: all-trans-hexaprenyl-diphosphate:isopentenyl-diphosphate hexaprenyltranstransferase
iubmb_reaction: R05612
name:
--- 
- trans-hexaprenyltranstransferase
- all-trans-heptaprenyl-diphosphate synthase
- heptaprenyl pyrophosphate synthase
- heptaprenyl diphosphate synthase
- heptaprenyl pyrophosphate synthetase

comment:
This enzyme will also use trans-trans-farnesyl diphosphate and all-trans-prenyl diphosphates of intermediate size as donors, but not dimethylallyl diphosphate.

reaction:
all-trans-hexaprenyl diphosphate + isopentenyl diphosphate = diphosphate + all-trans-heptaprenyl diphosphate [RN:R05612]


entry: 2.5.1.31
sysname: di-trans,poly-cis-decaprenyl-diphosphate:isopentenyl-diphosphate undecaprenylcistransferase
iubmb_reaction: R07269
kegg_reaction: R06447
name:
--- 
- di-trans,poly-cis-decaprenylcistransferase
- di-trans,poly-cis-undecaprenyl-diphosphate synthase
- undecaprenyl-diphosphate synthase
- bactoprenyl-diphosphate synthase
- UPP synthetase
- undecaprenyl diphosphate synthetase
- undecaprenyl pyrophosphate synthetase

comment:
This enzyme will also use trans,trans-farnesyl diphosphate and di-trans,poly-cis-prenyl diphosphates of intermediate size as donors. The two trans- bonds in the substrate and product are those furthest from the diphosphate group.

reaction:
di-trans,poly-cis-decaprenyl diphosphate + isopentenyl diphosphate = diphosphate + di-trans,poly-cis-undecaprenyl diphosphate [RN:R07269]


entry: 2.5.1.32
sysname: geranylgeranyl-diphosphate:geranylgeranyl-diphosphate geranylgeranyltransferase
iubmb_reaction: R07270 > R04218; R02065
name:
--- 
- phytoene synthase
- prephytoene-diphosphate synthase
- phytoene synthetase
- PSase
- geranylgeranyl-diphosphate geranylgeranyltransferase

comment:
Requires Mn2+ for activity. The enzyme appears to be stereospecific, normally producing 15-cis-phytoene. However, in Erwinia herbicola, the product is the 15-trans isomer [2].

reaction:
(1) 2 geranylgeranyl diphosphate = diphosphate + prephytoene diphosphate [RN:R02065]; (2) prephytoene diphosphate = phytoene + diphosphate [RN:R07270]


entry: 2.5.1.33
sysname: all-trans-pentaprenyl-diphosphate:isopentenyl-diphosphate pentaprenyltranstransferase
iubmb_reaction: R05613
name:
--- 
- trans-pentaprenyltranstransferase
- all-trans-hexaprenyl-diphosphate synthase
- hexaprenyl diphosphate synthase
- hexaprenyl pyrophosphate synthetase

comment:
This enzyme will also use trans,trans-farnesyl diphosphate and all-trans-geranylgeranyl diphosphate as donors.

reaction:
all-trans-pentaprenyl diphosphate + isopentenyl diphosphate = diphosphate + all-trans-hexaprenyl diphosphate [RN:R05613]


entry: 2.5.1.34
sysname: dimethylallyl-diphosphate:L-tryptophan dimethylallyltransferase
iubmb_reaction: R01657
name:
--- 
- tryptophan dimethylallyltransferase
- dimethylallylpyrophosphate:L-tryptophan dimethylallyltransferase
- dimethylallyltryptophan synthetase
- dimethylallylpyrophosphate:tryptophan dimethylallyl transferase
- DMAT synthetase
- 4-(gamma,gamma-dimethylallyl)tryptophan synthase

reaction:
dimethylallyl diphosphate + L-tryptophan = diphosphate + 4-(3-methylbut-2-enyl)-L-tryptophan [RN:R01657]


entry: 2.5.1.35
sysname: dimethylallyl-diphosphate:aspulvinone-E dimethylallyltransferase
reaction: 2 dimethylallyl diphosphate + aspulvinone E = 2 diphosphate + aspulvinone H [RN:R03799]
iubmb_reaction: R03799
name:
--- 
- aspulvinone dimethylallyltransferase
- dimethylallyl pyrophosphate:aspulvinone dimethylallyltransferase

comment:
This enzyme will also use as acceptor aspulvinone G, a hydroxylated derivative of the complex phenolic pigment aspulvinone E.


entry: 2.5.1.36
sysname: dimethylallyl-diphosphate:(6aS,11aS)-3,6a,9-trihydroxypterocarpan dimethylallyltransferase
comment: Part of the glyceollin biosynthesis system in soy bean.
iubmb_reaction: R07271 R07272
name:
--- 
- trihydroxypterocarpan dimethylallyltransferase
- glyceollin synthase
- dimethylallylpyrophosphate:3,6a,9-trihydroxypterocarpan dimethylallyltransferase
- dimethylallylpyrophosphate:trihydroxypterocarpan dimethylallyl transferase
- dimethylallyl-diphosphate:(6aS,11aS)-3,6a,9-trihydroxypterocarpan dimethyltransferase

reaction:
(1) dimethylallyl diphosphate + (6aS,11aS)-3,6a,9-trihydroxypterocarpan = diphosphate + 2-dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan [RN:R07271]; (2) dimethylallyl diphosphate + (6aS,11aS)-3,6a,9-trihydroxypterocarpan = diphosphate + 4-dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan [RN:R07272]


entry: 2.5.1.37
name: --- - Transferred to 4.4.1.20
comment:
Transferred entry: now EC 4.4.1.20, leukotriene-C4 synthase. The enzyme was incorrectly classified as a transferase. (EC 2.5.1.37 created 1989, deleted 2004)


entry: 2.5.1.39
sysname: solanesyl-diphosphate:4-hydroxybenzoate nonaprenyltransferase
comment: Involved in the biosynthesis of ubiquinone.
reaction: solanesyl diphosphate + 4-hydroxybenzoate = diphosphate + nonaprenyl-4-hydroxybenzoate [RN:R07273]
iubmb_reaction: R07273
kegg_reaction: R05000
name:
--- 
- 4-hydroxybenzoate nonaprenyltransferase
- nonaprenyl-4-hydroxybenzoate transferase
- 4-hydroxybenzoate transferase
- p-hydroxybenzoate dimethylallyltransferase
- p-hydroxybenzoate polyprenyltransferase
- p-hydroxybenzoic acid-polyprenyl transferase
- p-hydroxybenzoic-polyprenyl transferase


entry: 2.5.1.41
sysname: geranylgeranyl diphosphate:sn-glyceryl phosphate geranylgeranyltransferase
iubmb_reaction: R04158
name:
--- 
- phosphoglycerol geranylgeranyltransferase
- glycerol phosphate geranylgeranyltransferase
- geranylgeranyl-transferase
- prenyltransferase

reaction:
geranylgeranyl diphosphate + sn-glyceryl phosphate = diphosphate + sn-3-O-(geranylgeranyl)glyceryl 1-phosphate [RN:R04158]


entry: 2.5.1.42
sysname: geranylgeranyl diphosphate:sn-3-O-(geranylgeranyl)glycerol 1-phosphate geranylgeranyltransferase
iubmb_reaction: R04520
name:
--- 
- geranylgeranylglycerol-phosphate geranylgeranyltransferase
- geranylgeranyloxyglycerol phosphate geranylgeranyltransferase
- geranylgeranyltransferase II

reaction:
geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate = diphosphate + 2,3-bis-O-(geranylgeranyl)glycerol 1-phosphate [RN:R04520]


entry: 2.5.1.43
reaction: 3 S-adenosyl-L-methionine = 3 S-methyl-5'-thioadenosine + nicotianamine [RN:R00075]
iubmb_reaction: R00075
name:
--- 
- nicotianamine synthase
- S-adenosyl-L-methionine:S-adenosyl-L-methionine:S-adenosyl- methionine 3-amino-3-carboxypropyltransferase

sysname:
S-adenosyl-L-methionine:S-adenosyl-L-methionine:S-adenosyl-Lmethioni ne 3-amino-3-carboxypropyltransferase


entry: 2.5.1.44
name: --- - homospermidine synthase
sysname: putrescine:putrescine 4-aminobutyltransferase (ammonia-forming)
iubmb_reaction: R00018
comment:
The reaction of this enzyme occurs in three steps, with some of the intermediates presumably remaining enzyme-bound: NAD+-dependent dehydrogenation of putrescine (1a), transfer of the 4-aminobutylidene group from dehydroputrescine to a second molecule of putrescine (1b) and reduction of the imine intermediate to form homospermidine (1c). Hence the overall reaction is transfer of a 4-aminobutyl group. Differs from EC 2.5.1.45, homospermidine synthase (spermidine-specific), which cannot use putrescine as donor of the aminobutyl group. The reaction of this enzyme occurs in three steps: (i) NAD+-dependent dehydrogenation of putrescine, (ii) transfer of the 4-aminobutylidene group from dehydroputrescine to a second molecule of putrescine, (iii) reduction of the imine intermediate to form homospermidine. Hence the overall reaction is transfer of a 4-aminobutyl group. In the presence of putrescine, spermidine can function as a donor of the aminobutyl group, in which case, propane-1,3-diamine is released instead of ammonia. Differs from EC 2.5.1.45, homospermidine synthase (spermidine-specific), which cannot use putrescine as donor of the aminobutyl group.

reaction:
(1) 2 putrescine = sym-homospermidine + NH3 + H+ [RN:R00018]; (2) putrescine + spermidine = sym-homospermidine + propane 1,3-diamine


entry: 2.5.1.45
name: --- - homospermidine synthase (spermidine-specific)
sysname: spermidine:putrescine 4-aminobutyltransferase (propane-1,3-diamine-forming)
reaction: spermidine + putrescine = sym-homospermidine + propane-1,3-diamine [RN:R01919]
iubmb_reaction: R01919
comment:
The reaction of this enzyme occurs in three steps, with some of the intermediates presumably remaining enzyme-bound: (a) NAD+-dependent dehydrogenation of spermidine, (b) transfer of the 4-aminobutylidene group from dehydrospermidine to putrescine and (c) reduction of the imine intermediate to form homospermidine. This enzyme is more specific than EC 2.5.1.44, homospermidine synthase, which is found in bacteria, as it cannot use putrescine as donor of the 4-aminobutyl group. Forms part of the biosynthetic pathway of the poisonous pyrrolizidine alkaloids of the ragworts (Senecio).


entry: 2.5.1.46
name: --- - deoxyhypusine synthase
sysname: spermidine:eIF5A-lysine 4-aminobutyltransferase (propane-1,3-diamine-forming)
iubmb_reaction: R05329
kegg_reaction: R07477 R07478 R07479 R07480
comment:
The eukaryotic initiation factor eIF5A contains a hypusine residue that is essential for activity. This enzyme catalyses the first reaction of hypusine formation from one specific lysine residue of the eIF5A precursor. The reaction occurs in four steps: NAD+-dependent dehydrogenation of spermidine (1a), formation of an enzyme-imine intermediate by transfer of the 4-aminobutylidene group from dehydrospermidine to the active site lysine residue (Lys329 for the human enzyme; 1b), transfer of the same 4-aminobutylidene group from the enzyme intermediate to the e1F5A precursor (1c), reduction of the e1F5A-imine intermediate to form a deoxyhypusine residue (1d). Hence the overall reaction is transfer of a 4-aminobutyl group. For the plant enzyme, homospermidine can substitute for spermidine and putrescine can substitute for the lysine residue of the eIF5A precursor. Hypusine is formed from deoxyhypusine by the action of EC 1.14.99.29, deoxyhypusine monooxygenase.

reaction:
(1) [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine [RN:R05329]; (2) (1a) spermidine + NAD+ = dehydrospermidine + NADH; (3) (1b) dehydrospermidine + [enzyme]-lysine = N-(4-aminobutylidene)-[enzyme]-lysine + propane-1,3-diamine; (4) (1c) N-(4-aminobutylidene)-[enzyme]-lysine + [eIF5A-precursor]-lysine = N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + [enzyme]-lysine; (5) (1d) N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + NADH + H+ = [eIF5A-precursor]-deoxyhypusine + NAD+


entry: 2.5.1.47
sysname: O3-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase
reaction: O3-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate [RN:R00897]
iubmb_reaction: R00897
kegg_reaction: R03132 R03601 R04859
name:
--- 
- cysteine synthase
- O-acetyl-L-serine sulfhydrylase
- O-acetyl-L-serine sulfohydrolase
- O-acetylserine (thiol)-lyase
- O-acetylserine (thiol)-lyase A
- O-acetylserine sulfhydrylase
- O3-acetyl-L-serine acetate-lyase (adding hydrogen-sulfide)
- acetylserine sulfhydrylase
- cysteine synthetase
- S-sulfocysteine synthase

comment:
A pyridoxal-phosphate protein. Some alkyl thiols, cyanide, pyrazole and some other heterocyclic compounds can act as acceptors. Not identical with EC 2.5.1.51 (beta-pyrazolylalanine synthase), EC 2.5.1.52 (L-mimosine synthase) and EC 2.5.1.53 (uracilylalanine synthase).


entry: 2.5.1.48
sysname: O4-succinyl-L-homoserine:L-cysteine S-(3-amino-3-carboxypropyl)transferase
reaction: O-succinyl-L-homoserine + L-cysteine = L-cystathionine + succinate [RN:R03260]
iubmb_reaction: R03260
kegg_reaction: R00999 R01288 R02508 R03132 R04944 R04945 R04946
name:
--- 
- cystathionine gamma-synthase
- O-succinyl-L-homoserine succinate-lyase (adding cysteine)
- O-succinylhomoserine (thiol)-lyase
- homoserine O-transsuccinylase
- O-succinylhomoserine synthase
- O-succinylhomoserine synthetase
- cystathionine synthase
- cystathionine synthetase
- homoserine transsuccinylase

comment:
A pyridoxal-phosphate protein. Also reacts with hydrogen sulfide and methanethiol as replacing agents, producing homocysteine and methionine, respectively. In the absence of thiol, can also catalyse beta,gamma-elimination to form 2-oxobutanoate, succinate and ammonia.


entry: 2.5.1.49
sysname: O-acetyl-L-homoserine:methanethiol 3-amino-3-carboxypropyltransferase
reaction: O-acetyl-L-homoserine + methanethiol = L-methionine + acetate [RN:R00651]
iubmb_reaction: R00651
kegg_reaction: R01287 R02026 R03217 R04859
name:
--- 
- O-acetylhomoserine aminocarboxypropyltransferase
- O-acetyl-L-homoserine acetate-lyase (adding methanethiol)
- O-acetyl-L-homoserine sulfhydrolase
- O-acetylhomoserine (thiol)-lyase
- O-acetylhomoserine sulfhydrolase
- methionine synthase

comment:
Also reacts with other thiols and H2S, producing homocysteine or thioethers. The name methionine synthase is more commonly applied to EC 2.1.1.13, methionine synthase. The enzyme from baker's yeast also catalyses the reaction of EC 2.5.1.47 cysteine synthase, but more slowly.


entry: 2.5.1.50
sysname: O3-acetyl-L-serine:zeatin 2-amino-2-carboxyethyltransferase
reaction: O-acetyl-L-serine + zeatin = lupinate + acetate [RN:R03133]
iubmb_reaction: R03133
name:
--- 
- zeatin 9-aminocarboxyethyltransferase
- beta-(9-cytokinin)-alanine synthase
- beta-(9-cytokinin)alanine synthase
- O-acetyl-L-serine acetate-lyase (adding N6-substituted adenine)
- lupinate synthetase
- lupinic acid synthase
- lupinic acid synthetase

comment:
The enzyme acts not only on zeatin but also on other N6-substituted adenines. The reaction destroys their cytokinin activity and forms the corresponding 3-(adenin-9-yl)-L-alanine.


entry: 2.5.1.51
sysname: O3-acetyl-L-serine:pyrazole 1-(2-amino-2-carboxyethyl)transferase
reaction: O3-acetyl-L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + acetate [RN:R03134]
iubmb_reaction: R03134
name:
--- 
- beta-pyrazolylalanine synthase
- beta-(1-pyrazolyl)alanine synthase
- beta-pyrazolealanine synthase
- beta-pyrazolylalanine synthase (acetylserine)
- O3-acetyl-L-serine acetate-lyase (adding pyrazole)
- BPA-synthase
- pyrazolealanine synthase
- pyrazolylalaninase

comment:
The enzyme is highly specific for acetylserine and pyrazole. Not identical with EC 2.5.1.52 L-mimosine synthase.


entry: 2.5.1.52
name: --- - L-mimosine synthase - O3-acetyl-L-serine acetate-lyase (adding 3,4-dihydroxypyridin-1-yl)
sysname: O3-acetyl-L-serine:3,4-dihydroxypyridine 1-(2-amino-2-carboxyethyl)transferase
iubmb_reaction: R04091
comment:
Brings about the biosynthesis of L-mimosine in Mimosa and Leucaena sp. Not identical with EC 2.5.1.51 beta-pyrazolylalanine synthase.

reaction:
O3-acetyl-L-serine + 3,4-dihydroxypyridine = 3-(3,4-dihydroxypyridin-1-yl)-L-alanine + acetate [RN:R04091]


entry: 2.5.1.53
sysname: O3-acetyl-L-serine:uracil 1-(2-amino-2-carboxyethyl)transferase
reaction: O3-acetyl-L-serine + uracil = 3-(uracil-1-yl)-L-alanine + acetate [RN:R03131]
iubmb_reaction: R03131
name:
--- 
- uracilylalanine synthase
- O3-acetyl-L-serine acetate-lyase (adding uracil)
- isowillardiine synthase
- willardiine synthase

comment:
Both L-willardiine and L-isowillardiine are produced in the reaction. Not identical with EC 2.5.1.47 cysteine synthase.


entry: 2.5.1.54
iubmb_reaction: R01826
name:
--- 
- 3-deoxy-7-phosphoheptulonate synthase
- 2-dehydro-3-deoxy-phosphoheptonate aldolase
- 2-keto-3-deoxy-D-arabino-heptonic acid 7-phosphate synthetase
- 3-deoxy-D-arabino-2-heptulosonic acid 7-phosphate synthetase
- 3-deoxy-D-arabino-heptolosonate-7-phosphate synthetase
- 3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase
- 7-phospho-2-keto-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating)
- 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating)
- D-erythrose-4-phosphate-lyase
- D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating)
- DAH7-P synthase
- DAHP synthase
- DS-Co
- DS-Mn
- KDPH synthase
- KDPH synthetase
- deoxy-D-arabino-heptulosonate-7-phosphate synthetase
- phospho-2-dehydro-3-deoxyheptonate aldolase
- phospho-2-keto-3-deoxyheptanoate aldolase
- phospho-2-keto-3-deoxyheptonate aldolase
- phospho-2-keto-3-deoxyheptonic aldolase
- phospho-2-oxo-3-deoxyheptonate aldolase

sysname:
phosphoenolpyruvate:D-erythrose-4-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)

reaction:
phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate [RN:R01826]


entry: 2.5.1.55
iubmb_reaction: R03254
name:
--- 
- 3-deoxy-8-phosphooctulonate synthase
- 2-dehydro-3-deoxy-D-octonate-8-phosphate D-arabinose-5-phosphate-lyase (pyruvate-phosphorylating)
- 2-dehydro-3-deoxy-phosphooctonate aldolase
- 2-keto-3-deoxy-8-phosphooctonic synthetase
- 3-deoxy-D-manno-octulosonate-8-phosphate synthase
- 3-deoxy-D-mannooctulosonate-8-phosphate synthetase
- 3-deoxyoctulosonic 8-phosphate synthetase
- KDOP synthase
- phospho-2-keto-3-deoxyoctonate aldolase

sysname:
phosphoenolpyruvate:D-arabinose-5-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)

reaction:
phosphoenolpyruvate + D-arabinose 5-phosphate + H2O = 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate [RN:R03254]


entry: 2.5.1.56
reaction: phosphoenolpyruvate + N-acetyl-D-mannosamine + H2O = phosphate + N-acetylneuraminate [RN:R01804]
iubmb_reaction: R01804
kegg_reaction: R04435
name:
--- 
- N-acetylneuraminate synthase
- (NANA)condensing enzyme
- N-acetylneuraminate pyruvate-lyase (pyruvate-phosphorylating)
- NeuAc synthase

sysname:
phosphoenolpyruvate:N-acetyl-D-mannosamine C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)


entry: 2.5.1.57
sysname: phosphoenolpyruvate:N-acyl-D-mannosamine-6-phosphate 1-(2-carboxy-2-oxoethyl)transferase
comment: Acts on N-glycoloyl and N-acetyl-derivatives.
iubmb_reaction: R02769 > R04435
name:
--- 
- N-acylneuraminate-9-phosphate synthase
- N-acetylneuraminate 9-phosphate lyase
- N-acetylneuraminate 9-phosphate sialic acid 9-phosphate synthase
- N-acetylneuraminate 9-phosphate synthetase
- N-acylneuraminate-9-phosphate pyruvate-lyase (pyruvate-phosphorylating)
- sialic acid 9-phosphate synthetase

reaction:
phosphoenolpyruvate + N-acyl-D-mannosamine 6-phosphate + H2O = N-acylneuraminate 9-phosphate + phosphate [RN:R02769]


entry: 2.5.1.58
name: --- - protein farnesyltransferase - FTase
sysname: farnesyl-diphosphate:protein-cysteine farnesyltransferase
reaction: farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate
comment:
This enzyme, along with protein geranylgeranyltransferase types I (EC 2.5.1.59) and II (EC 2.5.1.60), constitutes the protein prenyltransferase family of enzymes. Catalyses the formation of a thioether linkage between the C-1 of an isoprenyl group and a cysteine residue fourth from the C-terminus of the protein. These protein acceptors have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably serine, methionine, alanine or glutamine; leucine makes the protein a substrate for EC 2.5.1.59. The enzymes are relaxed in specificity for A1, but cannot act if A2 is aromatic. Substrates of the prenyltransferases include Ras, Rho, Rab, other Ras-related small GTP-binding proteins, gamma-subunits of heterotrimeric G-proteins, nuclear lamins, centromeric proteins and many proteins involved in visual signal transduction. A zinc metalloenzyme that requires Mg2+ for activity.


entry: 2.5.1.59
name: --- - protein geranylgeranyltransferase type I - GGTase-I - GGTaseI
sysname: geranylgeranyl-diphosphate:protein-cysteine geranyltransferase
reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate
comment:
This enzyme, along with protein farnesyltransferase (EC 2.5.1.58) and protein geranylgeranyltransferase type II (EC 2.5.1.60), constitutes the protein prenyltransferase family of enzymes. Catalyses the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. These protein acceptors have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine; serine, methionine, alanine or glutamine makes the protein a substrate for EC 2.5.1.58. The enzymes are relaxed in specificity for A1, but cannot act if A2 is aromatic. Known targets of this enzyme include most gamma-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families. A zinc metalloenzyme. The Zn2+ is required for peptide, but not for isoprenoid, substrate binding.


entry: 2.5.1.60
sysname: geranylgeranyl-diphosphate:protein-cysteine geranyltransferase
reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate
name:
--- 
- protein geranylgeranyltransferase type II
- GGTaseII
- Rab geranylgeranyltransferase
- RabGGTase

comment:
This enzyme, along with protein farnesyltransferase (EC 2.5.1.58) and protein geranylgeranyltransferase type I (EC 2.5.1.59), constitutes the protein prenyltransferase family of enzymes. Attaches geranylgeranyl groups to two C-terminal cysteines in Ras-related GTPases of a single family, the Rab family (Ypt/Sec4 in lower eukaryotes) that terminate in XXCC, XCXC and CCXX motifs. Reaction is entirely dependent on the Rab substrate being bound to Rab escort protein (REP). Post-translational modification with the geranylgeranyl moiety is essential for Rab GTPases to be able to control the processes of membrane docking and fusion [5].


entry: 2.5.1.61
sysname: porphobilinogen:(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)met hyltransferase (hydrolysing)
reaction: 4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3 [RN:R00084]
iubmb_reaction: R00084
name:
--- 
- hydroxymethylbilane synthase
- HMB-synthase
- porphobilinogen deaminase
- pre-uroporphyrinogen synthase
- uroporphyrinogen I synthase
- uroporphyrinogen I synthetase
- uroporphyrinogen synthase
- uroporphyrinogen synthetase
- porphobilinogen ammonia-lyase (polymerizing)
- (4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)

comment:
The enzyme works by stepwise addition of pyrrolylmethyl groups until a hexapyrrole is present at the active centre. The terminal tetrapyrrole is then hydrolysed to yield the product, leaving a cysteine-bound dipyrrole on which assembly continues. In the presence of a second enzyme, EC 4.2.1.75 uroporphyrinogen-III synthase, which is often called cosynthase, the product is cyclized to form uroporphyrinogen-III. If EC 4.2.1.75 is absent, the hydroxymethylbilane cyclizes spontaneously to form uroporphyrinogen I.


entry: 2.5.1.62
name: --- - chlorophyll synthase
sysname: chlorophyllide-a:phytyl-diphosphate phytyltransferase
reaction: chlorophyllide a + phytyl diphosphate = chlorophyll a + diphosphate [RN:R06284]
iubmb_reaction: R06284
comment:
Requires Mg2+. The enzyme is modified by binding of the first substrate, phytyl diphosphate, before reaction of the modified enzyme with the second substrate, chlorophyllide a, can occur. The reaction also occurs when phytyl diphosphate is replaced by geranylgeranyl diphosphate.


entry: 2.5.1.64
sysname: isochorismate:2-oxoglutarate:cyclodienyltransferase (decarboxylating, pyruvate-forming)
iubmb_reaction: R06860
name:
--- 
- 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase
- 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase-alpha-ketoglutarate decarboxylase
- 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid synthase
- 6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate synthase
- SHCHC synthase
- 2-oxoglutarate decarboxylase/SHCHC synthase
- (1R,6R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase
- MenD

comment:
In the first step of the reaction, the oxoglutarate is decarboxylated and an adduct of the succinic semialdehyde is formed with thiamine diphosphate of the enzyme, as in both E1 of the 2-oxoglutarate dehydrogenase complex [EC 1.2.4.2, oxoglutarate dehydrogenase (succinyl-transferring)] and in the reaction of 2-oxoglutarate decarboxylase (EC 4.1.1.71), which liberates free succinic semialdehyde.

reaction:
2-oxoglutarate + isochorismate = (1S,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate + pyruvate + CO2 [RN:R06860]


entry: 2.5.1.65
name: --- - O-phosphoserine sulfhydrylase - O-phosphoserine(thiol)-lyase
sysname: O-phospho-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase
reaction: O-phospho-L-serine + hydrogen sulfide = L-cysteine + phosphate [RN:R07274]
iubmb_reaction: R07274
comment:
A pyridoxal-phosphate protein. The enzyme from Aeropyrum pernix acts on both O-phospho-L-serine and O3-acetyl-L-serine, in contrast with EC 2.5.1.47, cysteine synthase, which acts only on O3-acetyl-L-serine.


entry: 2.5.1.66
reaction: D-glyceraldehdye 3-phosphate + L-arginine = N2-(2-carboxyethyl)-L-arginine + phosphate
iubmb_reaction: (other) R05465
kegg_reaction: R05465
name:
--- 
- N2-(2-carboxyethyl)arginine synthase
- CEAS
- N2-(2-carboxyethyl)arginine synthetase
- CEA synthetase

sysname:
glyceraldhyde-3-phosphate:L-arginine N2-(2-hydroxy-3-oxopropyl) transferase (2-carboxyethyl-forming)

comment:
The enzyme requires thiamine diphosphate and catalyses the first step in the clavulanic-acid-biosynthesis pathway. The 2-hydroxy-3-oxo group transferred from glyceraldehyde 3-phosphate is isomerized during transfer to form the 2-carboxyethyl group.


entry: 2.5.1.-
name: --- []
reaction:
(1) trans,trans-Farnesyl diphosphate + Isopentenyl diphosphate <=> trans,trans,cis-Geranylgeranyl diphosphate + Pyrophosphate [RN:R05555]; (2) trans,trans,cis-Geranylgeranyl diphosphate + Isopentenyl diphosphate <=> Dehydrodolichol diphosphate + Pyrophosphate [RN:R05556]; (3) all-trans-Octaprenyl diphosphate + 4-Hydroxybenzoate <=> 3-Octaprenyl-4-hydroxybenzoate + Pyrophosphate [RN:R05615]; (4) all-trans-Hexaprenyl diphosphate + 4-Hydroxybenzoate <=> 3-Hexaprenyl-4-hydroxybenzoate + Pyrophosphate [RN:R05616]; (5) 1,4-Dihydroxy-2-naphthoate + all-trans-Octaprenyl diphosphate <=> 2-Demethylmenaquinone + Pyrophosphate + CO2 [RN:R05617]; (6) 1,4-Dihydroxy-2-naphthoate + Phytyl diphosphate <=> 2-Phytyl-1,4-naphthoquinone + CO2 + Pyrophosphate [RN:R06858]; (7) Heme <=> Heme O [RN:R07411]


entry: 2.6.1.1
sysname: L-aspartate:2-oxoglutarate aminotransferase
reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate [RN:R00355]
iubmb_reaction: R00355
kegg_reaction: R00694 R00734 R00896 R02433 R02619 R05052
name:
--- 
- aspartate transaminase
- glutamic-oxaloacetic transaminase
- glutamic-aspartic transaminase
- transaminase A
- AAT
- AspT
- 2-oxoglutarate-glutamate aminotransferase
- aspartate alpha-ketoglutarate transaminase
- aspartate aminotransferase
- aspartate-2-oxoglutarate transaminase
- aspartic acid aminotransferase
- aspartic aminotransferase
- aspartyl aminotransferase
- AST
- glutamate-oxalacetate aminotransferase
- glutamate-oxalate transaminase
- glutamic-aspartic aminotransferase
- glutamic-oxalacetic transaminase
- glutamic oxalic transaminase
- GOT (enzyme)
- L-aspartate transaminase
- L-aspartate-alpha-ketoglutarate transaminase
- L-aspartate-2-ketoglutarate aminotransferase
- L-aspartate-2-oxoglutarate aminotransferase
- L-aspartate-2-oxoglutarate-transaminase
- L-aspartic aminotransferase
- oxaloacetate-aspartate aminotransferase
- oxaloacetate transferase
- aspartate:2-oxoglutarate aminotransferase
- glutamate oxaloacetate transaminase

comment:
A pyridoxal-phosphate protein. Also acts on L-tyrosine, L-phenylalanine and L-tryptophan. Aspartate transaminase activity can be formed from the aromatic-amino-acid transaminase (EC 2.6.1.57) of Escherichia coli by controlled proteolysis [7], some EC 2.6.1.57 activity can be found in this enzyme from other sources [8]; indeed the enzymes are identical in Trichomonas vaginalis [6].


entry: 2.6.1.2
sysname: L-alanine:2-oxoglutarate aminotransferase
comment: A pyridoxal-phosphate protein. 2-Aminobutanoate can act slowly instead of alanine.
reaction: L-alanine + 2-oxoglutarate = pyruvate + L-glutamate [RN:R00258]
iubmb_reaction: R00258
name:
--- 
- alanine transaminase
- glutamic-pyruvic transaminase
- glutamic-alanine transaminase
- GPT
- beta-alanine aminotransferase
- alanine aminotransferase
- alanine-alpha-ketoglutarate aminotransferase
- alanine-pyruvate aminotransferase
- ALT
- glutamic acid-pyruvic acid transaminase
- glutamic-pyruvic aminotransferase
- L-alanine aminotransferase
- L-alanine transaminase
- L-alanine-alpha-ketoglutarate aminotransferase
- pyruvate transaminase
- pyruvate-alanine aminotransferase
- pyruvate-glutamate transaminase


entry: 2.6.1.4
sysname: glycine:2-oxoglutarate aminotransferase
comment: A pyridoxal-phosphate protein.
reaction: glycine + 2-oxoglutarate = glyoxylate + L-glutamate [RN:R00372]
iubmb_reaction: R00372
name:
--- 
- glycine transaminase
- glutamic-glyoxylic transaminase
- glycine aminotransferase
- glyoxylate-glutamic transaminase
- L-glutamate:glyoxylate aminotransferase
- glyoxylate-glutamate aminotransferase


entry: 2.6.1.5
sysname: L-tyrosine:2-oxoglutarate aminotransferase
reaction: L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate [RN:R00734]
iubmb_reaction: R00734
kegg_reaction: R00694 R07396
name:
--- 
- tyrosine transaminase
- tyrosine aminotransferase
- glutamic-hydroxyphenylpyruvic transaminase
- glutamic phenylpyruvic aminotransferase
- L-phenylalanine 2-oxoglutarate aminotransferase
- L-tyrosine aminotransferase
- phenylalanine aminotransferase
- phenylalanine transaminase
- phenylalanine-alpha-ketoglutarate transaminase
- phenylpyruvate transaminase
- phenylpyruvic acid transaminase
- tyrosine-alpha-ketoglutarate aminotransferase
- tyrosine-alpha-ketoglutarate transaminase
- tyrosine-2-ketoglutarate aminotransferase

comment:
A pyridoxal-phosphate protein. L-Phenylalanine can act instead of L-tyrosine. The mitochondrial enzyme may be identical with EC 2.6.1.1 (aspartate transaminase). The three isoenzymic forms are interconverted by EC 3.4.22.32 (stem bromelain) and EC 3.4.22.33 (fruit bromelain).


entry: 2.6.1.6
sysname: L-leucine:2-oxoglutarate aminotransferase
reaction: L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate [RN:R01090]
iubmb_reaction: R01090
kegg_reaction: R01214
name:
--- 
- leucine transaminase
- L-leucine aminotransferase
- leucine 2-oxoglutarate transaminase
- leucine aminotransferase
- leucine-alpha-ketoglutarate transaminase

comment:
A pyridoxal-phosphate protein. This enzyme differs from EC 2.6.1.42, branched-chain-amino-acid transaminase, in that it does not act on L-valine or L-isoleucine, although it does act on L-methionine. The mitochondrial form from rat liver differs in physical characteristics from the cytoplasmic form.


entry: 2.6.1.7
sysname: L-kynurenine:2-oxoglutarate aminotransferase
reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate [RN:R01956]
iubmb_reaction: R01956
kegg_reaction: R04171
name:
--- 
- kynurenine-oxoglutarate transaminase
- kynurenine transaminase (cyclizing)
- kynurenine 2-oxoglutarate transaminase
- kynurenine aminotransferase
- L-kynurenine aminotransferase

comment:
A pyridoxal-phosphate protein. Also acts on 3-hydroxykynurenine. The product 4-(2-aminophenyl)-2,4-dioxobutanoate is converted into kynurenate by a spontaneous reaction.


entry: 2.6.1.8
sysname: 2,5-diaminopentanoate:2-oxoglutarate aminotransferase
comment: A pyridoxal-phosphate protein. 2,5-Diaminoglutarate can act instead of diaminopentanoate.
reaction: 2,5-diaminopentanoate + 2-oxoglutarate = 5-amino-2-oxopentanoate + L-glutamate [RN:R03248]
iubmb_reaction: R03248
name:
--- 
- 2,5-diaminovalerate transaminase
- diamino-acid transaminase
- diamino acid aminotransferase


entry: 2.6.1.9
sysname: L-histidinol-phosphate:2-oxoglutarate aminotransferase
comment: A pyridoxal-phosphate protein.
iubmb_reaction: R03243
kegg_reaction: R00694 R00734
name:
--- 
- histidinol-phosphate transaminase
- imidazolylacetolphosphate transaminase
- glutamic-imidazoleacetol phosphate transaminase
- histidinol phosphate aminotransferase
- imidazoleacetol phosphate transaminase
- L-histidinol phosphate aminotransferase
- histidine:imidazoleacetol phosphate transaminase
- IAP transaminase
- imidazolylacetolphosphate aminotransferase

reaction:
L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate [RN:R03243]


entry: 2.6.1.10
name: --- - Deleted entry
comment:
Deleted entry: D-aspartate transaminase. Now included with EC 2.6.1.21 D-alanine transaminase (EC 2.6.1.10 created 1961, deleted 1972)


entry: 2.6.1.11
sysname: N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase
comment: A pyridoxal-phosphate protein. Also acts on L-ornithine and N2-succinyl-L-ornithine.
iubmb_reaction: R02283
name:
--- 
- acetylornithine transaminase
- acetylornithine delta-transaminase
- ACOAT
- acetylornithine 5-aminotransferase
- acetylornithine aminotransferase
- N-acetylornithine aminotransferase
- N-acetylornithine-delta-transaminase
- N2-acetylornithine 5-transaminase
- N2-acetyl-L-ornithine:2-oxoglutarate aminotransferase
- succinylornithine aminotransferase

reaction:
N2-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate [RN:R02283]


entry: 2.6.1.12
sysname: L-alanine:2-oxo-acid aminotransferase
comment: A pyridoxal-phosphate protein.
reaction: L-alanine + a 2-oxo acid = pyruvate + an L-amino acid [RN:R01261]
iubmb_reaction: R01261 > R00400
name:
--- 
- alanine-oxo-acid transaminase
- L-alanine-alpha-keto acid aminotransferase
- leucine-alanine transaminase
- alanine-keto acid aminotransferase
- alanine-oxo acid aminotransferase


entry: 2.6.1.13
sysname: L-ornithine:2-oxo-acid aminotransferase
comment: A pyridoxal-phosphate protein.
reaction: L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid [RN:R01343]
iubmb_reaction: R01343 > R00667
name:
--- 
- ornithine-oxo-acid transaminase
- ornithine delta-transaminase
- L-ornithine:alpha-ketoglutarate delta-aminotransferase
- OAT
- L-ornithine 5-aminotransferase
- L-ornithine aminotransferase
- ornithine 5-aminotransferase
- ornithine transaminase
- ornithine-alpha-ketoglutarate aminotransferase
- ornithine-2-oxoacid aminotransferase
- ornithine-keto acid aminotransferase
- ornithine-keto acid transaminase
- ornithine-ketoglutarate aminotransferase
- ornithine-oxo acid aminotransferase
- ornithine:alpha-oxoglutarate transaminase


entry: 2.6.1.15
sysname: L-glutamine:pyruvate aminotransferase
comment: A pyridoxal-phosphate protein. L-Methionine can act as donor; glyoxylate can act as acceptor.
reaction: L-glutamine + pyruvate = 2-oxoglutaramate + L-alanine [RN:R00576]
iubmb_reaction: R00576
name:
--- 
- glutamine-pyruvate transaminase
- glutaminase II
- L-glutamine transaminase L
- glutamine-oxo-acid transaminase glutamine transaminase L
- gamma-glutaminyltransferase
- glutamine transaminase
- glutamine-alpha-keto acid transaminase
- glutamine-keto acid aminotransferase
- glutamine-alpha-keto acid transamidase
- glutamine-oxo acid aminotransferase


entry: 2.6.1.16
sysname: L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
reaction: L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate [RN:R00768]
iubmb_reaction: R00768
name:
--- 
- glutamine-fructose-6-phosphate transaminase (isomerizing)
- hexosephosphate aminotransferase
- glucosamine-6-phosphate isomerase (glutamine-forming)
- D-fructose-6-phosphate amidotransferase
- glucosaminephosphate isomerase
- glucosamine 6-phosphate synthase
- GlcN6P synthase

comment:
Although the overall reaction is that of a transferase, the mechanism involves the formation of ketimine between fructose 6-phosphate and a 6-amino group from a lysine residue at the active site, which is subsequently displaced by ammonia (transamidination). Formerly EC 5.3.1.19.


entry: 2.6.1.17
sysname: N-succinyl-L-2,6-diaminoheptanedioate:2-oxoglutarate aminotransferase
comment: A pyridoxal-phosphate protein.
iubmb_reaction: R04475
name:
--- 
- succinyldiaminopimelate transaminase
- succinyldiaminopimelate aminotransferase
- N-succinyl-L-diaminopimelic glutamic transaminase

reaction:
N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate = N-succinyl-L-2-amino-6-oxoheptanedioate + L-glutamate [RN:R04475]


entry: 2.6.1.18
sysname: L-alanine:3-oxopropanoate aminotransferase
comment: A pyridoxal-phosphate protein.
reaction: L-alanine + 3-oxopropanoate = pyruvate + beta-alanine [RN:R00907]
iubmb_reaction: R00907
kegg_reaction: R04187
name:
--- 
- beta-alanine-pyruvate transaminase
- beta-alanine-pyruvate aminotransferase
- beta-alanine-alpha-alanine transaminase


entry: 2.6.1.19
sysname: 4-aminobutanoate:2-oxoglutarate aminotransferase
comment: Some preparations also act on beta-alanine, 5-aminopentanoate and (R,S)-3-amino-2-methylpropanoate.
reaction: 4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate [RN:R01648]
iubmb_reaction: R01648
kegg_reaction: R00908
name:
--- 
- 4-aminobutyrate transaminase
- beta-alanine-oxoglutarate transaminase
- aminobutyrate aminotransferase
- beta-alanine aminotransferase
- beta-alanine-oxoglutarate aminotransferase
- gamma-aminobutyrate aminotransaminase
- gamma-aminobutyrate transaminase
- gamma-aminobutyrate-alpha-ketoglutarate aminotransferase
- gamma-aminobutyrate-alpha-ketoglutarate transaminase
- gamma-aminobutyrate:alpha-oxoglutarate aminotransferase
- gamma-aminobutyric acid aminotransferase
- gamma-aminobutyric acid pyruvate transaminase
- gamma-aminobutyric acid transaminase
- gamma-aminobutyric acid-alpha-ketoglutarate transaminase
- gamma-aminobutyric acid-alpha-ketoglutaric acid aminotransferase
- gamma-aminobutyric acid-2-oxoglutarate transaminase
- gamma-aminobutyric transaminase
- 4-aminobutyrate aminotransferase
- 4-aminobutyrate-2-ketoglutarate aminotransferase
- 4-aminobutyrate-2-oxoglutarate aminotransferase
- 4-aminobutyrate-2-oxoglutarate transaminase
- 4-aminobutyric acid 2-ketoglutaric acid aminotransferase
- 4-aminobutyric acid aminotransferase
- aminobutyrate transaminase
- GABA aminotransferase
- GABA transaminase
- GABA transferase
- GABA-alpha-ketoglutarate aminotransferase
- GABA-alpha-ketoglutarate transaminase
- GABA-alpha-ketoglutaric acid transaminase
- GABA-alpha-oxoglutarate aminotransferase
- GABA-2-oxoglutarate aminotransferase
- GABA-2-oxoglutarate transaminase
- GABA-oxoglutarate aminotransferase
- GABA-oxoglutarate transaminase
- glutamate-succinic semialdehyde transaminase
- GabT


entry: 2.6.1.21
sysname: D-alanine:2-oxoglutarate aminotransferase
reaction: D-alanine + 2-oxoglutarate = pyruvate + D-glutamate [RN:R01148]
iubmb_reaction: R01148
kegg_reaction: R01582 R02459 R02851 R02924 R03041 R05053
name:
--- 
- D-amino-acid transaminase
- D-aspartate transaminase
- D-alanine aminotransferase
- D-aspartic aminotransferase
- D-alanine-D-glutamate transaminase
- D-alanine transaminase
- D-amino acid aminotransferase

comment:
A pyridoxal-phosphate protein. The enzyme from thermophilic Bacillus species acts on many D-amino acids with D-alanine and D-2-aminobutyrate as the best amino donors. It can similarly use any of several 2-oxo acids as amino acceptor, with 2-oxoglutarate and 2-oxobutyrate among the best. The enzyme from some other sources has a broader specificity [6].


entry: 2.6.1.22
sysname: (S)-3-amino-2-methylpropanoate:2-oxoglutarate aminotransferase
reaction: (S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate
iubmb_reaction: (other) R04188
kegg_reaction: R04188
name:
--- 
- (S)-3-amino-2-methylpropionate transaminase
- L-3-aminoisobutyrate transaminase
- beta-aminobutyric transaminase
- L-3-aminoisobutyric aminotransferase
- beta-aminoisobutyrate-alpha-ketoglutarate transaminase

comment:
Also acts on beta-alanine and other omega-amino acids having carbon chains between 2 and 5. The two enantiomers of the 2-methyl-3-oxopropanoate formed by the enzyme interconvert by enolization, so that this enzyme, together with EC 2.6.1.40, (R)-3-amino-2-methylpropionate-pyruvate transaminase, provide a route for interconversion of the enantiomers of 3-amino-2-methylpropanoate.


entry: 2.6.1.23
name: --- - 4-hydroxyglutamate transaminase - 4-hydroxyglutamate aminotransferase
sysname: 4-hydroxy-L-glutamate:2-oxoglutarate aminotransferase
reaction: 4-hydroxy-L-glutamate + 2-oxoglutarate = 4-hydroxy-2-oxoglutarate + L-glutamate [RN:R03266]
iubmb_reaction: R03266 > R05052
comment:
Oxaloacetate can replace 2-oxoglutarate. This enzyme may be identical with EC 2.6.1.1 aspartate transaminase.


entry: 2.6.1.24
sysname: 3,5-diiodo-L-tyrosine:2-oxoglutarate aminotransferase
iubmb_reaction: R03207
name:
--- 
- diiodotyrosine transaminase
- diiodotyrosine aminotransferase
- halogenated tyrosine aminotransferase
- halogenated tyrosine transaminase

comment:
A pyridoxal-phosphate protein. Also acts on 3,5-dichloro-, 3,5-dibromo- and 3-iodo-L-tyrosine, thyroxine and triiodothyronine.

reaction:
3,5-diiodo-L-tyrosine + 2-oxoglutarate = 4-hydroxy-3,5-diiodophenylpyruvate + L-glutamate [RN:R03207]


entry: 2.6.1.25
name: --- - Deleted entry
comment:
Deleted entry: thyroxine transaminase. Now included with EC 2.6.1.24 diiodotyrosine transaminase (EC 2.6.1.25 created 1972, deleted 1984)


entry: 2.6.1.26
sysname: L-3,5,3'-triiodothyronine:2-oxoglutarate aminotransferase
iubmb_reaction: R03952
name:
--- 
- thyroid-hormone transaminase
- 3,5-dinitrotyrosine transaminase
- thyroid hormone aminotransferase

comment:
A pyridoxal-phosphate protein. Acts on monoiodotyrosine, diiodotyrosine, triiodothyronine, thyroxine and dinitrotyrosine (unlike EC 2.6.1.24 diiodotyrosine transaminase, which does not act on dinitrotyrosine). Pyruvate or oxaloacetate can act as acceptors.

reaction:
L-3,5,3'-triiodothyronine + 2-oxoglutarate = 3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-2-oxopropanoate + L-glutamate [RN:R03952]


entry: 2.6.1.27
sysname: L-tryptophan:2-oxoglutarate aminotransferase
reaction: L-tryptophan + 2-oxoglutarate = (indol-3-yl)pyruvate + L-glutamate [RN:R00684]
iubmb_reaction: R00684
kegg_reaction: R02700 R04913
name:
--- 
- tryptophan transaminase
- L-phenylalanine-2-oxoglutarate aminotransferase
- tryptophan aminotransferase
- 5-hydroxytryptophan-ketoglutaric transaminase
- hydroxytryptophan aminotransferase
- L-tryptophan aminotransferase
- L-tryptophan transaminase

comment:
A pyridoxal-phosphate protein. Also acts on 5-hydroxytryptophan and, to a lesser extent, on the phenyl amino acids.


entry: 2.6.1.28
sysname: L-tryptophan:phenylpyruvate aminotransferase
comment: Valine, leucine and isoleucine can replace tryptophan as amino donor.
reaction: L-tryptophan + phenylpyruvate = (indol-3-yl)pyruvate + L-phenylalanine [RN:R01376]
iubmb_reaction: R01376
name:
--- 
- tryptophan-phenylpyruvate transaminase
- L-tryptophan-alpha-ketoisocaproate aminotransferase


entry: 2.6.1.29
sysname: diamine:2-oxoglutarate aminotransferase
reaction: An alpha,omega-diamine + 2-oxoglutarate = an omega-aminoaldehyde + L-glutamate [RN:R07275]
iubmb_reaction: R07275 > R01155
name:
--- 
- diamine transaminase
- amine transaminase
- amine-ketoacid transaminase
- diamine aminotransferase
- diamine-ketoglutaric transaminase


entry: 2.6.1.32
sysname: L-valine:(S)-3-methyl-2-oxopentanoate aminotransferase
reaction: L-valine + (S)-3-methyl-2-oxopentanoate = 3-methyl-2-oxobutanoate + L-isoleucine [RN:R02200]
iubmb_reaction: R02200
name:
--- 
- valine-3-methyl-2-oxovalerate transaminase
- valine-isoleucine transaminase
- valine-3-methyl-2-oxovalerate aminotransferase
- alanine-valine transaminase
- valine-2-keto-methylvalerate aminotransferase
- valine-isoleucine aminotransferase


entry: 2.6.1.33
sysname: dTDP-4-amino-4,6-dideoxy-D-glucose:2-oxoglutarate aminotransferase
comment: A pyridoxal-phosphate protein.
iubmb_reaction: R02773
kegg_reaction: R02772
name:
--- 
- dTDP-4-amino-4,6-dideoxy-D-glucose transaminase
- thymidine diphospho-4-amino-4,6-dideoxyglucose aminotransferase
- thymidine diphospho-4-amino-6-deoxyglucose aminotransferase
- thymidine diphospho-4-keto-6-deoxy-D-glucose transaminase
- thymidine diphospho-4-keto-6-deoxy-D-glucose-glutamic transaminase
- TDP-4-keto-6-deoxy-D-glucose transaminase

reaction:
dTDP-4-amino-4,6-dideoxy-D-glucose + 2-oxoglutarate = dTDP-4-dehydro-6-deoxy-D-glucose + L-glutamate [RN:R02773]


entry: 2.6.1.34
sysname: UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose:2-oxoglutarate aminotransferase
comment: A pyridoxal-phosphate protein.
iubmb_reaction: R04529
name:
--- 
- UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose transaminase
- uridine diphospho-4-amino-2-acetamido-2,4,6-trideoxyglucose aminotransferase

reaction:
UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose + 2-oxoglutarate = UDP-2-acetamido-4-dehydro-2,6-dideoxyglucose + L-glutamate [RN:R04529]


entry: 2.6.1.36
sysname: L-lysine:2-oxoglutarate 6-aminotransferase
reaction: L-lysine + 2-oxoglutarate = 2-aminoadipate 6-semialdehyde + L-glutamate [RN:R00457]
iubmb_reaction: R00457
name:
--- 
- L-lysine 6-transaminase
- lysine 6-aminotransferase
- lysine epsilon-aminotransferase
- lysine epsilon-transaminase
- lysine:2-ketoglutarate 6-aminotransferase
- L-lysine-alpha-ketoglutarate aminotransferase
- L-lysine-alpha-ketoglutarate 6-aminotransferase

comment:
A pyridoxal-phosphate protein. The product (allysine) is converted into the intramolecularly dehydrated form, 1-piperideine 6-carboxylate.


entry: 2.6.1.37
sysname: (2-aminoethyl)phosphonate:pyruvate aminotransferase
reaction: (2-aminoethyl)phosphonate + pyruvate = 2-phosphonoacetaldehyde + L-alanine [RN:R04152]
iubmb_reaction: R04152
name:
--- 
- 2-aminoethylphosphonate-pyruvate transaminase
- (2-aminoethyl)phosphonate transaminase
- (2-aminoethyl)phosphonate aminotransferase
- (2-aminoethyl)phosphonic acid aminotransferase
- 2-aminoethylphosphonate-pyruvate aminotransferase
- 2-aminoethylphosphonate aminotransferase

comment:
A pyridoxal-phosphate protein. 2-Aminoethylarsonate can replace 2-aminoethylphosphonate as a substrate.


entry: 2.6.1.38
sysname: L-histidine:2-oxoglutarate aminotransferase
reaction: L-histidine + 2-oxoglutarate = (imidazol-5-yl)pyruvate + L-glutamate [RN:R01161]
iubmb_reaction: R01161
name:
--- 
- histidine transaminase
- histidine aminotransferase
- histidine-2-oxoglutarate aminotransferase


entry: 2.6.1.39
sysname: L-2-aminoadipate:2-oxoglutarate aminotransferase
comment: A pyridoxal-phosphate protein.
reaction: L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamate [RN:R01939]
iubmb_reaction: R01939
kegg_reaction: R04029
name:
--- 
- 2-aminoadipate transaminase
- alpha-aminoadipate aminotransferase
- 2-aminoadipate aminotransferase
- 2-aminoadipic aminotransferase
- glutamic-ketoadipic transaminase
- glutamate-alpha-ketoadipate transaminase


entry: 2.6.1.40
sysname: (R)-3-amino-2-methylpropanoate:pyruvate aminotransferase
reaction: (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine [RN:R02050]
iubmb_reaction: R02050
kegg_reaction: R02048
name:
--- 
- (R)-3-amino-2-methylpropionate-pyruvate transaminase
- D-3-aminoisobutyrate-pyruvate transaminase
- beta-aminoisobutyrate-pyruvate aminotransferase
- D-3-aminoisobutyrate-pyruvate aminotransferase
- (R)-3-amino-2-methylpropionate transaminase
- D-beta-aminoisobutyrate:pyruvate aminotransferase

comment:
The two enantiomers of the 2-methyl-3-oxopropanoate formed by the enzyme interconvert by enolization, so that this enzyme, together with EC 2.6.1.22, (S)-3-amino-2-methylpropionate transaminase, provide a route for interconversion of the enantiomers of 3-amino-2-methylpropanoate.


entry: 2.6.1.41
sysname: D-methionine:pyruvate aminotransferase
comment: Oxaloacetate can replace pyruvate.
reaction: D-methionine + pyruvate = 4-methylthio-2-oxobutanoate + L-alanine [RN:R03001]
iubmb_reaction: R03001
kegg_reaction: R01344
name:
--- 
- D-methionine-pyruvate transaminase
- D-methionine transaminase
- D-methionine aminotransferase


entry: 2.6.1.42
sysname: branched-chain-amino-acid:2-oxoglutarate aminotransferase
reaction: L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate [RN:R01090]
iubmb_reaction: R01090
kegg_reaction: R01214 R02198 R02199
name:
--- 
- branched-chain-amino-acid transaminase
- transaminase B
- branched-chain amino acid aminotransferase
- branched-chain amino acid-glutamate transaminase
- branched-chain aminotransferase
- L-branched chain amino acid aminotransferase
- glutamate-branched-chain amino acid transaminase

comment:
Also acts on L-isoleucine and L-valine, and thereby differs from EC 2.6.1.6, leucine transaminase, which does not. It also differs from EC 2.6.1.66, valine-pyruvate transaminase.


entry: 2.6.1.43
sysname: 5-aminolevulinate:pyruvate aminotransferase
comment: A pyridoxal-phosphate protein.
reaction: 5-aminolevulinate + pyruvate = 4,5-dioxopentanoate + L-alanine [RN:R02271]
iubmb_reaction: R02271
name:
--- 
- aminolevulinate transaminase
- aminolevulinate aminotransferase, gamma,delta-dioxovalerate aminotransferase
- gamma,delta-dioxovaleric acid transaminase
- 4,5-dioxovalerate aminotransferase
- 4,5-dioxovaleric acid transaminase
- 4,5-dioxovaleric transaminase
- 5-aminolevulinic acid transaminase
- alanine-gamma,delta-dioxovalerate aminotransferase
- alanine-dioxovalerate aminotransferase
- alanine:4,5-dioxovalerate aminotransferase
- aminolevulinic acid transaminase
- dioxovalerate transaminase
- L-alanine-4,5-dioxovalerate aminotransferase
- L-alanine:4,5-dioxovaleric acid transaminase
- L-alanine:dioxovalerate transaminase
- DOVA transaminase
- 4,5-dioxovaleric acid aminotransferase


entry: 2.6.1.44
sysname: L-alanine:glyoxylate aminotransferase
reaction: L-alanine + glyoxylate = pyruvate + glycine [RN:R00369]
iubmb_reaction: R00369
name:
--- 
- alanine-glyoxylate transaminase
- AGT
- alanine-glyoxylate aminotransferase
- alanine-glyoxylic aminotransferase
- L-alanine-glycine transaminase

comment:
A pyridoxal-phosphate protein. With one component of the animal enzyme, 2-oxobutanoate can replace glyoxylate. A second component also catalyses the reaction of EC 2.6.1.51 serine-pyruvate transaminase.


entry: 2.6.1.46
sysname: L-2,4-diaminobutanoate:pyruvate aminotransferase
comment: A pyridoxal-phosphate protein.
reaction: L-2,4-diaminobutanoate + pyruvate = L-aspartate 4-semialdehyde + L-alanine [RN:R02293]
iubmb_reaction: R02293
name:
--- 
- diaminobutyrate-pyruvate transaminase
- diaminobutyrate-pyruvate aminotransferase
- L-diaminobutyric acid transaminase


entry: 2.6.1.47
sysname: L-alanine:oxomalonate aminotransferase
comment: A pyridoxal-phosphate protein.
reaction: L-alanine + oxomalonate = pyruvate + aminomalonate [RN:R02970]
iubmb_reaction: R02970
name:
--- 
- alanine-oxomalonate transaminase
- alanine-oxomalonate aminotransferase
- L-alanine-ketomalonate transaminase
- alanine-ketomalonate (mesoxalate) transaminase


entry: 2.6.1.48
sysname: 5-aminopentanoate:2-oxoglutarate aminotransferase
comment: A pyridoxal-phosphate protein.
reaction: 5-aminopentanoate + 2-oxoglutarate = 5-oxopentanoate + L-glutamate [RN:R02274]
iubmb_reaction: R02274
name:
--- 
- 5-aminovalerate transaminase
- 5-aminovalerate aminotransferase
- delta-aminovalerate aminotransferase
- delta-aminovalerate transaminase


entry: 2.6.1.49
sysname: 3,4-dihydroxy-L-phenylalanine:2-oxoglutarate aminotransferase
comment: A pyridoxal-phosphate protein.
iubmb_reaction: R02077
name:
--- 
- dihydroxyphenylalanine transaminase
- dopa transaminase
- dihydroxyphenylalanine aminotransferase
- aspartate-DOPP transaminase (ADT)
- L-dopa transaminase
- dopa aminotransferase
- glutamate-DOPP transaminase (GDT)
- phenylalanine-DOPP transaminase (PDT)

reaction:
3,4-dihydroxy-L-phenylalanine + 2-oxoglutarate = 3,4-dihydroxyphenylpyruvate + L-glutamate [RN:R02077]


entry: 2.6.1.50
sysname: L-glutamine:2,4,6/3,5-pentahydroxycyclohexanone aminotransferase
comment: A pyridoxal-phosphate protein.
iubmb_reaction: R02781
name:
--- 
- glutamine-scyllo-inositol transaminase
- glutamine scyllo-inosose aminotransferase
- L-glutamine-keto-scyllo-inositol aminotransferase
- glutamine-scyllo-inosose transaminase
- L-glutamine-scyllo-inosose transaminase

reaction:
L-glutamine + 2,4,6/3,5-pentahydroxycyclohexanone = 2-oxoglutaramate + 1-amino-1-deoxy-scyllo-inositol [RN:R02781]


entry: 2.6.1.51
name: --- - serine-pyruvate transaminase - SPT - hydroxypyruvate:L-alanine transaminase
sysname: L-serine:pyruvate aminotransferase
reaction: L-serine + pyruvate = 3-hydroxypyruvate + L-alanine [RN:R00585]
iubmb_reaction: R00585
comment:
A pyridoxal-phosphate protein. The liver enzyme may be identical with EC 2.6.1.44 alanine-glyoxylate transaminase.


entry: 2.6.1.52
sysname: O-phospho-L-serine:2-oxoglutarate aminotransferase
iubmb_reaction: R04173
kegg_reaction: R05085
name:
--- 
- phosphoserine transaminase
- PSAT
- phosphoserine aminotransferase
- 3-phosphoserine aminotransferase
- hydroxypyruvic phosphate-glutamic transaminase
- L-phosphoserine aminotransferase
- phosphohydroxypyruvate transaminase
- phosphohydroxypyruvic-glutamic transaminase
- 3-O-phospho-L-serine:2-oxoglutarate aminotransferase
- SerC
- PdxC
- 3PHP transaminase

comment:
A pyridoxal-phosphate protein. This enzyme catalyses the second step in the phosphorylated pathway of serine biosynthesis in Escherichia coli [2,3]. It also catalyses the third step in the biosynthesis of the coenzyme pyridoxal 5'-phosphate in Escherichia coli (using Reaction 2 above) [3]. In Escherichia coli, pyridoxal 5'-phosphate is synthesized de novo by a pathway that involves EC 1.2.1.72 (erythrose-4-phosphate dehydrogenase), EC 1.1.1.290 (4-phosphoerythronate dehydrogenase), EC 2.6.1.52 (phosphoserine transaminase), EC 1.1.1.262 (4-hydroxythreonine-4-phosphate dehydrogenase), EC 2.6.99.2 (pyridoxine 5'-phosphate synthase) and EC 1.4.3.5 (with pyridoxine 5'-phosphate as substrate). Pyridoxal phosphate is the cofactor for both activities and therefore seems to be involved in its own biosynthesis [4]. Non-phosphorylated forms of serine and threonine are not substrates [4].

reaction:
(1) O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate [RN:R04173]; (2) 4-phosphonooxy-L-threonine + 2-oxoglutarate = (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + L-glutamate


entry: 2.6.1.53
name: --- - Transferred to 1.4.1.13
comment:
Transferred entry: now EC 1.4.1.13 glutamate synthase (NADPH2) (EC 2.6.1.53 created 1972, deleted 1976)


entry: 2.6.1.54
sysname: pyridoxamine-5'-phosphate:2-oxoglutarate aminotransferase (D-glutamate-forming)
comment: Also acts, more slowly, on pyridoxamine.
reaction: pyridoxamine 5'-phosphate + 2-oxoglutarate = pyridoxal 5'-phosphate + D-glutamate [RN:R01580]
iubmb_reaction: R01580
kegg_reaction: R01147 R05839
name:
--- 
- pyridoxamine-phosphate transaminase
- pyridoxamine phosphate aminotransferase
- pyridoxamine 5'-phosphate-alpha-ketoglutarate transaminase
- pyridoxamine 5'-phosphate transaminase


entry: 2.6.1.55
sysname: taurine:2-oxoglutarate aminotransferase
reaction: taurine + 2-oxoglutarate = sulfoacetaldehyde + L-glutamate [RN:R01684]
iubmb_reaction: R01684
kegg_reaction: R00908
name:
--- 
- taurine-2-oxoglutarate transaminase
- taurine aminotransferase
- taurine transaminase
- taurine-alpha-ketoglutarate aminotransferase
- taurine-glutamate transaminase

comment:
A pyridoxal-phosphate protein. Also acts on D,L-3-amino-isobutanoate, beta-alanine and 3-aminopropanesulfonate. Involved in the microbial utilization of beta-alanine.


entry: 2.6.1.56
sysname: 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol:pyruvate aminotransferase
comment: L-Glutamate and L-glutamine can also act as amino donors.
iubmb_reaction: R03502
name:
--- 
- 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol transaminase
- guanidinoaminodideoxy-scyllo-inositol-pyruvate aminotransferase
- L-alanine-N-amidino-3-(or 5-)keto-scyllo-inosamine transaminase

reaction:
1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol + pyruvate = 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol + L-alanine [RN:R03502]


entry: 2.6.1.57
sysname: aromatic-amino-acid:2-oxoglutarate aminotransferase
reaction: An aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate [RN:R03120]
iubmb_reaction: R03120 > R00694 R00734
kegg_reaction: R01731 R07396
name:
--- 
- aromatic-amino-acid transaminase
- aromatic amino acid aminotransferase
- aromatic aminotransferase
- ArAT

comment:
A pyridoxal-phosphate protein. L-Methionine can also act as donor, but more slowly; oxaloacetate can act as acceptor. Controlled proteolysis converts the enzyme into EC 2.6.1.1 aspartate transaminase.


entry: 2.6.1.58
sysname: L-phenylalanine:pyruvate aminotransferase
reaction: L-phenylalanine + pyruvate = phenylpyruvate + L-alanine [RN:R00692]
iubmb_reaction: R00692
name:
--- 
- phenylalanine(histidine) transaminase
- phenylalanine (histidine) aminotransferase
- phenylalanine(histidine):pyruvate aminotransferase
- histidine:pyruvate aminotransferase
- L-phenylalanine(L-histidine):pyruvate aminotransferase

comment:
L-Histidine and L-tyrosine can act instead of L-phenylalanine; in the reverse reaction, L-methionine, L-serine and L-glutamine can replace L-alanine.


entry: 2.6.1.59
sysname: dTDP-4,6-dideoxy-D-galactose:2-oxoglutarate aminotransferase
comment: A pyridoxal-phosphate protein.
iubmb_reaction: R04438
name:
--- 
- dTDP-4-amino-4,6-dideoxygalactose transaminase
- thymidine diphosphoaminodideoxygalactose aminotransferase
- thymidine diphosphate 4-keto-6-deoxy-D-glucose transaminase

reaction:
dTDP-4-amino-4,6-dideoxy-D-galactose + 2-oxoglutarate = dTDP-4-dehydro-6-deoxy-D-galactose + L-glutamate [RN:R04438]


entry: 2.6.1.60
name: --- - aromatic-amino-acid-glyoxylate transaminase
sysname: aromatic-amino-acid:glyoxylate aminotransferase
reaction: an aromatic amino acid + glyoxylate = an aromatic oxo acid + glycine [RN:R03121]
iubmb_reaction: R03121
comment:
Phenylalanine, kynurenine, tyrosine and histidine can act as amino donors; glyoxylate, pyruvate and hydroxypyruvate can act as amino acceptors.


entry: 2.6.1.61
name: --- - Deleted entry
comment:
Deleted entry: (R)-3-amino-2-methylpropionate transaminase. Enzyme is identical to EC 2.6.1.40, (R)-3-amino-2-methylpropionate-pyruvate transaminase (EC 2.6.1.61 created 1982, deleted 2004)


entry: 2.6.1.62
sysname: S-adenosyl-L-methionine:8-amino-7-oxononanoate aminotransferase
comment: S-adenosylhomocysteine can also act as donor.
iubmb_reaction: R03231
name:
--- 
- adenosylmethionine-8-amino-7-oxononanoate transaminase
- 7,8-diaminonanoate transaminase
- 7,8-diaminononanoate transaminase
- DAPA transaminase
- 7,8-diaminopelargonic acid aminotransferase
- DAPA aminotransferase
- 7-keto-8-aminopelargonic acid
- diaminopelargonate synthase
- 7-keto-8-aminopelargonic acid aminotransferase

reaction:
S-adenosyl-L-methionine + 8-amino-7-oxononanoate = S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate [RN:R03231]


entry: 2.6.1.64
sysname: L-glutamine:phenylpyruvate aminotransferase
reaction: L-glutamine + phenylpyruvate = 2-oxoglutaramate + L-phenylalanine [RN:R01375]
iubmb_reaction: R01375
name:
--- 
- glutamine-phenylpyruvate transaminase
- glutamine transaminase K
- glutamine-phenylpyruvate aminotransferase

comment:
A pyridoxal-phosphate protein. L-Methionine, L-histidine and L-tyrosine can act as donors. The enzyme has little activity on pyruvate and glyoxylate (cf. EC 2.6.1.15 glutamine-pyruvate transaminase).


entry: 2.6.1.65
name: --- - N6-acetyl-beta-lysine transaminase - epsilon-acetyl-beta-lysine aminotransferase
sysname: 6-acetamido-3-aminohexanoate:2-oxoglutarate aminotransferase
comment: A pyridoxal-phosphate protein.
iubmb_reaction: R04028
kegg_reaction: R04029
reaction:
6-acetamido-3-aminohexanoate + 2-oxoglutarate = 6-acetamido-3-oxohexanoate + L-glutamate [RN:R04028]


entry: 2.6.1.66
sysname: L-valine:pyruvate aminotransferase
comment: Different from EC 2.6.1.42, branched-chain-amino-acid-transaminase.
reaction: L-valine + pyruvate = 3-methyl-2-oxobutanoate + L-alanine [RN:R01215]
iubmb_reaction: R01215
name:
--- 
- valine-pyruvate transaminase
- transaminase C
- valine-pyruvate aminotransferase
- alanine-oxoisovalerate aminotransferase


entry: 2.6.1.67
sysname: L-2-aminohexanoate:2-oxoglutarate aminotransferase
reaction: L-2-aminohexanoate + 2-oxoglutarate = 2-oxohexanoate + L-glutamate [RN:R03053]
iubmb_reaction: R03053
name:
--- 
- 2-aminohexanoate transaminase
- norleucine transaminase
- norleucine (leucine) aminotransferase
- "leucine L-norleucine: 2-oxoglutarate aminotransferase"

comment:
A pyridoxal-phosphate protein. Also acts on L-leucine and, more slowly, on L-isoleucine, L-2-aminopentanoate and L-aspartate.


entry: 2.6.1.68
sysname: L-ornithine:2-oxoglutarate-aminotransferase
reaction: L-ornithine + 2-oxoglutarate = 3,4-dihydro-2H-pyrrole-2-carboxylate + L-glutamate + H2O [RN:R00668]
iubmb_reaction: R00668
name:
--- 
- ornithine(lysine) transaminase
- ornithine(lysine) aminotransferase
- lysine/ornithine:2-oxoglutarate aminotransferase
- L-ornithine(L-lysine):2-oxoglutarate-aminotransferase

comment:
The enzyme from Trichomonas vaginalis also acts on L-lysine, producing 2,3,4,5-tetrahydropyridine-2-carboxylate.


entry: 2.6.1.69
name: --- - Deleted entry
comment:
Deleted entry: N2-acetylornithine 5-transaminase. Enzyme is identical to EC 2.6.1.11, acetylornithine transaminase (EC 2.6.1.69 created 1989, deleted 2004)


entry: 2.6.1.70
name: --- - aspartate-phenylpyruvate transaminase - aspartate-phenylpyruvate aminotransferase
sysname: L-aspartate:phenylpyruvate aminotransferase
reaction: L-aspartate + phenylpyruvate = oxaloacetate + L-phenylalanine [RN:R00695]
iubmb_reaction: R00695
comment:
The enzyme from Pseudomonas putida also acts on 4-hydroxyphenylpyruvate and, more slowly, on L-glutamate and L-histidine.


entry: 2.6.1.74
sysname: cephalosporin-C:2-oxoglutarate aminotransferase
iubmb_reaction: (other) R03063
kegg_reaction: R03063
name:
--- 
- cephalosporin-C transaminase
- cephalosporin C aminotransferase
- L-alanine:cephalosporin-C aminotransferase

comment:
A number of D-amino acids, including D-alanine, D-aspartate and D-methionine can also act as amino-group donors. Although this enzyme acts on several free D-amino acids, it differs from EC 2.6.1.21, D-alanine transaminase, in that it can use cephalosporin C as an amino donor.

reaction:
(7R)-7-(5-carboxy-5-oxopentanoyl)aminocephalosporinate + D-glutamate = cephalosporin C + 2-oxoglutarate


entry: 2.6.1.75
sysname: S-(4-bromophenyl)-L-cysteine:2-oxoglutarate aminotransferase
comment: A number of cysteine conjugates can also act.
iubmb_reaction: R04338
name:
--- 
- cysteine-conjugate transaminase
- cysteine conjugate aminotransferase
- cysteine-conjugate alpha-ketoglutarate transaminase (CAT-1)

reaction:
S-(4-bromophenyl)-L-cysteine + 2-oxoglutarate = S-(4-bromophenyl)mercaptopyruvate + L-glutamate [RN:R04338]


entry: 2.6.1.76
sysname: L-2,4-diaminobutanoate:2-oxoglutarate 4-aminotransferase
reaction: L-2,4-diaminobutanoate + 2-oxoglutarate = L-aspartate 4-semialdehyde + L-glutamate [RN:R06977]
iubmb_reaction: R06977
name:
--- 
- diaminobutyrate-2-oxoglutarate transaminase
- L-2,4-diaminobutyrate:2-ketoglutarate 4-aminotransferase
- 2,4-diaminobutyrate 4-aminotransferase
- diaminobutyrate aminotransferase
- DABA aminotransferase
- DAB aminotransferase
- EctB
- diaminibutyric acid aminotransferase
- L-2,4-diaminobutyrate:2-oxoglutarate 4-aminotransferase

comment:
A pyridoxal-phosphate protein that requires potassium for activity [4]. In the proteobacterium Acinetobacter baumannii, this enzyme is cotranscribed with the neighbouring ddc gene that also encodes EC 4.1.1.86, diaminobutyrate decarboxylase. Differs from EC 2.6.1.46, diaminobutyrate--pyruvate transaminase, which has pyruvate as the amino-group acceptor. This is the first enzyme in the ectoine-biosynthesis pathway, the other enzymes involved being EC 2.3.1.178, diaminobutyrate acetyltransferase and EC 4.2.1.108, ectoine synthase [3,4].


entry: 2.6.1.77
name: --- - taurine-pyruvate aminotransferase - Tpa
sysname: taurine:pyruvate aminotransferase
reaction: taurine + pyruvate = L-alanine + 2-sulfoacetaldehyde [RN:R05652]
iubmb_reaction: R05652
comment:
The enzyme from Bilophila wadsworthia requires pryidoxal 5'-phosphate as a cofactor, is reversible, and catalyses the first step of anaerobic taurine degradation. Hypotaurine (i.e. 2-aminoethanesulfinate) and beta-alanine are also significant donors of an amino group. Unlike, EC 2.6.1.55, taurine-2-oxoglutarate transaminase, 2-oxoglutarate is not an acceptor of amino groups.


entry: 2.6.1.78
sysname: L-arogenate:oxaloacetate aminotransferase
reaction: L-arogenate + oxaloacetate = prephenate + L-aspartate [RN:R01731]
iubmb_reaction: R01731
name:
--- 
- aspartate-prephenate aminotransferase
- prephenate transaminase (ambiguous)
- PAT (ambiguous)
- prephenate aspartate aminotransferase
- L-aspartate:prephenate aminotransferase

comment:
A pyridoxal-phosphate protein. Glutamate can also act as the amino donor, but more slowly (cf. EC 2.6.1.79, glutamate-prephenate aminotransferase).


entry: 2.6.1.79
sysname: L-arogenate:2-oxoglutarate aminotransferase
reaction: L-arogenate + 2-oxoglutarate = prephenate + L-glutamate [RN:R07276]
iubmb_reaction: R07276
name:
--- 
- glutamate-prephenate aminotransferase
- prephenate transaminase (ambiguous)
- PAT (ambiguous)
- L-glutamate:prephenate aminotransferase

comment:
A pyridoxal-phosphate protein. Aspartate can also act as the amino donor, but more slowly (cf. EC 2.6.1.78, aspartate-prephenate aminotransferase). The enzyme from higher plants shows a marked preference for prephenate as substrate compared to pyruvate, phenylpyruvate or 4-hydroxyphenylpyruvate [1].


entry: 2.6.1.80
name: --- - nicotianamine aminotransferase - NAAT - NAAT-I - NAAT-II - NAAT-III
sysname: nicotianamine:2-oxoglutarate aminotransferase; nicotianamine transaminase
reaction: nicotianamine + 2-oxoglutarate = 3"-deamino-3"-oxonicotianamine + L-glutamate [RN:R07277]
iubmb_reaction: R07277
comment:
A pyridoxal-phosphate protein. This enzyme is produced by grasses. They secrete both the nicotianamine and the transaminated product into the soil around them. Both compounds chelate iron(II) and iron(III); these chelators, called mugineic acid family phytosiderophores, are taken up by the grass, which is thereby supplied with iron.


entry: 2.6.1.81
sysname: N2-succinyl-L-ornithine:2-oxoglutarate 5-aminotransferase
iubmb_reaction: R04217
name:
--- 
- succinylornithine transaminase
- succinylornithine aminotransferase
- N2-succinylornithine 5-aminotransferase
- AstC
- SOAT

comment:
A pyridoxal-phosphate protein. Also acts on N2-acetyl-L-ornithine and L-ornithine, but more slowly [3]. In Pseudomonas aeruginosa, the arginine-inducible succinylornithine transaminase, acetylornithine transaminase (EC 2.6.1.11) and ornithine aminotransferase (EC 2.6.1.13) activities are catalysed by the same enzyme, but this is not the case in all species [5]. This is the third enzyme in the arginine succinyltransferase (AST) pathway for the catabolism of arginine [1]. This pathway converts the carbon skeleton of arginine into glutamate, with the concomitant production of ammonia and conversion of succinyl-CoA into succinate and CoA. The five enzymes involved in this pathway are EC 2.3.1.109 (arginine N-succinyltransferase), EC 3.5.3.23 (N-succinylarginine dihydrolase), EC 2.6.1.81 (succinylornithine transaminase), EC 1.2.1.71 (succinylglutamate-semialdehyde dehydrogenase) and EC 3.5.1.96 (succinylglutamate desuccinylase) [3, 6]. Of the five enzymes involved in arginine catabolism, this is the only one that is also involved in ornithine catabolism [4].

reaction:
N2-succinyl-L-ornithine + 2-oxoglutarate = N-succinyl-L-glutamate 5-semialdehyde + L-glutamate [RN:R04217]


entry: 2.6.1.82
sysname: butane-1,4-diamine:2-oxoglutarate aminotransferase
iubmb_reaction: R01155
name:
--- 
- putrescine aminotransferase
- putrescine-alpha-ketoglutarate transaminase
- YgjG
- putrescine:alpha-ketoglutarate aminotransferase
- PAT
- putrescine:2-oxoglutarate aminotransferase
- putrescine transaminase

comment:
A pyridoxal-phosphate protein [3]. The product, 4-aminobutanal, spontaneously cyclizes to form 1-pyrroline, which is a substrate for EC 1.5.1.35, 1-pyrroline dehydrogenase. Cadaverine and spermidine can also act as substrates [3]. Forms part of the arginine-catabolism pathway [2].

reaction:
(1) putrescine + 2-oxoglutarate = 4-aminobutanal + L-glutamate [RN:R01155]; (2) 4-aminobutanal = 1-pyrroline (spontaneous)


entry: 2.6.1.83
sysname: LL-2,6-diaminoheptanedioate:2-oxoglutarate aminotransferase
name:
--- 
- LL-diaminopimelate aminotransferase
- LL-diaminopimelate transaminase
- LL-DAP aminotransferase
- LL-DAP-AT

comment:
A pyridoxal-phosphate enzyme. In vivo, the reaction occurs in the opposite direction to that shown above. This is one of the final steps in the lysine-biosynthesis pathway of plants (ranging from mosses to flowering plants). meso-Diaminoheptanedioate, an isomer of LL-2,6-diaminoheptanedioate, and the structurally related compounds lysine and ornithine are not substrates. 2-Oxoglutarate cannot be replaced by oxaloacetate or pyruvate. It is not yet known if the substrate of the biosynthetic reaction is the cyclic or acyclic form of tetrahydropyridine-2,6-dicarboxylate.

reaction:
LL-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + L-glutamate + H2O


entry: 2.6.1.-
name: --- []
reaction:
(1) 3-Phosphonopyruvate + L-Glutamate <=> 2-Amino-3-phosphonopropanoate + 2-Oxoglutarate [RN:R04051]; (2) N6-Acetyl-LL-2,6-diaminoheptanedioate + 2-Oxoglutarate <=> N-Acetyl-L-2-amino-6-oxopimelate + L-Glutamate [RN:R04467]; (3) D-erythro-1-(Imidazol-4-yl)glycerol 3-phosphate + L-Glutamate <=> 5'-Phospho-D-1-ribulosylformimine + L-Glutamine [RN:R04554]; (4) 6-Aminohexanoate + 2-Oxoglutarate <=> Adipate semialdehyde + Glutamate [RN:R05507]; (5) N2-Acetyl-L-aminoadipate semialdehyde + L-Glutamate <=> N2-Acetyl-L-lysine + 2-Oxoglutarate [RN:R06844]


entry: 2.6.2.1
name: --- - Transferred to 2.1.4.1
comment:
Transferred entry: now EC 2.1.4.1 glycine amidinotransferase (EC 2.6.2.1 created 1961, deleted 1965)


entry: 2.6.3.1
sysname: pyruvate-oxime:acetone oximinotransferase
comment: Acetaldehyde can act instead of acetone; D-glucose oxime can act instead of pyruvate oxime.
reaction: pyruvate oxime + acetone = pyruvate + acetone oxime [RN:R03796]
iubmb_reaction: R03796
name:
--- 
- oximinotransferase
- transoximinase
- oximase
- pyruvate-acetone oximinotransferase
- transoximase


entry: 2.6.99.1
name: --- - dATP(dGTP)-DNA purinetransferase
sysname: dATP(dGTP):depurinated-DNA purine transferase
reaction: dATP(dGTP) + depurinated DNA = deoxyribose triphosphate + DNA [RN:R03904 R07278]
iubmb_reaction: R03904 R07278
comment:
The purine residue is transferred on to the apurinic site forming a normal glycosylic bond. dATP reacts at sites of the double-stranded depurinated DNA that lack adenine, and dGTP at sites that lack guanine.


entry: 2.6.99.2
iubmb_reaction: R05838
name:
--- 
- pyridoxine 5'-phosphate synthase
- pyridoxine 5-phosphate phospho lyase
- PNP synthase
- PdxJ

sysname:
1-deoxy-D-xylulose-5-phosphate:3-amino-2-oxopropyl phosphate 3-amino-2-oxopropyltransferase (phosphate-hydrolysing; cyclizing)

comment:
In Escherichia coli, the coenzyme pyridoxal 5'-phosphate is synthesized de novo by a pathway that involves EC 1.2.1.72 (erythrose-4-phosphate dehydrogenase), EC 1.1.1.290 (4-phosphoerythronate dehydrogenase), EC 2.6.1.52 (phosphoserine transaminase), EC 1.1.1.262 (4-hydroxythreonine-4-phosphate dehydrogenase), EC 2.6.99.2 (pyridoxine 5'-phosphate synthase) and EC 1.4.3.5 (with pyridoxine 5'-phosphate as substrate). 1-Deoxy-D-xylulose cannot replace 1-deoxy-D-xylulose 5-phosphate as a substrate [3].

reaction:
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = pyridoxine 5'-phosphate + phosphate + 2 H2O [RN:R05838]


entry: 2.6.-.-
name: --- []
reaction:
O-1-Alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + Choline <=> Plasmenylcholine + Ethanolamine [RN:R07386]


entry: 2.7.1.1
sysname: ATP:D-hexose 6-phosphotransferase
reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate [RN:R02848]
iubmb_reaction: R02848 > R00299 R00760 R00867 R01326 R01600 R01786 R01961 R02865 R03920
kegg_reaction: R00725 R00876 R01139 R01140 R01327 R01330 R01964 R01965 R02849 R02850 R02867 R02868
name:
--- 
- hexokinase
- hexokinase type IV glucokinase
- hexokinase D
- hexokinase type IV
- hexokinase (phosphorylating)
- ATP-dependent hexokinase
- glucose ATP phosphotransferase

comment:
D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase.


entry: 2.7.1.3
name: --- - ketohexokinase - ketohexokinase (phosphorylating)
sysname: ATP:D-fructose 1-phosphotransferase
reaction: ATP + D-fructose = ADP + D-fructose 1-phosphate [RN:R00866]
iubmb_reaction: R00866
comment:
D-Sorbose, D-tagatose and 5-dehydro-D-fructose and a number of other ketoses and their analogues can also act as substrates [4].


entry: 2.7.1.4
sysname: ATP:D-fructose 6-phosphotransferase
reaction: ATP + D-fructose = ADP + D-fructose 6-phosphate [RN:R00760]
iubmb_reaction: R00760 > R00867 R03920
name:
--- 
- fructokinase
- fructokinase (phosphorylating)
- D-fructokinase
- D-fructose(D-mannose)kinase


entry: 2.7.1.5
sysname: ATP:L-rhamnulose 1-phosphotransferase
reaction: ATP + L-rhamnulose = ADP + L-rhamnulose 1-phosphate [RN:R03014]
iubmb_reaction: R03014
kegg_reaction: R01902
name:
--- 
- rhamnulokinase
- RhuK
- rhamnulokinase (phosphorylating)
- L-rhamnulokinase
- L-rhamnulose kinase
- rhamnulose kinase


entry: 2.7.1.8
sysname: ATP:D-glucosamine phosphotransferase
reaction: ATP + D-glucosamine = ADP + D-glucosamine phosphate [RN:R01961]
iubmb_reaction: R01961
name:
--- 
- glucosamine kinase
- glucosamine kinase (phosphorylating)
- ATP:2-amino-2-deoxy-D-glucose-6-phosphotransferase
- aminodeoxyglucose kinase


entry: 2.7.1.10
sysname: ATP:alpha-D-glucose-1-phosphate 6-phosphotransferase
reaction: ATP + alpha-D-glucose 1-phosphate = ADP + alpha-D-glucose 1,6-bisphosphate [RN:R00949]
iubmb_reaction: R00949
name:
--- 
- phosphoglucokinase
- glucose-phosphate kinase
- phosphoglucokinase (phosphorylating)
- ATP:D-glucose-1-phosphate 6-phosphotransferase


entry: 2.7.1.11
sysname: ATP:D-fructose-6-phosphate 1-phosphotransferase
reaction: ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate [RN:R00756]
iubmb_reaction: R00756 > R04779
kegg_reaction: R00767 R00769 R00770 R01843 R01846 R01847 R01848 R03236 R03237 R03238 R03239
name:
--- 
- 6-phosphofructokinase
- phosphohexokinase
- phosphofructokinase I
- phosphofructokinase (phosphorylating)
- 6-phosphofructose 1-kinase
- ATP-dependent phosphofructokinase
- D-fructose-6-phosphate 1-phosphotransferase
- fructose 6-phosphate kinase
- fructose 6-phosphokinase
- nucleotide triphosphate-dependent phosphofructokinase
- phospho-1,6-fructokinase
- PFK

comment:
D-Tagatose 6-phosphate and sedoheptulose 7-phosphate can act as acceptors. UTP, CTP and ITP can act as donors. Not identical with EC 2.7.1.105 6-phosphofructo-2-kinase.


entry: 2.7.1.13
sysname: ATP:2-dehydro-D-gluconate 6-phosphotransferase
reaction: ATP + 2-dehydro-D-gluconate = ADP + 6-phospho-2-dehydro-D-gluconate [RN:R02658]
iubmb_reaction: R02658
kegg_reaction: R00162
name:
--- 
- dehydrogluconokinase
- ketogluconokinase
- 2-ketogluconate kinase
- ketogluconokinase (phosphorylating)
- 2-ketogluconokinase


entry: 2.7.1.19
sysname: ATP:D-ribulose-5-phosphate 1-phosphotransferase
reaction: ATP + D-ribulose 5-phosphate = ADP + D-ribulose 1,5-bisphosphate [RN:R01523]
iubmb_reaction: R01523
name:
--- 
- phosphoribulokinase
- phosphopentokinase
- ribulose-5-phosphate kinase
- phosphoribulokinase (phosphorylating)
- 5-phosphoribulose kinase
- ribulose phosphate kinase
- PKK
- PRuK
- PRK


entry: 2.7.1.21
sysname: ATP:thymidine 5'-phosphotransferase
reaction: ATP + thymidine = ADP + thymidine 5'-phosphate [RN:R01567]
iubmb_reaction: R01567
kegg_reaction: R02099
name:
--- 
- thymidine kinase
- thymidine kinase (phosphorylating)
- 2'-deoxythymidine kinase
- deoxythymidine kinase (phosphorylating)

comment:
Deoxyuridine can also act as acceptor, and dGTP can act as a donor. The deoxypyrimidine kinase complex induced by Herpes simplex virus catalyses this reaction as well as those of EC 2.7.1.114 (AMP-thymidine kinase), EC 2.7.1.118 (ADP-thymidine kinase) and EC 2.7.4.9 (dTMP-kinase).


entry: 2.7.1.23
sysname: ATP:NAD+ 2'-phosphotransferase
reaction: ATP + NAD+ = ADP + NADP+ [RN:R00104]
iubmb_reaction: R00104
name:
--- 
- NAD+ kinase
- DPN kinase
- nicotinamide adenine dinucleotide kinase (phosphorylating)
- nicotinamide adenine dinucleotide kinase
- NAD kinase
- NADK


entry: 2.7.1.24
sysname: ATP:dephospho-CoA 3'-phosphotransferase
reaction: ATP + dephospho-CoA = ADP + CoA [RN:R00130]
iubmb_reaction: R00130
name:
--- 
- dephospho-CoA kinase
- dephosphocoenzyme A kinase (phosphorylating)
- 3'-dephospho-CoA kinase
- dephosphocoenzyme A kinase


entry: 2.7.1.25
sysname: ATP:adenylyl-sulfate 3'-phosphotransferase
reaction: ATP + adenylyl sulfate = ADP + 3'-phosphoadenylyl sulfate [RN:R00509]
iubmb_reaction: R00509
kegg_reaction: R04928
name:
--- 
- adenylyl-sulfate kinase
- adenylylsulfate kinase (phosphorylating)
- 5'-phosphoadenosine sulfate kinase
- adenosine 5'-phosphosulfate kinase
- adenosine phosphosulfate kinase
- adenosine phosphosulfokinase
- adenosine-5'-phosphosulfate-3'-phosphokinase
- APS kinase

comment:
The human phosphoadenosine-phosphosulfate synthase (PAPS) system is a bifunctional enzyme (fusion product of two catalytic activities). In a first step, sulfate adenylyltransferase catalyses the formation of adenosine 5'-phosphosulfate (APS) from ATP and inorganic sulfate. The second step is catalysed by the adenylylsulfate kinase portion of 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase, which involves the formation of PAPS from enzyme-bound APS and ATP. In contrast, in bacteria, yeast, fungi and plants, the formation of PAPS is carried out by two individual polypeptides, sulfate adenylyltransferase (EC 2.7.7.4) and adenylyl-sulfate kinase (EC 2.7.1.25).


entry: 2.7.1.26
sysname: ATP:riboflavin 5'-phosphotransferase
reaction: ATP + riboflavin = ADP + FMN [RN:R00549]
iubmb_reaction: R00549
name:
--- 
- riboflavin kinase
- flavokinase
- FK
- riboflavin kinase (phosphorylating)
- riboflavine kinase


entry: 2.7.1.29
sysname: ATP:glycerone phosphotransferase
reaction: ATP + glycerone = ADP + glycerone phosphate [RN:R01011]
iubmb_reaction: R01011
name:
--- 
- glycerone kinase
- dihydroxyacetone kinase
- acetol kinase
- acetol kinase (phosphorylating)


entry: 2.7.1.30
sysname: ATP:glycerol 3-phosphotransferase
reaction: ATP + glycerol = ADP + sn-glycerol 3-phosphate [RN:R00847]
iubmb_reaction: R00847
name:
--- 
- glycerol kinase
- glycerokinase
- GK
- ATP:glycerol-3-phosphotransferase
- glycerol kinase (phosphorylating)
- glyceric kinase

comment:
Glycerone and L-glyceraldehyde can act as acceptors; UTP (and, in the case of the yeast enzyme, ITP and GTP) can act as donors.


entry: 2.7.1.31
sysname: ATP:(R)-glycerate 3-phosphotransferase
reaction: ATP + (R)-glycerate = ADP + 3-phospho-(R)-glycerate [RN:R01514]
iubmb_reaction: R01514
name:
--- 
- glycerate kinase
- glycerate kinase (phosphorylating)
- D-glycerate 3-kinase
- D-glycerate kinase
- glycerate-3-kinase
- GK
- D-glyceric acid kinase
- ATP:D-glycerate 2-phosphotransferase


entry: 2.7.1.32
sysname: ATP:choline phosphotransferase
comment: Ethanolamine and its methyl and ethyl derivatives can also act as acceptors.
reaction: ATP + choline = ADP + O-phosphocholine [RN:R01021]
iubmb_reaction: R01021
name:
--- 
- choline kinase
- choline kinase (phosphorylating)
- choline phosphokinase
- choline-ethanolamine kinase


entry: 2.7.1.33
sysname: ATP:(R)-pantothenate 4'-phosphotransferase
reaction: ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate [RN:R03018]
iubmb_reaction: R03018
kegg_reaction: R02971 R04391
name:
--- 
- pantothenate kinase
- pantothenate kinase (phosphorylating)
- pantothenic acid kinase
- ATP:pantothenate 4'-phosphotransferase
- D-pantothenate kinase


entry: 2.7.1.35
sysname: ATP:pyridoxal 5'-phosphotransferase
comment: Pyridoxine, pyridoxamine and various derivatives can also act as acceptors.
reaction: ATP + pyridoxal = ADP + pyridoxal 5'-phosphate [RN:R00174]
iubmb_reaction: R00174
kegg_reaction: R01909 R02493
name:
--- 
- pyridoxal kinase
- pyridoxal kinase (phosphorylating)
- pyridoxal 5-phosphate-kinase
- pyridoxal phosphokinase
- pyridoxine kinase


entry: 2.7.1.36
sysname: ATP:(R)-mevalonate 5-phosphotransferase
comment: CTP, GTP and UTP can also act as donors.
reaction: ATP + (R)-mevalonate = ADP + (R)-5-phosphomevalonate [RN:R02245]
iubmb_reaction: R02245
name:
--- 
- mevalonate kinase
- mevalonate kinase (phosphorylating)
- mevalonate phosphokinase
- mevalonic acid kinase
- mevalonic kinase
- mevalonate 5-phosphotransferase
- MVA kinase
- ATP:mevalonate 5-phosphotransferase


entry: 2.7.1.37
name:
--- 
- Transferred to 2.7.11.1, 2.7.11.8, 2.7.11.9, 2.7.11.10, 2.7.11.11, 2.7.11.12, 2.7.1.13, 2.7.11.21, 2.7.11.22, 2.7.11.24, 2.7.11.25, 2.7.11.30 and 2.7.12.1

comment:
Transferred entry: protein kinase. Now divided into EC 2.7.11.1 (non-specific serine/threonine protein kinase), EC 2.7.11.8 (Fas-activated serine/threonine kinase), EC 2.7.11.9 (Goodpasture antigen-binding protein kinase), EC 2.7.11.10 (IkB kinase), EC 2.7.11.11 (cAMP-dependent protein kinase), EC 2.7.11.12 (cGMP-dependent protein kinase), EC 2.7.1.13 (protein kinase C), EC 2.7.11.21 (polo kinase), EC 2.7.11.22 (cyclin-dependent kinase), EC 2.7.11.24 (mitogen-activated protein kinase), EC 2.7.11.25 (mitogen-activated protein kinase kinase kinase), EC 2.7.11.30 (receptor protein serine/threonine kinase) and EC 2.7.12.1 (dual-specificity kinase). (EC 2.7.1.37 created 1961 (EC 2.7.1.70 incorporated 2004), deleted 2005)


entry: 2.7.1.40
sysname: ATP:pyruvate 2-O-phosphotransferase
reaction: ATP + pyruvate = ADP + phosphoenolpyruvate [RN:R00200]
iubmb_reaction: R00200
kegg_reaction: R00430 R00572 R00659 R00724 R01138 R01858 R02320
name:
--- 
- pyruvate kinase
- phosphoenolpyruvate kinase
- phosphoenol transphosphorylase pyruvate kinase (phosphorylating)
- fluorokinase
- fluorokinase (phosphorylating)
- pyruvic kinase
- pyruvate phosphotransferase

comment:
UTP, GTP, CTP, ITP and dATP can also act as donors. Also phosphorylates hydroxylamine and fluoride in the presence of CO2.


entry: 2.7.1.41
sysname: D-glucose-1-phosphate:D-glucose-1-phosphate 6-phosphotransferase
reaction: 2 D-glucose 1-phosphate = D-glucose + D-glucose 1,6-bisphosphate [RN:R00016]
iubmb_reaction: R00016 > R00960
name:
--- 
- glucose-1-phosphate phosphodismutase
- glucose 1-phosphate transphosphorylase
- phosphodismutase


entry: 2.7.1.42
sysname: alpha-D-glucose-1-phosphate:riboflavin 5'-phosphotransferase
reaction: alpha-D-glucose 1-phosphate + riboflavin = D-glucose + FMN [RN:R00550]
iubmb_reaction: R00550
name:
--- 
- riboflavin phosphotransferase
- riboflavine phosphotransferase
- glucose-1-phosphate phosphotransferase
- G-1-P phosphotransferase
- D-glucose-1-phosphate:riboflavin 5'-phosphotransferase


entry: 2.7.1.45
sysname: ATP:2-dehydro-3-deoxy-D-gluconate 6-phosphotransferase
reaction: ATP + 2-dehydro-3-deoxy-D-gluconate = ADP + 6-phospho-2-dehydro-3-deoxy-D-gluconate [RN:R01541]
iubmb_reaction: R01541
name:
--- 
- 2-dehydro-3-deoxygluconokinase
- 2-keto-3-deoxygluconokinase
- 2-keto-3-deoxy-D-gluconic acid kinase
- 2-keto-3-deoxygluconokinase (phosphorylating)
- 2-keto-3-deoxygluconate kinase
- ketodeoxygluconokinase


entry: 2.7.1.48
sysname: ATP:uridine 5'-phosphotransferase
comment: Cytidine can act as acceptor; GTP and ITP can act as donors.
reaction: ATP + uridine = ADP + UMP [RN:R00964]
iubmb_reaction: R00964
name:
--- 
- uridine kinase
- pyrimidine ribonucleoside kinase
- uridine-cytidine kinase
- uridine kinase (phosphorylating)
- uridine phosphokinase

kegg_reaction:
R00513 R00516 R00517 R00962 R00967 R00968 R00970 R01548 R01549 R01880 R02091 R02096 R02097 R02327 R02332 R02371 R02372


entry: 2.7.1.49
name: --- - hydroxymethylpyrimidine kinase - hydroxymethylpyrimidine kinase (phosphorylating)
sysname: ATP:4-amino-5-hydroxymethyl-2-methylpyrimidine 5-phosphotransferase
comment: CTP, UTP and GTP can act as donors.
iubmb_reaction: R03471
reaction:
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-5-phosphonooxymethyl-2-methylpyrimidine [RN:R03471]


entry: 2.7.1.50
sysname: ATP:4-methyl-5-(2-hydroxyethyl)thiazole 2-phosphotransferase
iubmb_reaction: R04448
name:
--- 
- hydroxyethylthiazole kinase
- hydroxyethylthiazole kinase (phosphorylating)
- 4-methyl-5-(beta-hydroxyethyl)thiazole kinase

reaction:
ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole [RN:R04448]


entry: 2.7.1.52
sysname: ATP:beta-L-fucose 1-phosphotransferase
reaction: ATP + L-fucose = ADP + beta-L-fucose 1-phosphate [RN:R03161]
iubmb_reaction: R03161
name:
--- 
- fucokinase
- fucokinase (phosphorylating)
- fucose kinase
- L-fucose kinase
- L-fucokinase
- ATP:6-deoxy-L-galactose 1-phosphotransferase
- ATP:L-fucose 1-phosphotransferase

comment:
Requires a divalent cation for activity, with Mg2+ and Fe2+ giving rise to the highest enzyme activity. Forms part of a salvage pathway for reutilization of L-fucose. Can also phosphorylate D-arabinose, but more slowly.


entry: 2.7.1.55
sysname: ATP:D-allose 6-phosphotransferase
reaction: ATP + D-allose = ADP + D-allose 6-phosphate [RN:R03576]
iubmb_reaction: R03576
name:
--- 
- allose kinase
- allokinase (phosphorylating)
- allokinase
- D-allokinase
- D-allose-6-kinase


entry: 2.7.1.56
sysname: ATP:D-fructose-phosphate 6-phosphotransferase
comment: ITP, GTP or UTP can replace ATP.
reaction: ATP + D-fructose 1-phosphate = ADP + D-fructose 1,6-bisphosphate
iubmb_reaction: (other) R02071 R03236
kegg_reaction: R02071 R03236
name:
--- 
- 1-phosphofructokinase
- fructose-1-phosphate kinase
- 1-phosphofructokinase (phosphorylating)
- D-fructose-1-phosphate kinase
- fructose 1-phosphate kinase
- phosphofructokinase 1


entry: 2.7.1.58
sysname: ATP:2-dehydro-3-deoxy-D-galactonate 6-phosphotransferase
iubmb_reaction: R03387
name:
--- 
- 2-dehydro-3-deoxygalactonokinase
- 2-keto-3-deoxygalactonokinase
- 2-keto-3-deoxygalactonate kinase (phosphorylating)
- 2-oxo-3-deoxygalactonate kinase

reaction:
ATP + 2-dehydro-3-deoxy-D-galactonate = ADP + 2-dehydro-3-deoxy-D-galactonate 6-phosphate [RN:R03387]


entry: 2.7.1.59
sysname: ATP:N-acetyl-D-glucosamine 6-phosphotransferase
comment: The bacterial enzyme also acts on D-glucose.
reaction: ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate [RN:R01201]
iubmb_reaction: R01201
name:
--- 
- N-acetylglucosamine kinase
- acetylglucosamine kinase (phosphorylating)
- ATP:2-acetylamino-2-deoxy-D-glucose 6-phosphotransferase
- 2-acetylamino-2-deoxy-D-glucose kinase
- acetylaminodeoxyglucokinase


entry: 2.7.1.60
sysname: ATP:N-acyl-D-mannosamine 6-phosphotransferase
comment: Acts on the acetyl and glycolyl derivatives.
reaction: ATP + N-acyl-D-mannosamine = ADP + N-acyl-D-mannosamine 6-phosphate [RN:R02650]
iubmb_reaction: R02650 > R02705
name:
--- 
- N-acylmannosamine kinase
- acylmannosamine kinase (phosphorylating)
- acetylamidodeoxymannokinase
- acetylmannosamine kinase
- acylaminodeoxymannokinase
- acylmannosamine kinase
- N-acyl-D-mannosamine kinase
- N-acetylmannosamine kinase
- ATP:N-acetylmannosamine 6-phosphotransferase


entry: 2.7.1.62
sysname: phosphoramidate:hexose 1-phosphotransferase
reaction: phosphoramidate + hexose = NH3 + alpha-D-hexose 1-phosphate [RN:R03148]
iubmb_reaction: R03148
name:
--- 
- phosphoramidate-hexose phosphotransferase
- phosphoramidate-hexose transphosphorylase
- phosphoramidic-hexose transphosphorylase

comment:
Activity is observed with several hexoses; of these glucose is the best substrate and the product from it is alpha-D-glucose 1-phosphate. The phosphoramidate donor can be replaced by N-phosphoglycine and by an N-phosphohistidine. May be identical with EC 3.1.3.9 glucose-6-phosphatase.


entry: 2.7.1.63
sysname: polyphosphate:D-glucose 6-phosphotransferase
comment: Requires a neutral salt, e.g. KCl, for maximum activity. Also acts on glucosamine.
reaction: (phosphate)n + D-glucose = (phosphate)(n-1) + D-glucose 6-phosphate [RN:R02185]
iubmb_reaction: R02185 > R02187 R02189
name:
--- 
- polyphosphate-glucose phosphotransferase
- polyphosphate glucokinase
- polyphosphate-D-(+)-glucose-6-phosphotransferase
- polyphosphate-glucose 6-phosphotransferase


entry: 2.7.1.64
sysname: ATP:myo-inositol 1-phosphotransferase
reaction: ATP + myo-inositol = ADP + 1D-myo-inositol 3-phosphate [RN:R07279]
iubmb_reaction: R07279
kegg_reaction: R01182
name:
--- 
- inositol 3-kinase
- inositol-1-kinase (phosphorylating)
- myoinositol kinase
- myo-inositol 1-kinase


entry: 2.7.1.65
sysname: ATP:1-amino-1-deoxy-scyllo-inositol 4-phosphotransferase
iubmb_reaction: R03384
name:
--- 
- scyllo-inosamine 4-kinase
- scyllo-inosamine kinase (phosphorylating)
- scyllo-inosamine kinase
- ATP:inosamine phosphotransferase

comment:
Also acts on streptamine, 2-deoxystreptamine and 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol.

reaction:
ATP + 1-amino-1-deoxy-scyllo-inositol = ADP + 1-amino-1-deoxy-scyllo-inositol 4-phosphate [RN:R03384]


entry: 2.7.1.66
sysname: ATP:undecaprenol phosphotransferase
reaction: ATP + undecaprenol = ADP + undecaprenyl phosphate [RN:R05626]
iubmb_reaction: R05626
name:
--- 
- undecaprenol kinase
- isoprenoid alcohol kinase
- isoprenoid alcohol phosphokinase
- C55-isoprenoid alcohol phosphokinase
- isoprenoid alcohol kinase (phosphorylating)
- C55-isoprenoid alcohol kinase
- C55-isoprenyl alcohol phosphokinase
- polyisoprenol kinase


entry: 2.7.1.67
sysname: ATP:1-phosphatidyl-1D-myo-inositol 4-phosphotransferase
comment: This reaction is catalysed by at least two different isoforms.
reaction: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate [RN:R03361]
iubmb_reaction: R03361
name:
--- 
- 1-phosphatidylinositol 4-kinase
- phosphatidylinositol kinase (phosphorylating)
- phosphatidylinositol 4-kinase
- phosphatidylinositol kinase
- type II phosphatidylinositol kinase
- PI kinase
- PI 4-kinase


entry: 2.7.1.68
sysname: ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 5-phosphotransferase
iubmb_reaction: R03469
name:
--- 
- 1-phosphatidylinositol-4-phosphate 5-kinase
- diphosphoinositide kinase
- PIP kinase
- phosphatidylinositol 4-phosphate kinase
- phosphatidylinositol-4-phosphate 5-kinase
- type I PIP kinase

comment:
This enzyme can also phosphorylate PtdIns3P in the 4-position, and PtdIns, PtdIns3P and PtdIns(3,4)P2 in the 5-position in vitro, but to a lesser extent. The last of these reactions occurs in vivo and is physiologically relevant. Three different isoforms are known.

reaction:
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [RN:R03469]


entry: 2.7.1.69
sysname: protein-N(pi)-phosphohistidine:sugar N(pi)-phosphotransferase
reaction: protein N(pi)-phospho-L-histidine + sugar = protein histidine + sugar phosphate [RN:R03076]
kegg_reaction: R02780 R06229(G)
name:
--- 
- protein-N(pi)-phosphohistidine-sugar phosphotransferase
- glucose permease
- PTS permease
- phosphotransferase, phosphohistidinoprotein-hexose
- enzyme IIl4ac
- gene glC proteins
- gene bglC RNA formation factors
- PEP-dependent phosphotransferase enzyme II
- PEP-sugar phosphotransferase enzyme II
- phosphoenolpyruvate-sugar phosphotransferase enzyme II
- phosphohistidinoprotein-hexose phosphotransferase
- phosphohistidinoprotein-hexose phosphoribosyltransferase
- phosphoprotein factor-hexose phosophotransferase
- protein, specific or class, gene bglC
- ribonucleic acid formation factor, gene glC
- sucrose phosphotransferase system II
- protein-N(pi)-phosphohistidine:sugar N-pros-phosphotransferase

comment:
Enzyme II of the phosphotransferase system. Comprises a group of related enzymes. The protein substrate is a phosphocarrier protein of low molecular mass (9.5 kDa). The protein is phosphorylated in a reaction catalysed by EC 2.7.3.9 (phosphoenolpyruvate-protein phosphotransferase) and this acts as the phosphate donor for the above reaction. The enzyme translocates the sugar it phosphorylates into bacteria. Aldohexoses, and their glycosides and alditols, are phosphorylated on O-6, whereas fructose and sorbose are phosphorylated on O-1. Glycerone and disaccharides are also substrates.

iubmb_reaction:
R03076 > R00811 R02630 R02631 R02704 R02738 R03232 R04076 R04111 R04393 R04394 R05132 R05199 R05570 R05820 R06212(G) R06236(G) R06237(G)


entry: 2.7.1.70
name: --- - Deleted entry
comment:
Deleted entry: protamine kinase. This enzyme is not dependent on cAMP as was thought and is therefore identical to EC 2.7.1.37, protein kinase. (EC 2.7.1.70 created 1972, deleted 2004)


entry: 2.7.1.72
sysname: ATP:streptomycin 6-phosphotransferase
reaction: ATP + streptomycin = ADP + streptomycin 6-phosphate [RN:R02225]
iubmb_reaction: R02225
name:
--- 
- streptomycin 6-kinase
- streptidine kinase
- SM 6-kinase
- streptomycin 6-kinase (phosphorylating)
- streptidine kinase (phosphorylating)
- streptomycin 6-O-phosphotransferase
- streptomycin 6-phosphotransferase

comment:
dATP can replace ATP; and dihydrostreptomycin, streptidine and 2-deoxystreptidine can act as acceptors.


entry: 2.7.1.74
sysname: NTP:deoxycytidine 5'-phosphotransferase
reaction: NTP + deoxycytidine = NDP + dCMP [RN:R02321]
iubmb_reaction: R02321 > R01666
kegg_reaction: R00185
name:
--- 
- deoxycytidine kinase
- deoxycytidine kinase (phosphorylating)
- 2'-deoxycytidine kinase
- Ara-C kinase
- arabinofuranosylcytosine kinase
- deoxycytidine-cytidine kinase

comment:
Cytosine arabinoside can act as acceptor; all natural nucleoside triphosphates (except dCTP) can act as donors.


entry: 2.7.1.75
name: --- - Deleted entry
comment:
Deleted entry: thymidine kinase. Now EC 2.7.1.21 thymidine kinase (EC 2.7.1.75 created 1972, deleted 1976)


entry: 2.7.1.76
sysname: ATP:deoxyadenosine 5'-phosphotransferase
comment: Deoxyguanosine can also act as acceptor. Possibly identical with EC 2.7.1.74 deoxycytidine kinase.
reaction: ATP + deoxyadenosine = ADP + dAMP [RN:R02089]
iubmb_reaction: R02089
name:
--- 
- deoxyadenosine kinase
- purine-deoxyribonucleoside kinase deoxyadenosine kinase (phosphorylating)
- purine-deoxyribonucleoside kinase


entry: 2.7.1.77
sysname: nucleotide:nucleoside 5'-phosphotransferase
reaction: a nucleotide + a 2'-deoxynucleoside = a nucleoside + a 2'-deoxynucleoside 5'-phosphate [RN:R07341]
iubmb_reaction: R07341 > R02934 R05304
name:
--- 
- nucleoside phosphotransferase
- nonspecific nucleoside phosphotransferase
- nucleotide:3'-deoxynucleoside 5'-phosphotransferase

comment:
Phenyl phosphate and nucleoside 3'-phosphates can act as donors, although not so well as nucleoside 5'-phosphates. Nucleosides as well as 2'-deoxynucleosides can act as acceptors.


entry: 2.7.1.78
sysname: ATP:5'-dephosphopolynucleotide 5'-phosphotransferase
comment: Also acts on 5'-dephospho-RNA 3'-mononucleotides.
reaction: ATP + 5'-dephospho-DNA = ADP + 5'-phospho-DNA [RN:R03840]
iubmb_reaction: R03840
name:
--- 
- polynucleotide 5'-hydroxyl-kinase
- ATP:5'-dephosphopolynucleotide 5'-phosphatase
- PNK
- polynucleotide 5'-hydroxyl kinase (phosphorylating)
- 5'-hydroxyl polynucleotide kinase
- 5'-hydroxyl polyribonucleotide kinase
- 5'-hydroxyl RNA kinase
- DNA 5'-hydroxyl kinase
- DNA kinase
- polynucleotide kinase
- polynucleotide 5'-hydroxy-kinase


entry: 2.7.1.79
sysname: diphosphate:glycerol 1-phosphotransferase
comment: May be identical with EC 3.1.3.9 glucose-6-phosphatase.
reaction: diphosphate + glycerol = phosphate + glycerol 1-phosphate [RN:R01044]
iubmb_reaction: R01044
name:
--- 
- diphosphate-glycerol phosphotransferase
- PPi-glycerol phosphotransferase
- pyrophosphate-glycerol phosphotransferase


entry: 2.7.1.80
sysname: diphosphate:L-serine O-phosphotransferase
reaction: diphosphate + L-serine = phosphate + O-phospho-L-serine [RN:R00584]
iubmb_reaction: R00584
name:
--- 
- diphosphate-serine phosphotransferase
- pyrophosphate-serine phosphotransferase
- pyrophosphate-L-serine phosphotransferase


entry: 2.7.1.81
sysname: GTP:5-hydroxy-L-lysine O-phosphotransferase
comment: Both the natural 5-hydroxy-L-lysine and its 5-epimer act as acceptors.
reaction: GTP + 5-hydroxy-L-lysine = GDP + 5-phosphonooxy-L-lysine [RN:R03378]
iubmb_reaction: R03378
name:
--- 
- hydroxylysine kinase
- hydroxylysine kinase (phosphorylating)
- guanosine triphosphate:5-hydroxy-L-lysine O-phosphotransferase


entry: 2.7.1.84
sysname: ATP:O-alkylglycerone phosphotransferase
reaction: ATP + O-alkylglycerone = ADP + O-alkylglycerone phosphate [RN:R03944]
iubmb_reaction: R03944
name:
--- 
- alkylglycerone kinase
- alkyldihydroxyacetone kinase (phosphorylating)
- alkyldihydroxyacetone kinase


entry: 2.7.1.86
sysname: ATP:NADH 2'-phosphotransferase
reaction: ATP + NADH = ADP + NADPH [RN:R00105]
iubmb_reaction: R00105
name:
--- 
- NADH kinase
- reduced nicotinamide adenine dinucleotide kinase (phosphorylating)
- DPNH kinase
- reduced diphosphopyridine nucleotide kinase
- NADH2 kinase

comment:
CTP, ITP, UTP and GTP can also act as phosphate donors (in decreasing order of activity). The enzyme is specific for NADH. Activated by acetate.


entry: 2.7.1.87
sysname: ATP:streptomycin 3"-phosphotransferase
comment: Also phosphorylates dihydrostreptomycin, 3'-deoxydihydrostreptomycin and their 6-phosphates.
reaction: ATP + streptomycin = ADP + streptomycin 3"-phosphate [RN:R02227]
iubmb_reaction: R02227
name:
--- 
- streptomycin 3"-kinase
- streptomycin 3"-kinase (phosphorylating)
- streptomycin 3"-phosphotransferase


entry: 2.7.1.88
sysname: ATP:dihydrostreptomycin-6-phosphate 3'alpha-phosphotransferase
comment: 3'-Deoxydihydrostreptomycin 6-phosphate can also act as acceptor.
iubmb_reaction: R03395
name:
--- 
- dihydrostreptomycin-6-phosphate 3'alpha-kinase
- dihydrostreptomycin 6-phosphate kinase (phosphorylating)
- ATP:dihydrostreptomycin-6-P 3'alpha-phosphotransferase

reaction:
ATP + dihydrostreptomycin 6-phosphate = ADP + dihydrostreptomycin 3'alpha,6-bisphosphate [RN:R03395]


entry: 2.7.1.89
sysname: ATP:thiamine phosphotransferase
reaction: ATP + thiamine = ADP + thiamine phosphate [RN:R02134]
iubmb_reaction: R02134
name:
--- 
- thiamine kinase
- thiamin kinase (phosphorylating)
- thiamin phosphokinase
- ATP:thiamin phosphotransferase
- thiamin kinase


entry: 2.7.1.90
sysname: diphosphate:D-fructose-6-phosphate 1-phosphotransferase
reaction: diphosphate + D-fructose 6-phosphate = phosphate + D-fructose 1,6-bisphosphate [RN:R00764]
iubmb_reaction: R00764 > R02073
name:
--- 
- diphosphate-fructose-6-phosphate 1-phosphotransferase
- 6-phosphofructokinase (pyrophosphate)
- pyrophosphate-fructose 6-phosphate 1-phosphotransferase
- inorganic pyrophosphate-dependent phosphofructokinase
- inorganic pyrophosphate-phosphofructokinase
- pyrophosphate-dependent phosphofructo-1-kinase
- pyrophosphate-fructose 6-phosphate phosphotransferase


entry: 2.7.1.91
sysname: ATP:sphinganine 1-phosphotransferase
reaction: ATP + sphinganine = ADP + sphinganine 1-phosphate [RN:R02976]
iubmb_reaction: R02976
kegg_reaction: R01926
name:
--- 
- sphinganine kinase
- dihydrosphingosine kinase
- dihydrosphingosine kinase (phosphorylating)
- sphingosine kinase (phosphorylating)


entry: 2.7.1.92
sysname: ATP:5-dehydro-2-deoxy-D-gluconate 6-phosphotransferase
reaction: ATP + 5-dehydro-2-deoxy-D-gluconate = ADP + 6-phospho-5-dehydro-2-deoxy-D-gluconate [RN:R04351]
iubmb_reaction: R04351
kegg_reaction: R05661
name:
--- 
- 5-dehydro-2-deoxygluconokinase
- 5-keto-2-deoxygluconokinase
- 5-keto-2-deoxyglucono kinase (phosphorylating)
- DKH kinase


entry: 2.7.1.93
sysname: ATP:1-O-alkyl-sn-glycerol 3-phosphotransferase
reaction: ATP + 1-O-alkyl-sn-glycerol = ADP + 1-O-alkyl-sn-glycerol 3-phosphate [RN:R04126]
iubmb_reaction: R04126
name:
--- 
- alkylglycerol kinase
- 1-alkylglycerol kinase (phosphorylating)
- ATP-alkylglycerol phosphotransferase
- alkylglycerol phosphotransferase
- "ATP: 1-alkyl-sn-glycerol phosphotransferase"


entry: 2.7.1.94
sysname: ATP:acylglycerol 3-phosphotransferase
comment: Acts on both 1- and 2-acylglycerols.
reaction: ATP + acylglycerol = ADP + acyl-sn-glycerol 3-phosphate [RN:R03754]
iubmb_reaction: R03754 > R02757 R02758
name:
--- 
- acylglycerol kinase
- monoacylglycerol kinase
- monoacylglycerol kinase (phosphorylating)
- sn-2-monoacylglycerol kinase
- MGK
- monoglyceride kinase
- monoglyceride phosphokinase


entry: 2.7.1.95
sysname: ATP:kanamycin 3'-O-phosphotransferase
reaction: ATP + kanamycin = ADP + kanamycin 3'-phosphate
iubmb_reaction: (other) R01888
kegg_reaction: R01888
name:
--- 
- kanamycin kinase
- neomycin-kanamycin phosphotransferase
- kanamycin kinase (phosphorylating)
- neomycin phosphotransferase

comment:
Also acts on the antibiotics neomycin, paromomycin, neamine, paromamine, vistamycin and gentamicin A. An enzyme from Pseudomonas aeruginosa also acts on butirosin.


entry: 2.7.1.96
name: --- - Deleted entry
comment:
Deleted entry: NADH kinase. Now included with EC 2.7.1.86 NADH kinase (EC 2.7.1.96 created 1978, deleted 1978)


entry: 2.7.1.97
name: --- - Deleted entry
comment:
Deleted entry: identical with EC 2.7.1.125 rhodopsin kinase (EC 2.7.1.97 created 1978, deleted 1992)


entry: 2.7.1.98
name: --- - Deleted entry
comment:
Deleted entry: phosphoenolpyruvate-fructose phosphotransferase (EC 2.7.1.98 created 1978, deleted 1984)


entry: 2.7.1.99
name: --- - Transferred to 2.7.11.2
comment:
Transferred entry: now EC 2.7.11.2, [pyruvate dehydrogenase (acetyl-transferring)] kinase (EC 2.7.1.99 created 1978, deleted 2005)


entry: 2.7.1.100
sysname: ATP:S-methylmethyl-5-thio-D-ribose 1-phosphotransferase
comment: CTP also acts, but more slowly.
reaction: ATP + S-methyl-5-thio-D-ribose = ADP + S-methyl-5-thio-alpha-D-ribose 1-phosphate [RN:R04143]
iubmb_reaction: R04143
name:
--- 
- S-methyl-5-thioribose kinase
- 5-methylthioribose kinase (phosphorylating)
- methylthioribose kinase
- 5-methylthioribose kinase
- ATP:S5-methyl-5-thio-D-ribose 1-phosphotransferase


entry: 2.7.1.101
sysname: ATP:D-tagatose 6-phosphotransferase
reaction: ATP + D-tagatose = ADP + D-tagatose 6-phosphate [RN:R02927]
iubmb_reaction: R02927
name:
--- 
- tagatose kinase
- tagatose 6-phosphate kinase (phosphorylating)
- D-tagatose 6-phosphate kinase
- tagatose-6-phosphate kinase


entry: 2.7.1.102
sysname: ATP:D-hamamelose 2'-phosphotransferase
comment: Also acts, more slowly, on D-hamamelitol.
reaction: ATP + D-hamamelose = ADP + D-hamamelose 2'-phosphate [RN:R03766]
iubmb_reaction: R03766
name:
--- 
- hamamelose kinase
- hamamelose kinase (phosphorylating)
- "hamamelosekinase (ATP: hamamelose 2'-phosphotransferase)"
- ATP/hamamelose 2'-phosphotransferase


entry: 2.7.1.104
name: --- - Transferred to 2.7.99.1
comment:
Transferred entry: now EC 2.7.99.1, triphosphate-protein phosphotransferase (EC 2.7.1.104 created 1987, deleted 2005)


entry: 2.7.1.105
sysname: ATP:beta-D-fructose-6-phosphate 2-phosphotransferase
reaction: ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate [RN:R02732]
iubmb_reaction: R02732
name:
--- 
- 6-phosphofructo-2-kinase
- phosphofructokinase 2
- 6-phosphofructose 2-kinase
- 6-phosphofructo-2-kinase (phosphorylating)
- fructose 6-phosphate 2-kinase
- ATP:D-fructose-6-phosphate 2-phosphotransferase

comment:
Not identical with EC 2.7.1.11 6-phosphofructokinase. The enzyme co-purifies with EC 3.1.3.46 fructose-2,6-bisphosphate 2-phosphatase.


entry: 2.7.1.106
sysname: 3-phospho-D-glyceroyl-phosphate:alpha-D-glucose-1-phosphate 6-phosphotransferase
comment: D-Glucose 6-phosphate can act as acceptor, forming alpha-D-glucose 1,6-bisphosphate.
iubmb_reaction: R01660
name:
--- 
- glucose-1,6-bisphosphate synthase
- glucose 1,6-diphosphate synthase
- glucose-1,6-bisphosphate synthetase
- 3-phospho-D-glyceroyl-phosphate:D-glucose-1-phosphate 6-phosphotransferase

reaction:
3-phospho-D-glyceroyl phosphate + alpha-D-glucose 1-phosphate = 3-phospho-D-glycerate + alpha-D-glucose 1,6-bisphosphate [RN:R01660]


entry: 2.7.1.107
sysname: ATP:1,2-diacylglycerol 3-phosphotransferase
reaction: ATP + 1,2-diacylglycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate [RN:R02240]
iubmb_reaction: R02240
name:
--- 
- diacylglycerol kinase
- diglyceride kinase
- 1,2-diacylglycerol kinase (phosphorylating)
- 1,2-diacylglycerol kinase
- sn-1,2-diacylglycerol kinase
- DG kinase
- DGK
- ATP:diacylglycerol phosphotransferase
- arachidonoyl-specific diacylglycerol kinase
- diacylglycerol:ATP kinase


entry: 2.7.1.109
name: --- - Transferred to 2.7.11.31
comment:
Transferred entry: now EC 2.7.11.31, [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase (EC 2.7.1.109 created 1984, deleted 2005)


entry: 2.7.1.110
name: --- - Transferred to 2.7.11.3
comment:
Transferred entry: now EC 2.7.11.3, dephospho-[reductase kinase] kinase (EC 2.7.1.110 created 1984, deleted 2005)


entry: 2.7.1.111
name: --- - Deleted entry
comment:
Deleted entry. Now listed as EC 2.7.1.128 [acetyl-CoA carboxylase] kinase (EC 2.7.1.111 created 1984, deleted 1992)


entry: 2.7.1.112
name: --- - Transferred to 2.7.10.1 and 2.7.10.2
comment:
Transferred entry: protein-tyrosine kinase. Now EC 2.7.10.1, receptor protein-tyrosine kinase and EC 2.7.10.2, non-specific protein-tyrosine kinase (EC 2.7.1.112 created 1984, deleted 2005)


entry: 2.7.1.113
sysname: ATP:deoxyguanosine 5'-phosphotransferase
comment: Deoxyinosine can also act as acceptor.
reaction: ATP + deoxyguanosine = ADP + dGMP [RN:R01967]
iubmb_reaction: R01967
name:
--- 
- deoxyguanosine kinase
- deoxyguanosine kinase (phosphorylating)
- (dihydroxypropoxymethyl)guanine kinase
- 2'-deoxyguanosine kinase
- NTP-deoxyguanosine 5'-phosphotransferase


entry: 2.7.1.114
sysname: AMP:thymidine 5'-phosphotransferase
reaction: AMP + thymidine = adenosine + thymidine 5'-phosphate [RN:R01571]
iubmb_reaction: R01571
name:
--- 
- AMP-thymidine kinase
- adenylate-nucleoside phosphotransferase
- AMP:dThd kinase
- adenylic acid:deoxythymidine 5'-phosphotransferase
- AMP:deoxythymidine kinase
- AMP:deoxythymidine 5'-phosphotransferase
- thymidine phosphotransferase

comment:
The deoxypyrimidine kinase complex induced by Herpes simplex virus catalyses this reaction as well as those of EC 2.7.1.21 (thymidine kinase), EC 2.7.1.118 (ADP-thymidine kinase) and EC 2.7.4.9 (dTMP kinase).


entry: 2.7.1.115
name: --- - Transferred to 2.7.11.4
comment:
Transferred entry: now EC 2.7.11.4, [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase (EC 2.7.1.115 created 1986, deleted 2005)


entry: 2.7.1.116
name: --- - Transferred to 2.7.11.5
comment:
Transferred entry: now EC 2.7.11.5, [isocitrate dehydrogenase (NADP+)] kinase. (EC 2.7.1.116 created 1986, deleted 2005)


entry: 2.7.1.117
name: --- - Transferred to 2.7.11.18
comment:
Transferred entry: now EC 2.7.11.18, myosin-light-chain kinase (EC 2.7.1.117 created 1986, deleted 2005)


entry: 2.7.1.118
sysname: ADP:thymidine 5'-phosphotransferase
reaction: ADP + thymidine = AMP + thymidine 5'-phosphate [RN:R01568]
iubmb_reaction: R01568
name:
--- 
- ADP-thymidine kinase
- ADP:dThd phosphotransferase
- adenosine diphosphate-thymidine phosphotransferase

comment:
The deoxypyrimidine kinase complex induced by Herpes simplex virus catalyses this reaction as well as those of EC 2.7.1.21 (thymidine kinase), EC 2.7.1.114 (AMP-thymidine kinase) and EC 2.7.4.9 (dTMP kinase).


entry: 2.7.1.119
name: --- - hygromycin-B kinase - hygromycin B phosphotransferase
sysname: ATP:hygromycin-B 7"-O-phosphotransferase
reaction: ATP + hygromycin B = ADP + 7"-O-phosphohygromycin [RN:R03770]
iubmb_reaction: R03770
comment:
Phosphorylates the antibiotics hygromycin B, 1-N-hygromycin B and destomycin, but not hygromycin B2, at the 7"-hydroxy group in the destomic acid ring.


entry: 2.7.1.120
name: --- - Transferred to 2.7.11.17
comment:
Transferred entry: caldesmon kinase. Now part of EC 2.7.11.17, Ca2+/calmodulin-dependent protein kinase (EC 2.7.1.120 created 1989, modified 1990, deleted 2005)


entry: 2.7.1.123
name: --- - Transferred to 2.7.11.17
comment:
Transferred entry: calmodulin-dependent protein kinase. Now part of EC 2.7.11.17, Ca2+/calmodulin-dependent protein kinase (EC 2.7.1.123 created 1989, deleted 2005)


entry: 2.7.1.124
name: --- - Transferred to 2.7.11.6
comment:
Transferred entry: now EC 2.7.11.6, [tyrosine 3-monooxygenase] kinase (EC 2.7.1.124 created 1989, deleted 2005)


entry: 2.7.1.125
name: --- - Transferred to 2.7.11.14
comment:
Transferred entry: now EC 2.7.11.14, rhodopsin kinase (EC 2.7.1.125 created 1989 (EC 2.7.1.97 created 1978, incorporated 1992), deleted 2005)


entry: 2.7.1.126
name: --- - Transferred to 2.7.11.15
comment:
Transferred entry: now EC 2.7.11.15, beta-adrenergic-receptor kinase (EC 2.7.1.126 created 1989, deleted 2005)


entry: 2.7.1.127
sysname: ATP:1D-myo-inositol-1,4,5-trisphosphate 3-phosphotransferase
comment: Activated by Ca2+. Three isoforms have been shown to exist [3].
iubmb_reaction: R03433
name:
--- 
- inositol-trisphosphate 3-kinase
- 1D-myo-inositol-trisphosphate 3-kinase
- Ins(1,4,5)P3 3-kinase

reaction:
ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate [RN:R03433]


entry: 2.7.1.128
name: --- - Transferred to 2.7.11.27
comment:
Transferred entry: now EC 2.7.11.27, [acetyl-CoA carboxylase] kinase (EC 2.7.1.128 created 1990 (EC 2.7.1.111 created 1984, incorporated 1992), deleted 2005)


entry: 2.7.1.130
name: --- - tetraacyldisaccharide 4'-kinase - lipid-A 4'-kinase
iubmb_reaction: R04657
sysname:
ATP:2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-beta-D -1,6-glucosaminyl-beta-phosphate 4'-O-phosphotransferase

comment:
Involved with EC 2.7.1.129 (acyl-[acyl-carrier- protein]-UDP-N-acetylglucosamine O-acyltransferase) and EC 2.4.1.182 (lipid-A-disaccharide synthase) in the biosynthesis of the phosphorylated glycolipid, lipid A, in the outer membrane of Escherichia coli.

reaction:
ATP + [2-N,3-O-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl]-(1->6)-[2- N,3-O-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl phosphate] = ADP + [2-N,3-O-bis(3-hydroxytetradecanoyl)-4-O-phosphono-beta-D- glucosaminyl]-(1->6)-[2-N,3-O-bis(3-hydroxytetradecanoyl)-beta-D- glucosaminyl phosphate] [RN:R04657]


entry: 2.7.1.131
name: --- - Transferred to 2.7.11.29
comment:
Transferred entry: now EC 2.7.11.29, low-density-lipoprotein receptor kinase (EC 2.7.1.131 created 1990, deleted 2005)


entry: 2.7.1.133
name: --- - Deleted entry
comment:
Deleted entry: inositol-trisphosphate 6-kinase. Now included with EC 2.7.1.134, inositol-tetrakisphosphate 1-kinase (EC 2.7.1.133 created 1990, deleted 2002)


entry: 2.7.1.134
sysname: ATP:1D-myo-inositol-3,4,5,6-tetrakisphosphate 1-phosphotransferase
iubmb_reaction: R03479
kegg_reaction: R03428 R03429
name:
--- 
- inositol-tetrakisphosphate 1-kinase
- 1D-myo-inositol-tetrakisphosphate 1-kinase
- inositol-trisphosphate 6-kinase
- 1D-myo-inositol-trisphosphate 6-kinase
- ATP:1D-myo-inositol-1,3,4-trisphosphate 6-phosphotransferase
- inositol-trisphosphate 5-kinase
- 1D-myo-inositol-trisphosphate 5-kinase
- ATP:1D-myo-inositol-1,3,4-trisphosphate 5-phosphotransferase

comment:
This enzyme also phosphorylates Ins(1,3,4)P3 on O-5 and O-6. The phosphotransfer from ATP to either inositol 1,3,4-trisphosphate or inositol 3,4,5,6-tetrakisphosphate appears to be freely reversible to the extent that the enzyme can act like an inositol polyphosphate phosphatase in the presence of ADP. It can also catalyse an isomerization between Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP.

reaction:
ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate [RN:R03479]


entry: 2.7.1.137
sysname: ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase
comment: One mammalian isoform is known.
reaction: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate [RN:R03362]
iubmb_reaction: R03362
name:
--- 
- phosphatidylinositol 3-kinase
- 1-phosphatidylinositol 3-kinase
- type III phosphoinositide 3-kinase
- Vps34p
- type I phosphatidylinositol kinase


entry: 2.7.1.139
name: --- - Deleted entry
comment:
Deleted entry: inositol-trisphosphate 5-kinase. Now included with EC 2.7.1.134, inositol-tetrakisphosphate 1-kinase (EC 2.7.1.139 created 1992, deleted 2002)


entry: 2.7.1.140
name: --- - inositol-tetrakisphosphate 5-kinase - 1D-myo-inositol-tetrakisphosphate 5-kinase
sysname: ATP:1D-myo-inositol-1,3,4,6-tetrakisphosphate 5-phosphotransferase
comment: The enzyme from plants and yeast can also use Ins(1,2,3,4,6)P5 as a substrate [2].
iubmb_reaction: R03478
reaction:
ATP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate [RN:R03478]


entry: 2.7.1.141
name: --- - Transferred to 2.7.11.23
comment:
Transferred entry: now EC 2.7.11.23, [RNA-polymerase]-subunit kinase (EC 2.7.1.141 created 1992, deleted 2005)


entry: 2.7.1.143
name: --- - diphosphate-purine nucleoside kinase - pyrophosphate-purine nucleoside kinase
sysname: diphosphate:purine nucleoside phosphotransferase
reaction: diphosphate + a purine nucleoside = phosphate + a purine mononucleotide [RN:R03699]
iubmb_reaction: R03699
comment:
the enzyme from the Acholeplasma class of Mollicutes catalyses the conversion of adenosine, guanosine and inosine to AMP, GMP and IMP. ATP cannot substitute for diphosphate as a substrate.


entry: 2.7.1.145
sysname: ATP:deoxynucleoside 5'-phosphotransferase
reaction: ATP + 2'-deoxynucleoside = ADP + 2'-deoxynucleoside 5'-phosphate [RN:R05806]
iubmb_reaction: R05806
name:
--- 
- deoxynucleoside kinase
- multispecific deoxynucleoside kinase
- ms-dNK
- multisubstrate deoxyribonucleoside kinase
- multifunctional deoxynucleoside kinase
- D. melanogaster deoxynucleoside kinase
- Dm-dNK

comment:
The enzyme from embryonic cells of Drosophila melanogaster differs from other deoxynucleoside kinases [EC 2.7.1.76 (deoxyadenosine kinase) and EC 2.7.1.113 (deoxyguanosine kinase)] in its broad specificity for all four common deoxynucleosides.


entry: 2.7.1.146
sysname: ADP:D-fructose-6-phosphate 1-phosphotransferase
reaction: ADP + D-fructose 6-phosphate = AMP + D-fructose 1,6-bisphosphate [RN:R05805]
iubmb_reaction: R05805
name:
--- 
- ADP-specific phosphofructokinase
- ADP-6-phosphofructokinase, ADP-dependent phosphofructokinase

comment:
ADP can be replaced by GDP, ATP and GTP, to a limited extent. Divalent cations are necessary for activity, with Mg2+ followed by Co2+ being the most effective.


entry: 2.7.1.147
name: --- - ADP-specific glucokinase - ADP-dependent glucokinase
sysname: ADP:D-glucose 6-phosphotransferase
reaction: ADP + D-glucose = AMP + D-glucose 6-phosphate [RN:R05804]
iubmb_reaction: R05804
comment:
Requires Mg2+. The enzyme from Pyrococcus furiosus is highly specific for D-glucose; there is some activity with 2-deoxy-D-glucose, but no activity with D-fructose, D-mannose or D-galactose as the substrate. No activity is detected when ADP is replaced by ATP, GDP, phosphoenolpyruvate, diphosphate or polyphosphate.


entry: 2.7.1.148
name: --- - 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase - CDP-ME kinase
sysname: ATP:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol 2-phosphotransferase
iubmb_reaction: R05634
reaction:
ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol [RN:R05634]


entry: 2.7.1.149
name: --- - 1-phosphatidylinositol-5-phosphate 4-kinase - type II PIP kinase
sysname: ATP:1-phosphatidyl-1D-myo-inositol-5-phosphate 4-phosphotransferase
iubmb_reaction: R05803
reaction:
ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [RN:R05803]


entry: 2.7.1.150
sysname: ATP:1-phosphatidyl-1D-myo-inositol-3-phosphate 5-phosphotransferase
iubmb_reaction: R05802
name:
--- 
- 1-phosphatidylinositol-3-phosphate 5-kinase
- type III PIP kinase
- phosphatidylinositol 3-phosphate 5-kinase

reaction:
ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate [RN:R05802]


entry: 2.7.1.151
sysname: ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase
iubmb_reaction: R05800 R05801
name:
--- 
- inositol-polyphosphate multikinase
- IpK2
- IP3/IP4 6-/3-kinase
- IP3/IP4 dual-specificity 6-/3-kinase
- IpmK
- ArgRIII
- AtIpk2alpha
- AtIpk2beta
- inositol polyphosphate 6-/3-/5-kinase

comment:
This enzyme also phosphorylates Ins(1,4,5)P3 to Ins(1,3,4,5)P4, Ins(1,3,4,5)P4 to Ins(1,3,4,5,6)P5, and Ins(1,3,4,5,6)P4 to Ins(PP)P4, isomer unknown. The enzyme from the plant Arabidopsis thaliana can also phosphorylate Ins(1,3,4,6)P4 and Ins(1,2,3,4,6)P5 at the D-5-position to produce 1,3,4,5,6-pentakisphosphate and inositol hexakisphosphate (InsP6), respectively [3]. Yeast produce InsP6 from Ins(1,4,5)P3 by the actions of this enzyme and EC 2.7.1.158, inositol-pentakisphosphate 2-kinase [4].

reaction:
(1) ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate [RN:R05800]; (2) ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate [RN:R05801]


entry: 2.7.1.152
name: --- - Transferred to 2.7.4.21
comment:
Transferred entry: now EC 2.7.4.21 inositol-hexakisphosphate kinase. (EC 2.7.1.152 created 2002, deleted 2003)


entry: 2.7.1.153
name: --- - phosphatidylinositol-4,5-bisphosphate 3-kinase - type I phosphoinositide 3-kinase
sysname: ATP:1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 3-phosphotransferase
iubmb_reaction: R04545
comment:
This enzyme also catalyses the phosphorylation of PtdIns4P to PtdIns(3,4)P2, and of PtdIns to PtdIns3P. Four mammalian isoforms are known to exist.

reaction:
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate [RN:R04545]


entry: 2.7.1.154
sysname: ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 3-phosphotransferase
iubmb_reaction: R05795
name:
--- 
- phosphatidylinositol-4-phosphate 3-kinase
- type II phosphoinositide 3-kinase
- C2-domain-containing phosphoinositide 3-kinase
- phosphoinositide 3-kinase

comment:
This enzyme also phosphorylates PtdIns to PtdIns3P. Three mammalian isoforms have been found to date.

reaction:
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate [RN:R05795]


entry: 2.7.1.155
name: --- - diphosphoinositol-pentakisphosphate kinase
sysname: ATP:5-diphospho-1D-myo-inositol-pentakisphosphate phosphotransferase
reaction:
ATP + 5-diphospho-1D-myo-inositol pentakisphosphate = ADP + bis(diphospho)-1D-myo-inositol tetrakisphosphate (isomeric configuration unknown)


entry: 2.7.1.156
sysname: RTP:adenosylcobinamide phosphotransferase
reaction: RTP + adenosylcobinamide = adenosylcobinamide phosphate + RDP [RN:R05221 R06558]
iubmb_reaction: R05221 R06558
name:
--- 
- adenosylcobinamide kinase
- CobU
- adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase
- AdoCbi kinase/AdoCbi-phosphate guanylyltransferase

comment:
In Salmonella typhimurium LT2, under anaerobic conditions, CobU (EC 2.7.7.62 and EC 2.7.1.156), CobT (EC 2.4.2.21), CobC (EC 3.1.3.73) and CobS (EC 2.7.8.26) catalyse reactions in the nucleotide loop assembly pathway, which convert adenosylcobinamide (AdoCbi) into adenosylcobalamin (AdoCbl). CobT and CobC are involved in 5,6-dimethylbenzimidazole activation whereby 5,6-dimethylbenzimidazole is converted to its riboside, alpha-ribazole. The second branch of the nucleotide loop assembly pathway is the cobinamide (Cbi) activation branch where AdoCbi or adenosylcobinamide-phosphate is converted to the activated intermediate AdoCbi-GDP by Cob U. The final step in adenosylcobalamin biosynthesis is the condensation of AdoCbi-GDP with alpha-ribazole, which is catalysed by EC 2.7.8.26, adenosylcobinamide-GDP ribazoletransferase (CobS), to yield adenosylcobalamin. CobU is a bifunctional enzyme that has both kinase (EC 2.7.1.156) and guanylyltransferase (EC 2.7.7.62, adenosylcobinamide-phosphate guanylyltransferase) activities. However, both activities are not required at all times. The kinase activity has been proposed to function only when S. typhimurium is assimilating cobinamide whereas the guanylyltransferase activity is required for both assimilation of exogenous cobinamide and for de novo synthesis of adenosylcobalamin [4].


entry: 2.7.1.157
sysname: ATP:N-acetyl-D-galactosamine 1-phosphotransferase
reaction: ATP + N-acetyl-D-galactosamine = ADP + N-acetyl-alpha-D-galactosamine 1-phosphate
name:
--- 
- N-acetylgalactosamine kinase
- GALK2
- GK2
- GalNAc kinase
- N-acetylgalactosamine (GalNAc)-1-phosphate kinase

comment:
The enzyme is highly specific for GalNAc as substrate, but has slight activity with D-galactose [2]. Requires Mg2+, Mn2+ or Co2+ for activity, with Mg2+ resulting in by far the greatest stimulation of enzyme activity.


entry: 2.7.1.158
sysname: ATP:1D-myo-inositol 1,3,4,5,6-pentakisphosphate 2-phosphotransferase
reaction: ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol hexakisphosphate
name:
--- 
- inositol-pentakisphosphate 2-kinase
- IP5 2-kinase
- Gsl1p
- Ipk1p
- Plc1p
- inositol polyphosphate kinase
- inositol 1,3,4,5,6-pentakisphosphate 2-kinase
- Ins(1,3,4,5,6)P5 2-kinase

comment:
The enzyme can also use Ins(1,4,5,6)P4 [2] and Ins(1,4,5)P3 [3] as substrate. Inositol hexakisphosphate (phytate) accumulates in storage protein bodies during seed development and, when hydrolysed, releases stored nutrients to the developing seedling before the plant is capable of absorbing nutrients from its environment [5].


entry: 2.7.1.159
sysname: ATP:1D-myo-inositol 1,3,4-trisphosphate 5-phosphotransferase
name:
--- 
- inositol-1,3,4-trisphosphate 5/6-kinase
- Ins(1,3,4)P3 5/6-kinase
- inositol trisphosphate 5/6-kinase

comment:
In humans, this enzyme, along with EC 2.7.1.127 (inositol-trisphosphate 3-kinase), EC 2.7.1.140 (inositol-tetrakisphosphate 5-kinase) and EC 2.7.1.158 (inositol pentakisphosphate 2-kinase) is involved in the production of inositol hexakisphosphate (InsP6). InsP6 is involved in many cellular processes, including mRNA export from the nucleus [2]. Yeast do not have this enzyme, so produce InsP6 from Ins(1,4,5)P3 by the actions of EC 2.7.1.151 (inositol-polyphosphate multikinase) and EC 2.7.1.158 (inositol-pentakisphosphate 2-kinase) [2].

reaction:
(1) ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate; (2) ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate


entry: 2.7.1.160
sysname: 2'-phospho-[ligated tRNA]:NAD+ phosphotransferase
reaction: 2'-phospho-[ligated tRNA] + NAD+ = mature tRNA + ADP ribose 1",2"-phosphate + H2O
name:
--- 
- 2'-phosphotransferase
- yeast 2'-phosphotransferase
- Tpt1
- Tpt1p
- 2'-phospho-tRNA:NAD+ phosphotransferase

comment:
Catalyses the final step of tRNA splicing in the yeast Saccharomyces cerevisiae [2]. The reaction takes place in two steps: in the first step, the 2'-phosphate on the RNA substrate is ADP-ribosylated, causing the relase of nicotinamide and the formation of the reaction intermediate, ADP-ribosylated tRNA [6]. In the second step, dephosphorylated (mature) tRNA is formed along with ADP ribose 1",2"-cyclic phosphate. Highly specific for oligonucleotide substrates bearing an internal 2'-phosphate. Oligonucleotides with only a terminal 5'- or 3'-phosphate are not substrates [1].


entry: 2.7.1.-
name: --- []
reaction:
(1) Nicotinate D-ribonucleotide + ADP <=> Nicotinate D-ribonucleoside + ATP [RN:R03347]; (2) myo-Inositol hexakisphosphate + ADP <=> 1D-myo-Inositol 1,3,4,5,6-pentakisphosphate + ATP [RN:R05202]; (3) Phenol + Alkylphosphonate <=> Phenolic phosphate + Alkane [RN:R05625]; (4) Trehalose + Alkylphosphonate <=> Trehalose 6-phosphate [RN:R06229]


entry: 2.7.2.1
name: --- - acetate kinase - acetokinase - AckA - AK - acetic kinase - acetate kinase (phosphorylating)
sysname: ATP:acetate phosphotransferase
iubmb_reaction: R00315 R01353
comment:
Requires Mg2+ for activity. While purified enzyme from Escherichia coli is specific for acetate [4], others have found that the enzyme can also use propanoate as a substrate, but more slowly [7]. Acetate can be converted into the key metabolic intermediate acetyl-CoA by coupling acetate kinase with EC 2.3.1.8, phosphate acetyltransferase. Both this enzyme and EC 2.7.2.15, propionate kinase, play important roles in the production of propanoate [9].

reaction:
(1) ATP + acetate = ADP + acetyl phosphate [RN:R00315]; (2) ATP + propanoate = ADP + propanoyl phosphate [RN:R01353]


entry: 2.7.2.3
sysname: ATP:3-phospho-D-glycerate 1-phosphotransferase
reaction: ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate [RN:R01512]
iubmb_reaction: R01512
name:
--- 
- phosphoglycerate kinase
- PGK
- 3-PGK
- ATP-3-phospho-D-glycerate-1-phosphotransferase
- ATP:D-3-phosphoglycerate 1-phosphotransferase
- 3-phosphoglycerate kinase
- 3-phosphoglycerate phosphokinase
- 3-phosphoglyceric acid kinase
- 3-phosphoglyceric acid phosphokinase
- 3-phosphoglyceric kinase
- glycerate 3-phosphate kinase
- glycerophosphate kinase
- phosphoglyceric acid kinase
- phosphoglyceric kinase
- phosphoglycerokinase


entry: 2.7.2.4
name: --- - aspartate kinase - aspartokinase - AK - beta-aspartokinase - aspartic kinase
sysname: ATP:L-aspartate 4-phosphotransferase
reaction: ATP + L-aspartate = ADP + 4-phospho-L-aspartate [RN:R00480]
iubmb_reaction: R00480
comment:
The enzyme from Escherichia coli is a multifunctional protein, which also catalyses the reaction of EC 1.1.1.3 homoserine dehydrogenase.


entry: 2.7.2.5
name: --- - Transferred to 6.3.4.16
comment:
Transferred entry: now EC 6.3.4.16 carbamoyl-phosphate synthase (ammonia) (EC 2.7.2.5 created 1965, deleted 1978)


entry: 2.7.2.7
name: --- - butyrate kinase
sysname: ATP:butanoate 1-phosphotransferase
reaction: ATP + butanoate = ADP + butanoyl phosphate [RN:R01688]
iubmb_reaction: R01688
comment:
The enzyme from Clostridium sp. also acts, more slowly, on pentanoate and propanoate, and on some branched-chain fatty acids (cf. EC 2.7.1.14 sedoheptulokinase).


entry: 2.7.2.8
sysname: ATP:N-acetyl-L-glutamate 5-phosphotransferase
reaction: ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate [RN:R02649]
iubmb_reaction: R02649
name:
--- 
- acetylglutamate kinase
- N-acetylglutamate 5-phosphotransferase
- acetylglutamate phosphokinase
- N-acetylglutamate phosphokinase
- N-acetylglutamate kinase
- N-acetylglutamic 5-phosphotransferase


entry: 2.7.2.9
name: --- - Transferred to 6.3.5.5
comment:
Transferred entry: now EC 6.3.5.5 carbamoyl-phosphate synthase (glutamine-hydrolysing) (EC 2.7.2.9 created 1972, deleted 1978)


entry: 2.7.2.11
sysname: ATP:L-glutamate 5-phosphotransferase
comment: Product rapidly cyclizes to 5-oxoproline and phosphate.
reaction: ATP + L-glutamate = ADP + L-glutamate 5-phosphate [RN:R00239]
iubmb_reaction: R00239
name:
--- 
- glutamate 5-kinase
- ATP-L-glutamate 5-phosphotransferase
- ATP:gamma-L-glutamate phosphotransferase
- gamma-glutamate kinase
- gamma-glutamyl kinase
- glutamate kinase


entry: 2.7.2.14
name: --- - branched-chain-fatty-acid kinase - isobutyrate kinase
sysname: ATP:branched-chain-fatty-acid 1-phosphotransferase
reaction: ATP + 2-methylpropanoate = ADP + 2-methylpropanoyl phosphate [RN:R04002]
iubmb_reaction: R04002
comment:
3-Methylbutanoate, 2-methylbutanoate, pentanoate, butanoate and propanoate can also act as acceptors (cf. EC 2.7.2.7 butyrate kinase).


entry: 2.7.2.15
name: --- - propionate kinase - PduW - TdcD - propionate/acetate kinase
sysname: ATP:propanoate phosphotransferase
iubmb_reaction: R01353 R00315
comment:
Requires Mg2+. Both propanoate and acetate can act as a substrate. Involved in the anaerobic degradation of L-threonine in bacteria [1]. Both this enzyme and EC 2.7.2.1, acetate kinase, play important roles in the production of propanoate [1].

reaction:
(1) ATP + propanoate = ADP + propanoyl phosphate [RN:R01353]; (2) ATP + acetate = ADP + acetyl phosphate [RN:R00315]


entry: 2.7.2.-
name: --- []
reaction:
(1) 2-Phospho-D-glycerate + ATP <=> 2,3-Bisphospho-D-glycerate + ADP [RN:R02664]; (2) N2-Acetyl-L-aminoadipate + ATP <=> N2-Acetyl-L-aminoadipyl-delta-phosphate + ADP [RN:R06842]


entry: 2.7.3.2
sysname: ATP:creatine N-phosphotransferase
comment: N-Ethylglycocyamine can also act as acceptor.
reaction: ATP + creatine = ADP + phosphocreatine [RN:R01881]
iubmb_reaction: R01881
name:
--- 
- creatine kinase
- ATP:creatine phosphotransferase
- CK
- MM-CK
- MB-CK
- BB-CK
- creatine phosphokinase
- creatine phosphotransferase
- phosphocreatine kinase
- adenosine triphosphate-creatine transphosphorylase
- Mi-CK
- CK-BB
- CK-MM
- CK-MB
- CKMiMi
- MiMi-CK


entry: 2.7.3.3
sysname: ATP:L-arginine N-phosphotransferase
reaction: ATP + L-arginine = ADP + N-phospho-L-arginine [RN:R00554]
iubmb_reaction: R00554
name:
--- 
- arginine kinase
- arginine phosphokinase
- "adenosine 5'-triphosphate: L-arginine phosphotransferase"
- adenosine 5'-triphosphate-arginine phosphotransferase


entry: 2.7.3.5
name: --- - lombricine kinase
sysname: ATP:lombricine N-phosphotransferase
reaction: ATP + lombricine = ADP + N-phospholombricine [RN:R06976]
iubmb_reaction: R06976
kegg_reaction: R03691
comment:
Also acts on methylated lombricines such as thalassemine; the specificity varies with the source species.


entry: 2.7.3.8
sysname: ATP:ammonia phosphotransferase
reaction: ATP + NH3 = ADP + phosphoramide [RN:R00141]
iubmb_reaction: R00141
name:
--- 
- ammonia kinase
- phosphoramidate-adenosine diphosphate phosphotransferase
- phosphoramidate-ADP-phosphotransferase

comment:
Has a wide specificity. In the reverse direction, N-phosphoglycine and N-phosphohistidine can also act as phosphate donors, and ADP, dADP, GDP, CDP, dTDP, dCDP, IDP and UDP can act as phosphate acceptors (in decreasing order of activity).


entry: 2.7.3.9
sysname: phosphoenolpyruvate:protein-L-histidine N(pi)-phosphotransferase
reaction: phosphoenolpyruvate + protein histidine = pyruvate + protein N(pi)-phospho-L-histidine [RN:R02628]
iubmb_reaction: R02628
name:
--- 
- phosphoenolpyruvate-protein phosphotransferase
- phosphoenolpyruvate sugar phosphotransferase enzyme I
- phosphopyruvate-protein factor phosphotransferase
- phosphopyruvate-protein phosphotransferase
- sugar-PEP phosphotransferase enzyme I
- phosphoenolpyruvate:protein-L-histidine N-pros-phosphotransferase

comment:
Enzyme I of the phosphotransferase system (cf. EC 2.7.1.69 protein-N(pi)-phosphohistidine-sugar phosphotransferase). Acts only on histidine residues in specific phosphocarrier proteins of low molecular mass (9.5 kDa) involved in bacterial sugar transport. A similar reaction, where the protein is the enzyme EC 2.7.9.2 pyruvate, water dikinase, is part of the mechanism of that enzyme.


entry: 2.7.3.11
name: --- - Transferred to 2.7.13.1
comment:
Transferred entry: now EC 2.7.13.1, protein-histidine pros-kinase (EC 2.7.3.11 created 1989, deleted 2005)


entry: 2.7.3.12
name: --- - Transferred to 2.7.13.2
comment:
Transferred entry: now EC 2.7.13.2, protein-histidine tele-kinase (EC 2.7.3.12 created 1989, deleted 2005)


entry: 2.7.4.2
sysname: ATP:(R)-5-phosphomevalonate phosphotransferase
reaction: ATP + (R)-5-phosphomevalonate = ADP + (R)-5-diphosphomevalonate [RN:R03245]
iubmb_reaction: R03245
name:
--- 
- phosphomevalonate kinase
- ATP:5-phosphomevalonate phosphotransferase
- 5-phosphomevalonate kinase
- mevalonate phosphate kinase
- mevalonate-5-phosphate kinase
- mevalonic acid phosphate kinase


entry: 2.7.4.5
name: --- - Deleted entry
comment:
Deleted entry: deoxycytidylate kinase. Now included with EC 2.7.4.14 cytidylate kinase (EC 2.7.4.5 created 1961, deleted 1972)


entry: 2.7.4.6
sysname: ATP:nucleoside-diphosphate phosphotransferase
reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate [RN:R00331]
iubmb_reaction: R00331 > R00124 R00156 R00330 R00570 R00722 R01137 R01857 R02093 R02326 R02331 R03530
name:
--- 
- nucleoside-diphosphate kinase
- nucleoside 5'-diphosphate kinase
- nucleoside diphosphate (UDP) kinase
- nucleoside diphosphokinase
- nucleotide phosphate kinase
- UDP kinase
- uridine diphosphate kinase

comment:
Many nucleoside diphosphates can act as acceptors, while many ribo- and deoxyribonucleoside triphosphates can act as donors.


entry: 2.7.4.7
name: --- - phosphomethylpyrimidine kinase - hydroxymethylpyrimidine phosphokinase
sysname: ATP:4-amino-2-methyl-5-phosphomethylpyrimidine phosphotransferase
iubmb_reaction: R04509
reaction:
ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine [RN:R04509]


entry: 2.7.4.8
sysname: ATP:(d)GMP phosphotransferase
comment: dGMP can also act as acceptor, and dATP can act as donor.
reaction: ATP + GMP = ADP + GDP [RN:R00332]
iubmb_reaction: R00332
kegg_reaction: R02090
name:
--- 
- guanylate kinase
- deoxyguanylate kinase
- 5'-GMP kinase
- GMP kinase
- guanosine monophosphate kinase
- ATP:GMP phosphotransferase


entry: 2.7.4.9
sysname: ATP:dTMP phosphotransferase
reaction: ATP + dTMP = ADP + dTDP [RN:R02094]
iubmb_reaction: R02094
kegg_reaction: R02098
name:
--- 
- dTMP kinase
- thymidine monophosphate kinase
- thymidylate kinase
- thymidylate monophosphate kinase
- thymidylic acid kinase
- thymidylic kinase
- deoxythymidine 5'-monophosphate kinase
- TMPK
- thymidine 5'-monophosphate kinase


entry: 2.7.4.10
sysname: nucleoside-triphosphate:AMP phosphotransferase
comment: Many nucleoside triphosphates can act as donors.
reaction: nucleoside triphosphate + AMP = nucleoside diphosphate + ADP [RN:R00333]
iubmb_reaction: R00333 > R00157
name:
--- 
- nucleoside-triphosphate-adenylate kinase
- guanosine triphosphate-adenylate kinase
- nucleoside triphosphate-adenosine monophosphate transphosphorylase
- GTP:AMP phosphotransferase
- isozyme 3 of adenylate kinase


entry: 2.7.4.13
sysname: ATP:deoxynucleoside-phosphate phosphotransferase
comment: dATP can substitute for ATP.
reaction: ATP + deoxynucleoside phosphate = ADP + deoxynucleoside diphosphate [RN:R04267]
iubmb_reaction: R04267
name:
--- 
- (deoxy)nucleoside-phosphate kinase
- deoxynucleoside monophosphate kinase
- deoxyribonucleoside monophosphokinase
- deoxynucleoside-5'-monophosphate kinase


entry: 2.7.4.14
sysname: ATP:CMP phosphotransferase
comment: UMP and dCMP can also act as acceptors.
reaction: ATP + (d)CMP = ADP + (d)CDP [RN:R00512 R01665]
iubmb_reaction: R00512 R01665
kegg_reaction: R00158
name:
--- 
- cytidylate kinase
- deoxycytidylate kinase
- CMP kinase
- CTP:CMP phosphotransferase
- dCMP kinase
- deoxycytidine monophosphokinase
- UMP-CMP kinase
- ATP:UMP-CMP phosphotransferase
- pyrimidine nucleoside monophosphate kinase


entry: 2.7.4.15
sysname: ATP:thiamine-diphosphate phosphotransferase
reaction: ATP + thiamine diphosphate = ADP + thiamine triphosphate [RN:R00616]
iubmb_reaction: R00616
name:
--- 
- thiamine-diphosphate kinase
- ATP:thiamin-diphosphate phosphotransferase
- TDP kinase
- thiamin diphosphate kinase
- thiamin diphosphate phosphotransferase
- thiamin pyrophosphate kinase
- thiamine diphosphate kinase
- protein bound thiamin diphosphate:ATP phosphoryltransferase


entry: 2.7.4.16
sysname: ATP:thiamine-phosphate phosphotransferase
reaction: ATP + thiamine phosphate = ADP + thiamine diphosphate [RN:R00617]
iubmb_reaction: R00617
name:
--- 
- thiamine-phosphate kinase
- thiamin-monophosphate kinase
- thiamin monophosphatase
- thiamin monophosphokinase


entry: 2.7.4.17
sysname: 3-phospho-D-glyceroyl-phosphate:polyphosphate phosphotransferase
reaction: 3-phospho-D-glyceroyl phosphate + (phosphate)n = 3-phosphoglycerate + (phosphate)(n+1) [RN:R02188]
iubmb_reaction: R02188
name:
--- 
- 3-phosphoglyceroyl-phosphate-polyphosphate phosphotransferase
- diphosphoglycerate-polyphosphate phosphotransferase
- 1,3-diphosphoglycerate-polyphosphate phosphotransferase


entry: 2.7.4.19
name: --- - 5-methyldeoxycytidine-5'-phosphate kinase
sysname: ATP:5-methyldeoxycytidine-5'-phosphate phosphotransferase
reaction: ATP + 5-methyldeoxycytidine 5'-phosphate = ADP + 5-methyldeoxycytidine diphosphate [RN:R04235]
iubmb_reaction: R04235
comment:
The enzyme, from phage XP-12-infected Xanthomonas oryzae, converts m5dCMP into m5dCDP and then into m5dCTP.


entry: 2.7.4.20
sysname: dolichyl-diphosphate:polyphosphate phosphotransferase
reaction: dolichyl diphosphate + (phosphate)n = dolichyl phosphate + (phosphate)(n+1) [RN:R02186]
iubmb_reaction: R02186
name:
--- 
- dolichyl-diphosphate-polyphosphate phosphotransferase
- dolichylpyrophosphate:polyphosphate phosphotransferase


entry: 2.7.4.21
name: --- - inositol-hexakisphosphate kinase - ATP:1D-myo-inositol-hexakisphosphate phosphotransferase
sysname: ATP:1D-myo-inositol-hexakisphosphate 5-phosphotransferase
comment: Three mammalian isoforms are known to exist.
iubmb_reaction: (other) R05799
kegg_reaction: R05799
reaction:
(1) ATP + 1D-myo-inositol hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate; (2) ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate (isomeric configuration unknown)


entry: 2.7.4.22
sysname: ATP:UMP phosphotransferase
reaction: ATP + UMP = ADP + UDP
name:
--- 
- UMP kinase
- uridylate kinase
- UMPK
- uridine monophosphate kinase
- PyrH
- UMP-kinase
- SmbA

comment:
This enzyme is strictly specific for UMP as substrate and is used by prokaryotes in the de novo synthesis of pyrimidines, in contrast to eukaryotes, which use the dual-specificity enzyme UMP/CMP kinase (EC 2.7.4.14) for the same purpose [2]. This enzyme is the subject of feedback regulation, being inhibited by UTP and activated by GTP [1].


entry: 2.7.4.23
name: --- - ribose 1,5-bisphosphate phosphokinase - ribose 1,5-bisphosphokinase - PhnN
sysname: ATP:ribose-1,5-bisphosphate phosphotransferase
reaction: ATP + ribose 1,5-bisphosphate = ADP + 5-phospho-alpha-D-ribose 1-diphosphate
comment:
This enzyme, found in NAD supression mutants of Escherichia coli, synthesizes 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) without the participation of EC 2.7.6.1, ribose-phosphate diphosphokinase. Ribose, ribose 1-phosphate and ribose 5-phosphate are not substrates, and GTP cannot act as a phosphate donor.


entry: 2.7.5.2
name: --- - Transferred to 5.4.2.3
comment:
Transferred entry: now EC 5.4.2.3 phosphoacetylglucosamine mutase (EC 2.7.5.2 created 1961, deleted 1984)


entry: 2.7.5.5
name: --- - Transferred to 5.4.2.5
comment:
Transferred entry: now EC 5.4.2.5 phosphoglucomutase (glucose-cofactor) (EC 2.7.5.5 created 1972, deleted 1984)


entry: 2.7.6.1
sysname: ATP:D-ribose-5-phosphate diphosphotransferase
comment: dATP can also act as donor.
reaction: ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate [RN:R01049]
iubmb_reaction: R01049
name:
--- 
- ribose-phosphate diphosphokinase
- ribose-phosphate pyrophosphokinase
- PRPP synthetase
- phosphoribosylpyrophosphate synthetase
- PPRibP synthetase
- PP-ribose P synthetase
- 5-phosphoribosyl-1-pyrophosphate synthetase
- 5-phosphoribose pyrophosphorylase
- 5-phosphoribosyl-alpha-1-pyrophosphate synthetase
- phosphoribosyl-diphosphate synthetase
- phosphoribosylpyrophosphate synthase
- pyrophosphoribosylphosphate synthetase
- ribophosphate pyrophosphokinase
- ribose-5-phosphate pyrophosphokinase


entry: 2.7.6.2
sysname: ATP:thiamine diphosphotransferase
reaction: ATP + thiamine = AMP + thiamine diphosphate [RN:R00619]
iubmb_reaction: R00619
kegg_reaction: R00616
name:
--- 
- thiamine diphosphokinase
- thiamin kinase
- thiamine pyrophosphokinase
- ATP:thiamin pyrophosphotransferase
- thiamin pyrophosphokinase
- thiamin pyrophosphotransferase
- thiaminokinase
- thiamin:ATP pyrophosphotransferase
- TPTase


entry: 2.7.6.3
sysname: ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 6'-diphosphotransferase
iubmb_reaction: R03503
name:
--- 
- 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase
- 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
- H2-Pteridine-CH2OH pyrophosphokinase
- 7,8-dihydroxymethylpterin-pyrophosphokinase
- HPPK
- 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase
- hydroxymethyldihydropteridine pyrophosphokinase

reaction:
ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = AMP + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate [RN:R03503]


entry: 2.7.6.4
sysname: ATP:nucleoside-5'-phosphate diphosphotransferase
comment: The enzyme acts on the 5'-mono-, di- and triphosphate derivatives of purine nucleosides.
reaction: ATP + nucleoside 5'-phosphate = AMP + 5'-phosphonucleoside 3'-diphosphate [RN:R03258]
iubmb_reaction: R03258
name:
--- 
- nucleotide diphosphokinase
- nucleotide pyrophosphokinase
- ATP:nucleotide pyrophosphotransferase
- ATP nucleotide 3'-pyrophosphokinase
- nucleotide 3'-pyrophosphokinase


entry: 2.7.6.5
sysname: ATP:GTP 3'-diphosphotransferase
comment: GDP can also act as acceptor.
reaction: ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate [RN:R00429]
iubmb_reaction: R00429
name:
--- 
- GTP diphosphokinase
- stringent factor
- guanosine 3',5'-polyphosphate synthase
- GTP pyrophosphokinase
- ATP-GTP 3'-diphosphotransferase
- guanosine 5',3'-polyphosphate synthetase
- (p)ppGpp synthetase I
- (p)ppGpp synthetase II
- guanosine pentaphosphate synthetase
- GPSI
- GPSII


entry: 2.7.7.1
sysname: ATP:nicotinamide-nucleotide adenylyltransferase
reaction: ATP + nicotinamide ribonucleotide = diphosphate + NAD+ [RN:R00137]
iubmb_reaction: R00137
kegg_reaction: R03005
name:
--- 
- nicotinamide-nucleotide adenylyltransferase
- NAD+ pyrophosphorylase
- adenosine triphosphate-nicotinamide mononucleotide transadenylase
- ATP:NMN adenylyltransferase
- diphosphopyridine nucleotide pyrophosphorylase
- nicotinamide adenine dinucleotide pyrophosphorylase
- nicotinamide mononucleotide adenylyltransferase
- NMN adenylyltransferase

comment:
Nicotinate nucleotide can also act as acceptor. See also EC 2.7.7.18 nicotinate-nucleotide adenylyltransferase.


entry: 2.7.7.2
sysname: ATP:FMN adenylyltransferase
reaction: ATP + FMN = diphosphate + FAD [RN:R00161]
iubmb_reaction: R00161
name:
--- 
- FMN adenylyltransferase
- FAD pyrophosphorylase
- riboflavin mononucleotide adenylyltransferase
- adenosine triphosphate-riboflavin mononucleotide transadenylase
- adenosine triphosphate-riboflavine mononucleotide transadenylase
- FAD synthetase
- riboflavin adenine dinucleotide pyrophosphorylase
- riboflavine


entry: 2.7.7.3
sysname: ATP:pantetheine-4'-phosphate adenylyltransferase
reaction: ATP + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA [RN:R03035]
iubmb_reaction: R03035
name:
--- 
- pantetheine-phosphate adenylyltransferase
- dephospho-CoA pyrophosphorylase
- pantetheine phosphate adenylyltransferase
- dephospho-coenzyme A pyrophosphorylase
- 3'-dephospho-CoA pyrophosphorylase

comment:
The enzyme from several bacteria (e.g. Escherichia coli, Bacillus subtilis and Haemophilus influenzae) has been shown to be bifunctional and also to possess the activity of EC 2.3.1.157, glucosamine-1-phosphate N-acetyltransferase.


entry: 2.7.7.4
sysname: ATP:sulfate adenylyltransferase
reaction: ATP + sulfate = diphosphate + adenylyl sulfate [RN:R00529]
iubmb_reaction: R00529
kegg_reaction: R04929
name:
--- 
- sulfate adenylyltransferase
- ATP-sulfurylase
- adenosine-5'-triphosphate sulfurylase
- adenosinetriphosphate sulfurylase
- adenylylsulfate pyrophosphorylase
- ATP sulfurylase
- sulfurylase

comment:
The human phosphoadenosine-phosphosulfate synthase (PAPS) system is a bifunctional enzyme (fusion product of two catalytic activities). In a first step, sulfate adenylyltransferase catalyses the formation of adenosine 5'-phosphosulfate (APS) from ATP and inorganic sulfate. The second step is catalysed by the adenylylsulfate kinase portion of 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase, which involves the formation of PAPS from enzyme-bound APS and ATP. In contrast, in bacteria, yeast, fungi and plants, the formation of PAPS is carried out by two individual polypeptides, sulfate adenylyltransferase (EC 2.7.7.4) and adenylyl-sulfate kinase (EC 2.7.1.25).


entry: 2.7.7.5
sysname: ADP:sulfate adenylyltransferase
reaction: ADP + sulfate = phosphate + adenylyl sulfate [RN:R00530]
iubmb_reaction: R00530
name:
--- 
- sulfate adenylyltransferase (ADP)
- ADP-sulfurylase
- sulfate (adenosine diphosphate) adenylyltransferase
- adenosine diphosphate sulfurylase


entry: 2.7.7.6
sysname: nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed)
reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1) [RN:R00444]
iubmb_reaction: R00444 > R00435 R00441 R00442 R00443
name:
--- 
- DNA-directed RNA polymerase
- RNA polymerase
- RNA nucleotidyltransferase (DNA-directed)
- RNA polymerase I
- RNA polymerase II
- RNA polymerase III
- C RNA formation factors
- deoxyribonucleic acid-dependent ribonucleic acid polymerase
- DNA-dependent ribonucleate nucleotidyltransferase
- DNA-dependent RNA nucleotidyltransferase
- DNA-dependent RNA polymerase
- ribonucleate nucleotidyltransferase
- ribonucleate polymerase
- C ribonucleic acid formation factors
- ribonucleic acid nucleotidyltransferase
- ribonucleic acid polymerase
- ribonucleic acid transcriptase
- ribonucleic polymerase
- ribonucleic transcriptase
- RNA nucleotidyltransferase
- RNA transcriptase
- transcriptase

comment:
Catalyses DNA-template-directed extension of the 3'- end of an RNA strand by one nucleotide at a time. Can initiate a chain de novo. In eukaryotes, three forms of the enzyme have been distinguished on the basis of sensitivity to alpha-amanitin, and the type of RNA synthesized. See also EC 2.7.7.19 (polynucleotide adenylyltransferase) and EC 2.7.7.48 (RNA-directed RNA polymerase).


entry: 2.7.7.7
sysname: deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed)
reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1) [RN:R00379]
iubmb_reaction: R00379 > R00375 R00376 R00377 R00378
name:
--- 
- DNA-directed DNA polymerase
- DNA polymerase I
- DNA polymerase II
- DNA polymerase III
- DNA polymerase alpha
- DNA polymerase beta
- DNA polymerase gamma
- DNA nucleotidyltransferase (DNA-directed)
- deoxyribonucleate nucleotidyltransferase
- deoxynucleate polymerase
- deoxyribonucleic acid duplicase
- deoxyribonucleic acid polymerase
- deoxyribonucleic duplicase
- deoxyribonucleic polymerase
- deoxyribonucleic polymerase I
- DNA duplicase
- DNA nucleotidyltransferase
- DNA polymerase
- DNA replicase
- DNA-dependent DNA polymerase
- duplicase
- Klenow fragment
- sequenase
- Taq DNA polymerase
- Taq Pol I
- Tca DNA polymerase

comment:
Catalyses DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time. Cannot initiate a chain de novo. Requires a primer, which may be DNA or RNA. See also EC 2.7.7.49 RNA-directed DNA polymerase.


entry: 2.7.7.8
sysname: polyribonucleotide:phosphate nucleotidyltransferase
comment: ADP, IDP, GDP, UDP and CDP can act as donors.
reaction: RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate [RN:R07282]
iubmb_reaction: R07282 > R00437 R00438 R00439 R00440
name:
--- 
- polyribonucleotide nucleotidyltransferase
- polynucleotide phosphorylase
- PNPase
- nucleoside diphosphate:polynucleotidyl transferase
- polyribonucleotide phosphorylase


entry: 2.7.7.9
sysname: UTP:alpha-D-glucose-1-phosphate uridylyltransferase
reaction: UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose [RN:R00289]
iubmb_reaction: R00289
name:
--- 
- UTP-glucose-1-phosphate uridylyltransferase
- UDP glucose pyrophosphorylase
- glucose-1-phosphate uridylyltransferase
- UDPG phosphorylase
- UDPG pyrophosphorylase
- uridine 5'-diphosphoglucose pyrophosphorylase
- uridine diphosphoglucose pyrophosphorylase
- uridine diphosphate-D-glucose pyrophosphorylase
- uridine-diphosphate glucose pyrophosphorylase


entry: 2.7.7.10
sysname: UTP:alpha-D-hexose-1-phosphate uridylyltransferase
comment: alpha-D-Glucose 1-phosphate can also act as acceptor, but more slowly.
reaction: UTP + alpha-D-galactose 1-phosphate = diphosphate + UDP-galactose [RN:R00502]
iubmb_reaction: R00502
name:
--- 
- UTP-hexose-1-phosphate uridylyltransferase
- galactose-1-phosphate uridylyltransferase
- galactose 1-phosphate uridylyltransferase
- alpha-D-galactose 1-phosphate uridylyltransferase
- galactose 1-phosphate uridyltransferase
- UDPgalactose pyrophosphorylase
- uridine diphosphate galactose pyrophosphorylase
- uridine diphosphogalactose pyrophosphorylase


entry: 2.7.7.11
sysname: UTP:alpha-D-xylose-1-phosphate uridylyltransferase
reaction: UTP + alpha-D-xylose 1-phosphate = diphosphate + UDP-xylose [RN:R01471]
iubmb_reaction: R01471
name:
--- 
- UTP-xylose-1-phosphate uridylyltransferase
- xylose-1-phosphate uridylyltransferase
- uridylyltransferase, xylose 1-phosphate
- UDP-xylose pyrophosphorylase
- uridine diphosphoxylose pyrophosphorylase
- xylose 1-phosphate uridylyltransferase


entry: 2.7.7.12
sysname: UDP-glucose:alpha-D-galactose-1-phosphate uridylyltransferase
iubmb_reaction: R00955
name:
--- 
- UDP-glucose-hexose-1-phosphate uridylyltransferase
- uridyl transferase
- hexose-1-phosphate uridylyltransferase
- uridyltransferase
- hexose 1-phosphate uridyltransferase

reaction:
UDP-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDPgalactose [RN:R00955]


entry: 2.7.7.13
sysname: GTP:alpha-D-mannose-1-phosphate guanylyltransferase
comment: The bacterial enzyme can also use ITP and dGTP as donors.
reaction: GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose
iubmb_reaction: (other) R00885
kegg_reaction: R00885
name:
--- 
- mannose-1-phosphate guanylyltransferase
- GTP-mannose-1-phosphate guanylyltransferase
- PIM-GMP (phosphomannose isomerase-guanosine 5'-diphospho-D-mannose pyrophosphorylase)
- GDP-mannose pyrophosphorylase
- guanosine 5'-diphospho-D-mannose pyrophosphorylase
- guanosine diphosphomannose pyrophosphorylase
- guanosine triphosphate-mannose 1-phosphate guanylyltransferase
- mannose 1-phosphate guanylyltransferase (guanosine triphosphate)


entry: 2.7.7.14
sysname: CTP:ethanolamine-phosphate cytidylyltransferase
reaction: CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine [RN:R02038]
iubmb_reaction: R02038
kegg_reaction: R04247
name:
--- 
- ethanolamine-phosphate cytidylyltransferase
- phosphorylethanolamine transferase
- ET
- CTP-phosphoethanolamine cytidylyltransferase
- phosphoethanolamine cytidylyltransferase
- ethanolamine phosphate cytidylyltransferase


entry: 2.7.7.15
sysname: CTP:choline-phosphate cytidylyltransferase
reaction: CTP + choline phosphate = diphosphate + CDP-choline [RN:R01890]
iubmb_reaction: R01890
kegg_reaction: R02590
name:
--- 
- choline-phosphate cytidylyltransferase
- phosphorylcholine transferase
- CDP-choline pyrophosphorylase
- CDP-choline synthetase
- choline phosphate cytidylyltransferase
- CTP-phosphocholine cytidylyltransferase
- CTP:phosphorylcholine cytidylyltransferase
- cytidine diphosphocholine pyrophosphorylase
- phosphocholine cytidylyltransferase
- phosphorylcholine cytidylyltransferase
- phosphorylcholine:CTP cytidylyltransferase


entry: 2.7.7.16
name: --- - Transferred to 3.1.27.5
comment:
Transferred entry: now EC 3.1.27.5 pancreatic ribonuclease (EC 2.7.7.16 created 1961, deleted 1972, [transferred to EC 3.1.4.22, deleted 1980])


entry: 2.7.7.17
name: --- - Transferred to 3.1.27.1
comment:
Transferred entry: now EC 3.1.27.1 ribonuclease T2 (EC 2.7.7.17 created 1965, deleted 1972, [transferred to EC 3.1.4.23, deleted 1980])


entry: 2.7.7.18
sysname: ATP:nicotinate-ribonucleotide adenylyltransferase
reaction: ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+ [RN:R03005]
iubmb_reaction: R03005
kegg_reaction: R00137
name:
--- 
- nicotinate-nucleotide adenylyltransferase
- deamido-NAD+ pyrophosphorylase
- nicotinate mononucleotide adenylyltransferase
- deamidonicotinamide adenine dinucleotide pyrophosphorylase
- NaMN-ATase
- nicotinic acid mononucleotide adenylyltransferase


entry: 2.7.7.19
sysname: ATP:polynucleotide adenylyltransferase
reaction: ATP + RNA(n) = diphosphate + RNA(n+1) [RN:R00435]
iubmb_reaction: R00435
name:
--- 
- polynucleotide adenylyltransferase
- NTP polymerase
- RNA adenylating enzyme
- AMP polynucleotidylexotransferase
- ATP-polynucleotide adenylyltransferase
- ATP:polynucleotidylexotransferase
- poly(A) polymerase
- poly(A) synthetase
- polyadenylate nucleotidyltransferase
- polyadenylate polymerase
- polyadenylate synthetase
- polyadenylic acid polymerase
- polyadenylic polymerase
- terminal riboadenylate transferase
- poly(A) hydrolase
- RNA formation factors, PF1
- adenosine triphosphate:ribonucleic acid adenylyltransferase

comment:
Also acts slowly with CTP. Catalyses template-independent extension of the 3'- end of a DNA strand by one nucleotide at a time. Cannot initiate a chain de novo. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group. See also EC 2.7.7.6 DNA-directed RNA polymerase.


entry: 2.7.7.20
name: --- - Deleted entry
comment:
Deleted entry: This entry was identical with EC 2.7.7.25 tRNA adenylyltransferase (EC 2.7.7.20 created 1965, deleted 1972)


entry: 2.7.7.21
sysname: CTP:tRNA cytidylyltransferase
comment: May be identical with EC 2.7.7.25 tRNA adenylyltransferase.
reaction: CTP + tRNA(n) = diphosphate + tRNA(n+1) [RN:R07283]
iubmb_reaction: R07283
name:
--- 
- tRNA cytidylyltransferase
- tRNA CCA-pyrophosphorylase
- tRNA-nucleotidyltransferase
- transfer-RNA nucleotidyltransferase
- transfer ribonucleic acid nucleotidyl transferase
- CTP(ATP):tRNA nucleotidyltransferase
- transfer ribonucleate adenylyltransferase
- transfer RNA adenylyltransferase
- transfer ribonucleate nucleotidyltransferase
- ATP (CTP):tRNA nucleotidyltransferase
- ribonucleic cytidylic cytidylic adenylic pyrophosphorylase
- transfer ribonucleic adenylyl (cytidylyl) transferase
- transfer ribonucleic-terminal trinucleotide nucleotidyltransferase
- transfer ribonucleate cytidylyltransferase
- ribonucleic cytidylyltransferase
- -C-C-A pyrophosphorylase
- ATP(CTP)-tRNA nucleotidyltransferase
- tRNA adenylyl(cytidylyl)transferase
- ATP(CTP):tRNA nucleotidyltransferase
- tRNA adenylyltransferase
- ATP:tRNA adenylyltransferase


entry: 2.7.7.22
sysname: GDP:alpha-D-mannose-1-phosphate guanylyltransferase
reaction: GDP + alpha-D-mannose 1-phosphate = phosphate + GDP-mannose
iubmb_reaction: (other) R00883
kegg_reaction: R00883
name:
--- 
- mannose-1-phosphate guanylyltransferase (GDP)
- GDP mannose phosphorylase
- mannose 1-phosphate (guanosine diphosphate) guanylyltransferase
- GDP-mannose 1-phosphate guanylyltransferase
- guanosine diphosphate-mannose 1-phosphate guanylyltransferase
- guanosine diphosphomannose phosphorylase
- mannose 1-phosphate guanylyltransferase
- GDP:D-mannose-1-phosphate guanylyltransferase


entry: 2.7.7.23
sysname: UTP:N-acetyl-alpha-D-glucosamine-1-phosphate uridylyltransferase
iubmb_reaction: R00416
kegg_reaction: R00415
name:
--- 
- UDP-N-acetylglucosamine diphosphorylase
- UDP-N-acetylglucosamine pyrophosphorylase
- uridine diphosphoacetylglucosamine pyrophosphorylase
- UTP:2-acetamido-2-deoxy-alpha-D-glucose-1-phosphate uridylyltransferase
- UDP-GlcNAc pyrophosphorylase
- GlmU uridylyltransferase
- Acetylglucosamine 1-phosphate uridylyltransferase
- UDP-acetylglucosamine pyrophosphorylase
- uridine diphosphate-N-acetylglucosamine pyrophosphorylase
- uridine diphosphoacetylglucosamine phosphorylase
- acetylglucosamine 1-phosphate uridylyltransferase

reaction:
UTP + N-acetyl-alpha-D-glucosamine 1-phosphate = diphosphate + UDP-N-acetyl-D-glucosamine [RN:R00416]


entry: 2.7.7.24
sysname: dTTP:alpha-D-glucose-1-phosphate thymidylyltransferase
reaction: dTTP + alpha-D-glucose 1-phosphate = diphosphate + dTDP-glucose [RN:R02328]
iubmb_reaction: R02328
name:
--- 
- glucose-1-phosphate thymidylyltransferase
- glucose 1-phosphate thymidylyltransferase
- dTDP-glucose synthase
- dTDP-glucose pyrophosphorylase
- thymidine diphosphoglucose pyrophosphorylase
- thymidine diphosphate glucose pyrophosphorylase
- TDP-glucose pyrophosphorylase


entry: 2.7.7.25
sysname: ATP:tRNA adenylyltransferase
comment: May be identical with EC 2.7.7.21 tRNA cytidylyltransferase.
reaction: ATP + tRNA(n) = diphosphate + tRNA(n+1) [RN:R07284]
iubmb_reaction: R07284
name:
--- 
- tRNA adenylyltransferase
- tRNA CCA-pyrophosphorylase
- tRNA-nucleotidyltransferase
- transfer-RNA nucleotidyltransferase
- transfer ribonucleic acid nucleotidyl transferase
- CTP(ATP):tRNA nucleotidyltransferase
- transfer ribonucleate adenylyltransferase
- transfer ribonucleate adenyltransferase
- transfer RNA adenylyltransferase
- transfer ribonucleate nucleotidyltransferase
- ATP (CTP):tRNA nucleotidyltransferase
- ribonucleic cytidylic cytidylic adenylic pyrophosphorylase
- transfer ribonucleic adenylyl (cytidylyl) transferase
- transfer ribonucleic-terminal trinucleotide nucleotidyltransferase
- transfer ribonucleate cytidylyltransferase
- ribonucleic cytidylyltransferase
- -C-C-A pyrophosphorylase
- tRNA cytidylyltransferase
- ATP(CTP)-tRNA nucleotidyltransferase
- tRNA adenylyl(cytidylyl)transferase
- CTP:tRNA cytidylyltransferase


entry: 2.7.7.26
name: --- - Transferred to 3.1.27.3
comment:
Transferred entry: now EC 3.1.27.3 ribonuclease T1 (EC 2.7.7.26 created 1961 as EC 3.1.4.8, transferred 1965 to EC 2.7.7.26, deleted 1972)


entry: 2.7.7.27
sysname: ATP:alpha-D-glucose-1-phosphate adenylyltransferase
reaction: ATP + alpha-D-glucose 1-phosphate = diphosphate + ADP-glucose [RN:R00948]
iubmb_reaction: R00948
name:
--- 
- glucose-1-phosphate adenylyltransferase
- ADP glucose pyrophosphorylase
- glucose 1-phosphate adenylyltransferase
- adenosine diphosphate glucose pyrophosphorylase
- adenosine diphosphoglucose pyrophosphorylase
- ADP-glucose pyrophosphorylase
- ADP-glucose synthase
- ADP-glucose synthetase
- ADPG pyrophosphorylase
- ADP:alpha-D-glucose-1-phosphate adenylyltransferase


entry: 2.7.7.28
sysname: NTP:alpha-D-aldose-1-phosphate nucleotidyltransferase
reaction: nucleoside triphosphate + alpha-D-aldose 1-phosphate = diphosphate + NDP-hexose
iubmb_reaction: (other) R03149 R03318
kegg_reaction: R03149 R03318
name:
--- 
- nucleoside-triphosphate-aldose-1-phosphate nucleotidyltransferase
- NDP hexose pyrophosphorylase
- hexose 1-phosphate nucleotidyltransferase
- hexose nucleotidylating enzyme
- nucleoside diphosphohexose pyrophosphorylase
- hexose-1-phosphate guanylyltransferase
- GTP:alpha-D-hexose-1-phosphate guanylyltransferase
- GDP hexose pyrophosphorylase
- guanosine diphosphohexose pyrophosphorylase
- nucleoside-triphosphate-hexose-1-phosphate nucleotidyltransferase
- NTP:hexose-1-phosphate nucleotidyltransferase

comment:
In decreasing order of activity, guanosine, inosine and adenosine diphosphate hexoses are substrates in the reverse reaction, with either glucose or mannose as the sugar.


entry: 2.7.7.29
name: --- - Deleted entry
comment:
Deleted entry: hexose-1-phosphate guanylyltransferase. Enzyme is not specific for GTP and therefore is identical to EC 2.7.7.28, nucleoside-triphosphate-hexose-1-phosphate nucleotidyltransferase (EC 2.7.7.29 created 1972, deleted 2004)


entry: 2.7.7.30
sysname: GTP:beta-L-fucose-1-phosphate guanylyltransferase
reaction: GTP + beta-L-fucose 1-phosphate = diphosphate + GDP-L-fucose [RN:R01951]
iubmb_reaction: R01951
name:
--- 
- fucose-1-phosphate guanylyltransferase
- GDP fucose pyrophosphorylase
- guanosine diphosphate L-fucose pyrophosphorylase
- GDP-L-fucose pyrophosphorylase
- GDP-fucose pyrophosphorylase
- GTP:L-fucose-1-phosphate guanylyltransferase


entry: 2.7.7.31
sysname: nucleoside-triphosphate:DNA deoxynucleotidylexotransferase
reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1) [RN:R00379]
iubmb_reaction: R00379
name:
--- 
- DNA nucleotidylexotransferase
- terminal deoxyribonucleotidyltransferase
- terminal addition enzyme
- addase
- deoxynucleotidyl terminal transferase
- deoxyribonucleic acid nucleotidyltransferase
- deoxyribonucleic nucleotidyltransferase
- terminal deoxynucleotide transferase
- TdT

comment:
Catalyses template-independent extension of the 3'- end of a DNA strand by one nucleotide at a time. Cannot initiate a chain de novo. Nucleoside may be ribo- or deoxyribo-.


entry: 2.7.7.32
sysname: dTTP:alpha-D-galactose-1-phosphate thymidylyltransferase
reaction: dTTP + alpha-D-galactose 1-phosphate = diphosphate + dTDP-galactose [RN:R02329]
iubmb_reaction: R02329
name:
--- 
- galactose-1-phosphate thymidylyltransferase
- dTDP galactose pyrophosphorylase
- galactose 1-phosphate thymidylyl transferase
- thymidine diphosphogalactose pyrophosphorylase
- thymidine triphosphate:alpha-D-galactose 1-phosphate thymidylyltransferase


entry: 2.7.7.33
sysname: CTP:alpha-D-glucose-1-phosphate cytidylyltransferase
reaction: CTP + alpha-D-glucose 1-phosphate = diphosphate + CDP-glucose [RN:R00956]
iubmb_reaction: R00956
kegg_reaction: R02328
name:
--- 
- glucose-1-phosphate cytidylyltransferase
- CDP glucose pyrophosphorylase
- cytidine diphosphoglucose pyrophosphorylase
- cytidine diphosphate glucose pyrophosphorylase
- cytidine diphosphate-D-glucose pyrophosphorylase
- CTP:D-glucose-1-phosphate cytidylyltransferase


entry: 2.7.7.34
sysname: GTP:alpha-D-glucose-1-phosphate guanylyltransferase
comment: Also acts, more slowly, on D-mannose 1-phosphate.
reaction: GTP + alpha-D-glucose 1-phosphate = diphosphate + GDP-glucose [RN:R00954]
iubmb_reaction: R00954
name:
--- 
- glucose-1-phosphate guanylyltransferase
- GDP glucose pyrophosphorylase
- guanosine diphosphoglucose pyrophosphorylase


entry: 2.7.7.35
sysname: ADP:D-ribose-5-phosphate adenylyltransferase
reaction: ADP + D-ribose 5-phosphate = phosphate + ADP-ribose [RN:R01052]
iubmb_reaction: R01052
name:
--- 
- ribose-5-phosphate adenylyltransferase
- ADP ribose phosphorylase
- adenosine diphosphoribose phosphorylase


entry: 2.7.7.36
sysname: ADP:alpha-D-aldose-1-phosphate adenylyltransferase
reaction: ADP + alpha-D-aldose 1-phosphate = phosphate + ADP-aldose [RN:R03142]
iubmb_reaction: R03142
name:
--- 
- aldose-1-phosphate adenylyltransferase
- sugar-1-phosphate adenylyltransferase
- ADPaldose phosphorylase
- adenosine diphosphosugar phosphorylase
- ADP sugar phosphorylase
- adenosine diphosphate glucose:orthophosphate adenylyltransferase
- ADP:aldose-1-phosphate adenylyltransferase


entry: 2.7.7.37
sysname: NDP:alpha-D-aldose-1-phosphate nucleotidyltransferase
reaction: NDP + alpha-D-aldose 1-phosphate = phosphate + NDP-aldose [RN:R03143]
iubmb_reaction: R03143
kegg_reaction: R03077
name:
--- 
- aldose-1-phosphate nucleotidyltransferase
- sugar-1-phosphate nucleotidyltransferase
- NDPaldose phosphorylase
- glucose 1-phosphate inosityltransferase
- NDP sugar phosphorylase
- nucleoside diphosphosugar phosphorylase
- sugar phosphate nucleotidyltransferase
- nucleoside diphosphate sugar:orthophosphate nucleotidyltransferase
- sugar nucleotide phosphorylase
- NDP:aldose-1-phosphate nucleotidyltransferase

comment:
The enzyme works on a variety of alpha-D-aldose 1-phosphates and beta-L-aldose 1-phosphates (which have the same anomeric configuration as the former; see 2-Carb-6.2).


entry: 2.7.7.38
sysname: CTP:3-deoxy-D-manno-octulosonate cytidylyltransferase
reaction: CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate [RN:R03351]
iubmb_reaction: R03351
name:
--- 
- 3-deoxy-manno-octulosonate cytidylyltransferase
- CMP-3-deoxy-D-manno-octulosonate pyrophosphorylase
- 2-keto-3-deoxyoctonate cytidylyltransferase
- 3-Deoxy-D-manno-octulosonate cytidylyltransferase
- CMP-3-deoxy-D-manno-octulosonate synthetase
- CMP-KDO synthetase
- CTP:CMP-3-deoxy-D-manno-octulosonate cytidylyltransferase
- cytidine monophospho-3-deoxy-D-manno-octulosonate pyrophosphorylase


entry: 2.7.7.39
sysname: CTP:sn-glycerol-3-phosphate cytidylyltransferase
reaction: CTP + sn-glycerol 3-phosphate = diphosphate + CDP-glycerol [RN:R00856]
iubmb_reaction: R00856
name:
--- 
- glycerol-3-phosphate cytidylyltransferase
- CDP-glycerol pyrophosphorylase
- cytidine diphosphoglycerol pyrophosphorylase
- cytidine diphosphate glycerol pyrophosphorylase
- CTP:glycerol 3-phosphate cytidylyltransferase
- Gro-PCT


entry: 2.7.7.40
sysname: CTP:D-ribitol-5-phosphate cytidylyltransferase
reaction: CTP + D-ribitol 5-phosphate = diphosphate + CDP-ribitol [RN:R02921]
iubmb_reaction: R02921
name:
--- 
- D-ribitol-5-phosphate cytidylyltransferase
- CDP ribitol pyrophosphorylase
- cytidine diphosphate ribitol pyrophosphorylase
- ribitol 5-phosphate cytidylyltransferase
- cytidine diphosphoribitol pyrophosphorylase


entry: 2.7.7.41
sysname: CTP:phosphatidate cytidylyltransferase
reaction: CTP + phosphatidate = diphosphate + CDP-diacylglycerol [RN:R01799]
iubmb_reaction: R01799
name:
--- 
- phosphatidate cytidylyltransferase
- CDP diglyceride pyrophosphorylase
- CDP-diacylglycerol synthase
- CDP-diacylglyceride synthetase
- cytidine diphosphoglyceride pyrophosphorylase
- phosphatidate cytidyltransferase
- phosphatidic acid cytidylyltransferase
- CTP:1,2-diacylglycerophosphate-cytidyl transferase
- CTP-diacylglycerol synthetase
- DAG synthetase
- CDP-DG


entry: 2.7.7.42
sysname: ATP:[L-glutamate:ammonia ligase (ADP-forming)] adenylyltransferase
iubmb_reaction: R03473
name:
--- 
- "[glutamate-ammonia-ligase] adenylyltransferase"
- glutamine-synthetase adenylyltransferase
- ATP:glutamine synthetase adenylyltransferase
- adenosine triphosphate:glutamine synthetase adenylyltransferase

reaction:
ATP + [L-glutamate:ammonia ligase (ADP-forming)] = diphosphate + adenylyl-[L-glutamate:ammonia ligase (ADP-forming)] [RN:R03473]


entry: 2.7.7.43
sysname: CTP:N-acylneuraminate cytidylyltransferase
comment: Acts on N-acetyl- and N-glycolyl- derivatives.
reaction: CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate [RN:R02599]
iubmb_reaction: R02599 > R01117 R04215
name:
--- 
- N-acylneuraminate cytidylyltransferase
- CMP-sialate pyrophosphorylase
- CMP-sialate synthase
- cytidine 5'-monophosphosialic acid synthetase
- CMP-Neu5Ac synthetase
- CMP-NeuAc synthetase
- acylneuraminate cytidyltransferase
- CMP-N-acetylneuraminate synthetase
- CMP-N-acetylneuraminate synthase
- CMP-N-acetylneuraminic acid synthase
- CMP-NANA synthetase
- CMP-sialate synthetase
- CMP-sialic synthetase
- cytidine 5'-monophospho-N-acetylneuraminic acid synthetase
- cytidine 5-monophosphate N-acetylneuraminic acid synthetase
- cytidine monophosphosialic acid synthetase
- cytidine monophosphoacetylneuraminic synthetase
- cytidine monophosphosialate pyrophosphorylase
- cytidine monophosphosialate synthetase
- acetylneuraminate cytidylyltransferase


entry: 2.7.7.44
sysname: UTP:1-phospho-alpha-D-glucuronate uridylyltransferase
comment: Also acts slowly with CTP.
reaction: UTP + 1-phospho-alpha-D-glucuronate = diphosphate + UDP-glucuronate [RN:R01380]
iubmb_reaction: R01380
kegg_reaction: R01381
name:
--- 
- glucuronate-1-phosphate uridylyltransferase
- UDP-glucuronate pyrophosphorylase
- UDP-D-glucuronic acid pyrophosphorylase
- UDP-glucuronic acid pyrophosphorylase
- uridine diphosphoglucuronic pyrophosphorylase


entry: 2.7.7.45
sysname: GTP:GTP guanylyltransferase
comment: Also acts, more slowly, on GDP to form P1,P3-bis(5'-guanosyl) triphosphate.
reaction: 2 GTP = diphosphate + P1,P4-bis(5'-guanosyl) tetraphosphate [RN:R00012]
iubmb_reaction: R00012
name:
--- 
- guanosine-triphosphate guanylyltransferase
- diguanosine tetraphosphate synthetase
- GTP-GTP guanylyltransferase
- Gp4G synthetase
- guanosine triphosphate-guanose triphosphate guanylyltransferase


entry: 2.7.7.46
sysname: NTP:gentamicin 2"-nucleotidyltransferase
reaction: nucleoside triphosphate + gentamicin = diphosphate + 2"-nucleotidylgentamicin [RN:R02432]
iubmb_reaction: R02432
name:
--- 
- gentamicin 2"-nucleotidyltransferase
- gentamicin 2"-adenylyltransferase
- aminoglycoside adenylyltransferase
- gentamycin 2"-nucleotidyltransferase

comment:
ATP, dATP, CTP, ITP and GTP can act as donors; kanamycin, tobramycin and sisomicin can also act as acceptors. The nucleotidyl residue is transferred to the 2-hydroxy of the 3-amino-3-deoxy-D-glucose moiety in the antibiotic.


entry: 2.7.7.47
sysname: ATP:streptomycin 3"-adenylyltransferase
comment: Also acts on spectinomycin.
reaction: ATP + streptomycin = diphosphate + 3"-adenylylstreptomycin [RN:R02226]
iubmb_reaction: R02226
name:
--- 
- streptomycin 3"-adenylyltransferase
- streptomycin adenylate synthetase
- streptomycin adenyltransferase
- streptomycin adenylylase
- streptomycin adenylyltransferase
- streptomycin-spectinomycin adenylyltransferase
- AAD (3")
- aminoglycoside 3"-adenylyltransferase


entry: 2.7.7.48
sysname: nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)
reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1) [RN:R00444]
iubmb_reaction: R00444 > R00435
name:
--- 
- RNA-directed RNA polymerase
- RNA nucleotidyltransferase (RNA-directed)
- RNA-dependent ribonucleate nucleotidyltransferase
- 3D polymerase
- PB1 proteins
- PB2 proteins
- phage f2 replicase
- polymerase L
- Q-beta replicase
- ribonucleic acid replicase
- ribonucleic acid-dependent ribonucleate nucleotidyltransferase
- ribonucleic acid-dependent ribonucleic acid polymerase
- ribonucleic replicase
- ribonucleic synthetase
- RNA replicase
- RNA synthetase
- RNA transcriptase
- RDRP
- RNA-dependent RNA polymerase
- RNA-dependent RNA replicase
- transcriptase

comment:
Catalyses RNA-template-directed extension of the 3'- end of an RNA strand by one nucleotide at a time. Can initiate a chain de novo. See also EC 2.7.7.6 DNA-directed RNA polymerase.


entry: 2.7.7.49
sysname: deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed)
reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1) [RN:R00379]
iubmb_reaction: R00379
name:
--- 
- RNA-directed DNA polymerase
- DNA nucleotidyltransferase (RNA-directed)
- reverse transcriptase
- revertase
- RNA-dependent deoxyribonucleate nucleotidyltransferase
- RNA revertase
- RNA-dependent DNA polymerase
- RNA-instructed DNA polymerase
- RT

comment:
Catalyses RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. Cannot initiate a chain de novo. Requires an RNA or DNA primer. DNA can also serve as template. See also EC 2.7.7.7 DNA-directed DNA polymerase.


entry: 2.7.7.50
sysname: GTP:mRNA guanylyltransferase
iubmb_reaction: R03828
name:
--- 
- mRNA guanylyltransferase
- mRNA capping enzyme
- messenger RNA guanylyltransferase
- Protein lambda2

comment:
The enzyme can also modify synthetic poly(A) and poly(G) to form the structures m7G(5')pppAn and m7G(5')pppGn.

reaction:
GTP + (5')ppPur-mRNA = diphosphate + G(5')pppPur-mRNA (mRNA containing a guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue) [RN:R03828]


entry: 2.7.7.51
sysname: adenylyl-sulfate:ammonia adenylyltransferase
reaction: adenylyl sulfate + NH3 = adenosine 5'-phosphoramidate + sulfate [RN:R01619]
iubmb_reaction: R01619
name:
--- 
- adenylylsulfate-ammonia adenylyltransferase
- APSAT
- adenylylsulfate:ammonia adenylyltransferase


entry: 2.7.7.52
name: --- - RNA uridylyltransferase - terminal uridylyltransferase - TUT
sysname: UTP:RNA uridylyltransferase
reaction: UTP + RNA(n) = diphosphate + RNA(n+1) [RN:R00443]
iubmb_reaction: R00443
comment:
The enzyme requires an oligoribonucleotide or polyribonucleotide with a free terminal 3'-OH as a primer.


entry: 2.7.7.53
sysname: ADP:ATP adenylyltransferase
comment: GTP and adenosine tetraphosphate can also act as adenylyl acceptors.
reaction: ADP + ATP = phosphate + P1,P4-bis(5'-adenosyl) tetraphosphate [RN:R00126]
iubmb_reaction: R00126
kegg_reaction: R01618
name:
--- 
- ATP adenylyltransferase
- bis(5'-nucleosyl)-tetraphosphate phosphorylase (NDP-forming)
- diadenosinetetraphosphate alpha,beta-phosphorylase
- adenine triphosphate adenylyltransferase
- diadenosine 5',5'"-P1,P4-tetraphosphate alpha,beta-phosphorylase (ADP-forming)
- dinucleoside oligophosphate alpha,beta-phosphorylase


entry: 2.7.7.56
name: --- - tRNA nucleotidyltransferase - phosphate-dependent exonuclease - RNase PH - ribonuclease PH
sysname: tRNA:phosphate nucleotidyltransferase
reaction: tRNA(n+1) + phosphate = tRNA(n) + a nucleoside diphosphate [RN:R07285]
iubmb_reaction: R07285
comment:
Brings about the final exonucleolytic trimming of the 3'-terminus of tRNA precursors in Escherichia coli by a phosphorolysis, producing a mature 3'-terminus on tRNA and nucleoside diphosphate. Not identical with EC 2.7.7.8 polyribonucleotide nucleotidyltransferase.


entry: 2.7.7.57
sysname: CTP:N-methylethanolamine-phosphate cytidylyltransferase
reaction: CTP + N-methylethanolamine phosphate = diphosphate + CDP-N-methylethanolamine [RN:R03375]
iubmb_reaction: R03375
name:
--- 
- N-methylphosphoethanolamine cytidylyltransferase
- monomethylethanolamine phosphate cytidylyltransferase
- CTP:P-MEA cytidylyltransferase


entry: 2.7.7.59
name: --- - "[protein-PII] uridylyltransferase" - PII uridylyl-transferase - uridyl removing enzyme
sysname: UTP:[protein-PII] uridylyltransferase
reaction: UTP + [protein-PII] = diphosphate + uridylyl-[protein-PII] [RN:R04733]
iubmb_reaction: R04733
comment:
the enzyme uridylylates and de-uridylylates the small trimeric protein PII. The enzymes from Escherichia coli and Salmonella typhimurium have been wrongly identified, in some databases, as EC 2.7.7.12 (UDP-glucose-hexose-1-phosphate uridylyltransferase), from which it differs greatly in both reaction catalysed and sequence.


entry: 2.7.7.60
name: --- - 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase - MEP cytidylyltransferase
sysname: CTP:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
iubmb_reaction: R05633
reaction:
CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol [RN:R05633]


entry: 2.7.7.61
sysname: 2'-(5"-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase adenylyltransferase
reaction: 2'-(5"-triphosphoribosyl)-3'-dephospho-CoA + apo-citrate lyase = holo-citrate lyase + diphosphate
name:
--- 
- holo-ACP synthase
- 2'-(5"-phosphoribosyl)-3'-dephospho-CoA transferase
- 2'-(5"-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase
- CitX

comment:
Requires Mg2+. The enzyme from Escherichia coli can also use ATP, CTP, GTP and UTP as a substrate in vitro. The corresponding mononucleotides are transferred to serine-14 of the acyl carrier protein of citrate lyase with release of diphosphate; the linkage to serine is via a phosphodiester bond.


entry: 2.7.7.62
sysname: GTP:adenosylcobinamide-phosphate guanylyltransferase
reaction: GTP + adenosylcobinamide phosphate = diphosphate + adenosylcobinamide-GDP [RN:R05222]
iubmb_reaction: R05222
name:
--- 
- adenosylcobinamide-phosphate guanylyltransferase
- CobU
- adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase
- AdoCbi kinase/AdoCbi-phosphate guanylyltransferase

comment:
In Salmonella typhimurium LT2, under anaerobic conditions, CobU (EC 2.7.7.62 and EC 2.7.1.156), CobT (EC 2.4.2.21), CobC (EC 3.1.3.73) and CobS (EC 2.7.8.26) catalyse reactions in the nucleotide loop assembly pathway, which convert adenosylcobinamide (AdoCbi) into adenosylcobalamin (AdoCbl). CobT and CobC are involved in 5,6-dimethylbenzimidazole activation whereby 5,6-dimethylbenzimidazole is converted to its riboside, alpha-ribazole. The second branch of the nuclotide loop assembly pathway is the cobinamide (Cbi) activation branch where AdoCbi or adenosylcobinamide-phosphate is converted to the activated intermediate AdoCbi-GDP by the bifunctional enzyme Cob U. The final step in adenosylcobalamin biosynthesis is the condensation of AdoCbi-GDP with alpha-ribazole, which is catalysed by EC 2.7.8.26, cobalamin synthase (CobS), to yield adenosylcobalamin. CobU is a bifunctional enzyme that has both kinase (EC 2.7.1.156) and guanylyltransferase (EC 2.7.7.62) activities. However, both activities are not required at all times. The kinase activity has been proposed to function only when S. typhimurium is assimilating cobinamide whereas the guanylyltransferase activity is required for both assimilation of exogenous cobinamide and for de novo synthesis of adenosylcobalamin [4]. The guanylyltransferase reaction is a two-stage reaction with formation of a CobU-GMP intermediate [1]. Guanylylation takes place at histidine-46.


entry: 2.7.7.63
sysname: ATP:lipoate adenylyltransferase
name:
--- 
- lipoate-protein ligase
- LplA
- lipoate protein ligase
- lipoate-protein ligase A
- LPL
- LPL-B

comment:
Requires Mg2+. Selenolipoate and 6-thio-octanoate can also act as substrates, but more slowly [2]. Both D- and L-lipoate can act as a substrate but there is a preference for the naturally occurring D-form. The lipoyl cofactor is essential for the function of several key enzymes involved in oxidative metabolism, including pyruvate dehydrogenase (E2 domain), 2-oxoglutarate dehydrogenase (E2 domain), the branched-chain 2-oxoacid dehydrogenases and the glycine cleavage system (H protein) [6]. This enzyme attaches lipoic acid to the lipoyl domains of these proteins. The remaining steps in the production of lipoyl cofactor involve EC 2.3.1.181, lipoyl(octanoyl) transferase and EC 2.8.1.8, lipoyl synthase.

reaction:
(1) ATP + lipoate = diphosphate + lipoyl-AMP; (2) lipoyl-AMP + protein = protein N6-(lipoyl)lysine + AMP


entry: 2.7.8.1
sysname: CDP-ethanolamine:1,2-diacylglycerol ethanolaminephosphotransferase
reaction: CDP-ethanolamine + 1,2-diacylglycerol = CMP + a phosphatidylethanolamine [RN:R02057]
iubmb_reaction: R02057
kegg_reaction: R04920 R06364 R07384
name:
--- 
- ethanolaminephosphotransferase
- EPT
- diacylglycerol ethanolaminephosphotransferase
- CDPethanolamine diglyceride phosphotransferase
- phosphorylethanolamine-glyceride transferase


entry: 2.7.8.2
sysname: CDP choline:1,2-diacylglycerol cholinephosphotransferase
reaction: CDP-choline + 1,2-diacylglycerol = CMP + a phosphatidylcholine [RN:R01321]
iubmb_reaction: R01321
kegg_reaction: R04321 R04922 R07389
name:
--- 
- diacylglycerol cholinephosphotransferase
- phosphorylcholine-glyceride transferase
- alkylacylglycerol cholinephosphotransferase
- 1-alkyl-2-acetylglycerol cholinephosphotransferase
- cholinephosphotransferase
- CPT
- alkylacylglycerol choline phosphotransferase
- diacylglycerol choline phosphotransferase
- 1-alkyl-2-acetyl-m-glycerol:CDPcholine choline phosphotransferase
- CDP-choline diglyceride phosphotransferase
- cytidine diphosphocholine glyceride transferase
- cytidine diphosphorylcholine diglyceride transferase
- phosphocholine diacylglyceroltransferase
- sn-1,2-diacylglycerol cholinephosphotransferase
- 1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase

comment:
1-Alkyl-2-acylglycerol can act as acceptor; this activity was previously listed as EC 2.7.8.16, 1-alkyl-2-acylglycerol choline phosphotransferase.


entry: 2.7.8.4
sysname: CDP-ethanolamine:L-serine ethanolamine phosphotransferase
reaction: CDP-ethanolamine + L-serine = CMP + L-serine-phosphoethanolamine [RN:R02563]
iubmb_reaction: R02563
name:
--- 
- serine-phosphoethanolamine synthase
- serine ethanolamine phosphate synthetase
- serine ethanolamine phosphodiester synthase
- serine ethanolaminephosphotransferase
- serine-phosphinico-ethanolamine synthase
- serinephosphoethanolamine synthase


entry: 2.7.8.5
sysname: CDP-diacylglycerol:sn-glycerol-3-phosphate 3-phosphatidyltransferase
iubmb_reaction: R01801
name:
--- 
- CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
- glycerophosphate phosphatidyltransferase
- 3-phosphatidyl-1'-glycerol-3'-phosphate synthase
- CDPdiacylglycerol:glycerol-3-phosphate phosphatidyltransferase
- cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):sn-glycerol-3-phosphate phosphatidyltransferase
- phosphatidylglycerophosphate synthase
- phosphatidylglycerolphosphate synthase
- PGP synthase
- CDPdiacylglycerol-sn-glycerol-3-phosphate 3-phosphatidyltransferase
- CDPdiacylglycerol:sn-glycero-3-phosphate phosphatidyltransferase
- glycerol phosphate phosphatidyltransferase
- glycerol 3-phosphate phosphatidyltransferase
- phosphatidylglycerol phosphate synthase
- phosphatidylglycerol phosphate synthetase
- phosphatidylglycerophosphate synthetase
- sn-glycerol-3-phosphate phosphatidyltransferase

reaction:
CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate [RN:R01801]


entry: 2.7.8.6
sysname: UDP-galactose:undecaprenyl-phosphate galactose phosphotransferase
reaction: UDP-galactose + undecaprenyl phosphate = UMP + alpha-D-galactosyl-diphosphoundecaprenol [RN:R01535]
iubmb_reaction: R01535
name:
--- 
- undecaprenyl-phosphate galactose phosphotransferase
- poly(isoprenol)-phosphate galactose phosphotransferase
- poly(isoprenyl)phosphate galactosephosphatetransferase
- undecaprenyl phosphate galactosyl-1-phosphate transferase


entry: 2.7.8.7
sysname: CoA-[4'-phosphopantetheine]:apo-[acyl-carrier-protein] 4'-pantetheinephosphotransferase
iubmb_reaction: R01625
name:
--- 
- holo-[acyl-carrier-protein] synthase
- acyl carrier protein holoprotein (holo-ACP) synthetase
- holo-ACP synthetase
- coenzyme A:fatty acid synthetase apoenzyme 4'-phosphopantetheine transferase
- holosynthase
- acyl carrier protein synthetase
- holo-ACP synthase
- PPTase
- AcpS
- ACPS
- acyl carrier protein synthase
- P-pant transferase
- CoA:apo-[acyl-carrier-protein] pantetheinephosphotransferase

comment:
Requires Mg2+. All polyketide synthases, fatty-acid synthases and non-ribosomal peptide synthases require post-translational modification of their constituent acyl-carrier-protein (ACP) domains to become catalytically active. The inactive apo-proteins are converted into their active holo-forms by transfer of the 4'-phosphopantetheinyl moiety of CoA to the sidechain hydroxy group of a conserved serine residue in each ACP domain [3]. The enzyme from human can activate both the ACP domain of the human cytosolic multifunctional fatty acid synthase and that associated with human mitochondria as well as peptidyl-carrier and acyl-carrier-proteins from prokaryotes [6]. Removal of the 4-phosphopantetheinyl moiety from holo-ACP is carried out by EC 3.1.4.14, [acyl-carrier-protein] phosphodiesterase.

reaction:
CoA-[4'-phosphopantetheine] + apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein] [RN:R01625]


entry: 2.7.8.8
sysname: CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase
reaction: CDP-diacylglycerol + L-serine = CMP + 3-O-sn-phosphatidyl-L-serine [RN:R01800]
iubmb_reaction: R01800
name:
--- 
- CDP-diacylglycerol-serine O-phosphatidyltransferase
- phosphatidylserine synthase
- CDPdiglyceride-serine O-phosphatidyltransferase
- PS synthase
- cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase
- phosphatidylserine synthetase
- CDP-diacylglycerol-L-serine O-phosphatidyltransferase
- cytidine diphosphoglyceride-serine O-phosphatidyltransferase
- CDP-diglyceride-L-serine phosphatidyltransferase
- CDP-diglyceride:serine phosphatidyltransferase
- cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase


entry: 2.7.8.10
sysname: CDP-choline:sphingosine cholinephosphotransferase
reaction: CDP-choline + sphingosine = CMP + sphingosyl-phosphocholine [RN:R01929]
iubmb_reaction: R01929
name:
--- 
- sphingosine cholinephosphotransferase
- CDP-choline-sphingosine cholinephosphotransferase
- phosphorylcholine-sphingosine transferase
- cytidine diphosphocholine-sphingosine cholinephosphotransferase
- sphingosine choline phosphotransferase


entry: 2.7.8.11
sysname: CDP-diacylglycerol:myo-inositol 3-phosphatidyltransferase
reaction: CDP-diacylglycerol + myo-inositol = CMP + phosphatidyl-1D-myo-inositol [RN:R01802]
iubmb_reaction: R01802
name:
--- 
- CDP-diacylglycerol-inositol 3-phosphatidyltransferase
- CDP-diglyceride-inositol phosphatidyltransferase
- phosphatidylinositol synthase
- CDP-diacylglycerol-inositol phosphatidyltransferase
- CDP-diglyceride:inositol transferase
- cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:myo-inositol 3-phosphatidyltransferase
- CDP-DG:inositol transferase
- cytidine diphosphodiglyceride-inositol phosphatidyltransferase
- CDP-diacylglycerol:myo-inositol-3-phosphatidyltransferase
- CDP-diglyceride-inositol transferase
- cytidine diphosphoglyceride-inositol phosphatidyltransferase
- cytidine diphosphoglyceride-inositol transferase


entry: 2.7.8.12
sysname: CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase
reaction: CDP-glycerol + (glycerophosphate)n = CMP + (glycerophosphate)(n+1) [RN:R04042]
iubmb_reaction: R04042
name:
--- 
- CDP-glycerol glycerophosphotransferase
- teichoic-acid synthase
- cytidine diphosphoglycerol glycerophosphotransferase
- poly(glycerol phosphate) polymerase
- teichoic acid glycerol transferase
- glycerophosphate synthetase
- CGPTase


entry: 2.7.8.13
iubmb_reaction: R05629
kegg_reaction: R05628 R05630
name:
--- 
- phospho-N-acetylmuramoyl-pentapeptide-transferase
- MraY transferase
- UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala:C55-isoprenoid alcohol transferase
- UDP-MurNAc-Ala-gammaDGlu-Lys-DAla-DAla:undecaprenylphosphate transferase
- phospho-N-acetylmuramoyl pentapeptide translocase
- phospho-MurNAc-pentapeptide transferase
- phospho-NAc-muramoyl-pentapeptide translocase (UMP)
- phosphoacetylmuramoylpentapeptide translocase
- phosphoacetylmuramoylpentapeptidetransferase

sysname:
UDP-MurAc(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala):undecaprenyl-phos phate phospho-N-acetylmuramoyl-pentapeptide-transferase

reaction:
UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)- diphosphoundecaprenol [RN:R05629]


entry: 2.7.8.14
sysname: CDP-ribitol:poly(ribitol phosphate) ribitolphosphotransferase
comment: Formerly EC 2.4.1.55.
reaction: CDP-ribitol + (ribitol phosphate)n = CMP + (ribitol phosphate)(n+1) [RN:R04083 R06235]
iubmb_reaction: R04083 R06235(G)
name:
--- 
- CDP-ribitol ribitolphosphotransferase
- teichoic-acid synthase
- polyribitol phosphate synthetase
- teichoate synthetase
- poly(ribitol phosphate) synthetase
- polyribitol phosphate polymerase
- teichoate synthase


entry: 2.7.8.15
sysname: UDP-N-acetyl-D-glucosamine:dolichyl-phosphate N-acetyl-D-glucosaminephosphotransferase
iubmb_reaction: R01007 R05969(G)
name:
--- 
- UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase
- UDP-D-N-acetylglucosamine N-acetylglucosamine 1-phosphate transferase
- UDP-GlcNAc:dolichyl-phosphate GlcNAc-1-phosphate transferase
- UDP-N-acetyl-D-glucosamine:dolichol phosphate N-acetyl-D-glucosamine-1-phosphate transferase
- uridine diphosphoacetylglucosamine-dolichyl phosphate acetylglucosamine-1-phosphotransferase
- chitobiosylpyrophosphoryldolichol synthase
- dolichol phosphate N-acetylglucosamine-1-phosphotransferase
- UDP-acetylglucosamine-dolichol phosphate acetylglucosamine phosphotransferase
- UDP-acetylglucosamine-dolichol phosphate acetylglucosamine-1-phosphotransferase

reaction:
UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol [RN:R01007 R05969]


entry: 2.7.8.16
name: --- - Deleted entry
comment:
Deleted entry: 1-alkyl-2-acetylglycerol choline phosphotransferase. Now included with EC 2.7.8.2 diacylglycerol cholinephosphotransferase (EC 2.7.8.16 created 1983, deleted 1986)


entry: 2.7.8.17
sysname: UDP-N-acetyl-D-glucosamine:lysosomal-enzyme N-acetylglucosaminephosphotransferase
iubmb_reaction: R04291
name:
--- 
- UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase
- N-acetylglucosaminylphosphotransferase
- UDP-N-acetylglucosamine:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase
- UDP-GlcNAc:glycoprotein N-acetylglucosamine-1-phosphotransferase
- uridine diphosphoacetylglucosamine-lysosomal enzyme precursor acetylglucosamine-1-phosphotransferase
- uridine diphosphoacetylglucosamine-glycoprotein acetylglucosamine-1-phosphotransferase
- lysosomal enzyme precursor acetylglucosamine-1-phosphotransferase
- N-acetylglucosaminyl phosphotransferase
- UDP-acetylglucosamine:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase
- UDP-GlcNAc:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase
- UDP-N-acetylglucosamine:glycoprotein N-acetylglucosamine-1-phosphotransferase
- UDP-N-acetylglucosamine:glycoprotein N-acetylglucosaminyl-1-phosphotransferase

comment:
Some other glycoproteins with high-mannose can act as acceptors, but much more slowly than lysosomal enzymes.

reaction:
UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose = UMP + lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose [RN:R04291]


entry: 2.7.8.18
sysname: UDP-galactose:UDP-N-acetyl-D-glucosamine galactose phosphotransferase
comment: N-Acetylglucosamine end-groups in glycoproteins can also act as acceptors.
iubmb_reaction: R00504
name:
--- 
- UDP-galactose-UDP-N-acetylglucosamine galactose phosphotransferase
- uridine diphosphogalactose-uridine diphosphoacetylglucosamine galactose-1-phosphotransferase
- galactose-1-phosphotransferase
- galactosyl phosphotransferase

reaction:
UDP-galactose + UDP-N-acetyl-D-glucosamine = UMP + UDP-N-acetyl-6-(D-galactose-1-phospho)-D-glucosamine [RN:R00504]


entry: 2.7.8.19
sysname: UDP-glucose:glycoprotein-D-mannose glucosephosphotransferase
comment: Penultimate mannose residues on oligo-mannose type glycoproteins can act as acceptors.
iubmb_reaction: R04179
name:
--- 
- UDP-glucose-glycoprotein glucose phosphotransferase
- UDP-glucose:glycoprotein glucose-1-phosphotransferase
- GlcPTase
- Glc-phosphotransferase
- uridine diphosphoglucose-glycoprotein glucose-1-phosphotransferase

reaction:
UDP-glucose + glycoprotein D-mannose = UMP + glycoprotein 6-(D-glucose-1-phospho)-D-mannose [RN:R04179]


entry: 2.7.8.20
sysname: phosphatidylglycerol:membrane-derived-oligosaccharide-D-glucose glycerophosphotransferase
iubmb_reaction: R04511
kegg_reaction: R05081
name:
--- 
- phosphatidylglycerol-membrane-oligosaccharide glycerophosphotransferase
- phosphoglycerol transferase
- oligosaccharide glycerophosphotransferase
- phosphoglycerol transferase I

comment:
1,2-beta- and 1,6-beta-linked glucose residues in membrane polysaccharides and in synthetic glucosides can act as acceptors.

reaction:
phosphatidylglycerol + membrane-derived-oligosaccharide D-glucose = 1,2-diacyl-sn-glycerol + membrane-derived-oligosaccharide 6-(glycerophospho)-D-glucose [RN:R04511]


entry: 2.7.8.21
reaction: Transfer of a glycerophospho group from one membrane-derived oligosaccharide to another
name:
--- 
- membrane-oligosaccharide glycerophosphotransferase
- periplasmic phosphoglycerotransferase
- phosphoglycerol cyclase

sysname:
membrane-derived-oligosaccharide-6-(glycerophospho)-D-glucose:membra ne-derived-oligosaccharide-D-glucose glycerophosphotransferase

comment:
beta-Linked glucose residues in simple glucosides, such as gentiobiose, can act as acceptors. In the presence of low concentrations of acceptor, free cyclic 1,2-phosphoglycerol is formed.


entry: 2.7.8.22
sysname: CDP-choline:1-alkenyl-2-acylglycerol cholinephosphotransferase
reaction: CDP-choline + 1-alkenyl-2-acylglycerol = CMP + plasmenylcholine [RN:R03110]
iubmb_reaction: R03110
name:
--- 
- 1-alkenyl-2-acylglycerol choline phosphotransferase
- CDP-choline-1-alkenyl-2-acyl-glycerol phosphocholinetransferase


entry: 2.7.8.23
name: --- - carboxyvinyl-carboxyphosphonate phosphorylmutase
sysname: 1-carboxyvinyl carboxyphosphonate phosphorylmutase (decarboxylating)
reaction: 1-carboxyvinyl carboxyphosphonate = 3-(hydrohydroxyphosphoryl)pyruvate + CO2 [RN:R05165]
iubmb_reaction: R05165
comment:
catalyses the transfer and decarboxylation of the carboxy(hydroxy)phosphoryl group, HOOC-P(O)(OH)- (phosphoryl being a 3-valent group), in the formation of an unusual C-P bond that is involved in the biosynthesis of the antibiotic bialaphos.


entry: 2.7.8.25
sysname: ATP:3-dephospho-CoA 5"-triphosphoribosyltransferase
reaction: ATP + 3-dephospho-CoA = 2'-(5"-triphosphoribosyl)-3'-dephospho-CoA + adenine
name:
--- 
- triphosphoribosyl-dephospho-CoA synthase
- 2'-(5"-triphosphoribosyl)-3-dephospho-CoA synthase
- ATP:dephospho-CoA 5-triphosphoribosyl transferase
- CitG

comment:
ATP cannot be replaced by GTP, CTP, UTP, ADP or AMP. 2'-(5"-Triphosphoribosyl)-3'-dephospho-CoA is the precursor of the phosphoribosyl-3-dephospho-CoA prosthetic group of the acyl carrier protein subunit of EC 4.1.3.6, citrate (pro-3S) lyase.


entry: 2.7.8.26
sysname: adenosylcobinamide-GDP:alpha-ribazole ribazoletransferase
reaction: adenosylcobinamide-GDP + alpha-ribazole = GMP + adenosylcobalamin [RN:R05223]
iubmb_reaction: R05223
name:
--- 
- adenosylcobinamide-GDP ribazoletransferase
- CobS
- cobalamin synthase
- cobalamin-5'-phosphate synthase
- cobalamin (5'-phosphate) synthase

comment:
In Salmonella typhimurium LT2, under anaerobic conditions, CobU (EC 2.7.7.62 and EC 2.7.1.156), CobT (EC 2.4.2.21), CobC (EC 3.1.3.73) and CobS (EC 2.7.8.26) catalyse reactions in the nucleotide loop assembly pathway, which convert adenosylcobinamide (AdoCbi) into adenosylcobalamin (AdoCbl). CobT and CobC are involved in 5,6-dimethylbenzimidazole activation whereby 5,6-dimethylbenzimidazole is converted to its riboside, alpha-ribazole. The second branch of the nuclotide loop assembly pathway is the cobinamide activation branch where AdoCbi or adenosylcobinamide-phosphate is converted to the activated intermediate AdoCbi-GDP by the bifunctional enzyme Cob U. CobS catalyses the final step in adenosylcobalamin biosynthesis, which is the condensation of AdoCbi-GDP with alpha-ribazole to yield adenosylcobalamin.


entry: 2.7.8.-
name: --- []
reaction:
(1) CDP-ethanolamine + N-Acylsphingosine <=> CMP + Ceramide phosphoethanolamine [RN:R01503]; (2) Phosphatidylglycerol + CDP-diacylglycerol <=> Cardiolipin + CMP [RN:R02030]; (3) CMP-2-aminoethylphosphonate + N-Acylsphingosine <=> Ceramide 2-aminoethylphosphonate + CMP [RN:R04921]; (4) 2 Phosphatidylglycerol <=> Cardiolipin + Glycerol [RN:R07390]


entry: 2.7.9.1
sysname: ATP:pyruvate, phosphate phosphotransferase
reaction: ATP + pyruvate + phosphate = AMP + phosphoenolpyruvate + diphosphate [RN:R00206]
iubmb_reaction: R00206
name:
--- 
- pyruvate, phosphate dikinase
- pyruvate, orthophosphate dikinase
- pyruvate-phosphate dikinase (phosphorylating)
- pyruvate-inorganic phosphate dikinase
- pyruvate-phosphate dikinase
- pyruvate-phosphate ligase
- pyruvic-phosphate dikinase
- pyruvic-phosphate ligase
- pyruvate, P(i) dikinase
- PPDK


entry: 2.7.9.2
sysname: ATP:pyruvate, water phosphotransferase
comment: A manganese protein.
reaction: ATP + pyruvate + H2O = AMP + phosphoenolpyruvate + phosphate [RN:R00199]
iubmb_reaction: R00199
name:
--- 
- pyruvate, water dikinase
- phosphoenolpyruvate synthase
- pyruvate-water dikinase (phosphorylating)
- PEP synthetase
- phoephoenolpyruvate synthetase
- phosphoenolpyruvic synthase
- phosphopyruvate synthetase


entry: 2.7.9.4
name: --- - alpha-glucan, water dikinase - starch-related R1 protein, GWD
sysname: ATP:alpha-glucan, water phosphotransferase
reaction: ATP + alpha-glucan + H2O = AMP + phospho-alpha-glucan + phosphate
comment:
Requires Mg2+. ATP appears to be the only phosphate donor. No activity could be detected using GTP, UTP, phosphoenolpyruvate or diphosphate [1]. The protein phosphorylates glucans exclusively at the O-6 position of glucosyl residues [2]. The protein phosphorylates itself with the beta-phosphate of ATP, which is then transferred to the glucan [1].


entry: 2.7.9.5
name: --- - phosphoglucan, water dikinase - PWD - OK1
sysname: ATP:phospho-alpha-glucan, water phosphotransferase
reaction: ATP + [phospho-alpha-glucan] + H2O = AMP + O-phospho-[phospho-alpha-glucan] + phosphate
comment:
The enzyme phosphorylates granular starch that has previously been phosphorylated by EC 2.7.9.4, alpha-glucan, water dikinase; there is no activity with unphosphorylated glucans. It transfers the beta-phosphate of ATP to the phosphoglucan, whereas the gamma-phosphate is transferred to water [1]. In contrast to EC 2.7.9.4, which phosphorylates the glucose groups in glucans predominantly on the O-6 position, this enzyme phosphorylates glucose groups in phosphorylated starch predominantly on O-3 [2]. The protein phosphorylates itself with the beta-phosphate of ATP, which is then transferred to the glucan [1].


entry: 2.7.10.1
sysname: ATP:[protein]-L-tyrosine O-phosphotransferase (receptor-type)
reaction: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate [RN:R02584]
iubmb_reaction: R02584
name:
--- 
- receptor protein-tyrosine kinase
- AATK
- AATYK
- AATYK2
- AATYK3
- ACH
- ALK
- anaplastic lymphoma kinase
- ARK
- ATP:protein-tyrosine O-phosphotransferase (ambiguous)
- AXL
- Bek
- Bfgfr
- BRT
- Bsk
- C-FMS
- CAK
- CCK4
- CD115
- CD135
- CDw135
- Cek1
- Cek10
- Cek11
- Cek2
- Cek3
- Cek5
- Cek6
- Cek7
- CFD1
- CKIT
- CSF1R
- DAlk
- DDR1
- DDR2
- Dek
- DKFZp434C1418
- Drosophila Eph kinase
- DRT
- DTK
- Ebk
- ECK
- EDDR1
- Eek
- EGFR
- Ehk2
- Ehk3
- Elk
- EPH
- EPHA1
- EPHA2
- EPHA6
- EPHA7
- EPHA8
- EPHB1
- EPHB2
- EPHB3
- EPHB4
- EphB5
- ephrin-B3 receptor tyrosine kinase
- EPHT
- EPHT2
- EPHT3
- EPHX
- ERBB
- ERBB1
- ERBB2
- ERBB3
- ERBB4
- ERK
- Eyk
- FGFR1
- FGFR2
- FGFR3
- FGFR4
- FLG
- FLK1
- FLK2
- FLT1
- FLT2
- FLT3
- FLT4
- FMS
- Fv2
- HBGFR
- HEK11
- HEK2
- HEK3
- HEK5
- HEK6
- HEP
- HER2
- HER3
- HER4
- HGFR
- HSCR1
- HTK
- IGF1R
- INSR
- INSRR
- insulin receptor protein-tyrosine kinase
- IR
- IRR
- JTK12
- JTK13
- JTK14
- JWS
- K-SAM
- KDR
- KGFR
- KIA0641
- KIAA1079
- KIAA1459
- Kil
- Kin15
- Kin16
- KIT
- KLG
- LTK
- MCF3
- Mdk1
- Mdk2
- Mdk5
- MEhk1
- MEN2A/B
- Mep
- MER
- MERTK
- MET
- Mlk1
- Mlk2
- Mrk
- MST1R
- MTC1
- MUSK
- Myk1
- N-SAM
- NEP
- NET
- Neu
- neurite outgrowth regulating kinase
- NGL
- NOK
- nork
- novel oncogene with kinase-domain
- Nsk2
- NTRK1
- NTRK2
- NTRK3
- NTRK4
- NTRKR1
- NTRKR2
- NTRKR3
- Nuk
- NYK
- PCL
- PDGFR
- PDGFRA
- PDGFRB
- PHB6
- protein-tyrosine kinase (ambiguous)
- protein tyrosine kinase (ambiguous)
- PTK
- PTK3
- PTK7
- receptor protein tyrosine kinase
- RET
- RON
- ROR1
- ROR2
- ROS1
- RSE
- RTK
- RYK
- SEA
- Sek2
- Sek3
- Sek4
- Sfr
- SKY
- STK
- STK1
- TEK
- TIE
- TIE1
- TIE2
- TIF
- TKT
- TRK
- TRKA
- TRKB
- TRKC
- TRKE
- TYK1
- TYRO10
- Tyro11
- TYRO3
- Tyro5
- Tyro6
- TYRO7
- UFO
- VEGFR1
- VEGFR2
- VEGFR3
- Vik
- YK1
- Yrk

comment:
The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in Metazoans [1]. In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies.


entry: 2.7.10.2
sysname: ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
reaction: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate [RN:R02584]
iubmb_reaction: R02584
name:
--- 
- non-specific protein-tyrosine kinase
- ABL
- ABL1
- ABL2
- ABLL
- ACK1
- ACK2
- AGMX1
- ARG
- ATK
- ATP:protein-tyrosine O-phosphotransferase (ambiguous)
- BLK
- Bmk
- BMX
- BRK
- Bruton's tyrosine kinase
- Bsk
- BTK
- BTKL
- CAKb
- Cdgip
- CHK
- CSK
- CTK
- CYL
- cytoplasmic protein tyrosine kinase
- EMT
- ETK
- Fadk
- FAK
- FAK2
- FER
- Fert1/2
- FES
- FGR
- focal adhesion kinase
- FPS
- FRK
- FYN
- HCK
- HCTK
- HYL
- IMD1
- ITK
- IYK
- JAK1
- JAK2
- JAK3
- Janus kinase 1
- Janus kinase 2
- Janus kinase 3
- JTK1
- JTK9
- L-JAK
- LCK
- LSK
- LYN
- MATK
- Ntk
- p60c-src protein tyrosine kinase
- PKB
- protein-tyrosine kinase (ambiguous)
- PSCTK
- PSCTK1
- PSCTK2
- PSCTK4
- PSCTK5
- PTK2
- PTK2B
- PTK6
- PYK2
- RAFTK
- RAK
- Rlk
- Sik
- SLK
- SRC
- SRC2
- SRK
- SRM
- SRMS
- STD
- SYK
- SYN
- Tck
- TEC
- TNK1
- Tsk
- TXK
- TYK2
- TYK3
- YES1
- YK2
- ZAP70

comment:
Unlike EC 2.7.10.1, receptor protein-tyrosine kinase, this protein-tyrosine kinase does not have a transmembrane domain. In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into ten families [1].


entry: 2.7.11.1
sysname: ATP:protein phosphotransferase (non-specific)
reaction: ATP + a protein = ADP + a phosphoprotein [RN:R00162]
iubmb_reaction: R00162
kegg_reaction: R03632
name:
--- 
- non-specific serine/threonine protein kinase
- A-kinase
- AP50 kinase
- ATP-protein transphosphorylase
- calcium-dependent protein kinase C
- calcium/phospholipid-dependent protein kinase
- cAMP-dependent protein kinase
- cAMP-dependent protein kinase A
- casein kinase
- casein kinase (phosphorylating)
- casein kinase 2
- casein kinase I
- casein kinase II
- cGMP-dependent protein kinase
- CK-2
- CKI
- CKII
- cyclic AMP-dependent protein kinase
- cyclic AMP-dependent protein kinase A
- cyclic monophosphate-dependent protein kinase
- cyclic nucleotide-dependent protein kinase
- cyclin-dependent kinase
- cytidine 3',5'-cyclic monophosphate-responsive protein kinase
- dsk1
- glycogen synthase a kinase
- glycogen synthase kinase
- HIPK2
- Hpr kinase
- hydroxyalkyl-protein kinase
- M phase-specific cdc2 kinase
- mitogen-activated S6 kinase
- p82 kinase
- phosphorylase b kinase kinase
- PKA
- protein glutamyl kinase
- protein kinase (phosphorylating)
- protein kinase A
- protein kinase CK2
- protein kinase p58
- protein phosphokinase
- protein serine kinase
- protein serine-threonine kinase
- protein-aspartyl kinase
- protein-cysteine kinase
- protein-serine kinase
- Prp4 protein kinase
- Raf kinase
- Raf-1
- ribosomal protein S6 kinase II
- ribosomal S6 protein kinase
- serine kinase
- serine protein kinase
- serine-specific protein kinase
- serine(threonine) protein kinase
- serine/threonine protein kinase
- STK32
- T-antigen kinase
- threonine-specific protein kinase
- twitchin kinase
- type-2 casein kinase
- betaIIPKC
- epsilon PKC
- Wee 1-like kinase
- Wee-kinase
- WEE1Hu

comment:
This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analysed to date.


entry: 2.7.11.2
sysname: ATP:[pyruvate dehydrogenase (acetyl-transferring)] phosphotransferase
iubmb_reaction: R03449
name:
--- 
- "[pyruvate dehydrogenase (acetyl-transferring)] kinase"
- PDH kinase
- PDHK
- PDK
- PDK1
- PDK2
- PDK3
- PDK4
- pyruvate dehydrogenase kinase
- pyruvate dehydrogenase kinase (phosphorylating)
- pyruvate dehydrogenase kinase activator protein
- STK1

comment:
The enzyme has no activating compound but is specific for its substrate. It is a mitochondrial enzyme associated with the pyruvate dehydrogenase complex in mammals. Phosphorylation inactivates EC 1.2.4.1, pyruvate dehydrogenase (acetyl-transferring).

reaction:
ATP + [pyruvate dehydrogenase (acetyl-transferring)] = ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate [RN:R03449]


